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1. 发明申请

WO2020023566A1 METHODS OF SEPARATING HOST CELL LIPASES FROM A PRODUCTION PROTEIN IN CHROMATOGRAPHIC PROCESSES 审中-公开
公开(公告)号：WO2020023566A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/043132
申请日：2019-07-24
申请人： MERCK SHARP & DOHME CORP. , CHMIELOWSKI, Rebecca, A. , INSAIDOO, Francis, K. , MILLER, Justin, B. , ROUSH, David, J. , SHAH, Darshini , WELSH, John, P.
发明人： CHMIELOWSKI, Rebecca, A. , INSAIDOO, Francis, K. , MILLER, Justin, B. , ROUSH, David, J. , SHAH, Darshini , WELSH, John, P.
IPC分类号： B01D15/20 , C07K1/22 , C07K16/10 , C07K16/18
摘要： Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided are pharmaceutical compositions comprising less than 1 ppm of a host cell lipase.

2. 发明申请

WO2012103276A1 COMBINATIONS 审中-公开
标题翻译：组合
公开(公告)号：WO2012103276A1
公开(公告)日：2012-08-02
申请号：PCT/US2012/022638
申请日：2012-01-26
申请人： GLAXO WELLCOME MANUFACTURING PTE LTD , BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM , AUGER, Kurt R. , BOTTSFORD-MILLER, Justin , SOOD, Anil K.
发明人： AUGER, Kurt R. , BOTTSFORD-MILLER, Justin , SOOD, Anil K.
IPC分类号： A61K31/4439
CPC分类号： A61K31/506 , A61K31/337 , A61K31/4439 , A61K2300/00
摘要： The present invention relates to a method of treating ovarian cancer in a female human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a ovarian cancer treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2- pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and 2-[(5-chloro-2-[[3-methyl-1-(1-methylethyl)-1 H-pyrazol-5-yl]amino]-4- pyridinyl)amino]-N-methoxybenzamide, or a pharmaceutically acceptable salt thereof, and optionally 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4, 13α-triyl 4- acetate 2-benzoate 13-{(2 R ,3 S )-3-[( tert -butoxycarbonyl)amino]-2-hydroxy-3- phenylpropanoate}, to a human in need thereof.
摘要翻译：本发明涉及一种治疗女性卵巢癌的方法以及用于治疗的药物组合物。特别地，该方法涉及卵巢癌治疗方法，其包括施用5 - [[[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺，或其药学上可接受的盐和2 - [（5-氯-2 - [[3-甲基-1-（1-甲基乙基）-1H-吡唑-5-基]氨基] -4-吡啶基）氨基 ] -N-甲氧基苯甲酰胺或其药学上可接受的盐，以及任选的1,7β，10β-三羟基-9-氧代-5β，20-环氧塔塔酮-11-烯-2a，4,13-三酰基4-乙酸酯2-苯甲酸酯 13 - {（2R，3S）-3 - [（叔丁氧基羰基）氨基] -2-羟基-3-苯基丙酸乙酯}。

3. 发明申请

WO2009158466A1 SYSTEM AND METHOD FOR COLLISION-FREE CAD DESIGN OF PIPE AND TUBE PATHS 审中-公开
标题翻译：管道和管道无冲突CAD设计的系统与方法
公开(公告)号：WO2009158466A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048607
申请日：2009-06-25
申请人： SIEMENS PRODUCT LIFECYCLE MANAGEMENT SOFTWARE INC. , MILLER, Justin, H.
发明人： MILLER, Justin, H.
IPC分类号： G06F17/50
CPC分类号： G06F17/50 , G06F17/509 , G06F2217/08 , G06F2217/34
摘要： A system, method, and computer program product for automated creation of collision-free paths for pipes and tubes in a CAD system. A method includes receiving inputs, in a data processing system, defining at least a start point and destination point for a pipe in a CAD environment, and a diameter for the pipe. The method includes determining sample points between the start point and destination point. The method also includes building a graph including the sample points and the start point and the destination points as nodes and a plurality of edges connecting the nodes. The method also includes computing a path through the graph between the start point and the destination point. The method also includes, for each node in the path, testing each edge connected to the node to determine if there is a collision along the edge between a test object model and a background model geometry in the CAD environment, and removing from the graph any edge that has a collision. If there is no collision along an edge of the path, then designating the path as a successful path and displaying the successful path to a user by the data processing system.
摘要翻译：一种用于在CAD系统中自动创建管道和管道的无碰撞路径的系统，方法和计算机程序产品。一种方法包括在数据处理系统中接收在CAD环境中至少定义管道的起始点和目的地点的输入以及管道的直径。该方法包括确定起始点和目标点之间的采样点。该方法还包括构建包括采样点和起始点和目的地点作为节点的图形以及连接节点的多个边缘。该方法还包括计算通过起始点和目的地点之间的图形的路径。该方法还包括，对于路径中的每个节点，测试连接到节点的每个边缘，以确定沿着CAD环境中的测试对象模型和背景模型几何之间的边缘是否存在碰撞，以及从图形中移除任何边缘有碰撞。如果路径边缘没有碰撞，则将路径指定为成功路径，并通过数据处理系统向用户显示成功的路径。

4. 发明申请

WO2005052471A1 DUAL RESTRICTOR SHUT-OFF VALVE 审中-公开
标题翻译：双限位开关阀
公开(公告)号：WO2005052471A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/038969
申请日：2004-11-19
申请人： PARKER-HANNIFIN CORPORATION , GILL, Scott D, , MILLER, Justin C, , PILON, Frederick J,
发明人： GILL, Scott D, , MILLER, Justin C, , PILON, Frederick J,
IPC分类号： F25B41/06
CPC分类号： F25B41/06 , F25B2341/061 , F25B2500/21 , Y10T137/7838 , Y10T137/7847
摘要： A shut-off valve (10, 110) for pressurized fluids in an air cooling/heating apparatus having a first duct (14) receiving a first restrictor (30, 140) and a second restrictor (34). Both restrictors (30, 140, 34) are coaxially formed with a capillary (42, 142, 46) through which the pressurized fluid passes and which causes the rapid expansion of the fluid when the fluid exits from a distal end of the capillary (42, 142, 46). The outer surface of the restrictors (30, 140, 34) is in direct contact with the interior surface of the first duct (14). The valve (10, 110) can further include a sampling instrument (155) located between the restrictors (30, 140, 34).
摘要翻译：一种在空气冷却/加热设备中用于加压流体的截止阀（10,110），其具有接收第一限流器（30,140）和第二限流器（34）的第一管道（14）。两个限制器（30,140,34）与毛细管（42,142,46）同轴地形成，加压流体通过该毛细管通过，并且当流体从毛细管的远端（42）离开时，导致流体的快速膨胀，142,46）。限流器（30,140,34）的外表面与第一管道（14）的内表面直接接触。阀（10,110）还可以包括位于限流器（30,140,34）之间的采样仪器（155）。

5. 发明申请

WO2023039269A1 VACUUM PUMP 审中-公开
公开(公告)号：WO2023039269A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/043277
申请日：2022-09-13
申请人： MILWAUKEE ELECTRIC TOOL CORPORATION , MILLER, Justin , TURAKHIYA, Shrey, M.
发明人： MILLER, Justin , TURAKHIYA, Shrey, M.
IPC分类号： F04C25/02 , F04C18/34 , F04C23/02 , F04C29/00 , F04C29/12 , F04C27/00
摘要： A vacuum pump includes a motor, a pump coupled to the motor to receive torque therefrom, and a trestle including an inlet port, an outlet port, and a fluid pathway therebetween, the outlet port being fluidly connected to the pump. The vacuum pump also includes a first valve positioned within the fluid pathway and adjustable between an open state, in which an airflow induced by the pump is drawn through the inlet port, and a closed state, in which a reverse airflow through the inlet port is prevented, and a second valve positioned within the fluid pathway in series with the first valve and adjustable between an open state, in which the airflow induced by the pump is drawn through the inlet port, and a closed state, in which the reverse airflow through the inlet port is prevented when the motor is deactivated.

6. 发明申请

WO2021061504A1 METHODS AND COMPOSITIONS COMPRISING AN ANTI-CTLA4 MONOCLONAL ANTIBODY WITH REDUCED HOST CELL PROTEINS AND INCREASED POLYSORBATE-80 STABILITY 审中-公开
公开(公告)号：WO2021061504A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/051355
申请日：2020-09-18
申请人： MERCK SHARP & DOHME CORP. , CHMIELOWSKI, Rebecca, A. , INSAIDOO, Francis , MILLER, Justin, B. , SHAH, Darshini , ROUSH, David, J. , WELSH, John, P.
发明人： CHMIELOWSKI, Rebecca, A. , INSAIDOO, Francis , MILLER, Justin, B. , SHAH, Darshini , ROUSH, David, J. , WELSH, John, P.
IPC分类号： C07K1/22 , C07K16/18 , C07K16/22 , C07K16/32 , C07K16/36 , C07K16/00
摘要： Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided herein are compositions comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4). In another aspect, such compositions further comprise a reduced level of host cell proteins and/or increased level of polysorbate-80 (PS-80) stability.

7. 发明申请

WO2015179534A1 VALVE CONTROLLER 审中-公开
标题翻译：阀控制器
公开(公告)号：WO2015179534A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/031799
申请日：2015-05-20
申请人： TLX TECHNOLOGIES, LLC , MILLER, Justin , ROGALA, Jeff
发明人： ROGALA, Jeff
IPC分类号： F16K31/06 , H01F7/16
CPC分类号： F16K31/082 , F16K31/0672 , F16K31/0675 , F16K31/084 , H01F7/1615
摘要： A valve controller is provided. The valve controller includes an armature formed by a moving armature and an armature pin. The moving armature movable from a latched position in which it is decoupled from the armature pin and in contact with a core, to an unlatched position where it is decoupled from the core and in contact with the armature pin.
摘要翻译：提供阀门控制器。阀控制器包括由移动电枢和电枢销形成的电枢。移动衔铁可从闩锁位置移动，在该位置中，它从电枢销脱离并与芯接触，到达解锁位置，在该位置与芯脱离并与电枢销接触。

8. 发明申请

WO2014159984A1 PATIENT-SPECIFIC ASSEMBLIES, JIGS, AND METHODS FOR A PERSONALIZED TOTAL HIP ARTHROPLASTY SYSTEM 审中-公开
标题翻译：患者特异性组装，JIGS和个体化髋关节置换术的方法
公开(公告)号：WO2014159984A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/025568
申请日：2014-03-13
申请人： UNIVERSITY OF CINCINNATI , KELLEY, Todd , NISTOR, Vasile , CASSTEVENS, Earnest, Christopher , MILLER, Justin , STEGMAN, Jacob, James
发明人： KELLEY, Todd , NISTOR, Vasile , CASSTEVENS, Earnest, Christopher , MILLER, Justin , STEGMAN, Jacob, James
IPC分类号： A61B17/56
CPC分类号： A61B17/1746 , A61B17/15 , A61B17/175 , A61B2017/568 , A61B2090/034 , A61F2/4609 , A61F2002/3401 , A61F2002/4687 , G06F19/00 , Y10T29/49826
摘要： A patient- specific total hip arthroplasty system including surgical guide and jig instrumentation modeled by computer aided design using image data derived from a specific patient's relevant anatomy. Patient- specific jigs fit surface topography of portions of the acetabulum and femur of the patient and are designed to guide surgical implantation at very precise geometries unique to each patient. Patient- specific pin-locating jigs, pin-rail and spacer systems, acetabular reaming and impacting jigs, and femoral resection and version jigs are fabricated pre-operatively according to the models. Methods for fabricating jig components of the system and methods of performing a total hip arthroplasty utilizing the system are also disclosed.
摘要翻译：一种患者特异性全髋关节置换系统，包括通过计算机辅助设计建模的手术导管和夹具仪器，使用从特定患者相关解剖结果得出的图像数据。患者特异性夹具适合患者髋臼和股骨部分的表面形貌，并被设计为以非常精确的几何形状引导手术植入，每个患者独特。根据模型预先制作患者特定的针定位夹具，针轨和间隔系统，髋臼铰孔和冲击夹具以及股骨切除和版本夹具。还公开了用于制造系统的夹具部件的方法和使用该系统执行全髋关节置换术的方法。

9. 发明申请

WO2004060915A3 PROSTATE SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF. 审中-公开
标题翻译：前列腺特异性抗原，与其结合，其制备方法及其用途。
公开(公告)号：WO2004060915A3
公开(公告)日：2005-03-03
申请号：PCT/US0338453
申请日：2003-12-03
申请人： SLOAN KETTERING INST CANCER , DANISHEFSKY SAMUEL J , DUDKIN VADIM , MILLER JUSTIN
发明人： DANISHEFSKY SAMUEL J , DUDKIN VADIM , MILLER JUSTIN
IPC分类号： A61K39/21 , C07K14/16 , C12N9/64 , C07K9/00 , G01N33/574
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/55577 , A61K2039/6018 , A61K2039/6081 , A61K2039/627 , C07K9/00 , C07K16/3069 , C12N9/6445 , C12N2740/16122 , C12N2740/16134 , C12Y304/21077
摘要： The present invention provides compounds having formula (I): wherein W , W , R , R , R , R and R are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods of use thereof in the treatment of cancer, methods for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a normal or transformed PSA glycan or glycopeptide of the invention. In another aspect, the invention provides an immunoassay method for the quantitative determination of normal or transformed PSA in a biological sample. In another aspect, the invention provides an immunoassay kit for assessing the presence and/or amount of normal or transformed PSA in a sample. In another aspect, the invention provides a diagnostic kit for diagnosing an adenocarcinoma of the prostate in an individual suspected of suffering therefrom, or for differentiating between a benign pathology of the prostate and an adenocarcinoma of the prostate in an individual suspected of suffering therefrom.
摘要翻译：本发明提供具有式（I）的化合物：其中W 1，W 2，R 1，R 3，R 4，R 2A和R 2B如本文所定义 ; 并且另外提供其合成方法，其组合物及其在癌症治疗中的应用方法，用于预防癌症复发的方法，以及在受试者中诱导抗体的方法，包括向有需要的受试者施用，有效量的本文公开的任何本发明化合物，其以缀合形式或未偶联并与合适的免疫原性载体组合。另一方面，本发明提供了与本发明的正常或转化的PSA聚糖或糖肽特异性结合的抗体或抗体片段。另一方面，本发明提供了用于定量测定生物样品中正常或转化的PSA的免疫测定方法。在另一方面，本发明提供了用于评估样品中正常或转化的PSA的存在和/或量的免疫测定试剂盒。另一方面，本发明提供了一种诊断试剂盒，用于诊断怀疑患有其的个体中的前列腺腺癌，或用于区分怀疑患有前列腺的前列腺的良性病理和前列腺腺癌。

10. 发明申请

WO2004060915A2 PROSTATE SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF. 审中-公开
标题翻译：前列腺特异性抗原，与其结合，其制备方法及其用途。
公开(公告)号：WO2004060915A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/038453
申请日：2003-12-03
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , DANISHEFSKY, Samuel, J. , DUDKIN, Vadim , MILLER, Justin
发明人： DANISHEFSKY, Samuel, J. , DUDKIN, Vadim , MILLER, Justin
IPC分类号： C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/55577 , A61K2039/6018 , A61K2039/6081 , A61K2039/627 , C07K9/00 , C07K16/3069 , C12N9/6445 , C12N2740/16122 , C12N2740/16134 , C12Y304/21077
摘要： The present invention provides compounds having formula (I): wherein W 1 , W 2 , R 1 , R 3 , R 4 , R 2A and R 2B are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods of use thereof in the treatment of cancer, methods for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a normal or transformed PSA glycan or glycopeptide of the invention. In another aspect, the invention provides an immunoassay method for the quantitative determination of normal or transformed PSA in a biological sample. In another aspect, the invention provides an immunoassay kit for assessing the presence and/or amount of normal or transformed PSA in a sample. In another aspect, the invention provides a diagnostic kit for diagnosing an adenocarcinoma of the prostate in an individual suspected of suffering therefrom, or for differentiating between a benign pathology of the prostate and an adenocarcinoma of the prostate in an individual suspected of suffering therefrom.
摘要翻译：本发明提供具有式（I）的化合物：其中W 1，W 2，R 1，R 3，R 4，R 2A和R 2B如本文所定义 ; 并且另外提供其合成方法，其组合物及其在癌症治疗中的应用方法，用于预防癌症复发的方法，以及在受试者中诱导抗体的方法，包括向有需要的受试者施用，有效量的本文公开的任何本发明化合物，其以缀合形式或未偶联并与合适的免疫原性载体组合。另一方面，本发明提供了与本发明的正常或转化的PSA聚糖或糖肽特异性结合的抗体或抗体片段。另一方面，本发明提供了用于定量测定生物样品中正常或转化的PSA的免疫测定方法。另一方面，本发明提供了用于评估样品中正常或转化的PSA的存在和/或量的免疫测定试剂盒。另一方面，本发明提供了一种诊断试剂盒，用于诊断怀疑患有其的个体中的前列腺腺癌，或用于区分怀疑患有前列腺的前列腺的良性病理学和前列腺腺癌之间的差异。

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