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1. 发明申请

WO2004013735A3 STRUCTURED MAGNETIC PATTERN ANTI-COUNTERFEITING SYSTEM 审中-公开
标题翻译：结构磁性图案防伪系统
公开(公告)号：WO2004013735A3
公开(公告)日：2004-04-08
申请号：PCT/US0324389
申请日：2003-08-04
申请人： VERIFICATION SECURITY CORP , MCGREW STEPHEN P
发明人： MCGREW STEPHEN P
IPC分类号： G06K7/08 , G06K17/00 , G06K19/06 , G06K19/12
CPC分类号： G06K7/1417 , G06K7/087 , G06K19/06187 , G06K19/12 , G06K2017/0038 , G07D7/04
摘要： A system and associated method provide a marking of material to be applied to goods. In one embodiment, magnetic material is applied in a predetermined pattern. An accumulation of magnetic material in one orientation across the structured pattern may provide an automatically sensible value. Magnetically readable material may be provided as a predetermined, repeatable pattern, where the magnetic material is applied to a surface with a resolution in a range of at least 10,000 to 100 dots per inch.
摘要翻译：系统和相关方法提供要应用于货物的材料的标记。在一个实施例中，以预定图案施加磁性材料。通过结构化图案的一个取向的磁性材料的累积可以提供自动合理的值。磁性可读材料可以作为预定的可重复的图案提供，其中磁性材料以每英寸至少10,000至100点的范围内的分辨率施加到表面。

2. 发明申请

WO2010021873A2 APPARATUS, METHOD AND ARTICLE TO PERFORM ASSAYS USING ASSAY STRIPS 审中-公开
标题翻译：装置，方法和使用测定条进行测定的物品
公开(公告)号：WO2010021873A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/053404
申请日：2009-08-11
申请人： GENPRIME, INC. , FLEMING, James, E. , MCGREW, Jesse, M. , MCGREW, Stephen, P. , NICHOLES, Patrick , HUMPHREYS, Johnny
发明人： FLEMING, James, E. , MCGREW, Jesse, M. , MCGREW, Stephen, P. , NICHOLES, Patrick
IPC分类号： G01N35/00 , G01N30/74 , G06F19/00
CPC分类号： G01N21/77 , G01N21/8483 , G01N2035/00108 , G06F19/00 , G16H10/40 , G16H40/63
摘要： An assay system includes an optical imager to acquire high resolution images of assay strips (e.g., lateral flow immunochromatographic test strips) and performs image processing to identify individual assay strips and determine results for each assay strip, by quantifies the presence or absence of test signal line(s) and control signal line(s). Assay strips may be in a holder or carrier contained in a specimen container also holding a specimen. The assay system automatically logs all results and data to a database that stores a high resolution image of the original immunochromatographic assay, the values of test line(s) and control line(s), and the test result. A user interface directs an end user through operation.
摘要翻译：测定系统包括光学成像仪以获取测定条的高分辨率图像（例如横向流动免疫层析测试条）并执行图像处理以鉴定各个测定条并且确定每个测定条的结果，通过量化测试信号线和控制信号线的存在或不存在。测定条可以位于也容纳样本的样本容器中的容器或载体中。分析系统自动记录所有结果和数据到存储原始免疫色谱分析的高分辨率图像，测试线和控制线的值以及测试结果的数据库。用户界面指导最终用户进行操作。

3. 发明申请

WO2004102259A2 OPTICALLY VARIABLE FORM BIREFRINGENT STRUCTURE AND METHOD AND SYSTEM AND METHOD FOR READING SAME 审中-公开
标题翻译：光学可变形式的双重结构及其读取方法及系统及方法
公开(公告)号：WO2004102259A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/010252
申请日：2004-03-31
申请人： NEW LIGHT INDUSTRIES, LTD. , MCGREW, Stephen, P. , CARVER, Sally-Anne
发明人： MCGREW, Stephen, P. , CARVER, Sally-Anne
IPC分类号： G02F
CPC分类号： B42D25/391 , B42D25/00 , B42D25/23 , B42D25/328 , B42D25/425 , G02B5/1809 , G02B5/1857 , G02B5/3083 , G03H1/0011 , G03H1/0244 , G03H1/028 , G03H1/041 , G03H2001/0288
摘要： An anticounterfeiting device comprising a surface relief structure having both diffractive and polarizing properties. Polarization of reflected light is controlled by the orientation and composition of a fine grating structure whose shortest period is substantially smaller than the wavelength of visible light; and diffraction is controlled by a longer period component of the grating structure having a second orientation. Presence and arrangement of the polarizing properties of the device are detected by illuminating the device with polarized light and viewing the reflected light, or by illuminating the device with unpolarized light and viewing reflected light through a polarizer. Because such a device is difficult to copy or reverse engineer precisely, the authenticity of the device can be judged by the presence and arrangement of the polarization properties and the diffraction properties in the device.
摘要翻译：一种防伪装置，包括具有衍射和偏振性质的表面浮雕结构。反射光的极化由最短周期远小于可见光波长的精细光栅结构的取向和组成来控制; 并且衍射由具有第二取向的光栅结构的较长周期分量控制。通过用偏振光照射装置并观察反射光，或通过用非偏振光照亮装置并通过偏振器观察反射光来检测装置的偏振特性的存在和排列。由于这样的装置难以精确地复制或逆向工程，所以可以通过设备中的偏振特性和衍射特性的存在和布置来判断装置的真实性。

4. 发明申请

WO2021194635A1 COMBINATORIAL AFFINITY-BASED ANALYSIS ASSEMBLIES AND METHODS 审中-公开
公开(公告)号：WO2021194635A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/016075
申请日：2021-02-01
申请人： MCGREW, Stephen, P.
发明人： MCGREW, Stephen, P.
IPC分类号： C07K16/00 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/543
摘要： A binding affinity-based assay method is provided, the method comprising: providing a first set of known low specificity binding elements; presenting a known sample to the first set to define a first datum vector; providing a second set of known low-specificity binding elements, the first and second sets including the same known low-specificity binding elements; presenting an unknown sample to the second set to acquire a second datum vector; and comparing the first and second datum vectors to determine similarity or difference between the known and unknown samples.

5. 发明申请

WO2010021873A3 APPARATUS, METHOD AND ARTICLE TO PERFORM ASSAYS USING ASSAY STRIPS 审中-公开
标题翻译：装置，方法和使用测定条件进行测定的文章
公开(公告)号：WO2010021873A3
公开(公告)日：2010-06-24
申请号：PCT/US2009053404
申请日：2009-08-11
申请人： GENPRIME INC , FLEMING JAMES E , MCGREW JESSE M , MCGREW STEPHEN P , NICHOLES PATRICK , HUMPHREYS JOHNNY
发明人： FLEMING JAMES E , MCGREW JESSE M , MCGREW STEPHEN P , NICHOLES PATRICK , HUMPHREYS JOHNNY
IPC分类号： G01N35/00 , G01N30/74 , G06F19/00
CPC分类号： G01N21/77 , G01N21/8483 , G01N2035/00108 , G16H10/40 , G16H40/63
摘要： An assay system includes an optical imager to acquire high resolution images of assay strips (e.g., lateral flow immunochromatographic test strips) and performs image processing to identify individual assay strips and determine results for each assay strip, by quantifies the presence or absence of test signal line(s) and control signal line(s). Assay strips may be in a holder or carrier contained in a specimen container also holding a specimen. The assay system automatically logs all results and data to a database that stores a high resolution image of the original immunochromatographic assay, the values of test line(s) and control line(s), and the test result. A user interface directs an end user through operation.
摘要翻译：测定系统包括光学成像仪以获得测定条的高分辨率图像（例如横向流动免疫层析测试条），并执行图像处理以识别各个测定条，并通过量化测试信号的存在或不存在来确定每个测定条的结果线路和控制信号线。测定条可以在包含在也保持标本的样本容器中的保持器或载体中。测定系统将所有结果和数据自动记录到存储原始免疫色谱测定的高分辨率图像，测试线和对照线的值以及测试结果的数据库。用户界面指示最终用户通过操作。

6. 发明申请

WO2004013735A2 STRUCTURED MAGNETIC PATTERN ANTI-COUNTERFEITING SYSTEM 审中-公开
标题翻译：结构化的磁性图案防伪系统
公开(公告)号：WO2004013735A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/024389
申请日：2003-08-04
申请人： VERIFICATION SECURITY CORPORATION , MCGREW, Stephen, P.
发明人： MCGREW, Stephen, P.
IPC分类号： G06F
CPC分类号： G06K7/1417 , G06K7/087 , G06K19/06187 , G06K19/12 , G06K2017/0038 , G07D7/04
摘要： A system and associated method provide a marking of material to be applied to goods. In one embodiment, magnetic material is applied in a predetermined pattern. An accumulation of magnetic material in one orientation across the structured pattern may provide an automatically sensible value. Magnetically readable material may be provided as a predetermined, repeatable pattern, where the magnetic material is applied to a surface with a resolution in a range of at least 10,000 to 100 dots per inch.
摘要翻译：系统和相关方法提供了用于货物的材料的标记。在一个实施例中，磁性材料以预定图案施加。在整个结构化图案上的一个取向上的磁性材料的积聚可以提供自动可感知的值。磁性可读材料可以作为预定的可重复图案来提供，其中磁性材料以至少10,000至100点每英寸的分辨率施加到表面上。

7. 发明申请

WO1992001973A2 EMBOSSING TOOL 审中-公开
标题翻译：刺绣工具
公开(公告)号：WO1992001973A2
公开(公告)日：1992-02-06
申请号：PCT/US1991005085
申请日：1991-07-18
申请人： McGREW, Stephen, P.
IPC分类号： G03F07/00
CPC分类号： G03H1/0276 , G03F7/00 , G03H1/028 , G03H1/04 , G03H2001/0292 , G03H2001/0296 , G03H2001/043 , G03H2001/0482 , G03H2223/14 , G03H2224/04 , G03H2225/11 , G03H2260/14 , G03H2260/63 , G03H2270/13 , G03H2270/21
摘要： A method and apparatus for producing durable embossing tools is disclosed. An anisotropic etching process, such as ion etching, is used to etch a relief pattern into a hard substrate. A transfer layer is formed overlaying a generally smooth, seamless surface region of a substrate. A desired relief pattern is formed in the transfer layer, by exposing a photoresist, embossing, or the like. The substrate having the photoresist thereon is subjected to an anisotropic etch. The anisotropic etch continues until the transfer layer is completely removed and the relief pattern is formed in the upper surface of the embossing tool. The relative etch rates between the transfer layer and the surface region of the embossing tool are selected to provide the desired depth modulation in the surface of the embossing tool. An embossing tool produced according to the invention has a relatively hard surface and may thus be used for the mass production of holographic images without significant degradation of the pattern. Because the embossing tool can be made from an extremely hard material such as chromium or hardened steel, materials which previously could not be economically embossed with holograms, such as aluminum or steel, may now be embossed by an embossing tool made according to this invention.
摘要翻译：公开了一种生产耐用压花工具的方法和设备。使用诸如离子蚀刻的各向异性蚀刻工艺将浮雕图案蚀刻成硬质衬底。形成覆盖基板的大致光滑，无缝的表面区域的转印层。通过曝光光致抗蚀剂，压花等，在转印层中形成所需的浮雕图案。对其上具有光致抗蚀剂的基板进行各向异性蚀刻。各向异性蚀刻继续，直到转印层被完全去除，并且浮雕图案形成在压花工具的上表面中。选择转印层和压花工具的表面区域之间的相对蚀刻速率以在压花工具的表面中提供期望的深度调制。根据本发明制造的压花工具具有相对较硬的表面，因此可用于大量生产全息图像而不会显着降低图案。由于压花工具可以由诸如铬或硬化钢之类的非常硬的材料制成，所以以前不能经济地压印全息图的材料，例如铝或钢，现在可以通过根据本发明制造的压花工具来压花。

8. 发明申请

WO1982001595A1 DIFFRACTIVE COLOR AND TEXTURE EFFECTS FOR THE GRAPHIC ARTS 审中-公开
标题翻译：图形艺术的差异色彩和纹理效应
公开(公告)号：WO1982001595A1
公开(公告)日：1982-05-13
申请号：PCT/US1981001439
申请日：1981-10-27
申请人： MCGREW STEPHEN P
IPC分类号： G02B05/18
CPC分类号： G02B5/1842 , G03H1/0011
摘要： A method of producing color and texture effects on a surface (210, 400) without the use of pigments or actual texturing. Diffraction patterns generated by interference between two light beams (220, 230) are recorded in a suitable high-resolution photographic material (210, 400) and are used instead of paints or inks to provide desired color and texture effects in the various regions (440, 530) of an artistic or decorative composition. The resulting composition (210, 400) may contain spectrally pure or mixed colors and a wide range of static or dynamic textural illusions visible under a variety of lighting conditions.
摘要翻译：在不使用颜料或实际纹理的情况下，在表面（210,400）上产生颜色和纹理效果的方法。由两个光束（220,230）之间的干涉产生的衍射图案被记录在合适的高分辨率照相材料（210,400）中，并且代替涂料或油墨以在各个区域（440）中提供期望的颜色和纹理效果，530）艺术或装饰作品。所得到的组合物（210,400）可以包含光谱纯的或混合的颜色以及在各种照明条件下可见的宽范围的静态或动态纹理幻影。

9. 发明申请

WO2004031366A3 MANUFACTURING METHOD AND READOUT SYSTEM FOR BIOPOLYMER ARRAYS 审中-公开
标题翻译：生物多样性阵列的制造方法和读出系统
公开(公告)号：WO2004031366A3
公开(公告)日：2004-06-10
申请号：PCT/US0331490
申请日：2003-10-02
申请人： NEW LIGHT IND LTD , MCGREW STEPHEN P , LIGHTFOOT DONALD R
发明人： MCGREW STEPHEN P , LIGHTFOOT DONALD R
IPC分类号： B01J19/00 , C12N20060101 , C12Q1/68 , C40B40/06 , C40B50/14 , G01N27/26
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00385 , B01J2219/00432 , B01J2219/00434 , B01J2219/00439 , B01J2219/00497 , B01J2219/00518 , B01J2219/00527 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B50/14 , G01N33/54373 , C12Q2565/501 , C12Q2565/607 , C12Q2565/515
摘要： A method for manufacturing an array of biomolecules that have complementary binding species is disclosed. The method utilizes a master substrate containing a desired master array of binding molecules or ligands, e.g., DNA target molecules. A mixture of complementary, antiligand molecules, e.g., DNA probe molecules, are then hybridized to the ligands of the master array, forming an array of antiligand molecules reversibly bound to the molecules in the master array. The antiligand array is then transferred and bound to a separate substrate, to form a desired array of antiligand molecules on the separate substrate. The process may be repeated to produce multiple arrays or multiple generations of arrays. Also disclosed is a sensor array device and method. The device includes an array of vibratory tympanic elements, each having a specific analyte binding probe carried on the vibratory membrane of the element. A binding event is detected by a change in the vibrational resonance of a selected element.
摘要翻译：公开了一种制备具有互补结合物质的生物分子阵列的方法。该方法利用含有所需主要结合分子主阵列或配体的母基质，例如DNA靶分子。然后将互补的配子分子（例如DNA探针分子）的混合物与主阵列的配体杂交，形成可逆地结合到主阵列中的分子的反配体分子的阵列。然后将反配体阵列转移并结合到单独的底物上，以在分离的底物上形成所需的抗配体分子阵列。可以重复该过程以产生多个阵列或多代阵列。还公开了一种传感器阵列装置和方法。该装置包括振动鼓膜元件阵列，每个振动鼓膜元件具有承载在该元件的振动膜上的特定分析物结合探针。通过所选元件的振动共振的变化来检测结合事件。

10. 发明申请

WO1992001976A1 HOLOCOMPOSER 审中-公开
公开(公告)号：WO1992001976A1
公开(公告)日：1992-02-06
申请号：PCT/US1991005084
申请日：1991-07-18
申请人： McGREW, Stephen, P.
IPC分类号： G03H01/30
CPC分类号： G03H1/30 , G03H1/268 , G03H2001/0423 , G03H2001/0473 , G03H2001/2685 , G03H2001/269 , G03H2222/24 , G03H2225/11
摘要： A method is disclosed for making holographic images by recording an array of pixels (202) which together form a two or three dimensional composite image. Each pixel corresponds to a sampling of just those rays which would pass through a given point (205) on the surface of an ordinary hologram. Every common type of hologram can be made by this method, including 2D/3D holograms, stereograms, and full color holograms. Each pixel is a white light viewable hologram generated by recording a small hologram near the narrowest part of a converging bundle of rays of coherent light (520), usually with each ray corresponding to one point on the object, and the rays in a pixel being confined to a horizontal plane intersecting the surface of the object.

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