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1. 发明申请

WO1992014720A1 PROCESS FOR PRODUCING 4-SUBSTITUTED 'gamma'-LACTONE, AND NOVEL SUBSTANCE 审中-公开
标题翻译：用于生产4-取代的γ-LACTONE和新物质的方法
公开(公告)号：WO1992014720A1
公开(公告)日：1992-09-03
申请号：PCT/JP1992000150
申请日：1992-02-17
申请人： JAPAN TOBACCO INC. , FUJI FLAVOR CO., LTD. , KOSEKI, Koshi; , KAWAKAMI, Hiroshi; , EBATA, Takashi; , MATSUSHITA, Hajime; , ONO, Mikio
发明人： JAPAN TOBACCO INC. , FUJI FLAVOR CO., LTD.
IPC分类号： C07D307/32
CPC分类号： C07D307/33 , C07D307/58 , C07D315/00
摘要： A 4-substituted η-lactone is produced by introducing a 1-alkynyl group into the 1-carbon atom of 2,3-O-isopropylidene-D-ribofuranose, cleaving the resulting compound at the diol part to give a lactol, oxidizing it into a lactone, hydrolyzing the ketal group of the lactone, reducing the hydrolyzate, removing the 2- and 3-hydroxyl groups, and hydrogenating the double bond between the 2- and 3-carbon atoms of the product.

2. 发明申请

WO1992012143A1 PROCESS FOR PRODUCING CIS-WHISKEY-LACTONE 审中-公开
标题翻译：生产单丝酵母的方法
公开(公告)号：WO1992012143A1
公开(公告)日：1992-07-23
申请号：PCT/JP1991001780
申请日：1991-12-27
申请人： JAPAN TOBACCO INC. , YUKI GOSEI KOGYO CO., LTD. , EBATA, Takashi; , MATSUMOTO, Katsuya; , KOSEKI, Koshi; , KAWAKAMI, Hiroshi; , MATSUSHITA, Hajime; , YOSHIKOSHI, Hajime , OKANIWA, Masakazu
发明人： JAPAN TOBACCO INC. , YUKI GOSEI KOGYO CO., LTD.
IPC分类号： C07D307/32
CPC分类号： C07D307/33 , C07D315/00
摘要： A process for producing cis-whiskey-lactone represented by formula (A), which is one of the flavoring components of whiskey or wine, selectively and readily, which comprises hydrolyzing the lactone part of trans-whiskey-lactone with potassium hydroxide, adding an alkyl group to the product by the reaction with isopropyl bromide to form isopropyl (3S, 4S)-4-hydroxy-3-methyloctanoate, reacting the formed ester with diethyl azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylic ester to form isopropyl (3S, 4S)-4-(3', 5'-dinitrobenzoyloxy)-3-methyloctanoate, and hydrolying the formed ester with a 2 % aqueous sodium hydroxide solution.

3. 发明申请

WO1988001995A1 PROCESS FOR REDUCING ALDEHYDES OR KETONES 审中-公开
标题翻译：减少醛或酮的方法
公开(公告)号：WO1988001995A1
公开(公告)日：1988-03-24
申请号：PCT/JP1986000460
申请日：1986-09-10
申请人： JAPAN TOBACCO INC. , MIZUSAKI, Sigenobu , MATSUSHITA, Hajime , ISHIGURO, Shigeo , ICHINOSE, Hiroshi , IZUMI, Akira
发明人： JAPAN TOBACCO INC.
IPC分类号： C07C29/136
CPC分类号： C07C29/143 , C07C29/14 , C07C2601/14 , C07C31/125 , C07C33/20 , C07C35/08 , C07C33/26 , C07C31/12 , C07C33/22
摘要： A process for reducing aldehydes or ketones using a stable and highly active catalyst not soluble in a solvent, easily removable from the reaction system after completion of the reaction, and reusable. This process comprises reacting an aldehyde or a ketone with an alcohol using zirconium oxide hydrate as a catalyst.

4. 发明申请

WO1993018051A1 PROCESS FOR PRODUCING NUCLEOSIDE DERIVATIVE 审中-公开
标题翻译：生产核苷衍生物的方法
公开(公告)号：WO1993018051A1
公开(公告)日：1993-09-16
申请号：PCT/JP1993000283
申请日：1993-03-08
申请人： JAPAN TOBACCO INC. , KAWAKAMI, Hiroshi , EBATA, Takashi , OKANO, Koji , MATSUMOTO, Katsuya , KOSEKI, Koshi , MATSUSHITA, Hajime
发明人： JAPAN TOBACCO INC.
IPC分类号： C07H19/04
CPC分类号： C07H19/04 , C07H23/00
摘要： A process for producing a nucleoside derivative (1) by reacting a substituted 2,3-dihydrofuran derivative (2) with an organohalogen compound (3) containing a group 16 element of the periodic table to give a substituted 2-halotetrahydrofuran derivative (4), condensing the derivative (4) with a nucleic acid base to give a substituted nucleoside derivative (5), and reducing the derivative (5), wherein R represents hydrogen, alkyl or R -O-CH2-; R to R represent each hydrogen or a group containing a group 14-17 element of the periodic table; R represents optionally substituted alkyl or phenyl; A represents a group 16 element of the periodic table; B represents a nucleic acid base; and X represents halogen.
摘要翻译：通过使取代的2,3-二氢呋喃衍生物（2）与含有周期表第16族元素的有机卤素化合物（3）反应制备核苷衍生物（1）的方法，得到取代的2-卤代四氢呋喃衍生物（4）将衍生物（4）与核酸碱缩合得到取代的核苷衍生物（5），还原衍生物（5），其中R 1表示氢，烷基或R 6 -O-CH 2 - ; R 2至R 4表示每个氢或含有周期表第14-17族元素的基团; R 5表示任选取代的烷基或苯基; A表示周期表的第16族元素; B表示核酸碱基; X表示卤素。

5. 发明申请

WO1993025308A1 HYDRATED ZIRCONIUM OXIDE MODIFIED WITH ORGANO-SILICON COMPOUND AND CATALYSTS FOR ALCOHOL OXIDATION AND LACTONE PRODUCTION 审中-公开
标题翻译：用有机硅化合物修饰的水合氧化锆和用于酒精氧化和乳液生产的催化剂
公开(公告)号：WO1993025308A1
公开(公告)日：1993-12-23
申请号：PCT/JP1993000815
申请日：1993-06-17
申请人： JAPAN TOBACCO INC. , KUNO, Hideyuki , SHIBAGAKI, Makoto , TAKAHASHI, Kyoko , MATSUSHITA, Hajime
发明人： JAPAN TOBACCO INC.
IPC分类号： B01J31/02
CPC分类号： B01J21/066 , B01J31/0274 , B01J37/0209 , B01J2231/70 , B01J2231/763 , C07C45/29 , C07C45/39 , C07D309/30 , C07C47/02 , C07C47/11 , C07C49/403
摘要： Hydrated zirconium oxide modified with an organo-silicon compound, wherein 50-90 % of the hydroxyl groups present on the surface of hydrated zirconium oxide are substituted by said compound. The modified oxide can be efficiently utilized in the oxidation of an alcohol into an aldehyde or ketone and in the production of a lactone.
摘要翻译：用有机硅化合物改性的水合氧化锆，其中存在于水合氧化锆表面的50-90％的羟基被所述化合物取代。可以将改性氧化物有效地用于将醇氧化成醛或酮和在内酯的制备中。

6. 发明申请

WO1993023387A1 PROCESS FOR PRODUCING EPOXIDE 审中-公开
标题翻译：生产环氧化物的方法
公开(公告)号：WO1993023387A1
公开(公告)日：1993-11-25
申请号：PCT/JP1993000648
申请日：1993-05-18
申请人： JAPAN TABACCO INC. , MATSUMOTO, Katsuya; , EBATA, Takashi; , KOSEKI, Koshi; , OKANO, Koji; , KAWAKAMI, Hiroshi; , MATSUSHITA, Hajime;
发明人： JAPAN TABACCO INC.
IPC分类号： C07D301/03
CPC分类号： C07D301/14 , C07D301/02 , C07D301/24 , C07D303/04 , C07D493/04 , C07D493/08 , C07H3/10
摘要： A process for producing an epoxide represented by general formula (1a) or (1b), which comprises reacting an olefin represented by general formula (2) with a compound containing iodine and an acyloxy ion and treating the reaction product under a basic condition so as to form an oxirane ring on the stereochemically crowded side of the feed olefin. In formulae (1a), (1b) and (2), R , R , R and R represent each hydrogen, alkyl, alkenyl, aryl, alkoxy, aryloxy, acyl, alkoxycarbonyl, aryloxycarbonyl, aralkyl, silyl or silyloxy, provided that when each of these groups represents a divalent group, they may be combined together to represent a cyclic group, and that these groups may be the same or different from one another and further may be substituted or branched. The plane formed by the double bond, R , R , R and R has one side which is stereochemically more crowded than the other side.
摘要翻译：一种制备由通式（1a）或（1b）表示的环氧化物的方法，其包括使通式（2）表示的烯烃与含有碘和酰氧基离子的化合物反应，并在碱性条件下处理反应产物，以便以在进料烯烃的立体化学拥挤侧上形成环氧乙烷环。在式（1a），（1b）和（2）中，R 1，R 2，R 3和R 4分别表示氢，烷基，烯基，芳基，烷氧基，芳氧基，酰基，，芳氧基羰基，芳烷基，甲硅烷基或甲硅烷氧基，条件是当这些基团各自表示二价基团时，它们可以组合在一起以表示环状基团，并且这些基团可以彼此相同或不同，并且还可以被取代或分支。由双键形成的平面R 1，R 2，R 3和R 4具有立体化学比另一侧更拥挤的一面。

7. 发明申请

WO1992006986A1 PROCESS FOR PRODUCING D-ALTROSE 审中-公开
标题翻译：生产D-糖的方法
公开(公告)号：WO1992006986A1
公开(公告)日：1992-04-30
申请号：PCT/JP1991001376
申请日：1991-10-09
申请人： JAPAN TOBACCO INC. , MATSUMOTO, Katsuya , EBATA, Takashi , MATSUSHITA, Hajime
发明人： JAPAN TOBACCO INC.
IPC分类号： C07H03/02
CPC分类号： C07H3/10 , C07H3/02
摘要： A process for producing D-altrose (4) from levoglucosenone (1) substantially in three steps according to reaction scheme (I) through (III).

8. 发明申请

WO1994007903A1 NICOTINE DERIVATIVE 审中-公开
公开(公告)号：WO1994007903A1
公开(公告)日：1994-04-14
申请号：PCT/JP1993001434
申请日：1993-10-06
申请人： JAPAN TOBACCO INC. , SHIBAGAKI, Makoto , TAKAHASHI, Kyoko , MATSUSHITA, Hajime , KUNO, Hideyuki
发明人： JAPAN TOBACCO INC.
IPC分类号： C07H19/048
CPC分类号： C07D401/04 , C07H19/048
摘要： A novel sugar-containing nicotine derivative represented by general formula (1), wherein R represents a ribofuranosyl group; and X represents an oxygen atom or two hydrogen atoms. This compound is an excellent smoking taste modifier and has the effects of restoring the odor and taste of tobacco lost in the production of shredded tobacco and imparting a fine pattern of spreading to the smoke. Because the compound (1) has a characteristic structure containing ribofuranose in its molecule and also containing a physiologically active nicotine as the aglycon, it is expected to be used as a medicine with a reduced toxicity besides the smoking taste modifier. The invention also provides another novel nicotine derivative represented by general formula (2) wherein X is as defined above.
摘要翻译：一种由通式（1）表示的新型含糖尼古丁衍生物，其中R表示呋喃核糖基; X表示氧原子或两个氢原子。该化合物是优良的吸烟味调节剂，具有恢复在生产烟丝中失去的烟草的气味和味道的效果，并赋予烟雾细微的图案。由于化合物（1）在其分子中具有含有呋喃核糖的特征结构，并且还含有生理活性尼古丁作为糖苷配基，因此预期除了吸烟味调节剂之外，还可以使用毒性降低的药物。本发明还提供另一种由通式（2）表示的新型尼古丁衍生物，其中X如上所定义。

9. 发明申请

WO1994004547A1 NOVEL NICOTINE DERIVATIVE 审中-公开
标题翻译：新西兰人衍生物
公开(公告)号：WO1994004547A1
公开(公告)日：1994-03-03
申请号：PCT/JP1993001151
申请日：1993-08-17
申请人： JAPAN TOBACCO INC. , SHIBAGAKI, Makoto , TAKAHASHI, Kyoko , KUNO, Hideyuki , MATSUSHITA, Hajime
发明人： JAPAN TOBACCO INC.
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： A novel nicotine derivative represented by general formula (1) wherein R represents a hexose or a dihexose; and (a) represents (S)-(-)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl, (R)-(+)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl, (S)-(-)-5-(1-methyl-2-pyrrolidinyl)-2-pyridyl, or (R)-(+)-5-(1-methyl-2-pyrrolidinyl)-2-pyridyl.
摘要翻译：由通式（1）表示的新型尼古丁衍生物，其中R表示己糖或二己糖; 和（a）表示（S） - （ - ） - 3-（1-甲基-2-吡咯烷基）-2-吡啶基，（R） - （+） - 3-（1-甲基-2-吡咯烷基）-2 （S） - （ - ） - 5-（1-甲基-2-吡咯烷基）-2-吡啶基或（R） - （+） - 5-（1-甲基-2-吡咯烷基）-2- 吡啶基。

10. 发明申请

WO1992022548A1 PROCESS FOR PRODUCING 2',3'-DIDEOXY-'beta'-NUCLEOSIDE 审中-公开
标题翻译：制备2'，3'-二脱氧-β-球蛋白的方法
公开(公告)号：WO1992022548A1
公开(公告)日：1992-12-23
申请号：PCT/JP1992000752
申请日：1992-06-12
申请人： JAPAN TOBACCO INC. , KAWAKAMI, Hiroshi , MATSUMOTO, Katsuya , KOSEKI, Koshi , EBATA, Takashi , MATSUSHITA, Hajime , ITOH, Kazuo , NAOI, Yoshitake
发明人： JAPAN TOBACCO INC.
IPC分类号： C07D405/04
CPC分类号： C07D405/04 , C07F7/1804 , C07H19/06 , Y02P20/55
摘要： A process for producing a 2',3'-dideoxy- beta -nucleoside in a simplified manner in a high yield, which comprises condensing 1-O-acetyl-5-O-(t-butyldiphenysilyl)-2,3-dideoxy-2,2-di(phenylthio)-D- glycero-pentofuranose (IV), which is prepared from 5-(t-butyldiphenylsilyloxy)-2,2-di(phenylthio)-pentan-4-olide, with a pyrimidine derivative (V) in the presence of a Lewis acid catalyst, purifying the reaction product by chromatography into 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2.di(phenylthio)- beta -D- glycero-pentofuranosyl] pyrimidine (III), hydrodesulfurizing the pyrimidine (III) into 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy- beta -D-glycero- pentofuranosyl] pyrimidine (II), and deblocking the pyrimidine (II) into 2',3'-dideoxy- beta -uridine (I) (wherein X represents oxygen and Y represents hydrogen).

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