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1. 发明申请

WO2007101254A8 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE SYSTEM DISORDERS 审中-公开
标题翻译：用于治疗免疫系统疾病的组合物和方法
公开(公告)号：WO2007101254A8
公开(公告)日：2009-07-30
申请号：PCT/US2007062986
申请日：2007-02-28
申请人： TELOS PHARMACEUTICALS LLC , CHAVAN SURENDRA J , MOSS RONALD B , CARLO DENNIS J , MOLL THOMAS
发明人： CHAVAN SURENDRA J , MOSS RONALD B , CARLO DENNIS J , MOLL THOMAS
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K38/00 , A61K2039/505 , C07K14/70503 , C07K2319/30
摘要： The invention provides methods for ameliorating a sign or symptom associated with an autoimmune disease by administering a dimeric TIM-I ligand targeting molecule to a subject. The invention additionally provides methods for ameliorating a sign or symptom associated with transplant rejection by administering a dimeric TIM-I ligand targeting molecule to a subject.
摘要翻译：本发明提供了通过向对象施用二聚体TIM-1配体靶向分子来改善与自身免疫疾病相关的症状或症状的方法。本发明另外提供了通过向受试者施用二聚体TIM-1配体靶向分子来改善与移植排斥相关的症状或症状的方法。

2. 发明申请

WO0067787A3 HIV IMMUNOGENIC COMPOSITIONS AND METHODS 审中-公开
标题翻译： HIV免疫组化和方法
公开(公告)号：WO0067787A3
公开(公告)日：2001-04-26
申请号：PCT/US0012495
申请日：2000-05-05
申请人： IMMUNE RESPONSE CORP INC , MOSS RONALD B
发明人： MOSS RONALD B
IPC分类号： A61K39/21 , A61K39/39 , A61P31/18
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K2039/5252 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2740/16034
摘要： The invention provides immunogenic compositions which enhance beta-chemokine levels in a mammal. The immunogenic compositions contain an HIV antigen, an isolated nucleic acid molecule containing an immunostimulatory sequence (ISS) and an adjuvant. The HIV antigen can be a whole-killed HIV virus devoid of outer envelope protein gp120. Alternatively, the HIV antigen can be a whole-killed HIV virus, or a p24 antigen. Also provided is a method of inhibiting AIDS, by enhancing beta-chemokine production in the mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an isolated nucleic acid molecule containing an immunostimulatory sequence (ISS) and an adjuvant.
摘要翻译：本发明提供增强哺乳动物中β-趋化因子水平的免疫原性组合物。免疫原性组合物含有HIV抗原，含有免疫刺激序列（ISS）和佐剂的分离的核酸分子。 HIV抗原可以是没有外包膜蛋白gp120的全杀死HIV病毒。或者，HIV抗原可以是全杀死的HIV病毒或p24抗原。还提供了通过向哺乳动物施用含有HIV抗原的免疫原性组合物，含有免疫刺激序列（ISS）和佐剂的分离的核酸分子来增强哺乳动物的β-趋化因子产生来抑制AIDS的方法。

3. 发明申请

WO2005021726A3 IMMUNOGENIC HIV COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：免疫原性HIV组合物及相关方法
公开(公告)号：WO2005021726A3
公开(公告)日：2008-01-17
申请号：PCT/US2004027995
申请日：2004-08-27
申请人： IMMUNE RESPONSE CORP INC , MOSS RONALD B
发明人： MOSS RONALD B
IPC分类号： A61K39/21 , A61K47/00 , C12N20060101 , C12Q1/70
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/62 , A61K2039/627 , C07K14/005 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides immunogenic compositions which enhance the duration and strength of the immune response in a mammal. The immunogenic compositions contain an HIV antigen, an immunomer and an adjuvant. The HIV antigen can be a whole-killed HIV virus devoid of outer envelope protein gp120. Alternatively, the HIV antigen can be a whole-killed HIV virus, or a p24 antigen. Also provided are kits, the components of which, when combined, produce the immunogenic compositions of the invention. The invention also provides methods of making the immunogenic compositions, by combining an HIV antigen, an immunomer and optionally an adjuvant. The invention further provides a method of immunizing a mammal, by enhancing an immune response in the mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an immunomer and optionally an adjuvant. Also provided is a method of inhibiting in a mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an immunomer and optionally an adjuvant.
摘要翻译：本发明提供增强哺乳动物免疫反应持续时间和强度的免疫原性组合物。免疫原性组合物含有HIV抗原，免疫体和佐剂。 HIV抗原可以是没有外包膜蛋白gp120的全杀死HIV病毒。或者，HIV抗原可以是全杀死的HIV病毒或p24抗原。还提供了试剂盒，其组分在组合时产生本发明的免疫原性组合物。本发明还提供了通过组合HIV抗原，免疫体和任选的佐剂来制备免疫原性组合物的方法。本发明还提供了通过向哺乳动物施用含有HIV抗原，免疫体和任选的佐剂的免疫原性组合来增强哺乳动物的免疫应答来免疫哺乳动物的方法。还提供了通过向哺乳动物施用含有HIV抗原，免疫体和任选的佐剂的免疫原性组合物来抑制哺乳动物的方法。

4. 发明申请

WO2007101254A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE SYSTEM DISORDERS 审中-公开
标题翻译：用于治疗免疫系统疾病的组合物和方法
公开(公告)号：WO2007101254A3
公开(公告)日：2008-09-25
申请号：PCT/US2007062986
申请日：2007-02-28
申请人： TELOS PHARMACEUTICALS LLC , CHAVAN SURENDRA J , MOSS RONALD B , CARLO DENNIS J , MOLL THOMAS
发明人： CHAVAN SURENDRA J , MOSS RONALD B , CARLO DENNIS J , MOLL THOMAS
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K38/00 , A61K2039/505 , C07K14/70503 , C07K2319/30
摘要： The invention provides methods for ameliorating a sign or symptom associated with an autoimmune disease by administering a dimeric TIM-I ligand targeting molecule to a subject. The invention additionally provides methods for ameliorating a sign or symptom associated with transplant rejection by administering a dimeric TIM-I ligand targeting molecule to a subject.
摘要翻译：本发明提供了通过向对象施用二聚体TIM-1配体靶向分子来改善与自身免疫疾病相关的症状或症状的方法。本发明另外提供了通过向受试者施用二聚体TIM-1配体靶向分子来改善与移植排斥相关的症状或症状的方法。

5. 发明申请

WO2007101254A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE SYSTEM DISORDERS 审中-公开
标题翻译：用于治疗免疫系统疾病的组合物和方法
公开(公告)号：WO2007101254A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062986
申请日：2007-02-28
申请人： TELOS PHARMACEUTICALS LLC , CHAVAN, Surendra, J. , MOSS, Ronald, B. , CARLO, Dennis, J. , MOLL, Thomas
发明人： CHAVAN, Surendra, J. , MOSS, Ronald, B. , CARLO, Dennis, J. , MOLL, Thomas
CPC分类号： C07K16/2803 , A61K38/00 , A61K2039/505 , C07K14/70503 , C07K2319/30
摘要： The invention provides methods for ameliorating a sign or symptom associated with an autoimmune disease by administering a dimeric TIM-I ligand targeting molecule to a subject. The invention additionally provides methods for ameliorating a sign or symptom associated with transplant rejection by administering a dimeric TIM-I ligand targeting molecule to a subject.
摘要翻译：本发明提供了通过向对象施用二聚体TIM-1配体靶向分子来改善与自身免疫疾病相关的症状或症状的方法。本发明另外提供了通过向受试者施用二聚体TIM-1配体靶向分子来改善与移植排斥相关的症状或症状的方法。

6. 发明申请

WO2005021726A2 IMMUNOGENIC HIV COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：免疫原性HIV组合物及相关方法
公开(公告)号：WO2005021726A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/027995
申请日：2004-08-27
申请人： THE IMMUNE RESPONSE CORPORATION , MOSS, Ronald, B.
发明人： MOSS, Ronald, B.
IPC分类号： C12N
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/62 , A61K2039/627 , C07K14/005 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides immunogenic compositions which enhance the duration and strength of the immune response in a mammal. The immunogenic compositions contain an HIV antigen, an immunomer and an adjuvant. The HIV antigen can be a whole-killed HIV virus devoid of outer envelope protein gp120. Alternatively, the HIV antigen can be a whole-killed HIV virus, or a p24 antigen. Also provided are kits, the components of which, when combined, produce the immunogenic compositions of the invention. The invention also provides methods of making the immunogenic compositions, by combining an HIV antigen, an immunomer and optionally an adjuvant. The invention further provides a method of immunizing a mammal, by enhancing an immune response in the mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an immunomer and optionally an adjuvant. Also provided is a method of inhibiting in a mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an immunomer and optionally an adjuvant.
摘要翻译：本发明提供增强哺乳动物免疫反应持续时间和强度的免疫原性组合物。免疫原性组合物含有HIV抗原，免疫体和佐剂。 HIV抗原可以是没有外包膜蛋白gp120的全杀死HIV病毒。或者，HIV抗原可以是全杀死的HIV病毒或p24抗原。还提供了试剂盒，其组分在组合时产生本发明的免疫原性组合物。本发明还提供了通过组合HIV抗原，免疫体和任选的佐剂来制备免疫原性组合物的方法。本发明还提供了通过向哺乳动物施用含有HIV抗原，免疫体和任选的佐剂的免疫原性组合来增强哺乳动物的免疫应答来免疫哺乳动物的方法。还提供了通过向哺乳动物施用含有HIV抗原，免疫体和任选的佐剂的免疫原性组合物来抑制哺乳动物的方法。

7. 发明申请

WO2002058726A1 METHOD FOR TREATING AN HIV-INFECTED INDIVIDUAL BY COMBINING IMMUNIZATION WITH STRUCTURED INTERRUPTION OF ANTI-RETROVIRAL TREATMENT 审中-公开
标题翻译：通过结构化中断抗逆转录病毒疗法结合免疫治疗HIV感染个体的方法
公开(公告)号：WO2002058726A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/002077
申请日：2002-01-24
申请人： THE IMMUNE RESPONSE CORPORATION , MOSS, Ronald, B. , CARLO, Dennis, J.
发明人： MOSS, Ronald, B. , CARLO, Dennis, J.
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/545 , A61K2039/57 , C12N2740/16034 , A61K2300/00
摘要： The invention provides a method for the treatment of HIV infected individuals. The method is practiced by combining immunization with an HIV immunogenic composition with structured cycles of anti-retroviral treatment and withdrawal from treatment.
摘要翻译：本发明提供了一种治疗HIV感染个体的方法。该方法通过将免疫接种与具有抗逆转录病毒治疗和撤出治疗的结构化循环的HIV免疫原性组合物来实施。

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