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1. 发明申请

WO2008008215A3 METHOD FOR ENHANCING PDT EFFICACY USING A TYROSINE KINASE INHIBITOR 审中-公开
标题翻译：使用酪氨酸激酶抑制剂增强PDT效率的方法
公开(公告)号：WO2008008215A3
公开(公告)日：2008-09-04
申请号：PCT/US2007015263
申请日：2007-06-29
申请人： HEALTH RESEARCH INC , PANDEY RAVINDRA K , OSEROFF ALLAN , MORGAN JANET , ZHENG XIANG , WEIGUO LIU
发明人： PANDEY RAVINDRA K , OSEROFF ALLAN , MORGAN JANET , ZHENG XIANG , WEIGUO LIU
IPC分类号： A61K31/409
CPC分类号： A61K31/409 , A61K41/0061 , A61K41/0071
摘要： A method for treating hyperproliferative tissue in a mammal which tissue expresses ABCG2 including the steps of: a) systemically introducing from about 100 to about 1000 mg/kg of body weight of a tyrosine kinase inhibiting compound into the mammal; b) within from about 0.5 to about 24 hours after the introducing in step a) systemically introducing from about 0.05 to about 0.5 µmol per kilogram of body weight of a tumor avid photosensitizing compound, that acts as a substrate for ABC family transport protein, ABCG2 and that has a preferential light absorbance frequency; and c) exposing the hyperproliferative tissue to light at a fluence of from about 50 to about 150 J/cm 2 delivered at a rate of from about 5 to about 25 mW/cm 2 at the light absorbance frequency. The photosensitizing compound is preferably a tetrapyrollic photosensitizer compound where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pheophorbide including pyropheophorbides, purpurinimide, or bacteriopurpurinimide and derivatives thereof; provided that, the photosensizing compound is not a meso-tetra (3-hydroxyphenyl) derivative, is not a saccharide derivative and is not a hematoporphyrin.
摘要翻译：一种用于治疗组织表达ABCG2的哺乳动物的过度增殖组织的方法，包括以下步骤：a）将约100至约1000mg / kg体重的酪氨酸激酶抑制化合物全身引入哺乳动物; b）在步骤a）中引入后约0.5至约24小时内，全身引入约0.05至约0.5μmol/千克体重的肿瘤avid光敏化合物，其作为ABC家族转运蛋白ABCG2的底物并具有优先吸光度频率; 并且c）将过度增殖组织以约5至约25mW / cm 2的速率递送的约50至约150J / cm 2的能量密度曝光， SUP>在吸光度频率。光敏化合物优选为四级光敏剂化合物，其中四味化合物是二氢卟酚，细菌二氢卟酚，卟啉，含有偏高双歧杆菌，嘌呤酰亚胺或嘌呤嘌呤酰亚胺及其衍生物的脱镁叶绿素; 光敏化合物不是内消旋 - 四（3-羟基苯基）衍生物，不是糖衍生物，不是血卟啉。

2. 发明申请

WO2008008215A2 METHOD FOR ENHANCING PDT EFFICACY USING A TYROSINE KINASE INHIBITOR 审中-公开
标题翻译：利用酪氨酸激酶抑制剂增强PDT功效的方法
公开(公告)号：WO2008008215A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015263
申请日：2007-06-29
申请人： HEALTH RESEARCH, INC. , PANDEY, Ravindra, K. , OSEROFF, Allan , MORGAN, Janet , ZHENG, Xiang , WEIGUO, Liu
发明人： PANDEY, Ravindra, K. , OSEROFF, Allan , MORGAN, Janet , ZHENG, Xiang , WEIGUO, Liu
IPC分类号： A61K31/409
CPC分类号： A61K31/409 , A61K41/0061 , A61K41/0071
摘要： A method for treating hyperproliferative tissue in a mammal which tissue expresses ABCG2 including the steps of: a) systemically introducing from about 100 to about 1000 mg/kg of body weight of a tyrosine kinase inhibiting compound into the mammal; b) within from about 0.5 to about 24 hours after the introducing in step a) systemically introducing from about 0.05 to about 0.5 μmol per kilogram of body weight of a tumor avid photosensitizing compound, that acts as a substrate for ABC family transport protein, ABCG2 and that has a preferential light absorbance frequency; and c) exposing the hyperproliferative tissue to light at a fluence of from about 50 to about 150 J/cm 2 delivered at a rate of from about 5 to about 25 mW/cm 2 at the light absorbance frequency. The photosensitizing compound is preferably a tetrapyrollic photosensitizer compound where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pheophorbide including pyropheophorbides, purpurinimide, or bacteriopurpurinimide and derivatives thereof; provided that, the photosensizing compound is not a meso-tetra (3-hydroxyphenyl) derivative, is not a saccharide derivative and is not a hematoporphyrin.
摘要翻译：一种治疗哺乳动物中过度增殖组织的方法，所述组织表达ABCG2，所述方法包括以下步骤：a）将约100至约1000mg / kg体重的酪氨酸激酶抑制性化合物全身性地引入哺乳动物; b）在步骤a）中引入约0.5至约24小时后，系统地引入约0.05至约0.5μmol/千克体重的肿瘤亲合性光敏化合物，其充当ABC家族转运蛋白ABCG2的底物并且具有优先的光吸收频率; 和c）以约5至约25mW / cm 2的速率递送约50至约150J / cm 2的能量密度将过度增殖组织暴露于光下，在光吸收频率下。光敏化合物优选四吡咯类光敏剂化合物，其中四吡咯化合物为二氢卟酚，菌绿素，卟啉，脱镁叶绿酸包括焦脱镁叶绿酸，紫红素酰亚胺或细菌嘌呤亚胺及其衍生物; 条件是，光敏化合物不是一种内消旋 - 四（3-羟基苯基）衍生物，不是糖衍生物，也不是血卟啉。

3. 发明申请

WO2009105210A2 B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING 审中-公开
标题翻译： B环减少型D环氧化型四光子光敏剂在光动力疗法和肿瘤成像中的应用
公开(公告)号：WO2009105210A2
公开(公告)日：2009-08-27
申请号：PCT/US2009/001030
申请日：2009-02-19
申请人： HEALTH RESEARCH, INC. , LIU, Chao , DOBHAL, Mahabeer , POTTER, William , MORGAN, Janet , OSEROFF, Allan
发明人： LIU, Chao , DOBHAL, Mahabeer , POTTER, William , MORGAN, Janet , OSEROFF, Allan
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl 3 6H 2 O to oxidize the D ring and separating the resulting organic layer and drying.
摘要翻译：具有A，B，C和D环并具有减少的B环和氧化的D环的四吡咯类光敏剂和显像剂化合物。所述化合物优选具有至少95％的纯度，并且优选具有在C环的最靠近D环的不饱和碳原子处和C和D环之间的不饱和碳原子处连接的稠合体系。本发明还包括通过以B和D环氧化四吡咯化合物开始并将其溶解在卤代烃溶剂中并用足量的FeCl 3 3 / sub的硝基烷溶液处理它来制备化合物的方法，其产率超过95％ > 6H 2 O氧化D环并分离所得有机层并干燥。

4. 发明申请

WO2009038659A2 ORGANICALLY MODIFIED SILICA NANOPARTICLES WITH COVALENTLY INCORPORATED PHOTOSENSITIZERS FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY 审中-公开
标题翻译：有机改性二氧化硅纳米粒子与共用光敏剂在光动力疗法中的药物释放
公开(公告)号：WO2009038659A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/010608
申请日：2008-09-11
申请人： HEALTH RESEARCH, INC. , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , PANDEY, Ravindra , GOSWAMI, Lalit , OSEROFF, Allan , MORGAN, Janet , PRASAD, Paras , BERGEY, Earl , OHULCHANSKYY, Tymish , ROY, Indrajit
发明人： PANDEY, Ravindra , GOSWAMI, Lalit , OSEROFF, Allan , MORGAN, Janet , PRASAD, Paras , BERGEY, Earl , OHULCHANSKYY, Tymish , ROY, Indrajit
IPC分类号： A61K51/06
CPC分类号： A61K49/0093 , A61K41/0071 , A61K49/0036 , A61K49/1824 , A61K51/1244 , B82Y5/00
摘要： Nanoparticles containing covalently linked photosensitizer molecules that overcome the drawback of premature release and thus enhance the outcome of PDT. [Silica-based nanoparticles are provided containing at least one covalently linked photosensitizer. The photosensitizer is preferably a tetrapyrrole-based compounds related to porphyrins, chlorins, bacteriochlorins, benzochlorins, benzoporphyrin derivatives, pheophorbides including pyropheophorbides, and phthalocyanines, naphthanocyanines with and without fused ring systems and derivatives of all the above. The nanoparticle may also include covalently linked imaging agents, e.g. radionuclides, magnetic resonance (MR) and fluorescence imaging agents. The imaging agents and photosensitizers may be at a periphery (surface) of the nanoparticles to increase efficiency. Target-specific nanoparticles may be provided by incorporating biotargeting molecules such as specific antibodies at the surface that react with particular ligands to obtain target specificity. Diagnostic agents may be present in the antibody in addition to imaging agents and tumor specific photosensitizers.
摘要翻译：纳米粒子含有共价连接的光敏剂分子，克服了过早释放的缺点，从而增强了PDT的结果。 [提供含有至少一种共价连接的光敏剂的二氧化硅基纳米颗粒。光敏剂优选为与卟啉，二氢卟酚，细菌二氢卟酚，苯并二氢卟啉，苯并卟啉衍生物，包括焦脱镁叶绿酸和酞菁的脱镁叶绿酸，具有和不具有稠环体系的萘菁以及上述全部衍生物有关的四吡咯类化合物。纳米颗粒还可以包括共价连接的成像剂，例如，放射性核素，磁共振（MR）和荧光显像剂。成像剂和光敏剂可以位于纳米颗粒的外围（表面）以提高效率。靶特异性纳米颗粒可以通过将表面特异性抗体等生物靶向分子掺入到与特定配体反应以获得靶特异性的表面来提供。除显像剂和肿瘤特异性光敏剂外，诊断剂可存在于抗体中。

5. 发明申请

WO2009038659A3 ORGANICALLY MODIFIED SILICA NANOPARTICLES WITH COVALENTLY INCORPORATED PHOTOSENSITIZERS FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY 审中-公开
标题翻译：有机改性二氧化硅纳米颗粒与光合动力疗法中药物递送的共同合成光敏剂
公开(公告)号：WO2009038659A3
公开(公告)日：2009-09-03
申请号：PCT/US2008010608
申请日：2008-09-11
申请人： HEALTH RESEARCH INC , UNIV NEW YORK STATE RES FOUND , PANDEY RAVINDRA , GOSWAMI LALIT , OSEROFF ALLAN , MORGAN JANET , PRASAD PARAS , BERGEY EARL , OHULCHANSKYY TYMISH , ROY INDRAJIT
发明人： PANDEY RAVINDRA , GOSWAMI LALIT , OSEROFF ALLAN , MORGAN JANET , PRASAD PARAS , BERGEY EARL , OHULCHANSKYY TYMISH , ROY INDRAJIT
IPC分类号： B23B9/04
CPC分类号： A61K49/0093 , A61K41/0071 , A61K49/0036 , A61K49/1824 , A61K51/1244 , B82Y5/00
摘要： Nanoparticles containing covalently linked photosensitizer molecules that overcome the drawback of premature release and thus enhance the outcome of PDT. [Silica-based nanoparticles are provided containing at least one covalently linked photosensitizer. The photosensitizer is preferably a tetrapyrrole-based compounds related to porphyrins, chlorins, bacteriochlorins, benzochlorins, benzoporphyrin derivatives, pheophorbides including pyropheophorbides, and phthalocyanines, naphthanocyanines with and without fused ring systems and derivatives of all the above. The nanoparticle may also include covalently linked imaging agents, e.g. radionuclides, magnetic resonance (MR) and fluorescence imaging agents. The imaging agents and photosensitizers may be at a periphery (surface) of the nanoparticles to increase efficiency. Target-specific nanoparticles may be provided by incorporating biotargeting molecules such as specific antibodies at the surface that react with particular ligands to obtain target specificity. Diagnostic agents may be present in the antibody in addition to imaging agents and tumor specific photosensitizers.
摘要翻译：含有共价连接的光敏剂分子的纳米颗粒克服了过早释放的缺点，从而增强了PDT的结果。提供含有至少一种共价连接的光敏剂的基于二氧化硅的纳米颗粒。光敏剂优选为与卟啉，二氢卟酚，细菌二氢卟酚，苯并二氢卟酚，苯并卟啉衍生物，包括焦偏磷酸盐和酞菁的脱镁叶绿素，具有和不具有稠环体系的萘磺酸以及所有上述衍生物有关的四吡咯基化合物。纳米颗粒还可以包括共价连接的成像剂，例如。放射性核素，磁共振（MR）和荧光成像剂。成像剂和光敏剂可以在纳米颗粒的外围（表面）上以提高效率。可以通过在与特定配体反应的表面上并入生物靶向分子例如特异性抗体以获得靶特异性来提供靶特异性纳米颗粒。除成像剂和肿瘤特异性光敏剂之外，诊断剂可存在于抗体中。

6. 发明申请

WO2009105210A3 B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING 审中-公开
标题翻译：用于光化学治疗和肿瘤成像的B环减少D环氧化的光致变色光敏剂
公开(公告)号：WO2009105210A3
公开(公告)日：2009-12-30
申请号：PCT/US2009001030
申请日：2009-02-19
申请人： HEALTH RESEARCH INC , PANDEY RAVINDRA K , LIU CHAO , DOBHAL MAHABEER , POTTER WILLIAM , MORGAN JANET , OSEROFF ALLAN
发明人： PANDEY RAVINDRA K , LIU CHAO , DOBHAL MAHABEER , POTTER WILLIAM , MORGAN JANET , OSEROFF ALLAN
IPC分类号： A01N55/02
CPC分类号： C07D487/22
摘要： Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl36H2O to oxidize the D ring and separating the resulting organic layer and drying.
摘要翻译：具有A，B，C和D环并且具有还原的B环和氧化的D环的四味光敏剂和显影剂化合物。化合物优选具有至少95％的纯度，并且优选具有在C环的最接近D环的不饱和碳原子和C和D环之间的不饱和碳原子连接的稠合体系。本发明还包括通过用B和D环氧化的四元醇化合物开始制备化合物百分之九十五以上的方法，并将其溶解在卤代烃溶剂中，并用足够的FeCl 3·6H 2 O的硝基烷烃溶液处理以氧化D环并分离所得有机层并干燥。

7. 发明申请

WO2009105209A1 SILICA NANOPARTICLES POSTLOADED WITH PHOTOSENSITIZERS FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY 审中-公开
标题翻译：用光敏剂治疗药物递送的二氧化硅纳米粒子
公开(公告)号：WO2009105209A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/001029
申请日：2009-02-19
申请人： HEALTH RESEARCH, INC. , PANDEY, Ravindra, K. , GOSWAMI, Lalit, N. , OSEROFF, Allan , MORGAN, Janet , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , PRASAD, Paras , BERGEY, Earl
发明人： PANDEY, Ravindra, K. , GOSWAMI, Lalit, N. , OSEROFF, Allan , MORGAN, Janet , PRASAD, Paras , BERGEY, Earl
IPC分类号： A01N55/00 , A61K31/695
CPC分类号： A61K49/0032 , A61K41/0071 , A61K49/0093 , A61K51/1255
摘要： A nanoparticle including a polysiloxane base having an exterior surface and having a photosensitizer at least partly exposed at its exterior surface, said photosensitizer being secured to the exterior surface by loading the photosensitizer onto the surface after formation of the ploysiloxane base of the nanoparticle. The nanoparticle may have tumor targeting moieties and may be post loaded with cyanine dye. The nanoparticle preferably includes post loaded moieties providing at least two of tumor specificity, photodynamic properties and imaging capabilities and the photosensitizer is tagged with a radioisotope. A method for preparation of the nanoparticle is also provided.
摘要翻译：包含具有外表面并具有至少部分地在其外表面暴露的光敏剂的聚硅氧烷碱的纳米颗粒，所述光敏剂通过在形成纳米颗粒的聚硅氧烷碱之后将光敏剂加载到表面上而固定到外表面。纳米颗粒可以具有肿瘤靶向部分，并且可以用花青染料后载。纳米颗粒优选包括提供肿瘤特异性，光动力学特性和成像能力的至少两种的后加载部分，并且用放射性同位素标记光敏剂。还提供了制备纳米颗粒的方法。

8. 发明申请

WO2003078909A1 COMBINATION DEHYDRATOR AND CONDENSED WATER DISPENSER 审中-公开
标题翻译：组合脱水器和冷凝水分配器
公开(公告)号：WO2003078909A1
公开(公告)日：2003-09-25
申请号：PCT/US2003/007632
申请日：2003-03-11
申请人： MORGAN, Michael , MORGAN, Janet
发明人： MORGAN, Michael , MORGAN, Janet
IPC分类号： F26B19/00
CPC分类号： F26B9/066 , F25C1/10 , F26B21/001 , F26B21/086
摘要： A portable, atmospheric dehydrator and water condenser (110) for dehydrating fruits and vegetables while producing pure atmospheric condensation from humidity found in the air and purifying the water for dispensing and drinking purposes.
摘要翻译：一种便携式，大气脱水器和水冷凝器（110），用于使水果和蔬菜脱水，同时从空气中发现的湿度产生纯净的大气冷凝，并净化用于分配和饮用的水。

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