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1. 发明申请

WO2008128176A1 INFLUENZA POLYNUCLEOTIDES, EXPRESSION CONSTRUCTS, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：流感多核苷酸，表达结构，组成和使用方法
公开(公告)号：WO2008128176A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/060222
申请日：2008-04-14
申请人： NUCLEONICS, INC. , PACHUK, Catherine, J. , MCCALLUS, Daniel, E.
发明人： PACHUK, Catherine, J. , MCCALLUS, Daniel, E.
IPC分类号： A01N43/04 , C07H21/02 , C07H21/04 , C12N5/00 , C12N5/02 , C12N15/00
CPC分类号： C07K14/005 , A61K2039/53 , C12N2760/16122
摘要： The invention provides isolated RNA molecules containing a stretch of nucleotides from a conserved Influenza sequence, and provides complementary RNA molecules thereto. The RNA molecules of the invention are also substantially non-homologous to human sequences. The RNA molecules of the invention include double-stranded RNAs comprising a first region that is a conserved Influenza sequence, and a second region that is at least substantially complementary to the first region. Such double-stranded RNAs include single short hairpin RNAs (shRNAs) as well as multi-target hairpin RNAs containing a plurality, or several, stem-loop structures. The present invention further provides expression constructs that provide for expression of one, or a plurality, of RNA molecules of the invention. The RNA molecules, expression constructs, and compositions of the present invention find use in reducing levels of Influenza A RNA, in reducing Influenza A virus titer, and in treating or preventing Influenza virus infection. The invention is effective against at least human, swine and avian originating strains of Influenza A, and makes gene-silencing therapeutic strategies for combating Influenza A infection feasible.
摘要翻译：本发明提供了分离的RNA分子，其含有来自保守流感序列的一段核苷酸，并向其提供互补的RNA分子。本发明的RNA分子也与人序列基本上不同源。本发明的RNA分子包括双链RNA，其包含保守的流感序列的第一区域和至少基本上与第一区域互补的第二区域。这样的双链RNA包括单短发夹RNA（shRNA）以及含有多个或几个茎环结构的多靶发夹RNA。本发明还提供了表达本发明的一种或多种RNA分子的表达构建体。本发明的RNA分子，表达构建体和组合物用于降低甲型流感病毒RNA水平，降低甲型流感病毒滴度，以及用于治疗或预防流感病毒感染。本发明对至少人类，猪和禽流感A型流感病毒株有效，并且使抗甲型流感病毒的基因沉默治疗策略成为可能。

2. 发明申请

WO2006036872A3 TARGETING OPPOSITE STRAND REPLICATION INTERMEDIATES OF SINGLE-STRANDED VIRUSES BY RNAI 审中-公开
标题翻译：通过RNAI来针对单链条病毒复制中间体
公开(公告)号：WO2006036872A3
公开(公告)日：2006-08-17
申请号：PCT/US2005034371
申请日：2005-09-26
申请人： NUCLEONICS INC , MCCALLUS DANIEL E , GU BAOHUA , PACHUK CATHERINE J
发明人： MCCALLUS DANIEL E , GU BAOHUA , PACHUK CATHERINE J
IPC分类号： A61K31/713 , C12N15/113
CPC分类号： A61K31/713 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.
摘要翻译：本发明涉及通过双链RNA介导的基因沉默（RNAi）调节病毒复制的方法和组合物，其中抗病毒方法和组合物优先靶向单链RNA病毒的相反链复制中间体。

3. 发明申请

WO2006033756A2 MULTIPLE RNA POLYMERASE III PROMOTER EXPRESSION CONSTRUCTS 审中-公开
标题翻译：多重RNA聚合酶III促进剂表达构建体
公开(公告)号：WO2006033756A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/029976
申请日：2005-08-23
申请人： NUCLEONICS, INC. , PACHUK, Catherine, J. , MCCALLUS, Daniel, E. , SATISHCHANDRAN, Chandrasekhar , SIGG, Martin, D.
发明人： PACHUK, Catherine, J. , MCCALLUS, Daniel, E. , SATISHCHANDRAN, Chandrasekhar , SIGG, Martin, D.
IPC分类号： C12N15/113
CPC分类号： C12N15/111 , A61K38/00 , C12N15/1131 , C12N15/85 , C12N2310/14 , C12N2310/531 , C12N2320/32 , C12N2320/50 , C12N2330/50 , C12N2330/51 , C12N2840/20 , Y02A50/393
摘要： Expression constructs comprising at least two different RNA polymerase III promoters, wherein each promoter is operably linked to a nucleic acid sequence encoding an RNA effector molecule, are disclosed herein. Further provided are expression constructs comprising multiple polymerase III promoters operably linked to sequences encoding short hairpin RNA molecules, which may comprise single and/or multiple fingers. The provided constructs are useful for in vivo delivery of RNA molecules effective in gene silencing, including of viral genes including HBV and HCV.
摘要翻译：包含至少两种不同RNA聚合酶III启动子的表达构建体，其中每个启动子可操作地连接到编码RNA效应分子的核酸序列。进一步提供的是包含与编码短发夹RNA分子的序列可操作地连接的多个聚合酶III启动子的表达构建体，其可以包含单指和/或多指。所提供的构建体可用于在基因沉默中有效的RNA分子的体内递送，包括包括HBV和HCV的病毒基因。

4. 发明申请

WO2006033756A3 MULTIPLE RNA POLYMERASE III PROMOTER EXPRESSION CONSTRUCTS 审中-公开
标题翻译：多重RNA聚合酶III促进剂表达构建体
公开(公告)号：WO2006033756A3
公开(公告)日：2007-01-18
申请号：PCT/US2005029976
申请日：2005-08-23
申请人： NUCLEONICS INC , PACHUK CATHERINE J , MCCALLUS DANIEL E , SATISHCHANDRAN CHANDRASEKHAR , SIGG MARTIN D
发明人： PACHUK CATHERINE J , MCCALLUS DANIEL E , SATISHCHANDRAN CHANDRASEKHAR , SIGG MARTIN D
IPC分类号： C12N15/85 , A61K48/00 , A61P31/12 , C12N15/113
CPC分类号： C12N15/111 , A61K38/00 , C12N15/1131 , C12N15/85 , C12N2310/14 , C12N2310/531 , C12N2320/32 , C12N2320/50 , C12N2330/50 , C12N2330/51 , C12N2840/20
摘要： Expression constructs comprising at least two different RNA polymerase III promoters, wherein each promoter is operably linked to a nucleic acid sequence encoding an RNA effector molecule, are disclosed herein. Further provided are expression constructs comprising multiple polymerase III promoters operably linked to sequences encoding short hairpin RNA molecules, which may comprise single and/or multiple fingers. The provided constructs are useful for in vivo delivery of RNA molecules effective in gene silencing, including of viral genes including HBV and HCV.
摘要翻译：包含至少两种不同RNA聚合酶III启动子的表达构建体，其中每个启动子可操作地连接到编码RNA效应分子的核酸序列。进一步提供的是包含与编码短发夹RNA分子的序列可操作地连接的多个聚合酶III启动子的表达构建体，其可以包含单指和/或多指。所提供的构建体可用于在基因沉默中有效的RNA分子的体内递送，包括包括HBV和HCV的病毒基因。

5. 发明申请

WO2006036872A2 TARGETING OPPOSITE STRAND REPLICATION INTERMEDIATES OF SINGLE-STRANDED VIRUSES BY RNAI 审中-公开
标题翻译：用RNAi靶向单链病毒的反向链复制中间体
公开(公告)号：WO2006036872A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034371
申请日：2005-09-26
申请人： NUCLEONICS, INC. , MCCALLUS, Daniel, E. , GU, Baohua , PACHUK, Catherine, J.
发明人： MCCALLUS, Daniel, E. , GU, Baohua , PACHUK, Catherine, J.
IPC分类号： C12N15/113
CPC分类号： A61K31/713 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/463
摘要： The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.
摘要翻译：本发明涉及通过双链RNA介导的基因沉默（RNAi）调节病毒复制的方法和组合物，其中所述抗病毒方法和组合物优先靶向单链RNA病毒的相反链复制中间体

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