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1. 发明申请

WO2013052047A1 MULTIPURPOSE SEQUENTIAL DROPLET APPLICATOR 审中-公开
标题翻译：多用途顺序滴灌应用
公开(公告)号：WO2013052047A1
公开(公告)日：2013-04-11
申请号：PCT/US2011/055005
申请日：2011-10-06
申请人： McCarthy, Thomas Robert
发明人： McCarthy, Thomas Robert
IPC分类号： B41J2/04
CPC分类号： B05B7/0807 , B05B7/0846 , B05B9/035 , B05B9/04 , B05B12/04 , B05B14/30 , B08B3/04
摘要： Embodiments of this device or method repeatedly apply droplets of two or more liquids in an alternate or sequential manner to a target location on a surface for removing material from the surface, adding material to the surface, or using the surface to catalyze a reaction of components of the liquids. The droplets have essentially no contact with one another before reaching the surface (FIG. 12A thru 13H). The effect of the droplets on the target surface can be modified by a continuous or interrupted flow of air or other gas to the target surface (FIG. 27A thru 29H), or by application of radiations such as sonic or ultrasonic radiation, or various frequencies of electromagnetic radiation, to the target surface, or some combination of these. Means may be included for adjusting the temperature of the liquids and gasses.
摘要翻译：该装置或方法的实施方案以交替或顺序的方式将两种或更多种液体的液滴重复地施加到表面上的目标位置，以从表面去除材料，向表面添加材料，或者使用表面催化部件的反应的液体。液滴在到达表面之前基本上没有彼此接触（图12A到13H）。液滴对目标表面的影响可以通过连续或间断的空气或其他气体流向目标表面（图27A至29H）或通过施加诸如声波或超声波辐射或各种频率的电磁辐射，到目标表面，或这些的一些组合。可以包括用于调节液体和气体的温度的装置。

2. 发明申请

WO2011000793A3 PREPARATION AND CRYSTALLISATION OF S-[2-[1-(2-ETHYLBUTYL)CYCLOHEXYLCARBONYLAMINO]-PHENYL]-2-METHYLTHIOPROPIONATE 审中-公开
标题翻译： S- [2- [1-（2-乙基丁基）环丙基]氨基]苯基] - 苯基] -2-甲基噻二唑的制备和结晶
公开(公告)号：WO2011000793A3
公开(公告)日：2011-03-31
申请号：PCT/EP2010059112
申请日：2010-06-28
申请人： HOFFMANN LA ROCHE , COSTELLO DECLAN , HARNETT GERARD JOHN , HIDBER PIRMIN , HOFFMANN URSULA , MCCARTHY THOMAS , REENTS REINHARD , SMITH DENNIS A , SMYTH TIMOTHY
发明人： COSTELLO DECLAN , HARNETT GERARD JOHN , HIDBER PIRMIN , HOFFMANN URSULA , MCCARTHY THOMAS , REENTS REINHARD , SMITH DENNIS A , SMYTH TIMOTHY
IPC分类号： C07C327/30
CPC分类号： C07C327/30 , C07C2601/14
摘要： The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.
摘要翻译：本发明涉及制备作为有用的药物活性化合物的S- [2- [1-（2-乙基丁基）环己基羰基氨基] - 苯基] -2-甲硫基丙酸酯的方法。

3. 发明申请

WO2007106944A1 CONTRACEPTIVE COMPOSITION 审中-公开
标题翻译：承包组合物
公开(公告)号：WO2007106944A1
公开(公告)日：2007-09-27
申请号：PCT/AU2007/000352
申请日：2007-03-21
申请人： STARPHARMA PTY LIMITED , MCCARTHY, Thomas, David
发明人： MCCARTHY, Thomas, David
IPC分类号： A61K31/785 , A61P15/18 , A61P31/12
CPC分类号： A61K31/785 , Y10S977/754
摘要： The present invention relates to a contraceptive composition including an effective amount of a dendrimer compound including one or more naphthyl disulphonic acid surface groups, or a pharmaceutically acceptable salt or solvate of the dendrimer compound; and a pharmaceutically acceptable carrier, excipient and/or diluent therefor. The contraceptive composition may also exhibit antimicrobial activity. The invention also relates to a method of selectively reducing or preventing conception in a female animal, including a human, which method includes administering to the animal an effective amount of a contraceptive composition which composition includes an effective amount of a dendrimer compound including one or more naphthyl disulphonic acid surface groups, or a pharmaceutically acceptable salt or solvate of the dendrimer compound; and a pharmaceutically acceptable carrier, excipient and/or diluent therefor.
摘要翻译：本发明涉及一种避孕组合物，其包含有效量的包含一个或多个萘基二磺酸表面基团的树枝状大分子化合物，或其树枝状大分子化合物的药学上可接受的盐或溶剂合物; 和其药学上可接受的载体，赋形剂和/或稀释剂。避孕组合物还可以表现出抗微生物活性。本发明还涉及一种在女性动物（包括人）中选择性地减少或预防受孕的方法，该方法包括向动物施用有效量的避孕组合物，该组合物包含有效量的包括一种或多种的树突状化合物萘基二磺酸表面基团，或其树枝状大分子化合物的药学上可接受的盐或溶剂合物; 和其药学上可接受的载体，赋形剂和/或稀释剂。

4. 发明申请

WO2005113035A3 METALLIC COILS ENLACED WITH BIOLOGICAL OR BIODEGRADABLE OR SYNTHETIC POLYMERS OR FIBERS FOR EMBOLIZATION OF A BODY CAVITY 审中-公开
标题翻译：用生物可降解或合成聚合物或纤维填充身体的金属线圈
公开(公告)号：WO2005113035A3
公开(公告)日：2006-02-23
申请号：PCT/US2005018087
申请日：2005-05-23
申请人： MICRO THERAPEUTICS INC , PATTERSON WILLIAM R , SLEE EARL H , WILDER TOM , MCCARTHY THOMAS , STRAUSS BRIAN , MONSTADT HERMANN , HENKES HANS
发明人： PATTERSON WILLIAM R , SLEE EARL H , WILDER TOM , MCCARTHY THOMAS , STRAUSS BRIAN , MONSTADT HERMANN , HENKES HANS
IPC分类号： A61B17/00 , A61B17/12 , A61L31/02 , A61L31/10 , A61L31/12 , A61L31/16
CPC分类号： A61L31/18 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00004 , A61B2017/00526 , A61L31/022 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/606 , A61L2430/36
摘要： Vaso-occlusive coils comprising fibers. The vaso-occlusive coil (12) can be a helical coil or a double helix made of biocompatible metal wire whereas the fibers (14, 16, 18, 28) are enlaced between at least a winding of the coil (12) and are made of polymeric materials like copolymers of glycolic/lactic acid. The fibers (14, 16, 18, 28) or the coil (12) can be coated with a bioactive material. The device (10) can comprise a stretch-resistant member and can be radio-opaque.
摘要翻译：包含纤维的血管闭塞线圈。血管闭塞线圈（12）可以是由生物相容性金属丝制成的螺旋线圈或双螺旋，而纤维（14,16,18,28）被放置在线圈（12）的至少一个绕组之间并被制成的聚合材料，如乙醇酸/乳酸的共聚物。纤维（14,16,18,28）或线圈（12）可以涂覆有生物活性材料。装置（10）可以包括抗拉构件并且可以是不透射线的。

5. 发明申请

WO2016113668A1 PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS 审中-公开
标题翻译：吡咯啉衍生物作为ANGIOTENSIN II型2型拮抗剂
公开(公告)号：WO2016113668A1
公开(公告)日：2016-07-21
申请号：PCT/IB2016/050122
申请日：2016-01-12
申请人： NOVARTIS AG , BROWN, Jane , MCCARTHY, Thomas David , NAYLOR, Alan , WATTS, John Paul
发明人： BROWN, Jane , MCCARTHY, Thomas David , NAYLOR, Alan , WATTS, John Paul
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04 , A61K31/40 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D403/04 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04
摘要： The invention relates to heterocyclic angiotensin II type 2 (AT 2 ) receptor antagonists of formula (I), and pharmaceutically acceptable salts thereof, ((I) in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of neuropathic or inflammatory pain.
摘要翻译：本发明涉及式（I）的杂环血管紧张素II 2型（AT2）受体拮抗剂及其药学上可接受的盐，（（I）其中所有变量如说明书中所定义，其药物组合物，其组合，并将其用作药物，特别是用于治疗神经性或炎性疼痛。

6. 发明申请

WO2013102242A1 HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译：杂环化合物及其使用方法
公开(公告)号：WO2013102242A1
公开(公告)日：2013-07-11
申请号：PCT/AU2013/000003
申请日：2013-01-04
申请人： SPINIFEX PHARMACEUTICALS PTY LTD , MCCARTHY, Thomas David , NAYLOR, Alan
发明人： MCCARTHY, Thomas David , NAYLOR, Alan
IPC分类号： C07D207/16 , C07D205/04 , C07D207/22 , C07D209/18 , C07D209/42 , C07D209/94 , C07D403/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D498/10 , A61K31/40 , A61K31/397 , A61K31/4025 , A61K31/404 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D498/10 , C07D205/04 , C07D207/14 , C07D207/16 , C07D207/22 , C07D209/18 , C07D209/42 , C07D209/94 , C07D401/04 , C07D401/12 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D498/04
摘要： The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT 2 ) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT 2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.
摘要翻译：本发明涉及可用于拮抗血管紧张素II型2型（AT2）受体的杂环化合物。更具体地说，本发明涉及吡咯烷和氮杂环丁烷化合物，含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途，包括神经性疼痛，炎性疼痛，与神经元超敏反应相关的病症，神经传导速度受损，细胞增生障碍，与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生有关的疾病。

7. 发明申请

WO2012162050A2 ANTIFOULING BY ADHESION SUPPRESSION 审中-公开
标题翻译：防止粘合抑制
公开(公告)号：WO2012162050A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/038080
申请日：2012-05-16
申请人： WILKER, Jonathan , CLOUD, Joshua , CLARK, Christopher , MCCARTHY, Thomas , PURDUE RESEARCH FOUNDATION
发明人： WILKER, Jonathan , CLOUD, Joshua , CLARK, Christopher , MCCARTHY, Thomas
IPC分类号： C09D5/16 , C09D201/00 , C09D175/04
CPC分类号： C09D5/1625 , C09D5/1693
摘要： The disclosure described herein includes antifouling compositions, methods of antifouling by adhesion suppression and methods of selecting an antifouling composition which suppresses marine animal adhesion or reduces the strength of marine animal adhesion by reducing or quenching the oxidative adhesion chemistry of the marine animal.
摘要翻译：本文所述的公开内容包括防污组合物，通过粘合抑制的防污方法和选择防污组合物的方法，所述防污组合物通过减少或猝灭海洋动物的氧化粘附化学物质来抑制海洋动物粘附或降低海洋动物粘附的强度。

8. 发明申请

WO2012010843A1 SALT AND SOLVATES OF A TETRAHYDROISOQUINOLINE DERIVATIVE 审中-公开
标题翻译：四氢喹啉衍生物的盐和溶剂
公开(公告)号：WO2012010843A1
公开(公告)日：2012-01-26
申请号：PCT/GB2011/001096
申请日：2011-07-21
申请人： SPINIFEX PHARMACEUTICALS PTY LTD , MCCARTHY, Thomas, David , KELLY, Peter, Michael , BOYLE, Craig, James, Stewart , EBERLIN, Alexander, Redvers
发明人： MCCARTHY, Thomas, David , KELLY, Peter, Michael , BOYLE, Craig, James, Stewart , EBERLIN, Alexander, Redvers
IPC分类号： C07D217/26
CPC分类号： C07D217/26 , A61K31/47
摘要： (S)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid in substantially pure form is described together with its sodium salt and solvates. Methods for preparing the compound, its sodium salt and its solvates and pharmaceutical compositions comprising them are also described.
摘要翻译：与其钠盐和溶剂化物一起描述基本上纯的形式的（S）-2-（二苯基乙酰基）-1,2,3,4-四氢-6-甲氧基-5-（苯基甲氧基）-3-异喹啉羧酸。还描述了制备化合物，其钠盐及其溶剂合物的方法和包含它们的药物组合物。

9. 发明申请

WO2008121798A1 REINFORCED POLYMERIC MATERIALS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME 审中-公开
标题翻译：增强聚合材料，其制造方法和包含其的制品
公开(公告)号：WO2008121798A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058618
申请日：2008-03-28
申请人： UNIVERSITY OF MASSACHUSETTS , LESSER, Alan, J. , MCCARTHY, Thomas, J. , YOON, Joonsung , YORDEM, Onur, S.
发明人： LESSER, Alan, J. , MCCARTHY, Thomas, J. , YOON, Joonsung , YORDEM, Onur, S.
IPC分类号： C08K5/01 , C08K5/03
CPC分类号： C08L23/06 , C08K5/0008 , C08K5/01 , C08K5/13 , C08K5/1539 , C08L23/10 , C08L63/00 , Y10T428/268 , C08L23/02 , C08L2666/02
摘要： Disclosed herein is a polymeric composite comprising a first organic polymer that forms a first organic polymer phase; and a low molecular weight compound that exists in the form of a second crystalline phase; wherein the second crystalline phase is dispersed within the first organic polymer phase. Disclosed herein too is a polymeric composite comprising a first organic polymer that forms a first organic polymer phase; and a second phase that comprises a crystalline organic polymer, wherein the crystalline organic polymer has a different molecular structure from the first organic polymer; wherein the second phase is not covalently bonded to the first organic polymer phase and wherein the second phase has an average particle size of about 1 to about 20 micrometers.
摘要翻译：本文公开了包含形成第一有机聚合物相的第一有机聚合物的聚合复合材料; 和以第二结晶相形式存在的低分子量化合物; 其中所述第二结晶相分散在所述第一有机聚合物相内。本文还公开了包含形成第一有机聚合物相的第一有机聚合物的聚合复合材料; 和包含结晶有机聚合物的第二相，其中结晶有机聚合物与第一有机聚合物具有不同的分子结构; 其中所述第二相不共价键合到所述第一有机聚合物相，并且其中所述第二相的平均粒度为约1至约20微米。

10. 发明申请

WO2007045010A1 INHIBITORY COMPOUNDS 审中-公开
标题翻译：禁忌化合物
公开(公告)号：WO2007045010A1
公开(公告)日：2007-04-26
申请号：PCT/AU2006/000636
申请日：2006-05-15
申请人： STARPHARMA PTY LIMITED , HENDERSON, Scott, Andrew , HOLAN, George , KRIPPNER, Guy, Yeoman , McCARTHY, Thomas, David
发明人： HENDERSON, Scott, Andrew , HOLAN, George , KRIPPNER, Guy, Yeoman , McCARTHY, Thomas, David
IPC分类号： A61K47/48 , A61K31/166 , A61K31/74 , A61K31/785 , C08G69/08 , C08G69/10 , C08G83/00 , C08L77/10
CPC分类号： A61K31/795 , A61K31/166 , A61K31/74 , A61K31/785 , A61K47/59 , A61K47/645 , C08L101/005
摘要： The present invention provides an anionic dendrimer polymer of at least two generations. The present invention also provides for the production of these polymers and to their use in the inhibition of angiogenesis.
摘要翻译：本发明提供了至少两代的阴离子树枝状聚合物聚合物。本发明还提供这些聚合物的制备及其在抑制血管发生中的用途。

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