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1. 发明申请

WO2010011938A1 SYSTEMS AND METHODS FOR IMAGING USING ABSORPTION 审中-公开
标题翻译：使用吸收成像的系统和方法
公开(公告)号：WO2010011938A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051710
申请日：2009-07-24
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HART, Douglas, P. , FRIGERIO, Federico , MARINI, Davide, M.
发明人： HART, Douglas, P. , FRIGERIO, Federico , MARINI, Davide, M.
IPC分类号： G01N21/86
CPC分类号： A61B1/043 , A61B1/015 , A61B1/018 , A61B1/227 , A61B1/24 , A61B1/2736 , A61B5/0071 , A61B5/0088 , A61C5/62 , A61C5/90 , A61C9/0006 , A61C9/0053 , A61C19/04 , G01B11/02 , G01B11/022 , G01B11/024 , G01B11/06 , G01B11/0658 , G01B11/24 , G01N21/6456 , G01N2021/6421 , G01N2021/6439 , G01N2021/6491 , G06F19/00
摘要： The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth.
摘要翻译：利用介质的衰减和其它光学特性来测量传感器和目标表面之间介质的厚度。本文公开了各种介质，硬件布置和处理技术，其可以用于捕获这些厚度测量并在各种成像环境中获得目标表面的三维图像。这包括用于对内/凹表面以及外/凸表面进行成像的一般技术，以及这些技术对耳道成像，人牙列等的成像的特定适应。

2. 发明申请

WO2011156432A3 SCANNING MULTIFUNCTIONAL PARTICLES 审中-公开
标题翻译：扫描多功能颗粒
公开(公告)号：WO2011156432A3
公开(公告)日：2012-04-26
申请号：PCT/US2011039529
申请日：2011-06-07
申请人： FIREFLY BIOWORKS INC , PREGIBON DANIEL C , MARINI DAVIDE M , STONER ISAAC , WINDEMUTH ANDREAS , ERPS TIMOTHY
发明人： PREGIBON DANIEL C , MARINI DAVIDE M , STONER ISAAC , WINDEMUTH ANDREAS , ERPS TIMOTHY
IPC分类号： G01N33/483 , C12Q1/02 , C12Q1/68 , G01N15/14 , G01N21/47
CPC分类号： C12Q1/6825 , C12Q1/6809 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , C12Q1/6888 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , G01N15/14 , G01N21/47 , G01N21/6428 , G01N33/6803 , C12Q2565/626 , C12Q2525/161 , C12Q2525/191 , C12Q2533/107
摘要： The present invention provides, among other things, methods and systems for characterizing multifunctional objects using a flow-through device, such as, a flow cytometer. In some embodiments, an inventive method according to the present invention includes one more steps of (a) interrogating a plurality of objects (e.g., particles), wherein each individual object (e.g., particle) comprises one or more interrogation regions detectable as a sequence of events; (b) recording multiple events, wherein each individual event corresponds to each individual interrogation region detectable above a pre-determined triggering threshold; (c) grouping the recorded multiple events, and (d) characterizing the plurality of objects based on the grouped events.
摘要翻译：本发明尤其提供了使用流通装置如流式细胞仪来表征多功能物体的方法和系统。在一些实施例中，根据本发明的发明方法包括以下步骤：（a）询问多个对象（例如，粒子），其中每个单个对象（例如，粒子）包括可检测为序列的一个或多个询问区域的事件; （b）记录多个事件，其中每个单独的事件对应于在预先确定的触发阈值之上可检测的每个个别询问区域; （c）对记录的多个事件进行分组，以及（d）基于分组的事件来表征多个对象。

3. 发明申请

WO2006050257A3 DETECTION OF ION CHANNEL OR RECEPTOR ACTIVITY 审中-公开
标题翻译：检测离子通道或受体活性
公开(公告)号：WO2006050257A3
公开(公告)日：2009-05-07
申请号：PCT/US2005039260
申请日：2005-10-31
申请人： MASSACHUSETTS INST OF TECCHNOL , CHILDRENS MEDICAL CENTER , MARINI DAVIDE M , DESAI BIMAL , DELLING MARKUS , SOLIS DANIEL J , BELCHER ANGELA M , CLAPHAM DAVID E , FEBVAY SEBASTIEN , CARTER BRETT
发明人： MARINI DAVIDE M , DESAI BIMAL , DELLING MARKUS , SOLIS DANIEL J , BELCHER ANGELA M , CLAPHAM DAVID E , FEBVAY SEBASTIEN , CARTER BRETT
IPC分类号： G01N33/551
CPC分类号： C12Q1/005 , B82Y5/00 , B82Y10/00 , G01N21/554 , G01N33/542 , G01N33/54373 , G01N33/6872 , G01N2333/726
摘要： The invention provides nanosensors and nanosensor components for the detection of ion channel activity, receptor activity, or protein protein interactions. Certain of the nanosensor components comprise a nanoparticle and recognition domain. Following contact with cells and, optionally, internalization of the nanosensor component by a cell, the recognition domain binds to a target domain, e.g., a heterologous target domain, of a polypeptide of interest such as an ion channel subunit, G protein coupled receptor (GPCR), or G protein subunit. Ion channel activity, GPCR activity, or altered protein interaction results in a detectable signal. The nanoparticles may be functionalized so that they respond to the presence of an ion by altering their proximity. Certain of the nanosensors utilize the phenomenon of plasmon resonance to produce a signal while others utilize magnetic properties, RET, and/or ion-sensitive moieties. Also provided are polypeptides, e.g., ion channel subunits, comprising a heterologous target domain, and cell lines that express the polypeptides. Further provided are a variety of methods for detecting ion channel activity, receptor activity, or protein interaction and for identifying compounds that modulate one or more of these. In certain embodiments the invention allows the user to detect the activity of specific ion channels even in the presence of other channels that permit passage of the same ion(s) or result in activation of the same downstream targets, thereby achieving improved specificity in high throughput screens while at the same time providing a high signal to noise ratio.
摘要翻译：本发明提供用于检测离子通道活性，受体活性或蛋白质蛋白相互作用的纳米传感器和纳米传感器组分。某些纳米传感器组件包含纳米颗粒和识别结构域。在与细胞接触并且任选地，通过细胞使纳米传感器组分内化后，识别结构域结合感兴趣的多肽的靶结构域例如异源靶结构域，例如离子通道亚基，G蛋白偶联受体（ GPCR）或G蛋白亚基。离子通道活性，GPCR活性或改变的蛋白质相互作用导致可检测的信号。纳米颗粒可以被官能化，使得它们通过改变它们的接近度来响应离子的存在。某些纳米传感器利用等离子体共振现象来产生信号，而另一些利用磁性，RET和/或离子敏感部分。还提供了多肽，例如包含异源靶域的离子通道亚单位，以及表达多肽的细胞系。进一步提供了用于检测离子通道活性，受体活性或蛋白质相互作用以及鉴定调节这些中的一种或多种的化合物的各种方法。在某些实施方案中，本发明允许用户即使在允许相同离子通过或导致相同下游靶的活化的其它通道的存在下也检测特定离子通道的活性，从而实现高通量的改善的特异性屏幕同时提供高信噪比。

4. 发明申请

WO2011156432A2 SCANNING MULTIFUNCTIONAL PARTICLES 审中-公开
标题翻译：扫描多功能颗粒
公开(公告)号：WO2011156432A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039529
申请日：2011-06-07
申请人： FIREFLY BIOWORKS, INC. , PREGIBON, Daniel, C. , MARINI, Davide, M. , STONER, Isaac , WINDEMUTH, Andreas , ERPS, Timothy
发明人： PREGIBON, Daniel, C. , MARINI, Davide, M. , STONER, Isaac , WINDEMUTH, Andreas , ERPS, Timothy
IPC分类号： G01N33/483 , G01N15/14 , C12Q1/68 , C12Q1/02 , G01N21/47
CPC分类号： C12Q1/6825 , C12Q1/6809 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , C12Q1/6888 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , G01N15/14 , G01N21/47 , G01N21/6428 , G01N33/6803 , C12Q2565/626 , C12Q2525/161 , C12Q2525/191 , C12Q2533/107
摘要： The present invention provides, among other things, methods and systems for characterizing multifunctional objects using a flow-through device, such as, a flow cytometer. In some embodiments, an inventive method according to the present invention includes one more steps of (a) interrogating a plurality of objects (e.g., particles), wherein each individual object (e.g., particle) comprises one or more interrogation regions detectable as a sequence of events; (b) recording multiple events, wherein each individual event corresponds to each individual interrogation region detectable above a pre-determined triggering threshold; (c) grouping the recorded multiple events, and (d) characterizing the plurality of objects based on the grouped events.
摘要翻译：本发明尤其提供了使用流通装置如流式细胞仪来表征多功能物体的方法和系统。在一些实施例中，根据本发明的发明方法包括以下步骤：（a）询问多个对象（例如，粒子），其中每个单个对象（例如，粒子）包括可被检测为序列的一个或多个询问区域的事件; （b）记录多个事件，其中每个单独的事件对应于在预先确定的触发阈值之上可检测的每个个别询问区域; （c）对记录的多个事件进行分组，以及（d）基于分组的事件来表征多个对象。

5. 发明申请

WO2006050257A2 DETECTION OF ION CHANNEL OR RECEPTOR ACTIVITY 审中-公开
标题翻译：检测离子通道或受体活性
公开(公告)号：WO2006050257A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039260
申请日：2005-10-31
申请人： MASSACHUSETTS INSTITUTE OF TECCHNOLOGY , CHILDREN'S MEDICAL CENTER CORPORATION , HOWARD HUGHES MEDICAL INSTITUTE , MARINI, Davide, M. , DESAI, Bimal , DELLING, Markus , SOLIS, Daniel, J. , BELCHER, Angela, M. , CLAPHAM, David, E. , FEBVAY, Sebastien , CARTER, Brett
发明人： MARINI, Davide, M. , DESAI, Bimal , DELLING, Markus , SOLIS, Daniel, J. , BELCHER, Angela, M. , CLAPHAM, David, E. , FEBVAY, Sebastien , CARTER, Brett
IPC分类号： G01N33/53
CPC分类号： C12Q1/005 , B82Y5/00 , B82Y10/00 , G01N21/554 , G01N33/542 , G01N33/54373 , G01N33/6872 , G01N2333/726
摘要： The invention provides nanosensors and nanosensor components for the detection of ion channel activity, receptor activity, or protein protein interactions. Certain of the nanosensor components comprise a nanoparticle and recognition domain. Following contact with cells and, optionally, internalization of the nanosensor component by a cell, the recognition domain binds to a target domain, e.g., a heterologous target domain, of a polypeptide of interest such as an ion channel subunit, G protein coupled receptor (GPCR), or G protein subunit. Ion channel activity, GPCR activity, or altered protein interaction results in a detectable signal. The nanoparticles may be functionalized so that they respond to the presence of an ion by altering their proximity. Certain of the nanosensors utilize the phenomenon of plasmon resonance to produce a signal while others utilize magnetic properties, RET, and/or ion-sensitive moieties. Also provided are polypeptides, e.g., ion channel subunits, comprising a heterologous target domain, and cell lines that express the polypeptides. Further provided are a variety of methods for detecting ion channel activity, receptor activity, or protein interaction and for identifying compounds that modulate one or more of these. In certain embodiments the invention allows the user to detect the activity of specific ion channels even in the presence of other channels that permit passage of the same ion(s) or result in activation of the same downstream targets, thereby achieving improved specificity in high throughput screens while at the same time providing a high signal to noise ratio.
摘要翻译：本发明提供用于检测离子通道活性，受体活性或蛋白质蛋白相互作用的纳米传感器和纳米传感器组分。某些纳米传感器组件包含纳米颗粒和识别结构域。在与细胞接触并且任选地，通过细胞使纳米传感器组分内化后，识别结构域结合感兴趣的多肽的靶结构域例如异源靶结构域，例如离子通道亚基，G蛋白偶联受体（ GPCR）或G蛋白亚基。离子通道活性，GPCR活性或改变的蛋白质相互作用导致可检测的信号。纳米颗粒可以被官能化，使得它们通过改变它们的接近度来响应离子的存在。某些纳米传感器利用等离子体共振现象来产生信号，而另一些利用磁性，RET和/或离子敏感部分。还提供了多肽，例如包含异源靶域的离子通道亚单位，以及表达多肽的细胞系。进一步提供了用于检测离子通道活性，受体活性或蛋白质相互作用以及鉴定调节这些中的一种或多种的化合物的各种方法。在某些实施方案中，本发明允许用户即使在允许相同离子通过或导致相同下游靶的活化的其它通道的存在下也检测特定离子通道的活性，从而实现高通量的改善的特异性屏幕同时提供高信噪比。

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