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1. 发明申请

WO2012094703A1 COMBINATION THERAPY 审中-公开
标题翻译：组合治疗
公开(公告)号：WO2012094703A1
公开(公告)日：2012-07-19
申请号：PCT/AU2012/000014
申请日：2012-01-11
申请人： DIMERIX BIOSCIENCE PTY LTD , PFLEGER, Kevin Donald George , MCCALL, Elizabeth , WILLIAMS, James
发明人： PFLEGER, Kevin Donald George , MCCALL, Elizabeth , WILLIAMS, James
IPC分类号： A61K31/41 , A61K31/80 , A61P9/06 , A61K31/537 , A61P9/00 , A61P9/12 , A61P13/12
CPC分类号： A61K31/537 , A61K9/0019 , A61K9/2009 , A61K9/2054 , A61K31/28 , A61K31/4178 , A61K31/4184 , A61K31/80 , A61K45/06 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof, and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof; and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof which inhibits a component of the chemokine receptor pathway other than the chemokine receptor. Oral sustained release pharmaceutical compositions comprising the pharmaceutical composition, as well as injectable sustained release pharmaceutical compositions comprising the pharmaceutical composition are described. The invention further relates to tablets, capsules, injectable suspensions, and compositions for pulmonary or nasal delivery comprising the pharmaceutical composition. Also described are: methods for assessing the efficacy of the pharmaceutical composition; methods for assessing the inhibition or partial inhibition activity of the pharmaceutical composition; methods for the treatment, amelioration or prevention of a condition or disease comprising administering to a subject a therapeutically effective amount of the pharmaceutical composition; and the use of the pharmaceutical composition for the manufacture of a dosage form for the treatment of a disease.
摘要翻译：本发明涉及药物组合物，其包含：（a）至少一种血管紧张素受体阻断剂或其药学上可接受的盐，和（b）至少一种趋化因子受体途径抑制剂或其药学上可接受的盐。本发明还涉及药物组合物，其包含：（a）至少一种血管紧张素受体阻断剂或其药学上可接受的盐; 和（b）抑制除趋化因子受体以外的趋化因子受体途径的成分的至少一种趋化因子受体途径抑制剂或其药学上可接受的盐。描述包含药物组合物的口服缓释药物组合物，以及包含该药物组合物的可注射持续释放药物组合物。本发明还涉及包含药物组合物的片剂，胶囊，可注射悬浮液和用于肺或鼻输送的组合物。还描述了：用于评估药物组合物的功效的方法; 用于评估药物组合物的抑制或部分抑制活性的方法; 用于治疗，改善或预防病症或疾病的方法，包括向受试者施用治疗有效量的药物组合物; 以及该药物组合物用于制备用于治疗疾病的剂型的用途。

2. 发明申请

WO2009149493A1 NOVEL RECEPTOR HETERO-DIMERS/-OLIGOMERS 审中-公开
标题翻译：新的受体异构体/寡聚体
公开(公告)号：WO2009149493A1
公开(公告)日：2009-12-17
申请号：PCT/AU2009/000720
申请日：2009-06-09
申请人： DIMERIX BIOSCIENCE PTY LTD , PFLEGER, Kevin , SEE, Heng Boon , SEEBER, Ruth Marie , DALRYMPLE, Matthew Blake , WILLIAMS, James , MCCALL, Elizabeth
发明人： PFLEGER, Kevin , SEE, Heng Boon , SEEBER, Ruth Marie , DALRYMPLE, Matthew Blake , WILLIAMS, James , MCCALL, Elizabeth
IPC分类号： C07K14/72 , A61P9/00
CPC分类号： C07K14/72 , C12N15/62
摘要： A hetero-dimeric or hetero-oligomeric receptor, comprising at least one vasopressin receptor subunit associated with at least one angiotensin receptor subunit.
摘要翻译：异二聚体或异低聚受体，其包含与至少一个血管紧张素受体亚基相关联的至少一个加压素受体亚单位。

3. 发明申请

WO2003081488A1 MANAGEMENT SYSTEM FOR CONDUCTING A PROCEDURE AND METHOD FOR MANAGING A PURCHASE BY A CUSTOMER 审中-公开
标题翻译：用于执行由客户管理购买的程序的管理系统和方法
公开(公告)号：WO2003081488A1
公开(公告)日：2003-10-02
申请号：PCT/AU2003/000378
申请日：2003-03-27
申请人： ARGUS BIOMEDICAL PTY LTD , HICKS, Celia, Rachel , WILLIAMS, James , WRAY, Helen , COX, David , McCALL, Elizabeth
发明人： HICKS, Celia, Rachel , WILLIAMS, James , WRAY, Helen , COX, David , McCALL, Elizabeth
IPC分类号： G06F17/60
CPC分类号： G06Q10/10
摘要： A management system for conducting a procedure (10) comprising: client interface means (16) for providing the input of information from a client (12) and the supply of information to the client (12) in relation to the procedure; information acquisition means for acquiring prescribed information about a prospective candidate for the procedure via the client interface means; information storage means (60) for receiving and storing the acquired prescribed information about the candidate; information processing means for assessing the acquired prescribed information and determining the suitability of the candidate for the procedure on the basis of the prescribed information; and administrative means (14) for monitoring the conduct of the procedure in relation to the affected candidate and prompting the client for reporting prescribed information in relation to the procedure of the approved candidate; wherein the information acquisition means provides to the client a plurality of candidate processes for acquiring the prescribed information in a controlled and regulated manner and wherein the administrative means provides a plurality of administrative processes for administering and reporting on the prescribed information in a controlled and regulated manner.In a second embodiment of the invention there is a method for managing a purchase by a customer comprising the steps of: acquiring prescribed information regarding the customer's purchase; assessing the prescribed information to determine suitability of purchase; supplying product or service the subject of the purchase to the customer; and requesting customer provide prescribed reports, subsequent to supply, regarding suitability of purchase and details of any adverse events relating to purchase.
摘要翻译：一种用于执行程序（10）的管理系统，包括：客户接口装置（16），用于从客户端（12）提供信息的输入，并且相对于该过程向客户机（12）提供信息; 信息获取装置，用于经由所述客户接口装置获取关于所述过程的预期候选者的规定信息; 信息存储装置（60），用于接收和存储所获取的关于候选者的规定信息; 信息处理装置，用于基于所述规定的信息来评估所获取的规定信息并确定所述程序的候选者的适合性; 和管理手段（14），用于监测与受影响的候选人有关的程序的行为，并促使客户报告与批准的候选人的程序有关的规定信息; 其特征在于，所述信息获取单元向所述客户端提供多个候选处理，以受控和规制的方式获取所述规定的信息，并且其中所述管理装置提供多个管理过程，以受控方式管理和报告所述规定的信息在本发明的第二实施例中，存在一种用于管理客户的购买的方法，包括以下步骤：获取关于客户购买的规定信息; 评估规定的信息以确定购买的适用性; 向客户提供购买主题的产品或服务; 并请求客户在供货后提供有关购买适用性的规定报告，以及与购买有关的任何不良事件的详细信息。

4. 发明申请

WO2010129987A1 NOVEL RECEPTOR HETERO-DIMERS/-OLIGOMERS 审中-公开
标题翻译：新的受体异构体/寡聚体
公开(公告)号：WO2010129987A1
公开(公告)日：2010-11-18
申请号：PCT/AU2010/000520
申请日：2010-05-04
申请人： DIMERIX BIOSCIENCE PTY LTD , PFLEGER, Kevin Donald George , MCCALL, Elizabeth , WILLIAMS, James
发明人： PFLEGER, Kevin Donald George , MCCALL, Elizabeth , WILLIAMS, James
IPC分类号： G01N33/566 , C07K14/715 , C07K14/72 , C12N5/10 , G01N21/64 , G01N33/52 , G01N33/542 , G01N33/68
CPC分类号： C07K14/7155 , C07K14/4702 , C07K14/70571 , C07K14/715 , C07K2319/60 , G01N33/542 , G01N33/566 , G01N33/6863 , G01N33/74 , G01N33/9406 , G01N2333/70571 , G01N2333/715 , G01N2333/726 , G01N2500/00
摘要： A hetero-dimeric or hetero-oligomeric receptor, comprising at least one chemokine receptor subunit associated with at least one adrenergic receptor subunit
摘要翻译：异二聚体或异低聚受体，其包含与至少一个肾上腺素能受体亚单位相关联的至少一个趋化因子受体亚基

5. 发明申请

WO2010108232A1 NOVEL RECEPTOR HETERO-DIMERS/-OLIGOMERS 审中-公开
标题翻译：新的受体异构体/寡聚体
公开(公告)号：WO2010108232A1
公开(公告)日：2010-09-30
申请号：PCT/AU2010/000355
申请日：2010-03-26
申请人： DIMERIX BIOSCIENCE PTY LTD , PFLEGER, Kevin, Donald, George , DALRYMPLE, Matthew, Blake , WILLIAMS, James , MCCALL, Elizabeth
发明人： PFLEGER, Kevin, Donald, George , DALRYMPLE, Matthew, Blake , WILLIAMS, James , MCCALL, Elizabeth
IPC分类号： G01N33/566 , C12N5/10 , G01N33/542 , C07K14/715 , G01N21/64 , G01N33/68 , C07K14/72 , G01N33/52
CPC分类号： G01N33/74 , C07K14/7158 , G01N33/6863 , G01N2333/7158 , G01N2500/04
摘要： A hetero-dimeric or hetero-oligomeric receptor, comprising at least one chemokine receptor subunit associated with at least one angiotensin receptor subunit.
摘要翻译：异二聚体或异低聚受体，其包含与至少一个血管紧张素受体亚基相关联的至少一个趋化因子受体亚单位。

6. 发明申请

WO2010003170A1 NOVEL RECEPTOR HETERO-DIMERS/-OLIGOMERS 审中-公开
标题翻译：新的受体异构体/寡聚体
公开(公告)号：WO2010003170A1
公开(公告)日：2010-01-14
申请号：PCT/AU2009/000774
申请日：2009-06-17
申请人： DIMERIX BIOSCIENCE PTY LTD , PFLEGER, Kevin , SEE, Heng Boon , SEEBER, Ruth Marie , DALRYMPLE, Matthew Blake , WILLIAMS, James , MCCALL, Elizabeth
发明人： PFLEGER, Kevin , SEE, Heng Boon , SEEBER, Ruth Marie , DALRYMPLE, Matthew Blake , WILLIAMS, James , MCCALL, Elizabeth
IPC分类号： C07K14/72 , G01N33/566 , A61P5/38 , G01N33/74
CPC分类号： G01N33/74 , C07K14/705 , C07K14/72 , G01N33/9406 , G01N33/9433 , G01N2500/04
摘要： A hetero-dimeric or hetero-oligomeric receptor, comprising at least one alpha-adrenergic receptor subunit associated with at least one angiotensin receptor subunit.
摘要翻译：异二聚体或异低聚受体，其包含至少一个与至少一个血管紧张素受体亚单位相关的α-肾上腺素能受体亚基。

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