专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0027849A3 THERAPEUTIC POLYMORPHS OF A GABA-A ALPHA-5 INVERSE AGONIST AND PAMOATE FORMULATIONS OF THE SAME 审中-公开
标题翻译： GABA-A ALPHA-5反相激动剂及其相似的PAMOATE制剂的治疗多糖
公开(公告)号：WO0027849A3
公开(公告)日：2000-08-31
申请号：PCT/US9926622
申请日：1999-11-10
申请人： MERCK & CO INC , KAUFMAN MICHAEL J , MCCAULEY JAMES A , RUSH DANIEL J , TSCHAEN DAVID M , VARSOLONA RICHARD J , HO GUO JIE
发明人： KAUFMAN MICHAEL J , MCCAULEY JAMES A , RUSH DANIEL J , TSCHAEN DAVID M , VARSOLONA RICHARD J , HO GUO-JIE
IPC分类号： A61K9/08 , A61K9/28 , A61K31/5025 , A61K45/00 , A61K47/12 , A61P25/28 , C07D487/04 , C07C65/15
CPC分类号： C07D487/04
摘要： There is disclosed 3-(5-methylisoxazol-3-yl)-6-(1-methyl-1,2,3-triazol-4-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine in the form of a dihydrate, a dehydrate of the dihydrate and a pentahydrate, pharmaceutical compositions comprising the forms, the use of the forms for enhancing cognition, processes for producing the forms, their incorporation in pharmaceutical compositions comprising pamoate ions and the use of such ions for solubilizing neutral molecules.
摘要翻译：公开了3-（5-甲基异恶唑-3-基）-6-（1-甲基-1,2,3-三唑-4-基）甲氧基-1,2,4-三唑并[3,4-a] 二水合物形式的酞嗪，二水合物和五水合物的脱水剂，包含形式的药物组合物，用于增强认知的形式的使用，用于制备形式的方法，它们掺入包含双羟萘酸盐离子的药物组合物中的用途以及使用这种离子用于溶解中性分子。

2. 发明申请

WO1996022300A1 THERMODYNAMICALLY STABLE CRYSTAL FORM OF 4"e;-DEOXY-4"e;-EPI-METHYLAMINO AVERMECTIN B1a/B1b BENZOIC ACID SALT AND PROCESSES FOR ITS PREPARATION 审中-公开
标题翻译： 4“-DEOXY-4”-EPI-METHYLAMINO AVERMECTIN B1a / B1b苯甲酸盐的热稳定晶体形式及其制备方法
公开(公告)号：WO1996022300A1
公开(公告)日：1996-07-25
申请号：PCT/US1996000459
申请日：1996-01-16
申请人： MERCK & CO., INC. , CVETOVICH, Raymond , DEMCHAK, Richard , McCAULEY, James, A. , VARSOLONA, Richard, J.
发明人： MERCK & CO., INC.
IPC分类号： C07H17/08
CPC分类号： C07H19/01 , A01N43/90
摘要： The most thermodynamically stable crystalline form of the benzoic acid salt of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.
摘要翻译：通过从含有受控量的水的有机溶剂中结晶，得到作为半水合物的4“ - 脱氧-4” - 甲基氨基除虫菌素B1a / B1b的苯甲酸盐的最热力学稳定的结晶形式。

3. 发明申请

WO1995017396A1 POLYMORPHS OF LOSARTAN AND THE PROCESS FOR THE PREPARATION OF FORM II OF LOSARTAN 审中-公开
标题翻译：洛杉矶的多聚体和制备LOSARTAN II型的方法
公开(公告)号：WO1995017396A1
公开(公告)日：1995-06-29
申请号：PCT/US1994014768
申请日：1994-12-21
申请人： MERCK & CO., INC. , E.I. DU PONT DE NEMOURS AND COMPAGNY , THE DUPONT MERCK PHARMACEUTICAL COMPANY , CAMPBELL, Gordon, Creston, Jr. , DWIVEDI, Anil, M. , LEVORSE, Dorothy, A. , McCAULEY, James, A. , RAGHAVAN, Krishnaswamy, S.
发明人： MERCK & CO., INC. , E.I. DU PONT DE NEMOURS AND COMPAGNY , THE DUPONT MERCK PHARMACEUTICAL COMPANY
IPC分类号： C07D403/10
CPC分类号： C07D403/10
摘要： Polymorphic forms of Losartan (Formula I) and a process for the preparation of Form II of Losartan. Losartan is known to be useful in the treatment of hypertension.
摘要翻译：氯沙坦的多形态（式I）和氯沙坦形式II的制备方法。已知氯沙坦可用于治疗高血压。

4. 发明申请

WO2002080928A1 N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS 审中-公开
标题翻译： N-取代的NONARYL-HETEROCYCLO AMIDYL NMDA / NR2B拮抗剂
公开(公告)号：WO2002080928A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/010269
申请日：2002-04-02
申请人： MERCK & CO., INC. , LIVERTON, Nigel, J. , BUTCHER, John, W. , MCINTYRE, Charles, J. , CLAIBORNE, Christopher, F. , CLAREMON, David, A. , MCCAULEY, James, A. , ROMANO, Joseph, J. , THOMPSON, Wayne , MUNSON, Peter, M.
发明人： LIVERTON, Nigel, J. , BUTCHER, John, W. , MCINTYRE, Charles, J. , CLAIBORNE, Christopher, F. , CLAREMON, David, A. , MCCAULEY, James, A. , ROMANO, Joseph, J. , THOMPSON, Wayne , MUNSON, Peter, M.
IPC分类号： A61K31/55
CPC分类号： C07D265/30 , C07D207/09 , C07D211/26 , C07D241/04 , C07D401/12 , C07D409/12 , C07D417/12 , C07D473/00 , C07D487/04
摘要： Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐作为可用于缓解疼痛的NMDA NR2B拮抗剂是有效的。

5. 发明申请

WO1997003068A1 A TRIAZOLYLMETHYL-INDOLE ETHYLAMINE BISULFATE SALT 审中-公开
标题翻译：三唑基甲基 - 吲哚乙醚双磺酸盐
公开(公告)号：WO1997003068A1
公开(公告)日：1997-01-30
申请号：PCT/US1996011370
申请日：1996-07-08
申请人： MERCK & CO., INC. , CHENG, Chen, Y. , LARSEN, Robert, D. , McCAULEY, James, A. , VANDRILLA, Jennifer, L. , VERHOEVEN, Thomas, R.
发明人： MERCK & CO., INC.
IPC分类号： C07D403/06
CPC分类号： C07D249/08 , A61K31/4196 , C07D231/12 , C07D233/56
摘要： The bisulfate salt of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine is a selective agonist of 5-HT1-like receptors and is useful in the treatment of migraine and associated disorders.
摘要翻译： N，N-二甲基-2- [5-（1,2,4-三唑-1-基甲基）-1H-吲哚-3-基]乙胺的硫酸氢盐是5-HT1样受体的选择性激动剂，可用于治疗偏头痛及相关疾病。

6. 发明申请

WO1995023146A1 MORPHOLOGICAL FORMS OF (+)-N-[1'-(6-CYANO-1,2,3,4-TETRAHYDRO-2-NAPHTHALENYL)-3,4-DIHYDRO-4-HYDROXYSPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]YL]METHANESULFONAMIDE HYDROCHLORIDE 审中-公开
标题翻译：（+） - N- [1' - （6-氰基-1,2,3,4-四氢-2-萘磺酰基）-3,4-二氢-4-羟基吡啶并[2H-1-苯并噻吩-2-酮的形态学，4'-PIPERIDIN] YL]甲磺酰胺氢氯化物
公开(公告)号：WO1995023146A1
公开(公告)日：1995-08-31
申请号：PCT/US1995002265
申请日：1995-02-23
申请人： MERCK & CO., INC. , DESMOND, Richard , TSCHAEN, David, M. , McCAULEY, James, A. , VARSOLONA, Richard, J.
发明人： MERCK & CO., INC.
IPC分类号： C07D471/10
CPC分类号： C07D491/10
摘要： This invention relates to different morphological forms of (+)-N-[1'-(6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl)-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]yl]methanesulfonamide hydrochloride. These forms are prepared by selective crystallization or precipitation. In addition, this invention relates to the processes for the preparation of each of these forms.
摘要翻译：本发明涉及不同的形态形式的（+） - N- [1' - （6-氰基-1,2,3,4-四氢-2-萘基）-3,4-二氢-4-羟基螺[2H- 1-苯并吡喃-2,4'-哌啶]基]甲磺酰胺盐酸盐。这些形式通过选择性结晶或沉淀制备。此外，本发明涉及制备这些形式的各种方法。

7. 发明申请

WO1995005390A1 THERMODYNAMICALLY STABLE CRYSTAL FORM OF 4"e;-DEOXY-4"e;-EPI-METHYLAMINO AVERMECTIN B1a/B1b BENZOIC ACID SALT AND PROCESSES FOR ITS PREPARATION 审中-公开
标题翻译： 4“-DEOXY-4”-EPI-METHYLAMINO AVERMECTIN B1a / B1b苯甲酸盐的热稳定晶体形式及其制备方法
公开(公告)号：WO1995005390A1
公开(公告)日：1995-02-23
申请号：PCT/US1994009207
申请日：1994-08-15
申请人： MERCK & CO., INC. , CVETOVICH, Raymond , DEMCHAK, Richard , McCAULEY, James, A. , VARSALONA, Richard, J.
发明人： MERCK & CO., INC.
IPC分类号： C07H17/08
CPC分类号： C07H19/01 , A01N43/90
摘要： The most thermodynamically stable crystalline form of the benzoic acid salt of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.
摘要翻译：通过从含有受控量的水的有机溶剂中结晶，得到作为半水合物的4“ - 脱氧-4” - 甲基氨基除虫菌素B1a / B1b的苯甲酸盐的最热力学稳定的结晶形式。

8. 发明申请

WO2005019221A1 4-CYCLOALKYLAMINOPYRAZOLO PYRIMIDINE NMDA/NR2B ANTAGONISTS 审中-公开
标题翻译： 4-CYCLOALKYLAMINOPYRAZOLO PYRIMIDINE NMDA / NR2B ANTAGONISTS
公开(公告)号：WO2005019221A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/025961
申请日：2004-08-11
申请人： MERCK & CO., INC. , THOMPSON, Wayne , YOUNG, Steven, D. , PHILLIPS, Brian, T. , MUNSON, Peter , WHITTER, Willie , LIVERTON, Nigel , DIECKHAUS, Christine , BUTCHER, John , MCCAULEY, James, A. , MCINTYRE, Charles, J. , LAYTON, Mark, E. , SANDERSON, Philip, E.
发明人： THOMPSON, Wayne , YOUNG, Steven, D. , PHILLIPS, Brian, T. , MUNSON, Peter , WHITTER, Willie , LIVERTON, Nigel , DIECKHAUS, Christine , BUTCHER, John , MCCAULEY, James, A. , MCINTYRE, Charles, J. , LAYTON, Mark, E. , SANDERSON, Philip, E.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson’s disease, Alzheimer’s disease, epilepsy, depression, anxiety, ischemic brain injury including stroke, and other conditions.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐作为可用于治疗神经病症例如疼痛，帕金森病，阿尔茨海默氏病，癫痫，抑郁症，焦虑症，缺血性脑损伤（包括中风）的NMDA / NR2B拮抗剂是有效的，等条件。

9. 发明申请

WO1997015574A1 POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE 审中-公开
标题翻译：生长激素密码子的多形态
公开(公告)号：WO1997015574A1
公开(公告)日：1997-05-01
申请号：PCT/US1996016955
申请日：1996-10-23
申请人： MERCK & CO., INC. , DRAPER, Jerome, P. , DUBOST, David, C. , KAUFMAN, Michael, J. , MCCAULEY, James, A. , VANDRILLA, Jennifer, L. , VARSOLONA, Richard, J.
发明人： MERCK & CO., INC.
IPC分类号： C07D471/10
CPC分类号： C07D471/10 , A61K38/00 , C07K5/06034
摘要： This invention is concerned with polymorphic forms of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-amino-2-methylpropanamide methanesulfonate which is a growth hormone secretagogue that is useful in food animals to promote their growth thereby rendering the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, and to treat medical conditions which are improved by the anabolic effects of growth hormone. The instant polymorphic forms have advantages over the other known forms of N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)-ethyl]-2-amino-2-methylpropanamide methanesulfonate in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations. The present invention is also concerned with processes for preparing these polymorphic forms, pharmaceutical formulations comprising these polymorphic forms as active ingredients and the use of the polymorphic form of the compound and their formulations in the treatment of certain disorders.
摘要翻译：本发明涉及化合物N- [1（R） - [（1,2-二氢-1-甲磺酰基螺[3H-吲哚-3,4'-哌啶] -1'-基）羰基] - 2-（苯基甲氧基）乙基] -2-氨基-2-甲基丙酰胺甲磺酸盐，其是生物激素促分泌素，其可用于食用动物以促进其生长，从而使食用肉制品的生产更有效，并且在人类中，或以生长激素分泌不足为特征的医疗状况，以及治疗由生长激素的合成代谢作用改善的医疗状况。本发明的多晶型物质具有优于其他已知形式的N- [1（R） - [（1,2-二氢-1-甲磺酰基螺[3H-吲哚-3,4'-哌啶] -1'-基）羰基 ] -2-（苯基甲氧基） - 乙基] -2-氨基-2-甲基丙酰胺甲磺酸盐的热力学稳定性和药物制剂中的适用性。本发明还涉及制备这些多晶型物的方法，包含这些多晶型形式作为活性成分的药物制剂以及化合物的多晶形式及其制剂在治疗某些疾病中的用途。

10. 发明申请

WO1994011387A3 A PROCESS FOR THE PRODUCTION OF FINASTERIDE 审中-公开
公开(公告)号：WO1994011387A3
公开(公告)日：1994-05-26
申请号：PCT/US1993010659
申请日：1993-11-05
申请人： MERCK & CO., INC. , DOLLING, Ulf, H. , McCAULEY, James, A. , VARSOLONA, Richard, J.
发明人： MERCK & CO., INC.
IPC分类号： C07J73/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式