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1. 发明申请

WO2011071343A3 HETERODIMER CORE-SHELL NANOPARTICLE IN WHICH RAMAN-ACTIVE MOLECULES ARE LOCATED AT A BINDING PORTION OF A NANOPARTICLE HETERODIMER, USE THEREOF, AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：杂聚体核壳纳米颗粒，其中拉莫活性分子位于纳米颗粒异二聚体的结合部分，其用途和制备方法
公开(公告)号：WO2011071343A3
公开(公告)日：2011-10-13
申请号：PCT/KR2010008862
申请日：2010-12-10
申请人： KOREA RES INST CHEM TECH , SNU R&DB FOUNDATION , SUH YUNG DOUG , NAM JWA MIN , LIM DONG KWON , JEON KI SEOK
发明人： SUH YUNG DOUG , NAM JWA MIN , LIM DONG KWON , JEON KI SEOK
IPC分类号： B82B1/00 , B82B3/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/54373 , C12Q1/6816 , C12Q1/6834 , C12Q2563/107 , C12Q2563/155 , C12Q2565/628 , G01N33/54346 , C12Q2565/632 , C12Q2563/143 , C12Q2537/125
摘要： The present invention relates to a nanoparticle heterodimer in which Raman-active molecules are located at a binding portion of the nanoparticle heterodimer, and more particularly, to a core-shell nanoparticle heterodimer comprising: a gold or silver core having a surface to which oligonucleotides are bonded; and a gold or silver shell covering the core. In addition, the present invention relates to the core-shell nanoparticle heterodimer, to a method for preparing same, and to the use thereof.
摘要翻译：本发明涉及其中拉曼活性分子位于纳米颗粒异二聚体的结合部分的纳米颗粒异二聚体，并且更具体地涉及包含以下的核 - 壳纳米颗粒异二聚体：具有表面的金或银核心，寡核苷酸为键合; 和覆盖核心的金或银壳。另外，本发明涉及核 - 壳纳米粒子异二聚体，其制备方法，及其用途。

2. 发明申请

WO2005003394A2 BIO-BARCODE BASED DETECTION OF TARGET ANALYTES 审中-公开
标题翻译：基于生物条码的基于目标分析的检测
公开(公告)号：WO2005003394A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/020493
申请日：2004-06-25
申请人： NANOSPHERE, INC. , MIRKIN, Chad, A. , NAM, Jwa-Min , THAXTON, Shad, C.
发明人： MIRKIN, Chad, A. , NAM, Jwa-Min , THAXTON, Shad, C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6804 , C12Q1/682 , C12Q1/6834 , C12Q2565/113 , C12Q2563/179 , C12Q2565/501 , C12Q2563/155 , C12Q2563/149 , C12Q2563/143 , C12Q2531/113
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及筛选方法，组合物和试剂盒，用于检测一种或多种目标分析物的存在或不存在，例如，生物分子，在样品中。特别地，本发明涉及利用报道寡核苷酸作为生化条形码来检测溶液中的多种蛋白质结构或其他目标分析物的方法。

3. 发明申请

WO2004083377A3 MICROORGANISM-TEMPLATED NANOPARTICLE ASSEMBLY 审中-公开
公开(公告)号：WO2004083377A3
公开(公告)日：2004-09-30
申请号：PCT/US2003/025998
申请日：2003-08-18
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , LI, Zhi , NAM, Jwa-Min
发明人： MIRKIN, Chad, A. , LI, Zhi , NAM, Jwa-Min
IPC分类号： C12N1/14
摘要： The present invention provides a method of using microorganisms as templates to massively organize nanometer-sized “bricks” into ordered micro-structures, and eventually to functional macro-materials. The method is used to construct nanoparticles into size and shape controllable micrometer-structures using rod or sphere shaped microorganisms as templates. This bio-templating strategy is applicable to contruct micrometer-structures and materials by using magnetic, semiconductive, and noble nanoparticles with or without the help of biological engineering techniques.

4. 发明申请

WO2007084962A2 A FLUID MEMBRANE-BASED LIGAND DISPLAY SYSTEM FOR LIVE CELL ASSAYS AND DISEASE DIAGNOSIS APPLICATIONS 审中-公开
标题翻译：用于活细胞测定和疾病诊断应用的基于流体膜的配体显示系统
公开(公告)号：WO2007084962A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/060721
申请日：2007-01-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NAM, Jwa-Min , NAIR, Pradeep, M. , NEVE, Richard, M. , GRAY, Joe, W. , GROVES, John, T.
发明人： NAM, Jwa-Min , NAIR, Pradeep, M. , NEVE, Richard, M. , GRAY, Joe, W. , GROVES, John, T.
IPC分类号： G01N33/53
CPC分类号： G01N33/554
摘要： A supported membrane based, strategy for the presentation of soluble signaling molecules to living cells is described. In this system, the fluidity of the supported membrane enables localized enrichment of ligand density in a configuration reflecting cognate receptor distribution on the cell surface. Display of a ligand in non-fluid supported membranes produces significantly less cell adhesion and spreading, thus demonstrating that this technique provides a means to control functional soluble ligand exposure in a surface array format. Furthermore, this technique can be applied to tether natively membrane-bound signaling molecules such as ephrin Al to a supported lipid bilayer. Such a surface can modulate the spreading behavior of metastatic human breast cancer cells displaying ligands and biomolecules of choice. The SLB microenvironment provides a versatile platform that can be tailored to controllably and functionally present a multitude of cell signaling events in a parallel surface array format.
摘要翻译：描述了一种用于向活细胞呈递可溶性信号分子的支持膜的策略。在该系统中，支持的膜的流动性使得能够在反映细胞表面上的同源受体分布的构型中局部富集配体密度。在非流体支持的膜中显示配体产生显着更少的细胞粘附和扩散，因此证明该技术提供了以表面阵列形式控制功能性可溶性配体暴露的方法。此外，这种技术可以应用于系统地将膜结合的信号分子例如ephrin A1应用于支持的脂质双层。这种表面可以调节显示配体和选择的生物分子的转移性人乳腺癌细胞的扩散行为。 SLB微环境提供了一个通用平台，可以进行调整，以便可控地和功能地呈现并行表面阵列格式的多个单元信令事件。

5. 发明申请

WO2006078289A3 BIO-BARCODE BASED DETECTION OF TARGET ANALYTES 审中-公开
标题翻译：基于BIO-BARCODE的目标分析检测
公开(公告)号：WO2006078289A3
公开(公告)日：2007-02-08
申请号：PCT/US2005016545
申请日：2005-05-12
申请人： NANOSPHERE INC , MIRKIN CHAD A , NAM JWA-MIN , OH BYUNG-KEUN , THAXTON C SHAD , GEORGANOPOULOU DIMITRA
发明人： MIRKIN CHAD A , NAM JWA-MIN , OH BYUNG-KEUN , THAXTON C SHAD , GEORGANOPOULOU DIMITRA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2563/107 , C12Q2563/155 , C12Q2563/179 , C12Q2565/113
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，生物分子。特别地，本发明涉及利用报告寡核苷酸作为检测多种蛋白质结构或溶液中其它目标分析物的生化条形码的方法。

6. 发明申请

WO2005003394A3 BIO-BARCODE BASED DETECTION OF TARGET ANALYTES 审中-公开
标题翻译：基于BIO-BARCODE的目标分析检测
公开(公告)号：WO2005003394A3
公开(公告)日：2005-07-28
申请号：PCT/US2004020493
申请日：2004-06-25
申请人： NANOSPHERE INC , MIRKIN CHAD A , NAM JWA-MIN , THAXTON SHAD C
发明人： MIRKIN CHAD A , NAM JWA-MIN , THAXTON SHAD C
IPC分类号： C12Q1/68 , G01N33/543 , C07H21/00
CPC分类号： C12Q1/6816 , C12Q1/6804 , C12Q1/682 , C12Q1/6834 , C12Q2565/113 , C12Q2563/179 , C12Q2565/501 , C12Q2563/155 , C12Q2563/149 , C12Q2563/143 , C12Q2531/113
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，生物分子。特别地，本发明涉及利用报告寡核苷酸作为生化条形码来检测溶液中的多种蛋白质结构或其它目标分析物的方法。

7. 发明申请

WO2012070893A2 SINGLE NANOPARTICLE HAVING A NANOGAP BETWEEN A CORE MATERIAL AND A SHELL MATERIAL, AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：一种核材料与壳材料之间具有纳米棒的单纳米颗粒及其制造方法
公开(公告)号：WO2012070893A2
公开(公告)日：2012-05-31
申请号：PCT/KR2011009031
申请日：2011-11-24
申请人： KOREA RES INST CHEM TECH , SNU R&DB FOUNDATION , SUH YUNG DOUG , NAM JWA MIN , LIM DONG KWON , JEON KI SEOK
发明人： SUH YUNG DOUG , NAM JWA MIN , LIM DONG KWON , JEON KI SEOK
IPC分类号： G01N33/53 , A61K49/06 , G01N21/63 , G01N33/58
CPC分类号： G01N21/658 , A61K49/0002 , G01N33/54346 , G01N2021/653
摘要： The present invention relates to nanoparticles including a core and a shell surrounding the core between which a nanogap is formed, and a manufacturing method thereof, which can be usefully used for Raman analysis because they have a very high signal-amplifying effect and reproducibility by means of a plasmonic-coupling effect caused by the nanogap. Also, the present invention provides a method for detecting an analyte using the nanoparticles, and a kit for detecting an analyte containing the nanoparticles.
摘要翻译：本发明涉及纳米颗粒及其制造方法，该纳米颗粒包括芯和包围形成纳米间隙的核的壳，所述纳米间隙由于具有非常高的信号放大效果和再现性而可用于拉曼分析纳米间隙引起的等离子体耦合效应。而且，本发明提供了使用纳米颗粒检测分析物的方法以及用于检测包含纳米颗粒的分析物的试剂盒。

8. 发明申请

WO2007084192A3 A COLORIMETRIC BIO-BARCODE AMPLIFICATION ASSAY FOR ANALYTE DETECTION 审中-公开
标题翻译：用于分析物检测的彩色生物糖苷放大测定
公开(公告)号：WO2007084192A3
公开(公告)日：2009-04-30
申请号：PCT/US2006036101
申请日：2006-09-15
申请人： UNIV CALIFORNIA , NAM JWA-MIN , GROVES JOHN T
发明人： NAM JWA-MIN , GROVES JOHN T
IPC分类号： G01C3/14 , C12Q1/68
CPC分类号： G01N33/54346 , C12Q1/6804 , C12Q1/6816 , G01N21/253 , G01N21/64 , G01N21/65 , G01N21/658 , G01N33/54326 , G01N33/58 , C12Q2563/155 , C12Q2563/179
摘要： The present invention provides a method for detecting an analyte of interest via a bio-barcode assay. The present invention provides a colorimetric bio-barcode method that is capable of detecting minute concentrations of an analyte by relying on porous particles, which enable loading of a large number of barcode DNA per particle, and a metal particle-based colorimetric barcode detection method.
摘要翻译：本发明提供了一种通过生物条形码测定法检测感兴趣的分析物的方法。本发明提供了一种比色生物条形码方法，其能够通过依赖多孔颗粒来检测分析物的微量浓度，这使得能够加载大量每个颗粒的条形码DNA以及基于金属颗粒的比色条形码检测方法。

9. 发明申请

WO2007084962A3 A FLUID MEMBRANE-BASED LIGAND DISPLAY SYSTEM FOR LIVE CELL ASSAYS AND DISEASE DIAGNOSIS APPLICATIONS 审中-公开
标题翻译：用于活细胞测定和疾病诊断应用的基于流体膜的配体显示系统
公开(公告)号：WO2007084962A3
公开(公告)日：2009-02-26
申请号：PCT/US2007060721
申请日：2007-01-18
申请人： UNIV CALIFORNIA , NAM JWA-MIN , NAIR PRADEEP M , NEVE RICHARD M , GRAY JOE W , GROVES JOHN T
发明人： NAM JWA-MIN , NAIR PRADEEP M , NEVE RICHARD M , GRAY JOE W , GROVES JOHN T
IPC分类号： A61K9/127
CPC分类号： G01N33/554
摘要： A supported membrane based, strategy for the presentation of soluble signaling molecules to living cells is described. In this system, the fluidity of the supported membrane enables localized enrichment of ligand density in a configuration reflecting cognate receptor distribution on the cell surface. Display of a ligand in non-fluid supported membranes produces significantly less cell adhesion and spreading, thus demonstrating that this technique provides a means to control functional soluble ligand exposure in a surface array format. Furthermore, this technique can be applied to tether natively membrane-bound signaling molecules such as ephrin Al to a supported lipid bilayer. Such a surface can modulate the spreading behavior of metastatic human breast cancer cells displaying ligands and biomolecules of choice. The SLB microenvironment provides a versatile platform that can be tailored to controllably and functionally present a multitude of cell signaling events in a parallel surface array format.
摘要翻译：描述了一种用于向活细胞呈递可溶性信号分子的支持膜的策略。在该系统中，支持的膜的流动性使得能够在反映细胞表面上的同源受体分布的构型中局部富集配体密度。在非流体支持的膜中显示配体产生显着更少的细胞粘附和扩散，因此证明该技术提供了以表面阵列形式控制功能性可溶性配体暴露的方法。此外，这种技术可以应用于系统地将膜结合的信号分子例如ephrin A1应用于支持的脂质双层。这种表面可以调节显示配体和选择的生物分子的转移性人乳腺癌细胞的扩散行为。 SLB微环境提供了一个通用平台，可以进行调整，以便可控地和功能地呈现并行表面阵列格式的多个单元信令事件。

10. 发明申请

WO2009136741A1 NOVEL AU / AG CORE-SHELL COMPOSITE USEFUL FOR BIOSENSOR 审中-公开
标题翻译：新颖AU / AG芯壳复合材料可用于生物传感器
公开(公告)号：WO2009136741A1
公开(公告)日：2009-11-12
申请号：PCT/KR2009/002399
申请日：2009-05-07
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , NAM, Jwa-Min , LIM, Dong-Kwon , KIM, In-Jung
发明人： NAM, Jwa-Min , LIM, Dong-Kwon , KIM, In-Jung
IPC分类号： G01N33/58 , G01N21/65
CPC分类号： G01N21/658 , B82Y30/00 , G01N33/54346 , Y10T428/2991
摘要： In accordance with an aspect of the present invention, there is provided an Au/Ag core-shell composite including an Au nanoparticle; an Ag nanoparticle layer surrounding the Au nanoparticle; and a receptor having a target material recognition site bondable or reactable with a target material, wherein one end of the receptor is bonded on the surface of the Au nanoparticle, so that a portion of the receptor is embedded into the Ag nanoparticle layer, and the target material recognition site is exposed to the outside of the Ag nanoparticle layer. The Au/Ag core-shell composite can provide a stable bond between Au nanoparticle and organic molecule, and superior optical characteristics of Ag nanoparticle. Thus, a biosensor using the composite in accordance with anaspect of the present invention can effectively and efficiently detect target bio material and be variously used in medical and pharmaceutics.
摘要翻译：根据本发明的一个方面，提供一种包含Au纳米颗粒的Au / Ag核 - 壳复合材料; 围绕Au纳米颗粒的Ag纳米颗粒层; 以及具有可与靶材料结合或可与靶材料反应的靶材料识别位点的受体，其中所述受体的一端键合在所述Au纳米颗粒的表面上，使得所述受体的一部分嵌入到所述Ag纳米颗粒层中，并且靶材料识别位点暴露于Ag纳米颗粒层的外部。 Au / Ag核 - 壳复合材料可以在Au纳米颗粒和有机分子之间提供稳定的键合，并且具有优异的Ag纳米颗粒的光学特性。因此，使用根据本发明的复合材料的生物传感器可以有效且高效地检测目标生物材料，并且可以用于医疗和药物。

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