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1. 发明申请

WO2017087424A1 IMPLANTABLE DEVICE AND DELIVERY SYSTEM FOR RESHAPING A HEART VALVE ANNULUS 审中-公开
标题翻译：用于重置心瓣膜环的可植入装置和输送系统
公开(公告)号：WO2017087424A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062107
申请日：2016-11-15
申请人： MILLIPEDE, INC.
发明人： LASHINSKI, Randall , KRISTOFFERSEN, Kristian , RUST, Matthew , GLENN, Richard , DANIELS, Terry, Wayne , LEE, Michael , MACAULAY, Patrick
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61B17/064 , A61B2017/0647 , A61B2017/0649 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2/2466 , A61F2220/0016 , A61F2250/001
摘要： Systems, devices and methods related to various heart valve implants and for delivery of those heart valve implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. Anchors secure the implant to tissue and collars are used to decrease the angle between the struts and contract the frame. The implant thus expands from a first size inside of a delivery catheter, to a second and larger deployed size inside the heart to engage and anchor with the tissue, and then to a third and contracted size to re-size the annulus and/or provide a secure fit for a replacement heart valve. Various delivery systems including imaging capabilities for precise delivery, positioning and anchoring of the various implants are further described.
摘要翻译：描述了与各种心脏瓣膜植入物有关并用于输送那些心脏瓣膜植入物的系统，装置和方法。植入物可用于重新调整天然瓣膜环的尺寸或替换天然心脏瓣膜。植入物包括具有成角度支柱的可调整尺寸的框架。锚固件将植入物固定到组织上，并使用套环来减小支柱之间的角度并收缩框架。因此，植入物从输送导管内部的第一尺寸扩张到心脏内的第二和更大的展开尺寸，以与组织接合并锚定，然后扩张到第三和收缩尺寸以重新调整瓣环尺寸和/或提供安全适合更换心脏瓣膜。进一步描述了各种输送系统，包括用于精确输送，定位和锚定各种植入物的成像能力。

2. 发明申请

WO2018148584A1 IMPLANTABLE DEVICE AND DELIVERY SYSTEM FOR RESHAPING A HEART VALVE ANNULUS 审中-公开
公开(公告)号：WO2018148584A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017679
申请日：2018-02-09
申请人： MILLIPEDE, INC.
发明人： LASHINSKI, Randall , KRISTOFFERSEN, Kristian , RUST, Matthew , GLENN, Richard , DANIELS, Terry Wayne , LEE, Michael , MACAULAY, Patrick
IPC分类号： A61F2/24
摘要： Systems, devices and methods related to various heart valve implants and for delivery of those implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. The implant is secured to tissue with anchors that can rotate without axial advancement to engage tissue while drawing the implant closer to the tissue. Collars are used to decrease the angle between struts of a frame to contract the implant. The implants can include a rotatable shaft, such as a threaded shaft, located internally to an axially translatable collar. Rotation of the shaft transmits force to the collar to cause the collar to translate axially, closing the angle of adjacent struts and decreasing the width of the implant and thus of the annulus. The implants can be delivered, secured and contracted via a catheter. The implants are repositionable and retrievable via catheter.

3. 发明申请

WO2016130991A1 VALVE REPLACEMENT USING ROTATIONAL ANCHORS 审中-公开
标题翻译：阀门更换使用旋转锚杆
公开(公告)号：WO2016130991A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017866
申请日：2016-02-12
申请人： MILLIPEDE, INC.
发明人： LASHINSKI, Randall , RUST, Matthew , MACAULAY, Patrick , GLENN, Richard
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2433 , A61F2/2445 , A61F2220/0008 , A61F2220/0016 , A61F2230/0069
摘要： Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.
摘要翻译：描述了心脏瓣膜装置的特征。该装置可以包括具有构造成将装置固定到组织的锚的框架。框架可以包括用于附加固定植入装置的扩口端或裙部。该装置可以包括用于防止泄漏的诸如屏障和/或袖带的密封件。该装置可能收缩装置的血管内递送到心脏并膨胀以在心脏内固定，例如在二尖瓣环内。该装置可以包括更换阀。阀可以具有构造成沿着主流轴重新引导血流的小叶。

4. 发明申请

WO2017136596A1 MITRAL VALVE INVERSION PROSTHESES 审中-公开
标题翻译：二尖瓣反流假体
公开(公告)号：WO2017136596A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016284
申请日：2017-02-02
申请人： MILLIPEDE, INC.
发明人： LASHINSKI, Randall
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2220/0016 , A61F2250/001
摘要： Systems, devices and methods for resizing a valve annulus are described. An implant (910) is delivered proximate a mitral valve, the implant comprising a tubular body (940) and a plurality of piercing helical anchors (930), the tubular body comprising an proximal diameter and a distal diameter. Tissue proximate the mitral valve is engaged by rotating the plurality of anchors with corresponding rotational drivers. The tubular body may be transitioned from a first structural configuration having the proximal diameter smaller than the distal diameter to a second structural configuration having the proximal diameter larger than the distal diameter.
摘要翻译：描述了用于调整瓣膜环大小的系统，装置和方法。植入物（910）被输送到二尖瓣附近，植入物包括管状主体（940）和多个刺穿螺旋状锚定件（930），管状主体包括近侧直径和远侧直径。靠近二尖瓣的组织通过用相应的旋转驱动器旋转多个锚来接合。管状体可以从具有小于远端直径的近端直径的第一结构配置过渡到具有大于远端直径的近端直径的第二结构配置。

5. 发明申请

WO2014043527A3 MITRAL VALVE INVERSION PROSTHESES 审中-公开
标题翻译：麻醉阀逆变前景
公开(公告)号：WO2014043527A3
公开(公告)日：2015-06-11
申请号：PCT/US2013059751
申请日：2013-09-13
申请人： MILLIPEDE INC
发明人： LASHINSKI RANDALL
IPC分类号： A61F2/06
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2436 , A61F2/2442 , A61F2/2445 , A61F2/2457 , A61F2/2466 , A61F2/2487 , A61F2220/0016 , A61F2250/001 , A61H23/00
摘要： The present disclosure includes a method comprising inserting an implant proximate a mitral valve, the implant comprising a tubular body and a plurality of piercing members, the tubular body comprising an upper diameter and a lower diameter. The method also includes engaging tissue proximate the mitral valve by the plurality of piercing members and transitioning the tubular body from a first structural configuration to a second structural configuration by application of an expansive force to the tubular body proximate the upper diameter, the first structural configuration having the upper diameter smaller than the lower diameter and the second structural configuration having the upper diameter larger than the lower diameter. The present disclosure also includes associated systems and implants.
摘要翻译：本公开包括一种方法，包括将植入物接近二尖瓣插入，所述植入物包括管状体和多个刺穿构件，所述管状体包括上直径和下直径。所述方法还包括通过所述多个刺穿构件接合所述二尖瓣附近的组织，并且通过将所述管状体从第一结构构型转移到第二结构构型，通过向所述管状体施加接近所述上部直径的第一结构构造其上部直径小于下部直径，而第二结构构造的上部直径大于下部直径。本公开还包括相关联的系统和植入物。

6. 发明申请

WO2016011185A1 ADJUSTABLE ENDOLUMENAL MITRAL VALVE RING 审中-公开
标题翻译：可调节内螺纹阀门环
公开(公告)号：WO2016011185A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040622
申请日：2015-07-15
申请人： MILLIPEDE, INC.
发明人： LASHINSKI, Randall , RUST, Matthew , MACAULAY, Patrick , DANIELS, Terry Wayne , KRISTOFFERSEN, Kris
IPC分类号： A61F2/24 , A61B17/064
CPC分类号： A61F2/02 , A61B2017/0649 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2442 , A61F2/2445 , A61F2/2463 , A61F2/2466 , A61F2/93 , A61F2002/91591 , A61F2210/0023 , A61F2220/0016 , A61F2230/0065 , A61F2230/0069 , A61F2250/0006 , A61F2250/001
摘要： Excessive dilation of the annulus of a mitral valve may lead to regurgitation of blood during ventricular contraction. This regurgitation may lead to a reduction in cardiac output. Disclosed are systems and methods relating to an implant (3000) configured for reshaping a mitral valve. The implant comprises a plurality of struts with anchors (3003) for tissue engagement. The implant is compressible to a first, reduced diameter for transluminal navigation and delivery to the left atrium of a heart. The implant may then expand to a second, enlarged diameter to embed its anchors to the tissue surrounding and/or including the mitral valve. The implant may then contract to a third, intermediate diameter, pulling the tissue radially inwardly, thereby reducing the mitral valve and lessening any of the associated symptoms including mitral regurgitation.
摘要翻译：二尖瓣环的过度扩张可导致心室收缩时血液反流。这种反流可能导致心输出量的减少。公开了涉及用于重塑二尖瓣的植入物（3000）的系统和方法。植入物包括具有用于组织接合的锚固件（3003）的多个支柱。植入物可压缩至第一直径减小，用于经腔导航并输送到心脏的左心房。然后，植入物可以扩张到第二个扩大的直径，以将它的锚固件包围和/或包括二尖瓣。然后，植入物可以收缩到第三，中间直径，径向向内拉动组织，从而减少二尖瓣并减轻任何相关症状，包括二尖瓣反流。

7. 发明申请

WO2020018630A1 DEPLOYMENT RESTRAINT AND DELIVERY SYSTEM FOR IMPLANTABLE CARDIAC DEVICE 审中-公开
公开(公告)号：WO2020018630A1
公开(公告)日：2020-01-23
申请号：PCT/US2019/042139
申请日：2019-07-17
申请人： MILLIPEDE, INC.
发明人： GRISWOLD, Erik Christopher , LASHINSKI, Christopher Robert , LASHINSKI, Randall , LEE, Michael L.
IPC分类号： A61F2/24
摘要： Features for a restraint, such as a cap, are described. The restraint secures a cardiac device in a collapsed, delivery configuration for transcatheter delivery to a heart. The restraint may have a tubular sidewall extending from a proximal end to a distal end, a proximal opening defined by the sidewall at the proximal end and a channel defined by the sidewall and extending distally from the proximal opening. The restraint is configured to receive the implant in the collapsed configuration through the proximal opening to radially restrain the implant within the channel. The restraint eliminates the need for a surrounding sheath, reducing the delivery profile and size of the overall delivery system, among other advantages. The restraint may have an atraumatic leading edge to reduce the risk of injury to the patient.

8. 发明申请

WO2018148584A4 IMPLANTABLE DEVICE AND DELIVERY SYSTEM FOR RESHAPING A HEART VALVE ANNULUS 审中-公开
公开(公告)号：WO2018148584A4
公开(公告)日：2018-08-16
申请号：PCT/US2018/017679
申请日：2018-02-09
申请人： MILLIPEDE, INC.
发明人： LASHINSKI, Randall , KRISTOFFERSEN, Kristian , RUST, Matthew , GLENN, Richard , DANIELS, Terry Wayne , LEE, Michael , MACAULAY, Patrick
IPC分类号： A61F2/24
摘要： Systems, devices and methods related to various heart valve implants and for delivery of those implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. The implant is secured to tissue with anchors that can rotate without axial advancement to engage tissue while drawing the implant closer to the tissue. Collars are used to decrease the angle between struts of a frame to contract the implant. The implants can include a rotatable shaft, such as a threaded shaft, located internally to an axially translatable collar. Rotation of the shaft transmits force to the collar to cause the collar to translate axially, closing the angle of adjacent struts and decreasing the width of the implant and thus of the annulus. The implants can be delivered, secured and contracted via a catheter. The implants are repositionable and retrievable via catheter.

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