专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007145349A2 SUBSTITUTED PYRROLE DERIVATIVES 审中-公开
标题翻译：取代的吡咯衍生物
公开(公告)号：WO2007145349A2
公开(公告)日：2007-12-21
申请号：PCT/JP2007/062194
申请日：2007-06-12
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , ITO, Mitsuhiro , MATSUNAGA, Nobuyuki , YAMADA, Masami , HITAKA, Takenori , YAMAMOTO, Satoshi
发明人： ITO, Mitsuhiro , MATSUNAGA, Nobuyuki , YAMADA, Masami , HITAKA, Takenori , YAMAMOTO, Satoshi
CPC分类号： C07D417/06 , C07D403/06 , C07D413/06 , C07D471/04
摘要： The present invention provides novel pyrrole derivatives represented by formula (I): wherein R 1 represents a hydrogen atom, cyano, optionally halogenated C?1-6#191 alkyl or an optionally substituted C?1-6#191 alkoxy-carbonyl; R 2 and R 4 may be the same or different and represent a hydrogen atom, C?1-6#191 alkyl, C?2-6#191 alkenyl substituted with an optionally substituted hydroxy, an optionally substituted or oxidized thiol, etc.; R 3 represents an optionally substituted thiazolyl, an optionally substituted pyrazolyl, an optionally substituted oxazolyl, etc.; and R 5 represents an optionally substituted phenyl having a cyano at the 4- or 3-position, and androgen receptor antagonists containing the same.
摘要翻译：本发明提供由式（I）表示的新颖的吡咯衍生物：其中R 1表示氢原子，氰基，任意卤代的C 1-6〜18-18个烷基或任意取代的C 1-6〜＃191烷氧基 - 羰基; R 2和R 4可以相同或不同，表示氢原子，C 1-6 1-6烷基，C 2-6 - 任选取代的羟基，任选取代的或氧化的硫醇等; R 3表示任选取代的噻唑基，任选取代的吡唑基，任选取代的恶唑基等; R 5表示任选取代的在4-或3-位有氰基的苯基，和含有它们的雄激素受体拮抗剂。

2. 发明申请

WO2007077961A2 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF 审中-公开
标题翻译：熔融杂环化合物及其用途
公开(公告)号：WO2007077961A2
公开(公告)日：2007-07-12
申请号：PCT/JP2006326367
申请日：2006-12-27
申请人： TAKEDA PHARMACEUTICAL , FUKUMOTO SHOJI , MATSUNAGA NOBUYUKI , OHRA TAIICHI , OHYABU NORIO , HASUI TOMOAKI , MOTOYAJI TAKASHI , SIEDEM CHRISTOPHER STEPHEN , TANG TONY PISAL , DEMEESE LISA A , GAUTHIER CASSANDRA
发明人： FUKUMOTO SHOJI , MATSUNAGA NOBUYUKI , OHRA TAIICHI , OHYABU NORIO , HASUI TOMOAKI , MOTOYAJI TAKASHI , SIEDEM CHRISTOPHER STEPHEN , TANG TONY PISAL , DEMEESE LISA A , GAUTHIER CASSANDRA
IPC分类号： C07D403/04 , A61K31/423 , A61K31/538 , A61K31/542 , A61P9/04 , A61P9/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D417/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.
摘要翻译：本发明涉及其中每个符号如说明书中所定义的。该化合物具有优异的矿物质皮质激素受体拮抗作用，可用作预防或治疗高血压，心力衰竭等的药剂，具有稠合杂环的化合物或其前药或其盐; 以及预防或治疗高血压，心力衰竭等的药剂。

3. 发明申请

WO0240484A2 NOVEL IMIDAZOLE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF 审中-公开
标题翻译：新型咪唑衍生物，其制备方法及其用途
公开(公告)号：WO0240484A2
公开(公告)日：2002-05-23
申请号：PCT/JP0110002
申请日：2001-11-16
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , TASAKA AKIHIRO , HITAKA TAKENORI , MATSUNAGA NOBUYUKI , KUSAKA MASAMI , ADACHI MARI , AOKI ISAO , OJIDA AKIO
发明人： TASAKA AKIHIRO , HITAKA TAKENORI , MATSUNAGA NOBUYUKI , KUSAKA MASAMI , ADACHI MARI , AOKI ISAO , OJIDA AKIO
IPC分类号： C07D233/62 , A61K31/165 , A61K31/4174 , A61K31/4188 , A61K31/437 , A61K45/00 , A61P5/28 , A61P35/00 , A61P43/00 , C07D233/54 , C07D471/04 , C07D487/04
CPC分类号： C07D233/64 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound having a steroid C17,20-lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active compound of this compound from a mixture of optical isomers thereof, a compound of the formula:wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof, and a method for obtaining an optically active compound by optically resolving a mixture of optical isomers by the use of a resolving agent such as tartranilic acid and the like.
摘要翻译：本发明提供具有类固醇C17,20-裂解酶抑制活性并可用于治疗和预防诸如前列腺症，乳腺癌等肿瘤的化合物，以及将该化合物的光学活性化合物从其光学异构体的混合物，下式的化合物：其中每个符号如说明书中所定义，其盐或其前药，以及通过光学拆分光学异构体的混合物获得光学活性化合物的方法，使用分解剂如tart铵酸等。

4. 发明申请

WO1995002012A1 POLYACETAL RESIN COMPOSITION 审中-公开
标题翻译：聚酯树脂组合物
公开(公告)号：WO1995002012A1
公开(公告)日：1995-01-19
申请号：PCT/JP1994001112
申请日：1994-07-07
申请人： POLYPLASTICS CO., LTD. , KATSUMATA, Toru , MATSUNAGA, Nobuyuki
发明人： POLYPLASTICS CO., LTD.
IPC分类号： C08L59/00
CPC分类号： C08K5/005 , C08K5/3435 , C08L51/04 , C08L59/00 , C08L71/02 , C08L2666/02
摘要： A polyacetal resin composition which, even when exposed to light for long, is minimized in the degradation and discoloration of the resin and the bleeding of and discoloration due to the additives contained therein, can retain the initial surface conditions of a molding, and is excellent in weathering and environmental resistances. The composition comprises 100 parts by weight of a polyacetal resin (A), 0.01-2.0 parts by weight of an ultraviolet absorber (C), 0.01-4 parts by weight of a low-molecular-weight hindered amine (D-1) having a molecular weight below 700, 0.01-4 parts by weight of a high-molecular-weight hindered amine (D-2) having a molecular weight of at least 700, and optionally an oxyalkylene polymer (E). The composition may further contain a specified core-shell polymer and can provide a molding which, even when exposed to light for long, is minimized in the degradation and discoloration of the resin and the discoloration due to the bleeding of the additives, is excellent in weathering and environmental resistances, and has a lowered surface gloss.
摘要翻译：聚缩醛树脂组合物即使在长时间暴露于光下也能最小化树脂的降解和变色，并且由于其中所含的添加剂而引起的渗色和变色，可以保持成型的初始表面状态，并且优异耐候性和耐环境性。该组合物包含100重量份的聚缩醛树脂（A），0.01-2.0重量份的紫外线吸收剂（C），0.01-4重量份的具有低分子量受阻胺（D-1）分子量低于700，0.01-4重量份分子量至少为700的高分子量受阻胺（D-2），以及任选的氧化烯聚合物（E）。该组合物还可以含有特定的核 - 壳聚合物，并且可以提供一种成型体，即使在长时间暴露于光下也能最小化树脂的降解和变色以及由于添加剂的渗色引起的变色，耐候性和耐环境性，并且具有降低的表面光泽度。

5. 发明申请

WO2006064944A1 SUBSTITUTED PYRROLE DERIVATIVE 审中-公开
标题翻译：取代吡啶衍生物
公开(公告)号：WO2006064944A1
公开(公告)日：2006-06-22
申请号：PCT/JP2005/023215
申请日：2005-12-13
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , MATSUNAGA, Nobuyuki , ITO, Mitsuhiro , HITAKA, Takenori
发明人： MATSUNAGA, Nobuyuki , ITO, Mitsuhiro , HITAKA, Takenori
IPC分类号： C07D401/06 , C07D207/32 , A61K31/40 , A61P35/00
CPC分类号： C07D207/327 , C07D207/34 , C07D401/06 , C07D413/14
摘要： The present invention provides a novel pyrrole derivative having excellent androgen receptor antagonism, which is represented by the formula (I): wherein R 1 represents a hydrogen atom, a cyano group or a group represented by the formula COOR A (wherein R A represents an optional substituted C 1-6 alkyl group), R 2 and R 4 are the same or different, and each represents a hydrogen atom, a C 1-6 alkyl group, a C 3-6 cycloalkyl group, a trifluoromethyl group, an amino-C 1-6 alkyl group, a mono-or di-substituted amino-C 1-6 alkyl group, an optionally halogenated C 1-6 alkyl group substituted with an optionally substituted hydroxyl group, a C 2-6 alkenyl group substituted with an optionally substituted hydroxyl group, a C 1-6 alkyl group substituted with an optionally substituted and optionally oxidized thiol group, an optionally substituted with and optionally oxidized thiol group, a cyano group, an acyl group, an optionally substituted oxazolyl group or a 1,3-dioxolan-2-yl group, R 3 represents a group represented by the formula (a): (wherein X represents a halogen atom, Y represents a carbon atom or a nitrogen atom, Alk represents an optionally substituted C 1-4 alkylene group, and R B represents a hydrogen atom or an acyl group), and R 5 represents a phenyl group which has a cyano group at a 4-position or a 3-position thereof, and may be further substituted, or a salt thereof. The present invention also provides an androgen receptor antagonist containing the pyrrole derivative, or a salt thereof.
摘要翻译：本发明提供具有优异的雄激素受体拮抗作用的新颖的吡咯衍生物，其由式（I）表示：其中R 1表示氢原子，氰基或由式COOR表示的基团（其中R A表示任选的取代的C 1-6烷基），R 2和R 2， SUP> 4 <！ - SIPO - >相同或不同，并且各自表示氢原子，C 1-6烷基，C 3-6环烷基，三氟甲基，氨基-C 1-6烷基，单取代或二取代的氨基-C 1-6烷基，任选卤代的C

6. 发明申请

WO2002040484A3 NOVEL IMIDAZOLE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF 审中-公开
公开(公告)号：WO2002040484A3
公开(公告)日：2002-05-23
申请号：PCT/JP2001/010002
申请日：2001-11-16
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , TASAKA, Akihiro , HITAKA, Takenori , MATSUNAGA, Nobuyuki , KUSAKA, Masami , ADACHI, Mari , AOKI, Isao , OJIDA, Akio
发明人： TASAKA, Akihiro , HITAKA, Takenori , MATSUNAGA, Nobuyuki , KUSAKA, Masami , ADACHI, Mari , AOKI, Isao , OJIDA, Akio
IPC分类号： C07D487/04
摘要： The present invention provides a compound having a steroid C17,20-lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active compound of this compound from a mixture of optical isomers thereof, a compound of the formula:wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof, and a method for obtaining an optically active compound by optically resolving a mixture of optical isomers by the use of a resolving agent such as tartranilic acid and the like.

7. 发明申请

WO2007145349A3 SUBSTITUTED PYRROLE DERIVATIVES 审中-公开
标题翻译：取代的吡咯衍生物
公开(公告)号：WO2007145349A3
公开(公告)日：2008-04-03
申请号：PCT/JP2007062194
申请日：2007-06-12
申请人： TAKEDA PHARMACEUTICAL , ITO MITSUHIRO , MATSUNAGA NOBUYUKI , YAMADA MASAMI , HITAKA TAKENORI , YAMAMOTO SATOSHI
发明人： ITO MITSUHIRO , MATSUNAGA NOBUYUKI , YAMADA MASAMI , HITAKA TAKENORI , YAMAMOTO SATOSHI
IPC分类号： C07D403/06 , C07D413/06 , C07D417/06 , C07D471/04
CPC分类号： C07D417/06 , C07D403/06 , C07D413/06 , C07D471/04
摘要： The present invention provides novel pyrrole derivatives represented by formula (I): wherein R 1 represents a hydrogen atom, cyano, optionally halogenated C 1-6 alkyl or an optionally substituted C 1-6 alkoxy-carbonyl; R 2 and R 4 may be the same or different and represent a hydrogen atom, C 1-6 alkyl, C 2-6 alkenyl substituted with an optionally substituted hydroxy, an optionally substituted or oxidized thiol, etc.; R 3 represents an optionally substituted thiazolyl, an optionally substituted pyrazolyl, an optionally substituted oxazolyl, etc.; and R 5 represents an optionally substituted phenyl having a cyano at the 4- or 3-position, and androgen receptor antagonists containing the same.
摘要翻译：本发明提供由式（I）表示的新颖的吡咯衍生物：其中R 1表示氢原子，氰基，任选卤代的C 1-6烷基或任选取代的C 1-6烷氧羰基; R 2和R 4可以相同或不同，表示氢原子，C 1-6烷基，C 2〜被任选取代的羟基取代的6个链烯基，任选取代的或氧化的硫醇等; R 3表示任选取代的噻唑基，任选取代的吡唑基，任选取代的恶唑基等; R 5表示任选取代的在4-或3-位有氰基的苯基，和含有它们的雄激素受体拮抗剂。

8. 发明申请

WO2007077961A3 FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS 审中-公开
公开(公告)号：WO2007077961A3
公开(公告)日：2007-07-12
申请号：PCT/JP2006/326367
申请日：2006-12-27
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , FUKUMOTO, Shoji , MATSUNAGA, Nobuyuki , OHRA, Taiichi , OHYABU, Norio , HASUI, Tomoaki , MOTOYAJI, Takashi , SIEDEM, Christopher, Stephen , TANG, Tony, Pisal , DEMEESE, Lisa, A. , GAUTHIER, Cassandra
发明人： FUKUMOTO, Shoji , MATSUNAGA, Nobuyuki , OHRA, Taiichi , OHYABU, Norio , HASUI, Tomoaki , MOTOYAJI, Takashi , SIEDEM, Christopher, Stephen , TANG, Tony, Pisal , DEMEESE, Lisa, A. , GAUTHIER, Cassandra
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/423 , A61K31/538 , A61K31/542 , A61P9/04 , A61P9/12
摘要： The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式