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1. 发明申请

WO2005033698A1 BIOSENSOR 审中-公开
标题翻译：生物传感器
公开(公告)号：WO2005033698A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/030835
申请日：2004-09-21
申请人： ABBOTT LABORATORIES , PIERCE, Robin, D. , KARINKA, Shridhara, A. , NAGALE, Milind, P. , MEYER, Ross, D. , SCOTT, W., James , SANGHERA, Gurdial
发明人： PIERCE, Robin, D. , KARINKA, Shridhara, A. , NAGALE, Milind, P. , MEYER, Ross, D. , SCOTT, W., James , SANGHERA, Gurdial
IPC分类号： G01N33/487
CPC分类号： C12Q1/004
摘要： A biosensor in which at least one reagent constitutes a portion of a working electrode, a conductive track leading from a working electrode to an electrical contact associated with a working electrode, or an electrical contact associated with a working electrode. For example, the biosensor can have a mediator or an enzyme or both incorporated into the working electrode itself. Other reagents can be dispensed on the electrode itself either directly or by impregnating a matrix, such as a mesh or a membrane, with the enzyme, and then placing the impregnated mesh or membrane over the electrode. Alternatively, the biosensor can have a mediator or an enzyme or both incorporated into the conductive track leading from the working electrode to an electrical contact associated with the working electrode. In another alternative, the biosensor can have a mediator or an enzyme or both incorporated into the electrical contact associated with the working electrode itself. Furthermore, the biosensor can have a mediator or an enzyme or both incorporated into at least two of the foregoing components of the biosensor.
摘要翻译：一种生物传感器，其中至少一个试剂构成工作电极的一部分，从工作电极引导到与工作电极相关联的电接触的导电轨道或与工作电极相关联的电接触。例如，生物传感器可以具有引入工作电极本身的介体或酶或两者。其他试剂可直接分配在电极本身上，也可以通过用酶浸渍诸如网状物或膜的基质，然后将浸渍的网状物或膜放置在电极上。或者，生物传感器可以具有引入到从工作电极引导到与工作电极相关联的电接触的导电轨道中的介体或酶或两者。在另一个替代方案中，生物传感器可以具有介质或酶或两者结合到与工作电极本身相关联的电接触中。此外，生物传感器可以具有引入到生物传感器的至少两个前述组分中的介体或酶或两者。

2. 发明申请

WO2005033688A1 ELECTROCHEMICAL CELL 审中-公开
标题翻译：电化学细胞
公开(公告)号：WO2005033688A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/030834
申请日：2004-09-21
申请人： ABBOTT LABORATORIES , REID, Terence, A. , KARINKA, Shridhara, A. , NAGALE, Milind, P. , WANG, Yi , SANGHERA, Gurdial
发明人： REID, Terence, A. , KARINKA, Shridhara, A. , NAGALE, Milind, P. , WANG, Yi , SANGHERA, Gurdial
IPC分类号： G01N27/403
CPC分类号： G01N27/3272
摘要： An electrochemical cell for detection and quantification of analytes in a liquid sample, particularly a liquid sample having a small volume. In a preferred embodiment, the electrochemical cell comprises an assembly of conducting layers and insulating layers. The electrochemical cell can be formed by depositing conducting materials and insulating materials in alternating layers on an insulating substrate. It is preferred that the layer furthest from the insulating substrate be an insulating layer to minimize the damage of the conducting layers during handling of the electrochemical cell. A passage can be formed through the conducting layers and the insulating layers to expose the edges of the layers, which collectively form the wall or walls of the passage. The exposed edges of the conducting layers form the electrodes of the electrochemical cell. The electrochemical cell comprises at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode. In another embodiment, the assembly of conducting layers and insulating layers can be formed on both major surfaces of the insulating substrate. The assembly can comprise at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode.
摘要翻译：一种电化学电池，用于检测和定量液体样品中的分析物，特别是具有小体积的液体样品。在优选实施例中，电化学电池包括导电层和绝缘层的组件。电化学电池可以通过在绝缘基板上交替地沉积导电材料和绝缘材料来形成。优选地，离绝缘基板最远的层是绝缘层，以在处理电化学电池期间最小化导电层的损伤。可以通过导电层和绝缘层形成通道以暴露层的边缘，这些边缘共同形成通道的壁或壁。导电层的暴露边缘形成电化学电池的电极。电化学电池包括至少一个工作电极和至少一个其它电极，例如双用途参考/对电极。在另一个实施例中，导电层和绝缘层的组合可以形成在绝缘基板的两个主表面上。该组件可以包括至少一个工作电极和至少一个其它电极，例如双用途参考/对电极。

3. 发明申请

WO2007109090A3 PACKAGING OF MEMS DEVICES 审中-公开
标题翻译： MEMS器件的包装
公开(公告)号：WO2007109090A3
公开(公告)日：2007-12-27
申请号：PCT/US2007006535
申请日：2007-03-14
申请人： MICROCHEM CORP , JOHNSON DONALD W , NAGALE MILIND P
发明人： JOHNSON DONALD W , NAGALE MILIND P
IPC分类号： H01L21/30 , H01L21/46
CPC分类号： B81C1/00269
摘要： The present invention is directed to a process for packaging a microelectrical, micromechanical, microelectromechanical (MEMS) or microfluidic component on a substrate by forming cavities made from crosslinked photoresists on an easily removable second substrate, bonding the cavities to third substrates containing selected microdevices, then peeling off the removable second substrate.
摘要翻译：本发明涉及一种通过在易于除去的第二衬底上形成由交联的光致抗蚀剂制成的空腔，将空腔结合到含有选定的微型器件的第三衬底上来将微电子，微机械，微机电（MEMS）或微流体部件封装在衬底上的工艺，然后剥离可移除的第二基板。

4. 发明申请

WO2007109090A2 PACKAGING OF MEMS DEVICES 审中-公开
标题翻译： MEMS器件的封装
公开(公告)号：WO2007109090A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006535
申请日：2007-03-14
申请人： MICROCHEM CORP. , JOHNSON, Donald, W. , NAGALE, Milind, P.
发明人： JOHNSON, Donald, W. , NAGALE, Milind, P.
IPC分类号： H01L21/00
CPC分类号： B81C1/00269
摘要： The present invention is directed to a process for packaging a microelectrical, micromechanical, microelectromechanical (MEMS) or microfluidic component on a substrate by forming cavities made from crosslinked photoresists on an easily removable second substrate, bonding the cavities to third substrates containing selected microdevices, then peeling off the removable second substrate.
摘要翻译：本发明涉及一种通过在容易移除的第二基底上形成由交联光致抗蚀剂制成的空腔将微电微机电微机电（MEMS）或微流体组分封装在衬底上的方法，将空腔粘合到包含所选微器件的第三衬底，然后剥离可移除的第二基板。

5. 发明申请

WO2008027098A3 BIOSENSOR FOR MEASUREMENT OF SPECIES IN A BODY FLUID 审中-公开
标题翻译：生物传感器用于测量身体液体中的物种
公开(公告)号：WO2008027098A3
公开(公告)日：2008-11-06
申请号：PCT/US2007012796
申请日：2007-05-31
申请人： ESA BIOSCIENCES INC , NAGALE MILIND P , GAMACHE PAUL , GRANGER MICHAEL , ACWORTH IAN , SCOTT WILLIAM JAMES , ZINK ERIC W , BOWERS MARK L
发明人： NAGALE MILIND P , GAMACHE PAUL , GRANGER MICHAEL , ACWORTH IAN , SCOTT WILLIAM JAMES , ZINK ERIC W , BOWERS MARK L
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C12M3/00 , G01N15/06 , G01N27/00 , G01N33/53
CPC分类号： G01N33/5438 , C12Q1/001
摘要： Certain embodiments disclosed herein are directed to devices configured to detect the level of a biomarker in a body fluid. In some examples, the device includes two or more electrodes for electrochemical detection of the biomarker in the body fluid. Methods of using the device are also disclosed.
摘要翻译：本文公开的某些实施例涉及被配置为检测体液中生物标志物的水平的装置。在一些实例中，该装置包括用于体液中生物标志物的电化学检测的两个或更多个电极。还公开了使用该装置的方法。

6. 发明申请

WO2008027098A2 BIOSENSOR FOR MEASUREMENT OF SPECIES IN A BODY FLUID 审中-公开
标题翻译：生物传感器用于测量体液中的种类
公开(公告)号：WO2008027098A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/012796
申请日：2007-05-31
申请人： ESA BIOSCIENCES, INC. , NAGALE, Milind, P. , GAMACHE, Paul , GRANGER, Michael , ACWORTH, Ian , SCOTT, William, James , ZINK, Eric, W. , BOWERS, Mark, L.
发明人： NAGALE, Milind, P. , GAMACHE, Paul , GRANGER, Michael , ACWORTH, Ian , SCOTT, William, James , ZINK, Eric, W. , BOWERS, Mark, L.
IPC分类号： G01N33/53 , C12Q1/26 , C12M3/00
CPC分类号： G01N33/5438 , C12Q1/001
摘要： Certain embodiments disclosed herein are directed to devices configured to detect the level of a biomarker in a body fluid. In some examples, the device includes two or more electrodes for electrochemical detection of the biomarker in the body fluid. Methods of using the device are also disclosed.
摘要翻译：本文公开的某些实施例涉及配置成检测体液中生物标志物水平的装置。在一些示例中，该装置包括用于电化学检测体液中生物标志物的两个或更多个电极。也公开了使用该装置的方法。

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