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1. 发明申请

WO2008137981A1 HUMAN PARAINFLUENZA VIRUSES HAVING SEPARATED P AND C GENES 审中-公开
标题翻译：具有分离的P和C基因的人类流感病毒病毒
公开(公告)号：WO2008137981A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/063033
申请日：2008-05-08
申请人： US GOVERNMENT AS REPRESENTED BY THE SECY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , COLINS, Peter L. , MURPHY, Brian R. , SKIADOPOULOS, Mario H. , BARLETT, Emmalene J. , SCHMIDT, Alexander C. , CRUZ, Ann-marie M
发明人： COLINS, Peter L. , MURPHY, Brian R. , SKIADOPOULOS, Mario H. , BARLETT, Emmalene J. , SCHMIDT, Alexander C. , CRUZ, Ann-marie M
IPC分类号： C12N7/04 , C12N15/86 , A61K39/155
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C12N15/86 , C12N2760/18634 , C12N2760/18643 , C12N2760/18661
摘要： The invention provides self replicating infectious recombinant paramyxoviruses where the P and C genes are separated. The recombinant paramyxoviruses preferably have one or more attenuating mutations and/or at least one temperature sensitive mutation and one non-temperature sensitive mutation. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a C protein and a separate monocistronic polynucleotide encoding a P protein. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
摘要翻译：本发明提供了自我复制的感染性重组副粘病毒，其中P和C基因被分离。重组副粘病毒优选具有一个或多个减毒突变和/或至少一个温度敏感突变和一个非温度敏感突变。在一些实施方案中，重组副粘病毒具有编码C蛋白的单独变体多核苷酸和编码P蛋白的分离的单顺反子多核苷酸。还提供了使用如本文所述的重组副粘病毒的组合物和方法。

2. 发明申请

WO2008022196A3 DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS 审中-公开
公开(公告)号：WO2008022196A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/076004
申请日：2007-08-15
申请人： GOVERMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH ANDHUMAN SERVICES, THE , WHITEHEAD, Stephen, S. , BLANEY, Joseph, E. , MURPHY, Brian, R.
发明人： WHITEHEAD, Stephen, S. , BLANEY, Joseph, E. , MURPHY, Brian, R.
IPC分类号： C07H21/04 , C12N7/00 , A61K39/00 , A61K39/12 , A61K39/42
摘要： The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3' untranslated region (3'-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3'-UTR that removes sequence in the 5' direction as far as the 5' boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3'-UTR of a dengue virus of a first serotype with the 3'-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3'-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.

3. 发明申请

WO2007120120A3 ATTENUATED HUMAN PARAINFLUENZA VIRUS, METHODS AND USES THEREOF 审中-公开
公开(公告)号：WO2007120120A3
公开(公告)日：2007-10-25
申请号：PCT/US2006/000666
申请日：2006-01-10
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SKIADOPOULOS, Mario H. , MURPHY, Brian R. , COLLINS, Peter L. , NOLAN, Sheila
发明人： SKIADOPOULOS, Mario H. , MURPHY, Brian R. , COLLINS, Peter L. , NOLAN, Sheila
IPC分类号： C12N7/04 , C07K14/115
摘要： The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.

4. 发明申请

WO2007120120A2 ATTENUATED HUMAN PARAINFLUENZA VIRUS, METHODS AND USES THEREOF 审中-公开
标题翻译：衰老的人类流行性感冒病毒，其方法和用途
公开(公告)号：WO2007120120A2
公开(公告)日：2007-10-25
申请号：PCT/US2006000666
申请日：2006-01-10
申请人： US GOV HEALTH & HUMAN SERV , SKIADOPOULOS MARIO H , MURPHY BRIAN R , COLLINS PETER L , NOLAN SHEILA
发明人： SKIADOPOULOS MARIO H , MURPHY BRIAN R , COLLINS PETER L , NOLAN SHEILA
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/18722 , C12N2760/18743 , C12N2760/18761
摘要： The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
摘要翻译：本发明提供了自我复制的感染性重组副粘病毒。重组副粘病毒优选具有一个或多个减毒突变。在一些实施方案中，重组副粘病毒具有编码P蛋白的单独变体多核苷酸和编码V蛋白的分离的单顺反子多核苷酸。在一些实施方案中，重组副粘病毒具有至少一个温度敏感突变和一个非温度敏感突变。还提供了使用如本文所述的重组副粘病毒的组合物和方法。

5. 发明申请

WO2004027037A3 RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 2 (HPIV2) FROM cDNA AND USE OF RECOMBINANT HPIV2 IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS 审中-公开
标题翻译：来自cDNA的重组人间盘腺病毒2型（HPIV2）的恢复和重组HPIV2在免疫组化合物中的用途以及作为载体的免疫应答对PIV和其他人类病原体的免疫反应
公开(公告)号：WO2004027037A3
公开(公告)日：2005-12-22
申请号：PCT/US0329685
申请日：2003-09-18
申请人： US HEALTH , SKIADOPOULOS MARIO H , MURPHY BRIAN R , COLLINS PETER L
发明人： SKIADOPOULOS MARIO H , MURPHY BRIAN R , COLLINS PETER L
IPC分类号： A61K39/00 , A61K39/155 , C07K14/115 , C07K14/135 , C12N7/04 , C12N7/00 , A01N63/00 , C12N7/01 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/18334 , C12N2760/18634 , C12N2760/18643 , C12N2760/18722 , C12N2760/18734 , C12N2760/18743 , C12N2760/18762
摘要： Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV2 genome or antigenome.
摘要翻译：提供重组人副流感病毒2型（HPIV2）病毒和相关的免疫原性组合物和方法。根据本发明提供的重组HPIV2病毒，包括HPIV2嵌合和嵌合载体病毒在许可哺乳动物受试者，包括人中是感染性的和减毒的，并且可用于免疫原性组合物中，用于引发针对一种或多种PIV的免疫应答更多的非PIV病原体，或针对PIV和非PIV病原体。还提供了分离的多核苷酸分子和掺入重组HPIV2基因组或抗原组的载体。

6. 发明申请

WO2005014626A2 RECOMBINANT HUMAN METAPNEUMOVIRUS AND ITS USE 审中-公开
标题翻译：重组人类METAPNEUMOVIRUS及其使用
公开(公告)号：WO2005014626A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/005881
申请日：2004-02-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , COLLINS, Peter, L. , BIACCHESI, Stephane , BUCHHOLZ, Ursula , SKIADOPOULOS, Mario, H. , MURPHY, Brian, R.
发明人： COLLINS, Peter, L. , BIACCHESI, Stephane , BUCHHOLZ, Ursula , SKIADOPOULOS, Mario, H. , MURPHY, Brian, R.
IPC分类号： C07K14/005
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18362 , C12N2760/18634 , C12N2760/18643
摘要： Recombinant HMPV (rHMPV) and related immunogenic compositions and methods are provided. The rHMPVs, including chimeric and HMPV vector viruses, provided according to the current disclosure are infectious and attenuated in permissive mammalian subjects, including humans. The rHMPVs are useful in immunogenic compositions for eliciting an immune response against HPIV, against one or more non-HMPV pathogens, or against a HMPV and a non-HMPV pathogen. Also provided are isolated polynucloetide molecules and vectors incorporating a recombinant HMPV genome or antigenome.
摘要翻译：提供重组HMPV（rHMPV）和相关的免疫原性组合物和方法。根据本公开提供的rHMPV，包括嵌合和HMPV载体病毒，在许可的哺乳动物受试者，包括人中都是感染性的和减毒的。 rHMPV可用于免疫原性组合物，用于引发针对一种或多种非HMPV病原体或针对HMPV和非HMPV病原体的针对HPIV的免疫应答。还提供了分离的多核苷酸分子和掺入重组HMPV基因组或反基因组的载体。

7. 发明申请

WO2003092592A2 DENGUE TETRAVALENT VACCINE CONTAINING A COMMON 30 NUCLEOTIDE DELETION IN THE 3'-UTR OF DENGUE TYPES 1,2,3, AND 4, OR ANTIGENIC CHIMERIC DENGUE VIRUSES 1,2,3, AND 4 审中-公开
标题翻译：登革热灭活疫苗在宿主类型1,2,3和4的3'-UTR中具有共同的30个核苷酸残基，或者是抗原性的登革热病毒1,2,3和4
公开(公告)号：WO2003092592A2
公开(公告)日：2003-11-13
申请号：PCT/US2003/013279
申请日：2003-04-25
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , WHITEHEAD, Stephen, S. , MURPHY, Brian, R. , MARKOFF, Lewis , FALGOUT, Barry , BLANEY, Joseph , HANLEY, Kathryn
发明人： WHITEHEAD, Stephen, S. , MURPHY, Brian, R. , MARKOFF, Lewis , FALGOUT, Barry , BLANEY, Joseph , HANLEY, Kathryn
IPC分类号： A61K
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N2770/24134 , C12N2770/24161 , Y02A50/386
摘要： The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3'-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.
摘要翻译：本发明涉及登革病毒四价疫苗，其在登革病毒血清型1,2,3和4的基因组的3'非翻译区域中含有共同的30个核苷酸缺失（Delta30）或血清型1的抗原嵌合登革热病毒， 2,3和4。

8. 发明申请

WO0104335A8 HUMAN-BOVINE CHIMERIC RESPIRATORY SYNCYTIAL VIRUS VACCINES 审中-公开
标题翻译：人类猪流感呼吸道感染病毒疫苗
公开(公告)号：WO0104335A8
公开(公告)日：2003-02-06
申请号：PCT/US0017755
申请日：2000-06-23
申请人： US GOV HEALTH & HUMAN SERV , BUCHHOLZ URSULA , COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S , KREMPL CHRISTINE D
发明人： BUCHHOLZ URSULA , COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S , KREMPL CHRISTINE D
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , A61P11/00 , C07K14/14 , C12N7/00 , C12N7/04 , C12N15/86 , C12R1/93 , A61K38/17 , C12N15/62
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/544 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/203
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV "background" genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete "background" RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment including a protein or portion thereof. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.
摘要翻译：嵌合人 - 牛呼吸道合胞病毒（RSV）在人类和其他哺乳动物中具有感染性和减毒性，并且可用于引发抗RSV免疫应答的疫苗制剂中。还提供了分离的多核苷酸分子和掺入嵌合RSV基因组或抗原组的载体，其包括部分或完整的人或牛RSV“背景”基因组或与一个或多个异源基因或基因组片段不同的RSV菌株。本发明的嵌合人类牛RSV包括部分或完整的“背景”RSV基因组或在与一个或多个异源基因或基因组片段组合的人或牛RSV病毒株或亚组病毒之后衍生或构图的部分或完整的“背景” 的不同RSV株或亚组病毒形成人 - 牛嵌合RSV基因组或抗原组。在本发明的优选方面，嵌合RSV包含与来自人RSV的一个或多个异源基因或基因组片段组合的部分或完整的牛RSV背景基因组或反向异构体。感兴趣的基因包括任何NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因或包含蛋白质或其部分的基因组片段。在本发明的人 - 牛嵌合RSV内提供了多种额外的突变和核苷酸修饰，以产生所需的表型和结构效果。

9. 发明申请

WO0061611A9 PRODUCTION OF ATTENUATED CHIMERIC RESPIRATORY SYNCYTIAL VIRUS VACCINES FROM CLONED NUCLEOTIDE SEQUENCES 审中-公开
标题翻译：从克隆核苷酸序列中产生减毒的呼吸道同源病毒疫苗
公开(公告)号：WO0061611A9
公开(公告)日：2002-03-28
申请号：PCT/US0008802
申请日：2000-03-31
申请人： US HEALTH , COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S
发明人： COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S
IPC分类号： C12N15/09 , A61K9/12 , A61K39/155 , A61P31/14 , C07K14/135 , C12N7/00 , C12N7/04 , C12N7/08 , C12R1/93 , C12N15/45
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2760/18522 , C12N2760/18561
摘要： Chimeric respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing one or more heterologous gene(s) or gene segment(s) from one RSV subgroup or strain into a recipient RSV background of a different subgroup or strain. The resulting chimeric RSV virus or subviral particle is infectious and attenuated, preferably by introduction of selected mutations specifying attenuated phenotypes into a chimeric genome or antigenome to yield, for example, temperature sensitive (ts) and/or cold adapted (ca) vaccine strains. Alternatively, chimeric RSV and vaccine compositions thereof incorporate other mutations specifying desired structural and/or phenotypic characteristics in an infectious chimeric RSV. Such chimeric RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of one or more selected nucleotide sequence(s), gene(s), or gene segment(s) in a chimeric RSV clone. This provides a method for development of novel vaccines against diverse RSV strains by using a common attenuated backbone as a vector to express protective antigens of heterologous strains. The immune system of an individual is stimulated to induce protection against natural RSV infection, preferably in a multivalent manner to achieve protection against multiple RSV strains and/or subgroups.
摘要翻译：嵌合呼吸道合胞病毒（RSV）及其疫苗组合物通过将一个或多个异源基因或基因区段从一个RSV亚组或菌株引入到不同亚组或菌株的受体RSV背景中来产生。所得到的嵌合RSV病毒或亚病毒颗粒是感染性和减毒性的，优选通过将指定减毒表型的选定突变引入到嵌合基因组或反基因组中以得到例如温度敏感（ts）和/或冷适应（ca）疫苗株。或者，嵌合RSV及其疫苗组合物掺入在感染性嵌合RSV中指定所需结构和/或表型特征的其它突变。这种嵌合RSV包含通过嵌合RSV克隆中的一个或多个选定的核苷酸序列，基因或基因片段的插入，缺失，取代或重排而指定的所需突变。这提供了通过使用共同的减毒骨架作为表达异源株的保护性抗原的载体来开发针对不同RSV菌株的新型疫苗的方法。刺激个体的免疫系统以诱导针对天然RSV感染的保护，优选以多价方式实现针对多个RSV菌株和/或亚组的保护。

10. 发明申请

WO1998013501A2 3' GENOMIC PROMOTER REGION AND POLYMERASE GENE MUTATIONS RESPONSIBLE FOR ATTENUATION IN VIRUSES OF THE ORDER DESIGNATED MONONEGAVIRALES 审中-公开
标题翻译： 3“基因组促进剂区域和聚合酶基因突变负责在命名单克隆病毒的病毒中的衰减
公开(公告)号：WO1998013501A2
公开(公告)日：1998-04-02
申请号：PCT/US1997016718
申请日：1997-09-19
申请人： AMERICAN CYANAMID COMPANY , THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , UDEM, Stephen, A. , SIDHU, Mohinderjit, S. , TATEM, Joanne, M. , MURPHY, Brian, R. , RANDOLPH, Valerie, B.
发明人： AMERICAN CYANAMID COMPANY , THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C12N15/45
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622
摘要： Isolated, recombinantly-generated, attenuated, nonsegmented, negative-sense, single stranded RNA viruses of the Order Mononegavirales having at least one attenuating mutation in the 3' genomic promoter region and having at least one attenuating mutation in the RNA polymerase gene are described. Vaccines are formulated comprising such viruses and a physiologically acceptable carrier. The vaccines are used for immunizing an individual to induce protection against a nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales.
摘要翻译：描述了在3'基因组启动子区域具有至少一个减毒突变并且在RNA聚合酶基因中具有至少一个减毒突变的单单核苷酸单克隆的分离的，重组产生的，减毒的，非分段的，负义的单链RNA病毒。配制包含这种病毒和生理上可接受的载体的疫苗。疫苗用于免疫个体以诱导针对Mononegavirales单克隆的非分段的，负义的单链RNA病毒的保护。

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