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1. 发明申请

WO2007133580A2 METHODS FOR HEMATOPOIETIC STIMULATION 审中-公开
标题翻译： HEMATOPOIETIC STIMULATION的方法
公开(公告)号：WO2007133580A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011176
申请日：2007-05-07
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul
发明人： MORLEY, Paul
CPC分类号： A61K38/29 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/204 , A61K2300/00
摘要： The present invention is directed to new methods for treating a subject in need of hematopoietic stimulation. The present invention is also directed to new methods of neutrophil stimulation in a subject in need thereof. The present invention is also directed to new methods of platelet stimulation in a subject in need thereof. The methods comprise administering to the subject an effective amount of a peptide optionally in combination of a hematopoietic growth factor, wherein the peptide is: (i) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH 2 (SEQ ED NO: 1), where Xaa = Lys, Leu, He, NIe or Met, preferably Xaa = Lys; or (ii) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y (SEQ ID NO: 2), cyclized in the form of a lactam between GIu 22 and Lys 26 , Xaa = Leu, He, NIe or Met, Y = NH 2 Or OH. Preferably, Xaa is Leu and Y is NH 2 .
摘要翻译：本发明涉及用于治疗需要造血刺激的受试者的新方法。本发明还涉及有需要的受试者中嗜中性粒细胞刺激的新方法。本发明还涉及有需要的受试者中血小板刺激的新方法。所述方法包括向受试者施用有效量的任选地与造血生长因子组合的肽，其中所述肽是：（i）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn- Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH 2 （SEQ ID NO：1），其中Xaa = Lys，Leu，He，NIe或Met，优选Xaa = Lys; 或（ii）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp- Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y（SEQ ID NO：2），其中内酰胺形式在Glu 22和Lys 26之间环化， SUP，Xaa = Leu，He，NIe或Met，Y = NH 2或OH。优选地，Xaa是Leu，Y是NH 2。

2. 发明申请

WO2008016404A2 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 审中-公开
公开(公告)号：WO2008016404A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/010720
申请日：2007-05-02
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul , STOGNIEW, Martin , MACDONALD, Brian , MERUTKA, Gene, Scott , PALEPU, Nagesh, R.
发明人： MORLEY, Paul , STOGNIEW, Martin , MACDONALD, Brian , MERUTKA, Gene, Scott , PALEPU, Nagesh, R.
IPC分类号： A61K38/29 , A61K38/12 , A61K9/08 , A61P19/08
CPC分类号： A61K9/0075 , A61K9/0019 , A61K9/19 , A61K38/29 , A61K47/10 , A61K47/14 , A61K47/18
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以产生有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

3. 发明申请

WO2007130113A2 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007130113A2
公开(公告)日：2007-11-15
申请号：PCT/US2006/034546
申请日：2006-09-06
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul
发明人： MORLEY, Paul
IPC分类号： A61K38/29 , A61K31/59 , A61K33/06
CPC分类号： A61K31/59 , A61K33/06 , A61K38/29 , A61K2300/00
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose of 2 μg to 60 μg, wherein said PTH peptide analogue has a reduced phospholipase-C activity and maintains adenylate cyclase activity.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其剂量为2μg至60μg，其中所述PTH肽类似物具有降低的磷脂酶C活性并维持腺苷酸环化酶活性。

4. 发明申请

WO2005090404A2 COMPOSITIONS AND METHODS FOR DETECTING CYCLIC ANALOGS OF HPTH 审中-公开
标题翻译：用于检测HPTH循环模拟物的组合物和方法
公开(公告)号：WO2005090404A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008913
申请日：2005-03-17
申请人： ZELOS THEREPEUTICS, INC. , NATIONAL RESEARCH COUNCIL OF CANADA , MORLEY, Paul , GAO, Ping , WILLICK, Gordon, E.
发明人： MORLEY, Paul , GAO, Ping , WILLICK, Gordon, E.
IPC分类号： C07K16/26
CPC分类号： C07K14/635 , C07K16/26 , C07K2317/34 , G01N33/74 , G01N33/78 , G01N2333/635
摘要： The present invention is directed to novel antigens, antibodies and antigen binding fragments thereof, and to immunoassays and kits using these antigens and antibodies. The compositions and methods are useful in the determination of levels of cyclic analogs of hPTH in sample fluids, such as serum or plasma. The antibodies and methods of the invention have the particular advantage of possessing binding specificity for cyclic analogs of hPTH.
摘要翻译：本发明涉及新型抗原，抗体及其抗原结合片段，以及使用这些抗原和抗体的免疫测定和试剂盒。组合物和方法可用于测定样品流体如血清或血浆中hPTH的环状类似物的水平。本发明的抗体和方法具有对hPTH的环状类似物具有结合特异性的特别优点。

5. 发明申请

WO2005007184A2 CYCLIC ANALOGS OF HUMAN PARATHYROID HORMONE FOR THE TREATMENT OF CONDITIONS CHARACTERIZED BY HYPERPROLIFERATIVE SKIN CELLS 审中-公开
标题翻译：用于治疗由高增殖性皮肤细胞表征的病症的人类PARAMYROID HORMONE的循环模拟
公开(公告)号：WO2005007184A2
公开(公告)日：2005-01-27
申请号：PCT/CA2004/001003
申请日：2004-07-09
申请人： NATIONAL RESEARCH COUNCIL OF CANANDA , MORLEY, Paul , WHITFIELD, James, F.
发明人： MORLEY, Paul , WHITFIELD, James, F.
IPC分类号： A61K38/00
CPC分类号： A61K38/29
摘要： The present invention provides methods for treating conditions characterized by hyperproliferation of skin cells, by administering to an individual in need thereof a cyclic analog of human parathyroid hormone.
摘要翻译：本发明提供了治疗特征为皮肤细胞过度增生的病症的方法，通过向有需要的个体施用人甲状旁腺激素的环状类似物。

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