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1. 发明申请

WO2007133580A3 USE OF PTH (1-31) AND OPTIONALLY G-CSF FOR HEMATOPOIETIC STIMULATION 审中-公开
标题翻译：使用PTH（1-31）和选择性G-CSF用于HEMATOPOIETIC刺激
公开(公告)号：WO2007133580A3
公开(公告)日：2008-12-24
申请号：PCT/US2007011176
申请日：2007-05-07
申请人： ZELOS THERAPEUTICS INC , MORLEY PAUL
发明人： MORLEY PAUL
IPC分类号： A61K38/29 , A61K38/19 , A61P43/00
CPC分类号： A61K38/29 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/204 , A61K2300/00
摘要： The present invention is directed to new methods for treating a subject in need of hematopoietic stimulation. The present invention is also directed to new methods of neutrophil stimulation in a subject in need thereof. The present invention is also directed to new methods of platelet stimulation in a subject in need thereof. The methods comprise administering to the subject an effective amount of a peptide optionally in combination of a hematopoietic growth factor, wherein the peptide is: (i) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH2 (SEQ ED NO: 1), where Xaa = Lys, Leu, He, NIe or Met, preferably Xaa = Lys; or (ii) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y (SEQ ID NO: 2), cyclized in the form of a lactam between GIu22 and Lys26, Xaa = Leu, He, NIe or Met, Y = NH2 Or OH. Preferably, Xaa is Leu and Y is NH2.
摘要翻译：本发明涉及用于治疗需要造血刺激的受试者的新方法。本发明还涉及有需要的受试者中嗜中性粒细胞刺激的新方法。本发明还涉及有需要的受试者中血小板刺激的新方法。所述方法包括向受试者施用有效量的任选地与造血生长因子组合的肽，其中所述肽是：（i）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn- Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH2（SEQ ID NO：1）其中Xaa = Lys，Leu，He，NIe或Met，优选Xaa = Lys; 或（ii）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp- Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y（SEQ ID NO：2），在Glu22和Lys26之间以内酰胺的形式环化，Xaa = Leu，He，NIe或Met，Y = NH 2 或OH。优选地，Xaa是Leu，Y是NH 2。

2. 发明申请

WO2007130113A3 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007130113A3
公开(公告)日：2008-10-30
申请号：PCT/US2006034546
申请日：2006-09-06
申请人： ZELOS THERAPEUTICS INC , MORLEY PAUL
发明人： MORLEY PAUL
IPC分类号： A61K38/00 , C07K2/00
CPC分类号： A61K31/59 , A61K33/06 , A61K38/29 , A61K2300/00
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose of 2 µg to 60 µg, wherein said PTH peptide analogue has a reduced phospholipase-C activity and maintains adenylate cyclase activity.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用含有2μg至60μg的日剂量的甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其中所述PTH肽类似物具有降低的磷脂酶C活性并维持腺苷酸环化酶活性。

3. 发明申请

WO2007133580A2 METHODS FOR HEMATOPOIETIC STIMULATION 审中-公开
标题翻译： HEMATOPOIETIC STIMULATION的方法
公开(公告)号：WO2007133580A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011176
申请日：2007-05-07
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul
发明人： MORLEY, Paul
CPC分类号： A61K38/29 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/204 , A61K2300/00
摘要： The present invention is directed to new methods for treating a subject in need of hematopoietic stimulation. The present invention is also directed to new methods of neutrophil stimulation in a subject in need thereof. The present invention is also directed to new methods of platelet stimulation in a subject in need thereof. The methods comprise administering to the subject an effective amount of a peptide optionally in combination of a hematopoietic growth factor, wherein the peptide is: (i) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH 2 (SEQ ED NO: 1), where Xaa = Lys, Leu, He, NIe or Met, preferably Xaa = Lys; or (ii) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y (SEQ ID NO: 2), cyclized in the form of a lactam between GIu 22 and Lys 26 , Xaa = Leu, He, NIe or Met, Y = NH 2 Or OH. Preferably, Xaa is Leu and Y is NH 2 .
摘要翻译：本发明涉及用于治疗需要造血刺激的受试者的新方法。本发明还涉及有需要的受试者中嗜中性粒细胞刺激的新方法。本发明还涉及有需要的受试者中血小板刺激的新方法。所述方法包括向受试者施用有效量的任选地与造血生长因子组合的肽，其中所述肽是：（i）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn- Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH 2 （SEQ ID NO：1），其中Xaa = Lys，Leu，He，NIe或Met，优选Xaa = Lys; 或（ii）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp- Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y（SEQ ID NO：2），其中内酰胺形式在Glu 22和Lys 26之间环化， SUP，Xaa = Leu，He，NIe或Met，Y = NH 2或OH。优选地，Xaa是Leu，Y是NH 2。

4. 发明申请

WO2005090404A2 COMPOSITIONS AND METHODS FOR DETECTING CYCLIC ANALOGS OF HPTH 审中-公开
标题翻译：用于检测HPTH循环模拟物的组合物和方法
公开(公告)号：WO2005090404A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008913
申请日：2005-03-17
申请人： ZELOS THEREPEUTICS, INC. , NATIONAL RESEARCH COUNCIL OF CANADA , MORLEY, Paul , GAO, Ping , WILLICK, Gordon, E.
发明人： MORLEY, Paul , GAO, Ping , WILLICK, Gordon, E.
IPC分类号： C07K16/26
CPC分类号： C07K14/635 , C07K16/26 , C07K2317/34 , G01N33/74 , G01N33/78 , G01N2333/635
摘要： The present invention is directed to novel antigens, antibodies and antigen binding fragments thereof, and to immunoassays and kits using these antigens and antibodies. The compositions and methods are useful in the determination of levels of cyclic analogs of hPTH in sample fluids, such as serum or plasma. The antibodies and methods of the invention have the particular advantage of possessing binding specificity for cyclic analogs of hPTH.
摘要翻译：本发明涉及新型抗原，抗体及其抗原结合片段，以及使用这些抗原和抗体的免疫测定和试剂盒。组合物和方法可用于测定样品流体如血清或血浆中hPTH的环状类似物的水平。本发明的抗体和方法具有对hPTH的环状类似物具有结合特异性的特别优点。

5. 发明申请

WO2005007184A2 CYCLIC ANALOGS OF HUMAN PARATHYROID HORMONE FOR THE TREATMENT OF CONDITIONS CHARACTERIZED BY HYPERPROLIFERATIVE SKIN CELLS 审中-公开
标题翻译：用于治疗由高增殖性皮肤细胞表征的病症的人类PARAMYROID HORMONE的循环模拟
公开(公告)号：WO2005007184A2
公开(公告)日：2005-01-27
申请号：PCT/CA2004/001003
申请日：2004-07-09
申请人： NATIONAL RESEARCH COUNCIL OF CANANDA , MORLEY, Paul , WHITFIELD, James, F.
发明人： MORLEY, Paul , WHITFIELD, James, F.
IPC分类号： A61K38/00
CPC分类号： A61K38/29
摘要： The present invention provides methods for treating conditions characterized by hyperproliferation of skin cells, by administering to an individual in need thereof a cyclic analog of human parathyroid hormone.
摘要翻译：本发明提供了治疗特征为皮肤细胞过度增生的病症的方法，通过向有需要的个体施用人甲状旁腺激素的环状类似物。

6. 发明申请

WO1998005683A1 PARATHYROID HORMONE ANALOGUES FOR THE TREATMENT OF OSTEOPOROSIS 审中-公开
标题翻译：用于治疗OSTEOPOSOSIS的PARATHYROID HORMONE ANALOGUES
公开(公告)号：WO1998005683A1
公开(公告)日：1998-02-12
申请号：PCT/CA1997000547
申请日：1997-08-01
申请人： NATIONAL RESEARCH COUNCIL OF CANADA , BARBIER, Jean-René , MORLEY, Paul , NEUGEBAUER, Witold , ROSS, Virginia , WHITFIELD, James , WILLICK, Gordon, E.
发明人： NATIONAL RESEARCH COUNCIL OF CANADA
IPC分类号： C07K14/635
CPC分类号： A61K38/29 , C07K14/635
摘要： This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailabilities. The peptides described are derivatives of hPTH-(1-31) which are cyclized for example, by formation of Lactams between either Glu and Lys or Lys and Asp . In addition, the natural Lys may be substituted by either a Leu or other hydrophobic residues, such as Ile, norleucine, Met, Val, Ala, Trp, or Phe. Typically, these analogues have enhanced abilities to stimulate adenylyl cyclase in rat osteosarcoma cells, and show increased activities in bone restoration, using the ovariectomized rat model. The analogues also show enhanced activities and bioavailabilities, as demonstrated by their hypotensive effects in the rat. An assay which correlates hypotensive activity with osteogenic activity is also described.
摘要翻译：本发明描述了人甲状旁腺激素的类似物，其具有增加的骨修复活性和增加的生物利用度。描述的肽是hPTH-（1-31）的衍生物，其通过例如在Glu 22和Lys 26之间形成内聚物或Lys 26和Asp 30进行环化。此外，天然Lys 27可以被Leu或其它疏水残基取代，例如Ile，正亮氨酸，Met，Val，Ala，Trp或Phe。通常，这些类似物具有增强的能力，以刺激大鼠骨肉瘤细胞中的腺苷酸环化酶，并且使用卵巢切除的大鼠模型显示增加的骨修复活动。类似物还显示出增强的活性和生物利用度，如其在大鼠中的降血压作用所证明的。还描述了将降血压活性与成骨活性相关联的测定法。

7. 发明申请

WO2016077146A1 APPLICATION ASSIGNMENT RECONCILIATION AND LICENSE MANAGEMENT 审中-公开
标题翻译：应用指配重新授权和许可管理
公开(公告)号：WO2016077146A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/059229
申请日：2015-11-05
申请人： BLACKBERRY LIMITED , MORLEY, Paul Douglas
发明人： MORLEY, Paul Douglas , SMITH, Andrew Christopher , KHEIRI, Haseem UI Haq , WANG, Qiusheng David , SMITH, Kelsey McKinnon
IPC分类号： G06Q30/06
CPC分类号： H04L67/327 , G06Q30/06 , H04L67/02
摘要： The present disclosure involves systems, software, and computer-implemented methods for reconciling application assignments of different types to users and devices, and associating appropriate licenses for the applications to the users from purchase accounts managed by an external application store. An example method includes identifying a change in an assignment configuration for a user, the assignment configuration including a plurality of assignments of an application to the user; determining a winning assignment from the plurality of assignments; in response to determining the winning assignment, determining that the winning assignment requires a change to an external application store; and in response to determining that the winning assignment requires a change to the external application store, instructing the external application store to perform a configuration change corresponding to the winning assignment.
摘要翻译：本公开涉及用于将不同类型的应用程序分配与用户和设备进行协调的系统，软件和计算机实现的方法，以及将来自外部应用商店管理的购买帐户的应用程序的适当许可证关联到用户。示例性方法包括识别用户的分配配置的变化，所述分配配置包括对用户的应用的多个分配; 从所述多个分配中确定获胜分配; 响应于确定获胜分配，确定获胜分配需要改变外部应用商店; 并且响应于确定所述获胜分配需要改变所述外部应用商店，指示所述外部应用商店执行与所述获胜分配相对应的配置改变。

8. 发明申请

WO2008016404A3 PARATHYROID HORMONE ANALOGUES AND USES THEREOF 审中-公开
标题翻译： PARATHYROID HORMONE ANALOGUES及其用途
公开(公告)号：WO2008016404A3
公开(公告)日：2009-01-15
申请号：PCT/US2007010720
申请日：2007-05-02
申请人： ZELOS THERAPEUTICS INC , MORLEY PAUL , STOGNIEW MARTIN , MACDONALD BRIAN , MERUTKA GENE SCOTT , PALEPU NAGESH R
发明人： MORLEY PAUL , STOGNIEW MARTIN , MACDONALD BRIAN , MERUTKA GENE SCOTT , PALEPU NAGESH R
IPC分类号： A61K38/29 , A61K9/08 , A61K38/12 , A61P19/08
CPC分类号： A61K9/0075 , A61K9/0019 , A61K9/19 , A61K38/29 , A61K47/10 , A61K47/14 , A61K47/18
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以导致有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

9. 发明申请

WO2008016404A2 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 审中-公开
公开(公告)号：WO2008016404A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/010720
申请日：2007-05-02
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul , STOGNIEW, Martin , MACDONALD, Brian , MERUTKA, Gene, Scott , PALEPU, Nagesh, R.
发明人： MORLEY, Paul , STOGNIEW, Martin , MACDONALD, Brian , MERUTKA, Gene, Scott , PALEPU, Nagesh, R.
IPC分类号： A61K38/29 , A61K38/12 , A61K9/08 , A61P19/08
CPC分类号： A61K9/0075 , A61K9/0019 , A61K9/19 , A61K38/29 , A61K47/10 , A61K47/14 , A61K47/18
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以产生有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

10. 发明申请

WO2007130113A2 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007130113A2
公开(公告)日：2007-11-15
申请号：PCT/US2006/034546
申请日：2006-09-06
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul
发明人： MORLEY, Paul
IPC分类号： A61K38/29 , A61K31/59 , A61K33/06
CPC分类号： A61K31/59 , A61K33/06 , A61K38/29 , A61K2300/00
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose of 2 μg to 60 μg, wherein said PTH peptide analogue has a reduced phospholipase-C activity and maintains adenylate cyclase activity.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其剂量为2μg至60μg，其中所述PTH肽类似物具有降低的磷脂酶C活性并维持腺苷酸环化酶活性。

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