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1. 发明申请

WO2014022594A1 STROMA BIOMARKERS FOR PROSTATE CANCER PROGNOSIS 审中-公开
标题翻译：用于前列腺癌预防的STROMA生物标志物
公开(公告)号：WO2014022594A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/053093
申请日：2013-07-31
申请人： MERCOLA, Daniel , MCCLELLAND, Michael
发明人： MERCOLA, Daniel , MCCLELLAND, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2537/143 , C12Q2600/158 , G01N2800/60
摘要： Described are embodiments related to prostate cancer biomarkers and agents, systems, and kits for detecting and targeting the same, and associated prostate cancer diagnostic, prognostic, and therapeutic methods.
摘要翻译：描述了与用于检测和靶向相同的前列腺癌生物标志物和试剂，系统和试剂盒相关的实施方案，以及相关的前列腺癌诊断，预后和治疗方法。

2. 发明申请

WO2009152480A2 METHODS TO TREAT SOLID TUMORS 审中-公开
标题翻译：治疗固体肿瘤的方法
公开(公告)号：WO2009152480A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/047285
申请日：2009-06-12
申请人： VIVOCURE, INC. , ARRACH, Nabil , MCCLELLAND, Michael
发明人： ARRACH, Nabil , MCCLELLAND, Michael
IPC分类号： C12N15/11 , A61K48/00 , C12N15/63 , C12N1/21 , A61P35/00 , C12R1/42
CPC分类号： C12N15/74 , A61K48/00 , C12N15/1079 , C12N2830/008 , C12N2830/55
摘要： A high throughput method for identifying promoters differentially activated in solid tumors as compared to normal tissues is described. The promoters so identified may be used to drive production of RNA's or proteins useful in treating solid tumors including toxic RNA's or proteins and other therapeutic RNA's or proteins.
摘要翻译：描述了用于鉴定与正常组织相比在实体瘤中差异激活的启动子的高通量方法。如此鉴定的启动子可用于驱动可用于治疗实体瘤，包括毒性RNA或蛋白质和其他治疗性RNA或蛋白质的RNA或蛋白质的产生。

3. 发明申请

WO2010141143A2 ENGINEERED AVIRULENT BACTERIA STRAINS AND USE IN MEDICAL TREATMENTS 审中-公开
标题翻译：工程化的细菌菌株和用于医疗治疗
公开(公告)号：WO2010141143A2
公开(公告)日：2010-12-09
申请号：PCT/US2010/027245
申请日：2010-03-12
申请人： VIVOCURE, INC. , ARRACH, Nabil , MCCLELLAND, Michael
发明人： ARRACH, Nabil , MCCLELLAND, Michael
IPC分类号： A61K38/43 , A61K38/16 , A61K38/17 , A61K39/02 , A61P35/00
CPC分类号： C07K14/255 , A61K2035/11 , A61K2039/522 , C12N1/36
摘要： Provided in part herein are avirulent bacterial compositions suitable for use as medicaments for the treatment of various tumors. Also provided in part are methods for identifying and/or generating avirulent bacterial strains or engineered avirulent bacterial strains that can be formulated as medicaments. Also provided in part are methods of cancer treatment utilizing engineered avirulent bacteria as described herein. Engineered strains as described herein show normal or increased fitness in tumor tissue, while exhibiting reduced fitness in normal tissue. Compositions described herein may prove useful for the treatment of other medical conditions.
摘要翻译：在本文中部分提供了适用于治疗各种肿瘤的药物的无毒性细菌组合物。还部分提供了用于鉴定和/或产生可配制成药物的无毒力菌株或工程无毒力菌株的方法。还部分提供利用本文所述的工程无毒力细菌进行癌症治疗的方法。如本文所述的工程菌株在正常组织中表现出降低的适应度，正常或增加了肿瘤组织的适应度。本文所述的组合物可用于治疗其他医疗状况。

4. 发明申请

WO2005078899A1 COMPACT DYNAMOELECTRIC MACHINE 审中-公开
标题翻译：紧凑型电动机
公开(公告)号：WO2005078899A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/003615
申请日：2005-01-31
申请人： EMERSON ELECTRIC CO. , MCCLELLAND, Michael, L. , HORST, Gary, E.
发明人： MCCLELLAND, Michael, L. , HORST, Gary, E.
IPC分类号： H02K5/15
CPC分类号： H02K7/083 , H02K1/06 , H02K5/1732 , H02K11/048 , H02K19/103
摘要： A compact dynamoelectric machine having a rotor with a length which is less than the length of a corresponding stator core. The rotor is rotatable on a shaft supported by bearings, with at least one of the bearings being positioned longitudinally within the stator core. Two endshields define opposite ends of the machine. One of the endshields is configured for holding electronic components in arrangement integrated with the machine.
摘要翻译：一种紧凑型电动机，其具有长度小于相应定子芯长度的转子。转子可以在由轴承支撑的轴上旋转，其中至少一个轴承纵向定位在定子芯内。两个挡板定义了机器的两端。其中一个挡板被配置为保持与机器集成的布置的电子部件。

5. 发明申请

WO9955913A2 REDUCED COMPLEXITY NUCLEIC ACID TARGETS AND METHODS OF USING SAME 审中-公开
标题翻译：降低的复杂核酸目标及其使用方法
公开(公告)号：WO9955913A2
公开(公告)日：1999-11-04
申请号：PCT/US9909119
申请日：1999-04-27
申请人： SIDNEY KIMMEL CANCER CT , MCCLELLAND MICHAEL , WELSH JOHN , TRENKLE THOMAS
发明人： MCCLELLAND MICHAEL , WELSH JOHN , TRENKLE THOMAS
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C12M1/00 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6811 , C12Q1/6809 , C12Q1/6837 , C12Q2525/179
摘要： The invention provides a method of measuring the level of two or more nucleic acid molecules in a target by contacting a probe with a target comprising two or more nucleic acid molecules, wherein the nucleic acid molecules are arbitrarily sampled and wherein the arbitrarily sampled nucleic acid molecules comprise a subset of the nucleic acid molecules in a population of nucleic acid molecules; and detecting the amount of specific binding of the target to the probe. The invention also provides a method of measuring the level of two or more nucleic acid molecules in a target by contacting a probe with a target comprising two or more nucleic acid molecules, wherein the nucleic acid molecules are statistically sampled and wherein the statistically sampled nucleic acid molecules comprise a subset of the nucleic acid molecules in a population of nucleic acid molecules; and detecting the amount of specific binding of the target to the probe.
摘要翻译：本发明提供了通过使探针与包含两个或更多个核酸分子的靶接触来测量靶中两个或更多个核酸分子的水平的方法，其中所述核酸分子是任意取样的，并且其中所述任意取样的核酸分子包含核酸分子群体中的核酸分子的子集; 并检测目标与探针的特异性结合的量。本发明还提供了通过使探针与包含两个或更多个核酸分子的靶接触来测量靶中两个或更多个核酸分子的水平的方法，其中核酸分子被统计学地采样，并且其中统计学上采样的核酸分子包含核酸分子群体中的核酸分子的子集; 并检测目标与探针的特异性结合的量。

6. 发明申请

WO2013173517A1 STROMA BIOMARKERS FOR THE DIAGNOSIS OF PROSTATE CANCER 审中-公开
标题翻译：用于诊断前列腺癌的STROMA生物标志物
公开(公告)号：WO2013173517A1
公开(公告)日：2013-11-21
申请号：PCT/US2013/041241
申请日：2013-05-15
申请人： MCCLELLAND, Michael , MERCOLA, Daniel , LERNHARDT, Waldemar , ZHENYU, Jia
发明人： MERCOLA, Daniel , LERNHARDT, Waldemar , ZHENYU, Jia
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/5088 , G01N33/57434 , G01N2333/47 , G01N2333/4703 , G01N2333/78 , G01N2333/90203
摘要： The invention described herein relates in part to compositions, biomarkers and methods for diagnosis and prognosis of prostate lesions, including prostate cancer, including a tissue- based assay providing diagnostic and prognostic information related to prostate cancer. In some embodiments, the invention further relates to improvements in the ability to accurately diagnose prostate cancer, detect early-stage prostate cancer, and localize prostate lesions within the three-dimensional space of the prostate.
摘要翻译：本文描述的本发明部分地涉及用于前列腺损伤的诊断和预后的组合物，生物标志物和方法，包括前列腺癌，包括提供与前列腺癌相关的诊断和预后信息的基于组织的测定。在一些实施方案中，本发明进一步涉及准确诊断前列腺癌，检测早期前列腺癌和定位前列腺三维空间内的前列腺损伤的能力的改进。

7. 发明申请

WO2009152480A3 METHODS TO TREAT SOLID TUMORS 审中-公开
标题翻译：治疗固体肿瘤的方法
公开(公告)号：WO2009152480A3
公开(公告)日：2010-06-17
申请号：PCT/US2009047285
申请日：2009-06-12
申请人： VIVOCURE INC , ARRACH NABIL , MCCLELLAND MICHAEL
发明人： ARRACH NABIL , MCCLELLAND MICHAEL
IPC分类号： C12N15/11 , A61K48/00 , A61P35/00 , C12N1/21 , C12N15/63 , C12R1/42
CPC分类号： C12N15/74 , A61K48/00 , C12N15/1079 , C12N2830/008 , C12N2830/55
摘要： A high throughput method for identifying promoters differentially activated in solid tumors as compared to normal tissues is described. The promoters so identified may be used to drive production of RNA's or proteins useful in treating solid tumors including toxic RNA's or proteins and other therapeutic RNA's or proteins.
摘要翻译：描述了用于鉴定与正常组织相比在实体瘤中差异激活的启动子的高通量方法。如此鉴定的启动子可用于驱动可用于治疗实体瘤，包括毒性RNA或蛋白质和其他治疗性RNA或蛋白质的RNA或蛋白质的产生。

8. 发明申请

WO2006124735A1 RESILIENT ISOLATION MEMBERS AND RELATED METHODS OF REDUCING ACOUSTIC NOISE AND/OR STRUCTURAL VIBRATION IN AN ELECTRIC MACHINE 审中-公开
标题翻译：振动分离器及减少电动机噪声和/或结构振动的相关方法
公开(公告)号：WO2006124735A1
公开(公告)日：2006-11-23
申请号：PCT/US2006/018652
申请日：2006-05-11
申请人： EMERSON ELECTRIC CO. , WILLIAMS, Donald, J. , HORST, Gary, E. , MODI, Chetan, O. , MCCLELLAND, Michael, L.
发明人： WILLIAMS, Donald, J. , HORST, Gary, E. , MODI, Chetan, O. , MCCLELLAND, Michael, L.
IPC分类号： H02K5/15 , H02K5/24
CPC分类号： H02K5/24 , H02K5/15
摘要： A resilient isolation member is configured for use with an electric machine having a housing, a stator within the housing, and an end shield. The resilient isolation member includes first and second end portions, a sidewall extending between the first and second end portions, and a lip is disposed along an outer surface of the sidewall. The resilient isolation member is sized for mounting between the end shield and the stator, with the first and second end portions respectively abutting against a first inner portion of the end shield and a portion of the stator and with the lip abutting against a second inner portion of the end shield and a portion of the housing.
摘要翻译：弹性隔离构件构造成用于具有壳体，壳体内的定子和端盖的电机。弹性隔离构件包括第一和第二端部，在第一和第二端部之间延伸的侧壁，并且唇缘沿侧壁的外表面设置。弹性隔离构件的尺寸适于安装在端部屏蔽件和定子之间，其中第一和第二端部分别抵靠端部屏蔽件的第一内部部分和定子的一部分，并且唇缘抵靠第二内部部分的端盖和壳体的一部分。

9. 发明申请

WO9955913A9 REDUCED COMPLEXITY NUCLEIC ACID TARGETS AND METHODS OF USING SAME 审中-公开
标题翻译：降低的复杂核酸目标及其使用方法
公开(公告)号：WO9955913A9
公开(公告)日：2000-03-30
申请号：PCT/US9909119
申请日：1999-04-27
申请人： SIDNEY KIMMEL CANCER CT , MCCLELLAND MICHAEL , WELSH JOHN , TRENKLE THOMAS
发明人： MCCLELLAND MICHAEL , WELSH JOHN , TRENKLE THOMAS
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C12M1/00 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6811 , C12Q1/6809 , C12Q1/6837 , C12Q2525/179
摘要： The invention provides a method of measuring the level of two or more nucleic acid molecules in a target by contacting a probe with a target comprising two or more nucleic acid molecules, wherein the nucleic acid molecules are arbitrarily sampled and wherein the arbitrarily sampled nucleic acid molecules comprise a subset of the nucleic acid molecules in a population of nucleic acid molecules; and detecting the amount of specific binding of the target to the probe. The invention also provides a method of measuring the level of two or more nucleic acid molecules in a target by contacting a probe with a target comprising two or more nucleic acid molecules, wherein the nucleic acid molecules are statistically sampled and wherein the statistically sampled nucleic acid molecules comprise a subset of the nucleic acid molecules in a population of nucleic acid molecules; and detecting the amount of specific binding of the target to the probe.
摘要翻译：本发明提供了通过使探针与包含两个或更多个核酸分子的靶接触来测量靶中两个或更多个核酸分子的水平的方法，其中所述核酸分子是任意取样的，并且其中所述任意取样的核酸分子包含核酸分子群体中的核酸分子的子集; 并检测目标与探针的特异性结合的量。本发明还提供了通过使探针与包含两个或更多个核酸分子的靶接触来测量靶中两个或更多个核酸分子的水平的方法，其中核酸分子被统计学地采样，并且其中统计学上采样的核酸分子包含核酸分子群体中的核酸分子的子集; 并检测目标与探针的特异性结合的量。

10. 发明申请

WO2010141143A3 ENGINEERED AVIRULENT BACTERIA STRAINS AND USE IN MEDICAL TREATMENTS 审中-公开
标题翻译：工程化的细菌菌株和用于医疗治疗
公开(公告)号：WO2010141143A3
公开(公告)日：2011-03-03
申请号：PCT/US2010027245
申请日：2010-03-12
申请人： VIVOCURE INC , ARRACH NABIL , MCCLELLAND MICHAEL
发明人： ARRACH NABIL , MCCLELLAND MICHAEL
IPC分类号： A61K38/43 , A61K38/16 , A61K38/17 , A61K39/02 , A61P35/00
CPC分类号： C07K14/255 , A61K2035/11 , A61K2039/522 , C12N1/36
摘要： Provided in part herein are avirulent bacterial compositions suitable for use as medicaments for the treatment of various tumors. Also provided in part are methods for identifying and/or generating avirulent bacterial strains or engineered avirulent bacterial strains that can be formulated as medicaments. Also provided in part are methods of cancer treatment utilizing engineered avirulent bacteria as described herein. Engineered strains as described herein show normal or increased fitness in tumor tissue, while exhibiting reduced fitness in normal tissue. Compositions described herein may prove useful for the treatment of other medical conditions.
摘要翻译：在本文中部分提供了适用于治疗各种肿瘤的药物的无毒性细菌组合物。还部分提供了用于鉴定和/或产生可配制成药物的无毒力菌株或工程无毒力菌株的方法。还部分提供利用本文所述的工程无毒力细菌进行癌症治疗的方法。在本文所述的工程菌株在正常组织中表现出降低的适应度，正常或增加了肿瘤组织的适应度。本文描述的组合物可用于治疗其他医疗状况。

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