会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • ANTIGEN-BINDING MOLECULES THAT PROMOTE ANTIGEN CLEARANCE
    • 促进抗原清除的抗原结合分子
    • WO2011122011A2
    • 2011-10-06
    • PCT/JP2011/001888
    • 2011-03-30
    • CHUGAI SEIYAKU KABUSHIKI KAISHAIGAWA, TomoyukiISHII, ShinyaMAEDA, AtsuhikoNAKAI, Takashi
    • IGAWA, TomoyukiISHII, ShinyaMAEDA, AtsuhikoNAKAI, Takashi
    • C07K16/00
    • C07K16/18A61K2039/505A61K2039/545C07K14/70535C07K16/248C07K16/28C07K16/2866C07K16/4241C07K2317/24C07K2317/31C07K2317/52C07K2317/71C07K2317/72C07K2317/76C07K2317/77C07K2317/92C07K2317/94C07K2319/30
    • An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies.
    • 本发明的目的是提供促进抗原结合分子介导的抗原向细胞摄取的方法,促进血浆中抗原浓度降低的方法,增加单一抗原结合分子可以抗原数目的方法 结合,用于改善抗原结合分子的药代动力学的方法,改进用于促进抗原摄入细胞的抗原结合分子,能够促进血浆中抗原浓度降低的抗原结合分子,能够重复结合抗原的抗原结合分子, 具有改善的药代动力学的抗原结合分子,包含这种抗原结合分子的药物组合物,以及用于制备上述那些的方法。 本发明人发现,通过在血浆pH下具有人FcRn结合活性的抗体和在早期内体体内的pH低于等离子体pH下抗原结合活性较低的抗体促进了对细胞的吸收; 这样的抗体可以增加单个抗体分子可以结合的抗原的数量; 可以通过施用这样的抗体来促进血浆中抗原的降低; 可以通过使用这样的抗体来改善抗体药代动力学。
    • 4. 发明申请
    • ANTIBODIES WITH MODIFIED AFFINITY TO FCRN THAT PROMOTE ANTIGEN CLEARANCE
    • 具有改良亲和力的抗体以促进抗原性清除
    • WO2011122011A3
    • 2012-01-05
    • PCT/JP2011001888
    • 2011-03-30
    • CHUGAI PHARMACEUTICAL CO LTDIGAWA TOMOYUKIISHII SHINYAMAEDA ATSUHIKONAKAI TAKASHI
    • IGAWA TOMOYUKIISHII SHINYAMAEDA ATSUHIKONAKAI TAKASHI
    • C07K16/00
    • C07K16/18A61K2039/505A61K2039/545C07K14/70535C07K16/248C07K16/28C07K16/2866C07K16/4241C07K2317/24C07K2317/31C07K2317/52C07K2317/71C07K2317/72C07K2317/76C07K2317/77C07K2317/92C07K2317/94C07K2319/30
    • An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies.
    • 本发明的目的是提供促进抗原结合分子介导的细胞吸收细胞的方法,促进血浆中抗原浓度降低的方法,增加单个抗原结合分子可以抗原数目的方法 结合,用于改善抗原结合分子的药代动力学的方法,改善促进抗原摄入细胞的抗原结合分子,能够促进血浆中抗原浓度降低的抗原结合分子,能够重复结合抗原的抗原结合分子, 具有改善的药物动力学的抗原结合分子,包含这种抗原结合分子的药物组合物,以及用于制备上述那些的方法。 本发明人发现,通过在血浆pH下具有人FcRn结合活性的抗体和在早期内体内pH下比在血浆pH下具有较低的抗原结合活性来促进对细胞的吸收; 这样的抗体可以增加单个抗体分子可以结合的抗原的数量; 可以通过施用这样的抗体来促进血浆中抗原的降低; 并且可以通过使用这样的抗体来改善抗体药代动力学。