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1. 发明申请

WO2014047325A1 SGC STIMULATORS 审中-公开
标题翻译： SGC刺激者
公开(公告)号：WO2014047325A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060680
申请日：2013-09-19
申请人： IRONWOOD PHARMACEUTICALS, INC. , NAKAI, Takashi , PERL, Nicholas, Robert , MOORE, Joel
发明人： NAKAI, Takashi , PERL, Nicholas, Robert , MOORE, Joel
IPC分类号： C07D413/14 , A61K31/506 , A61P7/00 , A61P9/00 , A61P15/00
CPC分类号： A61K31/513 , A61K31/4155 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D413/14 , C07D487/04 , A61K2300/00
摘要： The present patent application discloses at least the compounds according to Formula I or Formula lb shown below, or pharmaceutically acceptable salts thereof, wherein ring B, J B , n, J D , J, o, X, R C and R A are as described herein.
摘要翻译：本专利申请公开了至少下述式I或式Ib的化合物或其药学上可接受的盐，其中环B，JB，n，JD，J，o，X，RC和RA如本文所述。

2. 发明申请

WO2013101830A1 2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS 审中-公开
标题翻译： 2 - 苄基，3-（吡咯烷-2-基）取代的吡唑可用作SGC刺激物
公开(公告)号：WO2013101830A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/071654
申请日：2012-12-26
申请人： IRONWOOD PHARMACEUTICALS, INC. , KIM, Charles , NAKAI, Takashi , MOORE, Joel , PERL, Nicholas, Robert , IM, G-yoon, Jamie , BARDEN, Timothy, Claude , IYENGAR, Rajesh, R. , ZIMMER, Daniel, P. , FRETZEN, Angelika , RENHOWE, Paul, Allan
发明人： KIM, Charles , NAKAI, Takashi , MOORE, Joel , PERL, Nicholas, Robert , IM, G-yoon, Jamie , BARDEN, Timothy, Claude , IYENGAR, Rajesh, R. , ZIMMER, Daniel, P. , FRETZEN, Angelika , RENHOWE, Paul, Allan
IPC分类号： C07D413/14 , C07D403/04 , C07D417/14 , A61K31/4155 , A61P43/00
CPC分类号： A61K31/52 , A61K31/4439 , A61K31/506 , A61K31/513 , A61K31/519 , A61K45/06 , C07D403/04 , C07D413/14 , C07D417/14 , C07D473/00 , C07D487/04 , C07D513/22
摘要： 2-Benzyl, 3 - (pyrimidin- 2 -YL) substituted pyrazoles are described. They are useful as stimulators of sGC, particularly NO - independent, heme - dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述2-苄基，3-（嘧啶-2-基）取代的吡唑。它们可用作sGC的刺激剂，特别是NO-不依赖于血红素依赖性刺激物。这些化合物可用于治疗，预防或治疗本文公开的各种疾病。

3. 发明申请

WO2011122011A2 ANTIGEN-BINDING MOLECULES THAT PROMOTE ANTIGEN CLEARANCE 审中-公开
标题翻译：促进抗原清除的抗原结合分子
公开(公告)号：WO2011122011A2
公开(公告)日：2011-10-06
申请号：PCT/JP2011/001888
申请日：2011-03-30
申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA , IGAWA, Tomoyuki , ISHII, Shinya , MAEDA, Atsuhiko , NAKAI, Takashi
发明人： IGAWA, Tomoyuki , ISHII, Shinya , MAEDA, Atsuhiko , NAKAI, Takashi
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , A61K2039/545 , C07K14/70535 , C07K16/248 , C07K16/28 , C07K16/2866 , C07K16/4241 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies.
摘要翻译：本发明的目的是提供促进抗原结合分子介导的抗原向细胞摄取的方法，促进血浆中抗原浓度降低的方法，增加单一抗原结合分子可以抗原数目的方法结合，用于改善抗原结合分子的药代动力学的方法，改进用于促进抗原摄入细胞的抗原结合分子，能够促进血浆中抗原浓度降低的抗原结合分子，能够重复结合抗原的抗原结合分子，具有改善的药代动力学的抗原结合分子，包含这种抗原结合分子的药物组合物，以及用于制备上述那些的方法。本发明人发现，通过在血浆pH下具有人FcRn结合活性的抗体和在早期内体体内的pH低于等离子体pH下抗原结合活性较低的抗体促进了对细胞的吸收; 这样的抗体可以增加单个抗体分子可以结合的抗原的数量; 可以通过施用这样的抗体来促进血浆中抗原的降低; 可以通过使用这样的抗体来改善抗体药代动力学。

4. 发明申请

WO2011115804A1 SGC STIMULATORS 审中-公开
标题翻译： SGC刺激者
公开(公告)号：WO2011115804A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/027824
申请日：2011-03-10
申请人： IRONWOOD PHARMACEUTICALS, INC. , MOORE, Joel , JIA, James , NAKAI, Takashi , KIM, Charles , LEE, Thomas, Wai-Ho , YANG, Jane
发明人： MOORE, Joel , JIA, James , NAKAI, Takashi , KIM, Charles , LEE, Thomas, Wai-Ho , YANG, Jane
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D495/04 , A61K31/53 , A61K31/506 , A61K31/4406 , A61K31/4409 , A61P9/00 , A61P13/00 , A61P15/00
CPC分类号： C07D495/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述式I化合物。它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。这些化合物可用于治疗，预防或治疗本文公开的各种疾病。

5. 发明申请

WO2016044441A1 SGC STIMULATORS 审中-公开
标题翻译： SGC刺激者
公开(公告)号：WO2016044441A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050458
申请日：2015-09-16
申请人： IRONWOOD PHARMACEUTICALS, INC. , PERL, Nicholas , NAKAI, Takashi , LEE, Thomas Wai-Ho
发明人： PERL, Nicholas , NAKAI, Takashi , LEE, Thomas Wai-Ho , RENNIE, Glen Robert , RENHOWE, Paul Allan , IYENGAR, Rajesh R.
IPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , A61K31/4985 , A61P9/10
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04
摘要： The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, Formula I' wherein ring D, ring A, ring E, ring F, J B , n, J D , J, o, R C1 , R C2 , W, J E , r, J F , s, Z 1 , Z 2 and Z 3 are as defined herein.
摘要翻译：本专利申请公开了至少下述式I'或其药学上可接受的盐，式I'的化合物，其中环D，环A，环E，环F，JB，n，JD，J，o，RC1 ，RC2，W，JE，r，JF，s，Z1，Z2和Z3如本文所定义。

6. 发明申请

WO2012003405A4 SGC STIMULATORS 审中-公开
标题翻译： SGC刺激剂
公开(公告)号：WO2012003405A4
公开(公告)日：2012-02-23
申请号：PCT/US2011042716
申请日：2011-06-30
申请人： IRONWOOD PHARMACEUTICALS INC , KIM CHARLES , NAKAI TAKASHI , WAI-HO LEE THOMAS , MOORE JOEL , PERL NICHOLAS ROBERT , ROHDE JASON , IYENGAR RAJESH R , MERMERIAN ARA
发明人： KIM CHARLES , NAKAI TAKASHI , WAI-HO LEE THOMAS , MOORE JOEL , PERL NICHOLAS ROBERT , ROHDE JASON , IYENGAR RAJESH R , MERMERIAN ARA
IPC分类号： C07D401/04 , A61K31/4155 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
摘要： Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述了式（I）的化合物。它们可用作sGC的刺激物，特别是不依赖于NO的血红素依赖性刺激物。这些化合物可用于治疗，预防或控制本文公开的各种病症。

7. 发明申请

WO2012003405A1 SGC STIMULATORS 审中-公开
标题翻译： SGC刺激者
公开(公告)号：WO2012003405A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042716
申请日：2011-06-30
申请人： IRONWOOD PHARMACEUTICALS, INC. , KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara
发明人： KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/4155
CPC分类号： C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
摘要： Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述式（I）的化合物。它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。这些化合物可用于治疗，预防或治疗本文公开的各种疾病。

8. 发明申请

WO2011100359A1 CANNABINOID AGONISTS 审中-公开
公开(公告)号：WO2011100359A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024237
申请日：2011-02-09
申请人： IRONWOOD PHARMACEUTICALS, INC. , ROHDE, Jason , PENG, Bo , NAKAI, Takashi , SPROTT, Kevin , MERMERIAN, Ara , SCHAIRER, Wayne, C.
发明人： ROHDE, Jason , PENG, Bo , NAKAI, Takashi , SPROTT, Kevin , MERMERIAN, Ara , SCHAIRER, Wayne, C.
IPC分类号： C07D491/048 , C07D495/04 , C07D519/00 , A61K31/407 , A61K31/404 , A61P37/00 , A61P29/00
CPC分类号： C07D495/04 , A61K31/404 , A61K31/407 , A61K31/424 , A61K31/429 , A61K31/437 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D491/048 , C07D513/04 , C07D519/00
摘要： The present disclosure relates to compounds useful as agonists of the cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment of various disorders, either alone or in combination therapy. The compounds of the invention have Formula (I).
摘要翻译：本公开涉及可用作大麻素受体的激动剂的化合物。本公开还提供药学上可接受的组合物，其包含本公开的化合物和使用该组合物单独或联合治疗中各种疾病的治疗方法。本发明的化合物具有式（I）。

9. 发明申请

WO2014144100A3 SGC STIMULATORS 审中-公开
标题翻译： SGC刺激者
公开(公告)号：WO2014144100A3
公开(公告)日：2014-11-06
申请号：PCT/US2014028370
申请日：2014-03-14
申请人： NAKAI TAKASHI , MOORE JOEL , PERL NICHOLAS ROBERT , IYENGAR RAJESH R , MERMERIAN ARA , IM G-YOON JAMIE , LEE THOMAS WAI-HO , HUDSON COLLEEN , RENNIE GLEN ROBERT , JIA JAMES , RENHOWE PAUL ALLEN , BARDEN TIMOTHY CLAUDE , YU XIANG Y , SHEPPECK JAMES EDWARD , IYER KARTHIK , JUNG JOON
发明人： NAKAI TAKASHI , MOORE JOEL , PERL NICHOLAS ROBERT , IYENGAR RAJESH R , MERMERIAN ARA , IM G-YOON JAMIE , LEE THOMAS WAI-HO , HUDSON COLLEEN , RENNIE GLEN ROBERT , JIA JAMES , RENHOWE PAUL ALLEN , BARDEN TIMOTHY CLAUDE , YU XIANG Y , SHEPPECK JAMES EDWARD , IYER KARTHIK , JUNG JOON
IPC分类号： C07D413/14 , A61K31/506 , A61P3/00 , A61P9/00 , A61P15/00 , A61P25/00 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
摘要： Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述了式（I'）和（I）的化合物，其可用作sGC的刺激剂，特别是NO-非依赖性血红素依赖性刺激物。这些化合物也可用于治疗，预防或治疗本文公开的各种疾病。

10. 发明申请

WO2014144100A2 SGC STIMULATORS 审中-公开
标题翻译： SGC刺激剂
公开(公告)号：WO2014144100A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028370
申请日：2014-03-14
申请人： NAKAI, Takashi , MOORE, Joel , PERL, Nicholas Robert , IYENGAR, Rajesh R. , MERMERIAN, Ara , IM, G-Yoon Jamie , LEE, Thomas Wai-Ho , HUDSON, Colleen , RENNIE, Glen Robert , JIA, James , RENHOWE, Paul Allen , BARDEN, Timothy Claude , YU, Xiang Y , SHEPPECK, James Edward , IYER, Karthik , JUNG, Joon
发明人： NAKAI, Takashi , MOORE, Joel , PERL, Nicholas Robert , IYENGAR, Rajesh R. , MERMERIAN, Ara , IM, G-Yoon Jamie , LEE, Thomas Wai-Ho , HUDSON, Colleen , RENNIE, Glen Robert , JIA, James , RENHOWE, Paul Allen , BARDEN, Timothy Claude , YU, Xiang Y , SHEPPECK, James Edward , IYER, Karthik , JUNG, Joon
IPC分类号： C07D413/14
CPC分类号： A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
摘要： Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述了式（I'）和（I）的化合物，其可用作sGC的刺激物，特别是不依赖NO的血红素依赖性刺激物。这些化合物也可用于治疗，预防或管理本文公开的各种病症。

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