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1. 发明申请

WO2006094681A1 FASERFREIES TRANSDERMALES THERAPEUTISCHES SYSTEM UND VERFAHREN ZU SEINER HERSTELLUNG 审中-公开
标题翻译：不含纤维的透皮治疗系统及其制造方法
公开(公告)号：WO2006094681A1
公开(公告)日：2006-09-14
申请号：PCT/EP2006/001840
申请日：2006-02-28
申请人： LTS LOHMANN THERAPIE-SYSTEME AG , MECONI, Reinhold , SCHUMANN, Klaus
发明人： MECONI, Reinhold , SCHUMANN, Klaus
IPC分类号： A61K9/70 , A61K47/32 , A61K47/34 , A61K31/465
CPC分类号： A61K9/7038 , A61K9/703 , A61K9/7046 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/196 , A61K31/21 , A61K31/465 , A61K31/565
摘要： Die Erfindung betrifft ein transdermales therapeutisches System, das frei von faserförmigen Bestandteilen ist, sowie ein Verfahren zur Herstellung eines derartigen transdermalen therapeutischen Systems, bei dem eine wirkstoffhaltige Zubereitung mit einem Druckverfahren auf die Haftkleberschicht des transdermalen therapeutischen Systems aufgebracht wird.
摘要翻译：本发明涉及一种透皮治疗系统，其不含纤维状的成分，以及用于制造这样的透皮治疗系统，其中，与印刷方法的含有活性物质的制剂被施加到经皮治疗系统的粘合层的方法。

2. 发明申请

WO1995015158A1 PFLASTER CONTAINING AN ACTIVE SUBSTANCE 审中-公开
标题翻译：药的膏药
公开(公告)号：WO1995015158A1
公开(公告)日：1995-06-08
申请号：PCT/EP1994003866
申请日：1994-11-23
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , MECONI, Reinhold , SEIBERTZ, Frank
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG
IPC分类号： A61K09/70
CPC分类号： A61K9/7084
摘要： The proposed plaster containing an active substance for the controlled release of active substances comprises a backing layer, a reservoir layer adjacent to it which contains active substance and softens at body temperature, a membrane which controls the release of the active substance, an adhesive system with which the plaster can be fixed to the skin, and a removable protective layer. The proposed plaster is characterized by the fact that the reservoir layer which softens at body temperature is separated from the control membrane by a device made of a material which is not permeable to the active substance and extends right across the mutually opposing surfaces of the reservoir and membrane and has at least one passage for the reservoir layer.
摘要翻译：活性用于活性物质的从背面层，与其相邻的控制释放贴剂，在体温下软化物质容纳，贮存层，药物释放控制膜，该贴剂在皮肤上使压敏粘合剂设备和可去除的保护层的固定含有药物的，其特征在于，在体温下软化贮库层是由从控制膜的材料制成不渗透到活性材料的装置间隔开，在盖延伸的贮存器和所述膜的整个面对表面，并且具有用于在体温下贮存层的软化的至少一个通道。

3. 发明申请

WO2004069231A1 TRANSDERMALES THERAPEUTISCHES SYSTEM MIT VERBESSERTEM HAUTKLEBEVERHALTEN 审中-公开
标题翻译：具有改善皮肤黏合行为透皮治疗系统
公开(公告)号：WO2004069231A1
公开(公告)日：2004-08-19
申请号：PCT/EP2004/000490
申请日：2004-01-22
申请人： LTS LOHMANN THERAPIE-SYSTEME AG , MECONI, Reinhold , SEIBERTZ, Frank
发明人： MECONI, Reinhold , SEIBERTZ, Frank
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K9/0014 , A61K47/06 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/38 , A61K47/44
摘要： Gegenstand der Erfindung ist ein Transdermales therapeutisches System (TTS), welches eine Rückschicht und mindestens eine Hautkontaktschicht enthält, die einen pharmazeutischen Wirkstoff und mindestens ein Polymer enthält und während der Anwendung des transdermalen therapeutischen Systems dessen Haftung auf der Haut des Anwenders gewährleistet. Diese Hautkontaktschicht ist gekennzeichnet durch das Vorhandensein eines die Klebkraft modifizierenden Stoffs, wozu Carbopol, Dexpanthenol, Lanolin und Tylose zählen. In bevorzugten Ausführungsformen besitzt die Hautkontaktschicht einen Gehalt an Lanolin und / oder Dexpanthenol, der mindestens 0,5 Gew.-% beträgt.
摘要翻译：本发明是一种经皮治疗系统（TTS），其包括衬背层和含有药物活性剂和至少一种聚合物和所述透皮治疗系统的应用期间的至少一个皮肤接触层确保向使用者的皮肤的粘附力。这种皮肤接触层的特征在于，密合性改性物质的存在下，向其中卡波姆，右泛醇，羊毛脂和Tylose中计数。在优选的实施方案中，皮肤接触层具有羊毛脂和/或右泛醇，其为至少0.5重量％的含量。

4. 发明申请

WO1989001789A1 DEVICE FOR CONTROLLED RELEASE OF NICOTINE, PROCESS FOR MANUFACTURING IT, AND USE THEREOF 审中-公开
标题翻译：用于控制释放NICOTINE的装置，其制造方法及其使用
公开(公告)号：WO1989001789A1
公开(公告)日：1989-03-09
申请号：PCT/DE1988000479
申请日：1988-08-03
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , JAEGER, Halvor , HOFFMANN, Hans-Rainer , MECONI, Reinhold , KLEIN, Robert-Peter
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG
IPC分类号： A61L15/03
CPC分类号： G01N33/521 , A61K9/7023 , A61K31/465
摘要： The device described has an adhesive nicotine reservoir with uniform or non-uniform distribution of the nicotine. The reservoir is manufactured using a hot-melt adhesive with a processing temperature of 40 to 80 degrees Celsius, preferably 40 to 60 degrees Celsius, and ideally between 40 and 55 degrees Celsius. Also described is a process for manufacturing the device with continuous or intermittent application of nicotine-containing molten hot-melt adhesive at an adhesive temperature between 40 and 80, preferably 40 and 60, and ideally 40 and 55 degrees Celsius, to a support and, if necessary, application of a layer of protective material.

5. 发明申请

WO1989001788A1 DEVICE FOR RELEASE OF NITROGLYCERINE ONTO THE SKIN, PROCESS FOR ITS MANUFACTURE AND USE THEREOF 审中-公开
标题翻译：用于将氮氧化物释放到皮肤上的装置，其制造方法及其用途
公开(公告)号：WO1989001788A1
公开(公告)日：1989-03-09
申请号：PCT/DE1988000478
申请日：1988-08-03
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , JAEGER, Halvor , HOFFMANN, Hans-Rainer , MECONI, Reinhold , KLEIN, Robert-Peter
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG
IPC分类号： A61L15/03
CPC分类号： A61K9/7053 , G01N33/521
摘要： The invention concerns a device for the controlled release of nitrglycerine on to human or animal skin, preferably in plaster form, with a backing layer impermeable to nitroglycerine, an adhesive single- or multi-compartment reservoir containing nitroglycerine for uniform or non-uniform distribution of the nitroglycerine, and, if necessary, a detachable protective layer impermeable to nitroglycerine. The reservoir is manufactured using hot-melt adhesives with a processing temperature between 40 DEG and 80 DEG C, preferably 40 and 60 DEG C, and ideally 40 and 55 DEG C. Also described is a process for manufacturing the device in which the melted hot-melt adhesive containing the nitroglycerine to be released is applied continuously or intermittently to a support at a hot-melt adhesive temperature between 40 and 80 DEG C, preferably 40 and 60 DEG C, and ideally 45 and 55 DEG C, and in which, if necessary, a protective coating material is applied.
摘要翻译：本发明涉及一种用于将硝酸甘油控制释放到人或动物皮肤上，优选石膏形式的装置，其具有不可渗透到硝酸甘油的背衬层，含有硝化甘油的粘合剂单室或多室容器用于均匀或不均匀分布硝酸甘油，以及如果需要的话，硝酸甘油不可渗透的可拆卸保护层。储存器使用加热温度在40℃至80℃，优选40℃至60℃，理想地为40℃至55℃的热熔粘合剂制造。还描述了一种制造该熔融热的装置的方法包含要释放的硝酸甘油的粘合剂粘合剂在40至80℃，优选40至60℃，理想地为45至55℃的热熔粘合剂温度下连续或间歇地施加到载体上，如果需要，施加保护涂层材料。

6. 发明申请

WO1998023266A1 METHOD FOR PRODUCING A THERAPEUTIC SYSTEM IN THE FORM OF PLASTER 审中-公开
标题翻译：用于生产路面形治疗系统
公开(公告)号：WO1998023266A1
公开(公告)日：1998-06-04
申请号：PCT/EP1997005608
申请日：1997-10-10
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH , MECONI, Reinhold , RADEMACHER, Tina , SCHUMANN, Klaus , SEIBERTZ, Frank
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH
IPC分类号： A61K09/70
CPC分类号： B65D75/32 , A61K9/7023
摘要： The invention relates to the production, conveyance and storage of a therapeutic system in the form of plaster comprising an active layer which is oversaturated with an active substance. Said layer contains the active substance in a homogenous dispersion or solution. The method is characterized in that when it is carried out it avoids procedural parameters which favour or trigger crystallization of the active substance and avoids all type of pressure effects on the plaster and especially the active layer during implementation.
摘要翻译：一种用于石膏样治疗系统的与含有在均匀分散体或溶液中的活性物质的过饱和的药物活性层，其特征在于，它被执行有利避免活性成分结晶或触发工艺参数生产，运输和贮存过程是和它的应用避免了在路面上的任何类型的压力应用，更具体地在有源层。

7. 发明申请

WO1995019162A1 ESTRADIOL PENETRATION INTENSIFIER FOR TRANSDERMAL ADMINISTRATION 审中-公开
标题翻译：雌二醇渗透放大器透皮给药
公开(公告)号：WO1995019162A1
公开(公告)日：1995-07-20
申请号：PCT/EP1995000032
申请日：1995-01-05
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , MECONI, Reinhold , SEIBERTZ, Frank
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG
IPC分类号： A61K09/70
CPC分类号： A61K9/7069 , A61K31/565 , A61K31/57 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/22 , A61K2300/00
摘要： A dressing containing an active agent for the controlled delivery of estradiol or its pharmaceutically acceptable derivatives alone or in combination with gestagens from a backing layer, a reservoir containing active agent secured thereto made using adhesives and at least one penetration intensifier and a removable protective layer is distinguished in that the penetration intensifier is selected from carboxylic acid-based substances.
摘要翻译：为雌二醇或它的药学上可接受的衍生物单独或与从背层，这是使用压敏粘合剂和至少一种渗透增强剂，和一可去除的保护层中产生的相关联含有活性物质的储器，其特征在于孕激素组合的受控释放的含活性物质的贴剂该渗透促进剂是基于羧酸的物质中选择。

8. 发明申请

WO1994026257A1 TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ESTRADIOL 审中-公开
标题翻译： ESTRADIOLHALTIGES透皮治疗系统
公开(公告)号：WO1994026257A1
公开(公告)日：1994-11-24
申请号：PCT/EP1994001279
申请日：1994-04-25
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , MERCK PATENT GMBH , MECONI, Reinhold , SEIBERTZ, Frank , HORSTMANN, Michael , LICHTENBERGER, Rainer
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , MERCK PATENT GMBH
IPC分类号： A61K09/70
CPC分类号： A61K9/7053 , A61K9/7069 , A61K9/7076 , A61K31/565
摘要： The invention concerns a transdermal therapeutic system designed for the controlled release of estradiol or any of its pharmaceutically acceptable derivatives, alone or in combination with gestagenes, the system comprising a back film, an active-substance reservoir which is joined to the back film and is produced using pressure sensitive adhesives, and a detachable protective film. The system is characterized in that the pressure sensitive adhesive contains esters of colophonium.

9. 发明申请

WO1992022292A1 NITROGLYCERINE PLASTER AND PROCESS FOR MAKING IT 审中-公开
标题翻译： NITROGLYCERINE PLASTER及其制造方法
公开(公告)号：WO1992022292A1
公开(公告)日：1992-12-23
申请号：PCT/EP1992001169
申请日：1992-05-25
申请人： SCHWARZ PHARMA AG , LTS LOHMANN THERAPIE-SYSTEME GmbH & Co. KG , BEUTNER, Dieter , KNOBELSDORFF, V., Henning , WOLFF, Hans-Michael , HOFFMANN, Rainer , MECONI, Reinhold , KLEIN, Robert, Peter
发明人： SCHWARZ PHARMA AG , LTS LOHMANN THERAPIE-SYSTEME GmbH & Co. KG
IPC分类号： A61K31/21
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/21
摘要： The invention relates to a dermal plaster for the transdermal provision of nitroglycerine consisting of a carrier film and a removable protective film and a special adhesive mass containing nitroglycerine on the basis of a cross-linked acrylate-vinyl acetate copolymer in which the monomer mix used for polymerisation contains 21 to 40 % wt. vinyl acetate, 55 to 70 % wt. of an acrylic acid-C2-8-alkyl ester and 3 to 10 % wt. of an acrylic acid-C2-4-hydroxyalkyl ester and which is cross-linked by heating and the removal of any solvents present after the addition of a customary cross-linking agent and the nitroglycerine. The special adhesive mass of the invention has not only a high absorption capacity but also a high and controllable capacity for giving off nitroglycerine so that the delivery area of the plaster can be kept small for the necessary quantity to be delivered daily and hence the cost of the plaster is very low. At the same time, the manufacturing process is simplified by the simple adhesive compound, there is not need for the addition of further substances to improve the transepidermal conveyance of substances and the cost of the plaster can thus be kept down and the risk of skin irritation is avoided.

10. 发明申请

WO1989001787A1 DEVICE FOR RELEASE OF SUBSTANCES, PROCESS FOR ITS MANUFACTURE AND USE THEREOF 审中-公开
标题翻译：用于释放物质的装置，其制造及其使用的方法
公开(公告)号：WO1989001787A1
公开(公告)日：1989-03-09
申请号：PCT/DE1988000477
申请日：1988-08-03
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , JAEGER, Halvor , HOFFMANN, Hans-Rainer , MECONI, Reinhold , KLEIN, Robert-Peter
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG
IPC分类号： A61L15/03
CPC分类号： G01N33/521 , A61K9/7023
摘要： phe invention concerns a device for the release of substances made of hot-melt adhesives, with uniform or non-uniform distribution of the substances. The hot-melt adhesive has a processing temperature between 40 and 80 degrees Celsius, preferably between 40 and 60 degrees Celsius, and ideally between 40 and 55 degrees Celsius. Also described is a process for manufacturing the device in which the melted hot melt-adhesive containing the substances to be released is applied continuously or intermittently to a support at a hot-melt adhesive temperature between 40 and 80 degrees Celsius, preferably 40 and 60 degrees Celsius, and ideally 45 and 55 degrees Celsius, and in which, if necessary, a protective coating material is applied.

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