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1. 发明申请

WO2007095336A2 PRODUCTION OF HIV 审中-公开
标题翻译：生产艾滋病毒
公开(公告)号：WO2007095336A2
公开(公告)日：2007-08-23
申请号：PCT/US2007004049
申请日：2007-02-15
申请人： IMMUNE RESPONSE CORP INC , LYDERSEN BJORN K , LOWRY PETER W
发明人： LYDERSEN BJORN K , LOWRY PETER W
CPC分类号： C12N7/00 , A61K39/12 , A61K39/21 , A61K2039/5252 , A61K2039/55561 , A61K2039/55566 , C12N2740/16034
摘要： The present invention provides methods for producing HIV and HIV antigen by propagating HIV, in particular HIV-I, in cells grown in chemically defined, protein free medium. The invention also provides HIV antigen produced by such methods.
摘要翻译：本发明提供了通过在化学界定的无蛋白培养基中生长的细胞中传播HIV特别是HIV-1产生HIV和HIV抗原的方法。本发明还提供了通过这些方法产生的HIV抗原。

2. 发明申请

WO0154716A3 GENETICALLY ENGINEERED TUMOR CELL VACCINES 审中-公开
标题翻译：遗传工程肿瘤细胞疫苗
公开(公告)号：WO0154716A3
公开(公告)日：2002-03-07
申请号：PCT/US0102731
申请日：2001-01-26
申请人： SIDNEY KIMMEL CANCER CT , IMMUNE RESPONSE CORP INC , SOBOL ROBERT E , SHAWLER DANIEL L , BARTHOLOMEW RICHARD M , CARLO DENNIS J , GOLD DANIEL P
发明人： SOBOL ROBERT E , SHAWLER DANIEL L , BARTHOLOMEW RICHARD M , CARLO DENNIS J , GOLD DANIEL P
IPC分类号： A61K39/00 , A61K48/00 , A61P35/00 , A61P37/04 , A61K39/39
CPC分类号： A61K39/0011 , A61K48/00 , A61K2039/5152 , A61K2039/5156
摘要： The invention provides a composition for stimulating an immune response in a patient having an adenocarcinoma, including a patient having colorectal cancer, containing allogeneic tumor cells and a physiologically acceptable carrier. The allogeneic tumor cells can be SW620, COLO 205, or SW403 cells. The invention composition can also contain an allogeneic cell expressing a cytokine. An allogeneic tumor cell can additionally express CD80. The invention additionally provides a method of stimulating an immune response in a patient having an adenocarcinoma, including a patient having colorectal cancer, by administering to the patient one or more allogeneic tumor cells, wherein the allogeneic cell stimulates an immune response to autologous tumor cells in the patient.
摘要翻译：本发明提供了一种用于在具有腺癌的患者中刺激免疫应答的组合物，包括具有结肠直肠癌的患者，其含有同种异体肿瘤细胞和生理上可接受的载体。同种异体肿瘤细胞可以是SW620，COLO 205或SW403细胞。本发明组合物还可含有表达细胞因子的同种异体细胞。同种异体肿瘤细胞可另外表达CD80。本发明另外提供了通过向患者施用一种或多种同种异体肿瘤细胞来刺激具有腺癌的患者（包括患有结肠直肠癌的患者）中的免疫应答的方法，其中同种异体细胞刺激对自体肿瘤细胞的免疫应答患者。

3. 发明申请

WO9312814A3 VACCINATION AND METHODS AGAINST DISEASES RESULTING FROM PATHOGENIC RESPONSES BY SPECIFIC T CELL POPULATIONS 审中-公开
标题翻译：针对特定细胞群体的病原性反应疾病的疫苗和方法
公开(公告)号：WO9312814A3
公开(公告)日：1993-09-30
申请号：PCT/US9211159
申请日：1992-12-21
申请人： IMMUNE RESPONSE CORP INC
发明人： HOWELL MARK D , BROSTOFF STEVEN W , CARLO DENNIS J
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K39/00 , A61K47/48 , A61K48/00 , A61P29/00 , A61P37/00 , C07K14/725 , C12P21/02 , G01N33/569
CPC分类号： C07K14/7051 , A61K39/00 , A61K48/00 , A61K2039/53
摘要： The present invention provides vaccines and a means of vaccinating a vertebrate so as to prevent or control specific T cell mediated pathologies, including autoimmune diseases and the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. Such a peptide can bind to conventional antigens complexed to MHC antigen presenting cells or to superantigens. Means of determining appropriate amino acid sequences for such vaccines are also provided. The vaccine is administered to the vertebrate in a manner that induces an immune response directed against the TCR of T cells mediating the pathology. This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. The invention additionally provides specific β-chain variable regions of T cell receptors, designated Vβ3, Vβ4, Vβ12, Vβ14 and V, β17, which are associated with the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and multiple sclerosis (MS). Also provided are means to detect, prevent and treat RA and MS. Methods of administering DNA or RNA encoding the polypeptides useful as vaccines of the present invention into the tissue cells of an individual is also provided.

4. 发明申请

WO2005021726A3 IMMUNOGENIC HIV COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：免疫原性HIV组合物及相关方法
公开(公告)号：WO2005021726A3
公开(公告)日：2008-01-17
申请号：PCT/US2004027995
申请日：2004-08-27
申请人： IMMUNE RESPONSE CORP INC , MOSS RONALD B
发明人： MOSS RONALD B
IPC分类号： A61K39/21 , A61K47/00 , C12N20060101 , C12Q1/70
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/62 , A61K2039/627 , C07K14/005 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides immunogenic compositions which enhance the duration and strength of the immune response in a mammal. The immunogenic compositions contain an HIV antigen, an immunomer and an adjuvant. The HIV antigen can be a whole-killed HIV virus devoid of outer envelope protein gp120. Alternatively, the HIV antigen can be a whole-killed HIV virus, or a p24 antigen. Also provided are kits, the components of which, when combined, produce the immunogenic compositions of the invention. The invention also provides methods of making the immunogenic compositions, by combining an HIV antigen, an immunomer and optionally an adjuvant. The invention further provides a method of immunizing a mammal, by enhancing an immune response in the mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an immunomer and optionally an adjuvant. Also provided is a method of inhibiting in a mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an immunomer and optionally an adjuvant.
摘要翻译：本发明提供增强哺乳动物免疫反应持续时间和强度的免疫原性组合物。免疫原性组合物含有HIV抗原，免疫体和佐剂。 HIV抗原可以是没有外包膜蛋白gp120的全杀死HIV病毒。或者，HIV抗原可以是全杀死的HIV病毒或p24抗原。还提供了试剂盒，其组分在组合时产生本发明的免疫原性组合物。本发明还提供了通过组合HIV抗原，免疫体和任选的佐剂来制备免疫原性组合物的方法。本发明还提供了通过向哺乳动物施用含有HIV抗原，免疫体和任选的佐剂的免疫原性组合来增强哺乳动物的免疫应答来免疫哺乳动物的方法。还提供了通过向哺乳动物施用含有HIV抗原，免疫体和任选的佐剂的免疫原性组合物来抑制哺乳动物的方法。

5. 发明申请

WO9844945A9 NON-INFECTIOUS, PROTEASE DEFECTIVE HIV PARTICLES AND NUCLEIC ACID MOLECULES ENCODING THEREFOR 审中-公开
标题翻译：非感染性，保护性缺陷性HIV颗粒和编码其的核酸分子
公开(公告)号：WO9844945A9
公开(公告)日：1999-07-22
申请号：PCT/US9806690
申请日：1998-04-03
申请人： IMMUNE RESPONSE CORP INC
发明人： LUFTIG RONALD B
IPC分类号： A61K39/00 , C07K14/16 , C12N7/04 , G01N33/569 , A61K39/21 , A61K39/42 , C07H21/02 , C07H21/04 , C07K14/155 , C07K16/10 , C12N7/08 , C12Q1/68 , C12Q1/70 , G01N33/577 , G01N33/60 , G01N33/68
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2740/16062 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , G01N33/56988
摘要： This invention is directed toward mutated DNA, proteins, or protein fragments and particles from the L-2 cell line. The invention is also directed to diagnostic, prophylactic and therapeutic methods of making and using the DNA, protein and particles.
摘要翻译：本发明涉及来自L-2细胞系的突变的DNA，蛋白质或蛋白质片段和颗粒。本发明还涉及制备和使用DNA，蛋白质和颗粒的诊断，预防和治疗方法。

6. 发明申请

WO9212996A3 Vaccination and methods against diseases resultingfrom pathogenic responses by specific T cell popu lations 审中-公开
标题翻译：疫苗接种和针对特定T细胞群体致病反应所致疾病的方法
公开(公告)号：WO9212996A3
公开(公告)日：1992-12-10
申请号：PCT/US9200482
申请日：1992-01-21
申请人： IMMUNE RESPONSE CORP INC
发明人： HOWELL MARK D , BROSTOFF STEVEN W , CARLO DENNIS J
IPC分类号： A61K39/00 , A61K38/00 , A61K39/39 , A61K39/395 , A61K48/00 , A61P25/00 , A61P29/00 , A61P37/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/46 , C07K14/705 , C07K14/725 , C07K16/00 , C07K16/28 , C07K16/42 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/569
CPC分类号： C07K16/2809 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/7051 , C07K16/4258
摘要： The present invention provides vaccines and a means of vaccinating a vertebrate so as to prevent or control specific T cell mediated pathologies, including autoimmune diseases and the unregulatedreplication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. Such a peptide can bind to conventional antigens complexed to MHC antigen presenting cells or to superantigens. Means of determining appropriate amino acid sequences for such vaccines are also provided. The vaccine is administered to the vertebrate in a manner that induces an immune response directed against the TCR of T cells mediating the pathology. This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. The invention aditionally provides specific β-chain variable regions of T cell receptors, designated Vβ3, Vβ4, Vβ12, Vβ14 and Vβ17, which are associated with the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and multiple sclerosis (MS). Also provided are means to detect, prevent and treat RA and MS. Methods of administering DNA or RNA encoding the polypeptides useful as vaccines of the present invention into the tissue cells of an individual is also provided.

7. 发明申请

WO0067787A3 HIV IMMUNOGENIC COMPOSITIONS AND METHODS 审中-公开
标题翻译： HIV免疫组化和方法
公开(公告)号：WO0067787A3
公开(公告)日：2001-04-26
申请号：PCT/US0012495
申请日：2000-05-05
申请人： IMMUNE RESPONSE CORP INC , MOSS RONALD B
发明人： MOSS RONALD B
IPC分类号： A61K39/21 , A61K39/39 , A61P31/18
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K2039/5252 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2740/16034
摘要： The invention provides immunogenic compositions which enhance beta-chemokine levels in a mammal. The immunogenic compositions contain an HIV antigen, an isolated nucleic acid molecule containing an immunostimulatory sequence (ISS) and an adjuvant. The HIV antigen can be a whole-killed HIV virus devoid of outer envelope protein gp120. Alternatively, the HIV antigen can be a whole-killed HIV virus, or a p24 antigen. Also provided is a method of inhibiting AIDS, by enhancing beta-chemokine production in the mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an isolated nucleic acid molecule containing an immunostimulatory sequence (ISS) and an adjuvant.
摘要翻译：本发明提供增强哺乳动物中β-趋化因子水平的免疫原性组合物。免疫原性组合物含有HIV抗原，含有免疫刺激序列（ISS）和佐剂的分离的核酸分子。 HIV抗原可以是没有外包膜蛋白gp120的全杀死HIV病毒。或者，HIV抗原可以是全杀死的HIV病毒或p24抗原。还提供了通过向哺乳动物施用含有HIV抗原的免疫原性组合物，含有免疫刺激序列（ISS）和佐剂的分离的核酸分子来增强哺乳动物的β-趋化因子产生来抑制AIDS的方法。

8. 发明申请

WO9906544A8 MEMBRANE-BOUND CYTOKINE COMPOSITIONS AND METHODS OF MODULATING AN IMMUNE RESPONSE USING SAME 审中-公开
标题翻译：膜结合的细胞因子组合物和使用其调节免疫反应的方法
公开(公告)号：WO9906544A8
公开(公告)日：2000-04-27
申请号：PCT/US9815622
申请日：1998-07-27
申请人： IMMUNE RESPONSE CORP INC
发明人： SOO HOO WILLIAM
IPC分类号： C12N15/09 , A61K35/12 , A61K35/66 , A61K39/00 , A61K39/39 , A61K48/00 , A61P35/00 , A61P37/02 , C07K14/475 , C07K14/52 , C07K14/535 , C07K14/705 , C07K14/71 , C12N15/11 , C07H21/04 , C12N15/63
CPC分类号： A61K39/0011 , A61K39/39 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522 , A61K2039/6031 , C07K14/52 , C07K14/535 , C07K14/71 , C07K2319/00 , C07K2319/02
摘要： The present invention provides a cellular vaccine having a membrane-bound fusion protein that includes a non-antibody immunomodulatory molecule operatively fused to a heterologous membrane attachment domain. Non-antibody immunomodulatory molecules useful in the invention include immunostimulatory and immunosuppressive molecules such as cytokines. In one embodiment, the invention provides a cellular vaccine having a membrane-bound fusion protein that includes a non-antibody immunomodulatory molecule operatively fused to a heterologous membrane attachment domain and, additionally, a disease-associated antigen or immunogenic epitope thereof. Further provided by the invention are methods of modulating an immune response against a disease-associated antigen by administering to an individual a cellular vaccine having a membrane-bound fusion protein that includes a non-antibody immunomodulatory molecule operatively fused to a heterologous membrane attachment domain.
摘要翻译：本发明提供了具有膜结合融合蛋白的细胞疫苗，其包括可操作地融合到异源膜连接结构域的非抗体免疫调节分子。可用于本发明的非抗体免疫调节分子包括免疫刺激和免疫抑制分子如细胞因子。在一个实施方案中，本发明提供了具有膜结合融合蛋白的细胞疫苗，其包括可操作地融合到异源膜连接结构域的非抗体免疫调节分子，以及另外与疾病相关的抗原或其免疫原性表位。本发明还提供了通过向个体施用具有膜结合融合蛋白的细胞疫苗来调节针对疾病相关抗原的免疫应答的方法，所述融合蛋白包括可操作地融合到异源膜附着结构域的非抗体免疫调节分子。

9. 发明申请

WO9615653A3 Vial retainer 审中-公开
标题翻译：小瓶保持架
公开(公告)号：WO9615653A3
公开(公告)日：1996-07-25
申请号：PCT/US9513960
申请日：1995-10-31
申请人： IMMUNE RESPONSE CORP INC
发明人： FILIMON GARY , PEZZOLI PATRICK
IPC分类号： B01L9/00 , B01L9/06
CPC分类号： B01L9/06
摘要： 0he present invention provides a vial retainer which engages the top portion (10) of one or more vials. The retainer is a solid block of material with a base planar surface (15) and a top planar surface (10) and having a series of evenly spaced widening apertures through the block. So that the diameter of the aperture through the bottom surface (50) is larger than the diameter of the aperture at the top surface (40).

10. 发明申请

WO2006012641A3 METHODS FOR DETECTING AND TREATING AUTOIMMUNE DISORDERS 审中-公开
标题翻译：检测和治疗自身免疫性疾病的方法
公开(公告)号：WO2006012641A3
公开(公告)日：2007-12-13
申请号：PCT/US2005026915
申请日：2005-07-29
申请人： UNIV OREGON HEALTH & SCIENCE , US GOV VETERANS AFFAIRS , IMMUNE RESPONSE CORP INC , VANDENBARK ARTHUR A , OFFNER HALINA , BARTHOLOMEW RICHARD
发明人： VANDENBARK ARTHUR A , OFFNER HALINA , BARTHOLOMEW RICHARD
IPC分类号： A01N37/18 , A61K49/00
CPC分类号： A61K39/0008 , A61K2039/55566 , C07K14/7051 , G01N33/564 , A61K2300/00
摘要： The present disclosure relates to methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that increases FOXP3 expression, thereby inhibiting the autoimmune disease. Further disclosed herein are methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease.
摘要翻译：本公开涉及通过向受试者施用治疗有效量的增加FOXP3表达的组合物从而抑制自身免疫疾病来抑制自身免疫疾病的方法。本文进一步公开的是用于在受试者中检测自身免疫性疾病或自身免疫性疾病的倾向的方法，以及用于评估自身免疫性疾病治疗功效的方法。

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