专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997030982A1 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT 审中-公开
标题翻译：与内皮素受体拮抗剂活性-2,1,3- BENZOTHIA（OXA）DIAZOLDERIVATE
公开(公告)号：WO1997030982A1
公开(公告)日：1997-08-28
申请号：PCT/EP1997000818
申请日：1997-02-20
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG , DORSCH, Dieter , OSSWALD, Mathias , MEDERSKI, Werner , WILM, Claudia , SCHMITGES, Claus , CHRISTADLER, Maria , ANZALI, Soheila
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
IPC分类号： C07D285/14
CPC分类号： C07D285/14 , C07D271/12 , C07D417/04 , C07D417/14
摘要： The invention concerns compounds of formula (I), in which R is (i), (ii) or (iii); n is 0, 1 or 2; X means O or S; and R , R , R and R have different meanings, or a cyclized tautomeric shape. The invention also concerns the (E) isomers and salts of these compounds which display endothelin receptor antagonistic properties.
摘要翻译：式（I）其中R是（i）中，化合物（ii）或（iii）中，n是0，1或2，X是O或S，且R <1>，R <2>，R <3>， [R <4>不同的含义，或互变异构体闭环的形式，和（e）的异构体和它们的盐显示出内皮素受体拮抗剂的性质。

2. 发明申请

WO1997026244A1 CHINOLINE-2-(1H)-ONES 审中-公开
标题翻译：喹啉-2（1H） - 酮
公开(公告)号：WO1997026244A1
公开(公告)日：1997-07-24
申请号：PCT/EP1997000084
申请日：1997-01-10
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG , ACKERMANN, Karl-August , GOTTSCHLICH, Rudolf , HÖLZEMANN, Günter , LEIBROCK, Joachim , RAUTENBERG, Wilfried , SEYFRIED, Christoph
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
IPC分类号： C07D215/22
CPC分类号： C07D215/22 , C07D401/10
摘要： The invention relates to chinoline-2-(1H)-ones derivatives of the formula (I), in which R , R and R are each independently H, Hal, A or OA; R is H, -(CH2)m-NR R , R is H, -(CH2)n-NR R , R is H, A or together with R -(CH2)4 or -(CH2)5-; R is H, A or (CH2)m- with a bond for an identical or adjacent ring B or D or together with R -(CH2)4- or -(CH2)5-; X is -CHR -, -NR -, -O-, -S-; A is alkyl with 1 to 6 C-atoms; Hal is F, Cl, Br or I; m is 1 to 3; and n is 0 to 3, at least one of the two radicals R or R having the meaning -(CH2)m-NR R or -(CH2)n-NR R . The invention also relates to the salts and solvates of said derivatives, and the use of said compounds and the biocompatible salts for the treatment of neurodegenerative changes in functions of the central nervous system.
摘要翻译：本发明涉及喹啉-2-式（I）的（1H） - 酮衍生物，其中R <1>，R <2>和R <3>各自独立地是H，哈尔，A或OA，R <4> H， - （CH 2）M-NR <6> - [R <7>，R <5>为H， - （CH 2）N-NR <6> - [R <7>，R <6>是H，A或，其中R一起< 7> - （CH2）4-或 - （CH2）5-，R <7>是H，或 - （CH 2）间具有键合到相同或相邻的环B或D或，其中R <6一起> - （CH2）4-或 - （CH2）5 - ，X为-CHR <5> - ， - NR <5> - ， - O-，-S - ，A是具有1-6个C原子的烷基中，Hal为F， Cl，Br或I，M 1-3和n是0-3，但两个基团中的至少一个R <4>或R <5>是 - （CH 2）M-NR <6> - [R <7>或 - （CH 2）N-NR <6> - [R <7>有，以及它们的盐和溶剂化物。本发明还涉及使用这些化合物作为以及它们用于在CNS功能神经变性治疗生理上可接受的盐。

3. 发明申请

WO1997023451A1 TYROSIN-DERIVATE AS ALPHA-V-INTEGRIN INHIBITORS 审中-公开
标题翻译：酪氨酸衍生物作为ALPHA-V整联蛋白抑制剂
公开(公告)号：WO1997023451A1
公开(公告)日：1997-07-03
申请号：PCT/EP1996005646
申请日：1996-12-16
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG , DIEFENBACH, Beate , FITTSCHEN, Claus , GANTE, Joachim , GOODMAN, Simon , WIESNER, Matthias , RIPPMANN, Friedrich
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
IPC分类号： C07C311/06
CPC分类号： C07D211/62 , C07C271/28 , C07C279/08 , C07C311/06 , C07C311/14 , C07C311/19 , Y02P20/55
摘要： Disclosed are compounds of formula (I) in which X represents alkylene with 1-6 C atoms or 1,4-piperidyl; Y is absent or represents O, CONH or -CC-; R represents H, CN, N3, NH2, H2N-C(=NH) or H2N-(C=NH)-NH (the primary amino groups can also be provided with conventional amino protective groups); R , R each independently of one another represent H, A, A-SO2-, Ar-SO2, campher-10-SO2-, COOA or a conventional amino protective group; A, R each independently of one another represent H or alkyl with 1-10 C atoms; and Ar represents phenyl or benzyl which is unsubstituted or single-substituted with CH3. Also disclosed are the physiologically tolerable salts of these compounds. The compounds and salts thereof can be used as alpha v-integrin inhibitors, in particular for treating tumours, osteoporoses, osteolytic disorders and for suppressing angiogenesis.
摘要翻译：式（I），其中X是亚烷基具有1-6个C原子或1,4-亚哌啶基的化合物; Y不存在，O，CONH或-CC-; [R <1>为H，CN，N 3，NH 2，H 2 N-C（= NH）或H 2 N-（C = NH）-NH，其中伯氨基团还可以提供与常规的氨基保护基团; [R <2>，R <3>各自独立地是H，A，A-SO 2 - 中，Ar-SO 2 - ，樟脑-10- SO 2 - ，COOA或常用的氨基保护基; A，R <4>各自独立地为H或具有1-10个C原子，并且Ar是未取代的或单取代的由CH 3取代的苯基或苄基，以及它们的生理学可接受的盐的烷基，可以使用如αv型整联蛋白抑制剂，特别是用于治疗由肿瘤疾病，骨质疏松，溶骨性疾病和用于抑制血管生成被使用。

4. 发明申请

WO1997014716A1 CYCLOPEPTIDE DERIVATIVES 审中-公开
标题翻译： CYCLO肽衍生物
公开(公告)号：WO1997014716A1
公开(公告)日：1997-04-24
申请号：PCT/EP1996004462
申请日：1996-10-14
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG , JONCZYK, Alfred , GOODMAN, Simon, Lawrence , DIEFENBACH, Beate , SUTTER, Arne , KESSLER, Horst
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
IPC分类号： C07K14/75
CPC分类号： C07K7/64 , A61K38/00 , C07K14/75 , Y02P20/55
摘要： The invention relates to compounds of the formula (I) R -Q -X-Q -R , in which: Q , Q , each independent of one another, are missing or are -NH-(CH2)n-CO-; R , R , each independent of one another, are missing or are cyclo-(Arg-Gly-Asp-Z), wherein Z is missing in the side chain of Q or Q or if Q and/or Q are missing, is bound to X, at least one of the groups R or R always having to be included; X is -CO-R -CO-, and if R -Q - or R -Q - are missing is R , R , R , Het-CO or a fluorescent pigment residue linked through a -CONH-, -COO-, -NH-C(=S)-NH-, -NH-C(=O)-NH-, -SO2NH- or -NHCO- bond; and Z, R , R , R , R , Het and n have the meanings given in claim 1. The invention also relates to the salts of said compounds. Said compounds and their salts can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, angiogenic diseases and in tumour therapy.
摘要翻译：式（I）R <1> -Q <1> -XQ <2> -R <2>其中Q <1>，Q <2>各自独立地不存在或-NH-（CH 2）N-CO-的化合物，R <1>，R <2>不存在各自独立地为或环 - （Arg - 甘氨酸 - 天冬氨酸-Z），其中Z在侧链至Q <1>或Q <2>，或者，如果Q <1>，和 /或Q <2>不存在，键合至X，并且其中R中的至少一个<1>或R <2>必须始终包含的，X是-CO-R <18> - CO-和如果R <1 > -Q <1> - 或R <2> -Q <2> - 缺失 - [R <10>，R <13>，R <16>中，Het-CO，或经由-CONH-，-COO - ， - NH-C（= S）-NH-，-NH-C（= O）-NH - ， - SO 2 NH-或-NHCO-键连接的荧光染料基团，和Z，R <10>，R <13>， [R <16>，R <18>中，Het和n具有权利要求1中给出的含义和它们的盐可以用作整联蛋白抑制剂，特别是用于循环，血栓形成障碍，心肌梗死，冠状动脉心脏疾病，动脉硬化症的预防和治疗，血管生成病症和在肿瘤治疗中使用。

5. 发明申请

WO1992021734A1 VINYL COMPOUNDS AND LIQUID-CRYSTAL MEDIUM 审中-公开
标题翻译：乙烯基化合物和液晶中间体
公开(公告)号：WO1992021734A1
公开(公告)日：1992-12-10
申请号：PCT/EP1992001185
申请日：1992-05-26
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , BARTMANN, Ekkehard , PLACH, Herbert , EIDENSCHINK, Rudolf , REIFFENRATH, Volker , PAULUTH, Detlef , POETSCH, Eike , SCHOEN, Sabine , MEYER, Volker , JUNGE, Michael , HITTICH, Reinhard
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
IPC分类号： C09K19/30
CPC分类号： C07D239/26 , C07C22/00 , C07C22/04 , C07C22/08 , C07C25/24 , C07C43/192 , C07C43/225 , C07C381/00 , C07C2601/14 , C07D213/26 , C07D319/06 , C09K19/3001 , C09K19/3003 , C09K19/3028 , C09K2019/0444
摘要： The invention concerns vinyl compounds of formula (I), in which R is H, an alkyl or alkenyl group with 1 to 15 C-atoms which may be unsubstituted, substituted singly by CN or CF3 or substituted at least singly by halogen, one or more CH2 units in these groups being replaceable, independently of each other by -O-, -S-, (α), -CO-, -CO-O-, -O-CO- or -O-CO-O- in such a way that O-atoms are not linked directly to each other; A?1 and A2¿, independently of each other, are (a) a trans-1,4-cyclohexylene group in which one or more non-adjacent CH¿2? groups can be replaced by -O- and/or -S-, (b) a 1,4-phenyl group in which one or two CH groups can be replaced by N, (c) a 1,4-cyclohexenylene, 1,4-bicyclo(2,2,2)octylene, piperidine-1,4-diyl, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl or 1,2,3,4-tetrahydronaphthalene-2,6-diyl group, where the groups (a) and (b) may be substituted by CN or fluorine; Z?1 and Z2¿, independently of each other, are -CO-O-, -O-CO-, -CH¿2?O-, -OCH2-, -CH2CH2-, -CH=CH-, -C=C- or a single bond, one of the groups Z?1 and Z2¿ may also be -(CH¿2?)4- or -CH=CH-CH2CH2-; Q is a single bond, -O-, -CH2-CH2-, -C=C-, trans-CH=CH-, -COO- or -CH2O-; X?1¿ is H, F or Cl; X2 is F, Cl, CF¿3? or SF5; Y is H, F or Cl; r is 0 to 4; n is 0 or 1; and m is 0, 1, 2 or 3; with the proviso that, when Y = H and Q = single bond, X?1 and X2¿ are Cl. Such compounds are suitable for use as components of liquid-crystal media.

6. 发明申请

WO1992017813A1 ELECTRO-OPTICAL SYSTEM 审中-公开
标题翻译：电光系统
公开(公告)号：WO1992017813A1
公开(公告)日：1992-10-15
申请号：PCT/EP1991000636
申请日：1991-04-06
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , SCHEUBLE, Bernhard , BAUR, Günter , FEHRENBACH, Waltraud , WEBER, Barbara
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
IPC分类号： G02F01/1335
CPC分类号： G02F1/1396 , G02F1/133528 , G02F1/13363 , G02F1/13471 , G02F1/1393 , G02F2001/133531 , G02F2001/1398 , G02F2413/08
摘要： An electro-optical system according to the preamble of claim 1 is described in which the angle psi formed by the polarization device on the inlet side with the liquid cristal molecule directors on the first substrate surface is optimized to achieve high contrast and/or high brightness and/or contrast and chromaticity which are highly independent of viewing angle.
摘要翻译：描述根据权利要求1的前序部分的电光学系统，其中由入射侧的偏振装置形成的角度psi与第一衬底表面上的液体分支分子指向器优化以实现高对比度和/或高亮度和/或高度独立于视角的对比度和色度。

7. 发明申请

WO1992017398A1 PROCESS FOR THE PRODUCTION OF ELEMENTARY IODINE 审中-公开
标题翻译：过程中产生的元素碘
公开(公告)号：WO1992017398A1
公开(公告)日：1992-10-15
申请号：PCT/EP1991001239
申请日：1991-07-03
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , CASES, Jaime , ENGELBREIT, Claus , IBACACHE, Eugenio
IPC分类号： C01B07/14
CPC分类号： C01B7/14
摘要： Elementary iodine is produced from salts containing iodine in various oxidation states using a reducing agent or an oxidation agent and water as solvent. The process is characterized by being carried out with the raw materials in suspension.
摘要翻译：使用还原剂或氧化剂和水作为溶剂，以含有各种氧化态的碘的盐产生基本碘。该方法的特征在于用原料悬浮进行。

8. 发明申请

WO1992013928A1 LIQUID-CRYSTAL COMPOUNDS 审中-公开
标题翻译：液晶化合物
公开(公告)号：WO1992013928A1
公开(公告)日：1992-08-20
申请号：PCT/EP1992000270
申请日：1992-02-07
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , REIFFENRATH, Volker , PLACH, Herbert , PAULUTH, Detlef , HITTICH, Reinhard , POETSCH, Eike , GEELHAAR, Thomas , WEBER, Georg , BARTMANN, Ekkehard
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
IPC分类号： C09K19/30
CPC分类号： C07C17/2635 , C07C17/269 , C07C17/354 , C07C25/18 , C07C25/24 , C07C39/42 , C07C43/1747 , C07C43/192 , C07C43/225 , C07C63/72 , C07C69/76 , C07C2601/14 , C09K19/12 , C09K19/3003 , C09K19/3028 , C09K19/3048 , C09K2019/0407 , C09K2019/0444 , C07C21/18
摘要： Described are liquid-crystal compounds of formula (I), in which R may be H, an alkyl or alkylene group with 1 to 15 C-atoms which is unsubstituted or which is substituted with a single CN or CF3 group or with at least one halogen atom, whereby one or more CH2 groups in these alkyl or alkylene groups may be replaced, independently of each other, by -O-, -S-, - -, -CO-, -CO-O-, O-CO- or -O-CO-O in such a way that O-atoms are not bonded directly to each other; Z1 and Z, independently of each other, may be -CH2CH2-, -CH=CH-, -C=C- or a single bond, whereby one of the groups Z1 and Z may also be -(CH2)4 or -CH=CH-CH2CH2-; A and A1, independently of each other, may be the trans-1,4-cyclohexylene group (in which one or two non-adjacent CH2 groups may be replaced by -O-), an unsubstituted 1,4-phenylene group or a 1,4-phenylene group substituted with one or two F and/or Cl atoms, wherein one or two CH groups may be replaced by N; m may be 0, 1, 2 or 3; o and s may be 0, 1 or 2, with the provision that s + o >/= 2; W may be -O-, -COO- or a single bond; Q may be -O-, -CH=CH- or a single bond; r may be from 1 to 7; t may be from 0 to 7; and Y may be F, Cl, CF3, OCF3, CHF2, OCHF2 or OCH2F. Such compounds are suitable for use as components of liquid-crystal media.
摘要翻译：描述了式（I）的液晶化合物，其中R可以是H，具有1至15个C原子的烷基或亚烷基是未取代的或被单个CN或CF 3基团取代或至少一个卤素原子，其中这些烷基或亚烷基中的一个或多个CH 2基团可以彼此独立地被-O - ， - S - ， - ， - ， - CO - ， - CO-O-，O -CO-或-O-CO-O，使得O原子彼此不直接键合; Z 1和Z彼此独立地可以是-CH 2 CH 2 - ， - CH = CH - ， - C = C-或单键，其中基团Z 1和Z中的一个也可以是 - （CH 2）4或-CH = CH-CH 2 CH 2; A和A1彼此独立地可以是反式-1,4-亚环己基（其中一个或两个不相邻的CH 2基可被-O-取代），未取代的1,4-亚苯基或被一个或两个F和/或Cl原子取代的1,4-亚苯基，其中一个或两个CH基团可被N代替; m可以是0,1,2或3; o和s可以是0,1或2，其规定为s + o> / = 2; W可以是-O-，-COO-或单键; Q可以是-O - ， - CH = CH-或单键; r可以是1到7; t可以是0到7; Y可以是F，Cl，CF 3，OCF 3，CHF 2，OCHF 2或OCH 2 F。这些化合物适合用作液晶介质的组分。

9. 发明申请

WO1992004421A1 LIQUID-CRYSTAL MIXTURE 审中-公开
标题翻译：液晶混合液
公开(公告)号：WO1992004421A1
公开(公告)日：1992-03-19
申请号：PCT/EP1991000430
申请日：1991-03-07
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , FINKENZELLER, Ulrich , WILHELM, Stefan , JUBB, Raymond
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
IPC分类号： C09K19/00
CPC分类号： C09K19/3068 , C09K19/02 , C09K19/3001 , C09K19/42 , C09K19/542 , C09K19/544 , C09K2019/546
摘要： The invention concerns a liquid-crystal mixture for use in an electro-optical liquid-crystal system with the following properties: the system contains a dielectrically positive liquid-crystal mixture and another optically transparent material between two electrodes which may optionally be mounted on substrate plates. The liquid-crystal molecules are irregularly oriented when the liquid crystal is 'off'. One of the refractive indices of the liquid-crystal mixture is substantially the same as that of the nM matrix and/or the ratio of the mass of the liquid-crystal mixture to that of the optically transparent material is 1.5 or more. Transmission in one of the two switching states of the system is less than in the other state, irrespective of the polarization of the incident light. The system is characterized in that, in order to reduce the solubility and/or the temperature dependence of the solubility of the liquid-crystal mixture and/or one or more components of the liquid crystal in the matrix material, the liquid-crystal mixture is made up of liquid-crystal compounds with a mean double-refraction index Δn such that 0.09 « Δn « 0.20 (20 °C, 589 nm).

10. 发明申请

WO1991019772A1 LIQUID CRYSTALLINE MEDIUM 审中-公开
标题翻译：液晶介质
公开(公告)号：WO1991019772A1
公开(公告)日：1991-12-26
申请号：PCT/EP1991001037
申请日：1991-06-05
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , RIEGER, Bernhard , REIFFENRATH, Volker , HITTICH, Reinhard
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
IPC分类号： C09K19/30
CPC分类号： C09K19/3003 , C09K19/3001
摘要： A liquid crystalline medium based on a mixture of polar compounds with positive dielectric anisotropy is characterized in that it contains one or more compounds of formula (I), where Q stands for alkylene with up to 5 carbon atoms or a single bond, X stands for H or F and R stands for alkyl, oxaalkyl, fluoroalkyl or alkenyl, each with up to 7 carbon atoms.
摘要翻译：基于具有正介电各向异性的极性化合物的混合物的液晶介质含有一种或多种具有通式（I）的化合物，其中Q是具有至多5个C原子的亚烷基或单键，X 代表H或F，并且R代表各自具有至多7个C原子的烷基，氧杂烷基，氟代烷基或链烯基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式