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1. 发明申请

WO2013074657A3 SOLID PHASE MICRO-EXTRACTION (SPME) DEVICES 审中-公开
标题翻译：固相微萃取（SPME）装置
公开(公告)号：WO2013074657A3
公开(公告)日：2014-07-03
申请号：PCT/US2012065056
申请日：2012-11-14
申请人： SMITHS DETECTION INC , MANNING DAVID D , SCHREIBER KENNETH C , FREDEEN KENNETH J , RIEHM GEORGE E , WEAVER GREG , LAVERACK JOHN R
发明人： MANNING DAVID D , SCHREIBER KENNETH C , FREDEEN KENNETH J , RIEHM GEORGE E , WEAVER GREG , LAVERACK JOHN R
IPC分类号： G01N1/04
CPC分类号： B01D15/00 , G01N1/405 , G01N2030/009 , G01N2030/062 , G01N2035/1053
摘要： Provided herein are improved solid phase micro-extraction (SPME) devices, systems comprising such devices, and methods of use and manufacture thereof. In particular, SPME devices provided herein are configured to prevent damage (e.g., to the device and/or to a system in which they are employed) incurred, for example, through user error.
摘要翻译：本文提供了改进的固相微萃取（SPME）装置，包括这种装置的系统及其使用和制造方法。特别地，本文提供的SPME设备被配置为防止例如通过用户错误而引起的损坏（例如，对于它们被使用的设备和/或其系统）。

2. 发明申请

WO2006014872A2 NOVEL PROCESSES FOR STEREOSELECTIVE SYNTHESIS OF TRANS ISATX 247 审中-公开
标题翻译：用于异位选择性合成的ISATX的新方法247
公开(公告)号：WO2006014872A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/026319
申请日：2005-07-26
申请人： AMR TECHNOLOGY, INC. , MOLINO, Bruce, F. , YANG, Zhicai , MAENG, Jun-Ho , MANNING, David, D.
发明人： MOLINO, Bruce, F. , YANG, Zhicai , MAENG, Jun-Ho , MANNING, David, D.
IPC分类号： C07K7/64
CPC分类号： C07K7/645
摘要： The present invention relates to a process for preparation of a trans ISA TX 247 compound of the formula: where R 1 = H or D; R 2 = H or D; and R 3 = H or D, by application of organozirconium chemistry. The process involves reacting an acetyl cyclosporin aldehyde with an organozirconium reagent to provide acetyl cyclosporin diene (the acetate of trans ISA TX 247) and deacetylating the acetyl cyclosporin diene to produce the trans -isomer of ISA TX 247. The present invention also relates to a process for preparing the same trans ISA TX 247 compound, using olefin cross metathesis. The process involves: olefin cross metathesis of acetyl cyclosporin A to afford acetyl cyclosporin α,β-unsaturated aldehyde; Wittig reaction of the acetyl cyclosporin α,β-unsaturated aldehyde to provide acetyl cyclosporin diene; and deacetylation of the acetyl cyclosporin diene to produce the trans ISA TX 247 compound. Also disclosed are processes for preparing an acetyl cyclosporin α,β-unsaturated aldehyde compound and a cyclosporin triene analogue compound.
摘要翻译：本发明涉及一种制备的方法

3. 发明申请

WO2009155054A2 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF 审中-公开
标题翻译： 5-HT3受体调节剂，制备方法及其用途
公开(公告)号：WO2009155054A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/045484
申请日：2009-05-28
申请人： ALBANY MOLECULAR RESEARCH, INC. , MANNING, David, D. , CIOFFI, Christopher, L.
发明人： MANNING, David, D. , CIOFFI, Christopher, L.
IPC分类号： A61K31/553 , C07D487/04 , A61P25/00 , A61P1/00
CPC分类号： A61K31/55 , A61K31/437 , A61K31/439 , C07D451/14 , C07D453/02 , C07D471/06 , C07D487/06 , C07D519/00
摘要： Novel 5-HT 3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
摘要翻译：公开了新的5-HT 3受体调节剂。这些化合物用于治疗各种疾病，包括化疗诱发的恶心和呕吐，术后恶心呕吐和肠易激综合征。制备这些化合物的方法也在本发明中描述。

4. 发明申请

WO2012006321A3 NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF 审中-公开
标题翻译：新型抗菌化合物，其制备方法及其用途
公开(公告)号：WO2012006321A3
公开(公告)日：2013-08-01
申请号：PCT/US2011043028
申请日：2011-07-06
申请人： ALBANY MOLECULAR RES INC , CARR GRANT J , MANNING DAVID D , YANG ZHICAI , GUO CHENG , MAENG JUN-HO , RABENSTEIN JOHN , MICHELS PETER C , CHASE MATTHEW W
发明人： CARR GRANT J , MANNING DAVID D , YANG ZHICAI , GUO CHENG , MAENG JUN-HO , RABENSTEIN JOHN , MICHELS PETER C , CHASE MATTHEW W
IPC分类号： C07C50/22
CPC分类号： C07H15/252 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/706 , C07H5/06 , C12P7/66 , C12P19/28 , C12R1/465
摘要： The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
摘要翻译：本发明涉及具有抗菌活性的新型治疗剂，其制备方法以及含有它们作为活性成分的药物，兽医和营养组合物。本发明还涉及新型治疗剂例如用作治疗细菌感染的药物或食品添加剂或帮助受试者体内体重增加的用途。

5. 发明申请

WO2012006321A2 NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF 审中-公开
标题翻译：新型抗菌化合物，其制备方法及其用途
公开(公告)号：WO2012006321A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/043028
申请日：2011-07-06
申请人： ALBANY MOLECULAR RESEARCH, INC. , CARR, Grant, J. , MANNING, David, D. , YANG, Zhicai , GUO, Cheng , MAENG, Jun-Ho , RABENSTEIN, John , MICHELS, Peter, C. , CHASE, Matthew, W.
发明人： CARR, Grant, J. , MANNING, David, D. , YANG, Zhicai , GUO, Cheng , MAENG, Jun-Ho , RABENSTEIN, John , MICHELS, Peter, C. , CHASE, Matthew, W.
IPC分类号： A61K31/706 , C07H5/06 , A61K31/704 , A61K31/7056 , A61K31/7048 , A61P31/04 , A61P43/00 , C12P19/28 , C12N1/20
CPC分类号： C07H15/252 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/706 , C07H5/06 , C12P7/66 , C12P19/28 , C12R1/465
摘要： The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
摘要翻译：本发明涉及具有抗菌活性的新型治疗剂，其制备方法以及含有它们作为活性成分的药物，兽医和营养组合物。本发明还涉及新型治疗剂例如用作治疗细菌感染的药物或食品添加剂或帮助受试者体内体重增加的用途。

6. 发明申请

WO2011008572A3 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF 审中-公开
标题翻译： 5-HT3受体调节剂，其制备方法和用途
公开(公告)号：WO2011008572A3
公开(公告)日：2011-06-03
申请号：PCT/US2010040617
申请日：2010-06-30
申请人： ALBANY MOLECULAR RES INC , GUZZO PETER R , MANNING DAVID D , EARLY WILLIAM
发明人： GUZZO PETER R , MANNING DAVID D , EARLY WILLIAM
IPC分类号： C07D487/04 , A61K31/5517 , A61P25/00 , C07D403/04
CPC分类号： C07D513/06 , A61K31/439 , A61K31/55 , A61K31/5517 , A61K45/06 , C07D453/02 , C07D487/04 , C07D513/04
摘要： Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
摘要翻译：公开了新的5-HT 3受体调节剂。这些化合物用于治疗各种疾病，包括化疗引起的恶心和呕吐，手术后恶心和呕吐以及肠易激综合征。制备这些化合物的方法也描述在本发明中。

7. 发明申请

WO2009155054A3 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF 审中-公开
标题翻译： 5-HT3受体调节剂，制备方法及其用途
公开(公告)号：WO2009155054A3
公开(公告)日：2010-02-18
申请号：PCT/US2009045484
申请日：2009-05-28
申请人： ALBANY MOLECULAR RES INC , MANNING DAVID D , CIOFFI CHRISTOPHER L
发明人： MANNING DAVID D , CIOFFI CHRISTOPHER L
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , A61K31/437 , A61K31/439 , C07D451/14 , C07D453/02 , C07D471/06 , C07D487/06 , C07D519/00
摘要： Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
摘要翻译：公开了新的5-HT 3受体调节剂。这些化合物用于治疗各种疾病，包括化疗诱发的恶心和呕吐，术后恶心呕吐和肠易激综合征。制备这些化合物的方法也在本发明中描述。

8. 发明申请

WO1996020236A1 POLYGLYCOMERS 审中-公开
公开(公告)号：WO1996020236A1
公开(公告)日：1996-07-04
申请号：PCT/US1995013361
申请日：1995-10-13
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , KIESSLING, Laura, L. , MANNING, David, D.
发明人： WISCONSIN ALUMNI RESEARCH FOUNDATION
IPC分类号： C08G61/12
CPC分类号： C08G61/12 , A61K47/59 , A61K47/61
摘要： A polyglycomer is disclosed of formula (I), wherein L is a linker selected from the group of -O-(CH2)m-, -NH-(CH2)m-, -O-(CH2)m-X-, and -NH-(CH2)m-X-, wherein X = S or O and m is 2-10, wherein R and R are selected from the group consisting of saccharide moieties, and wherein n is between 1 and 2000. A method of creating a polyglycomer is also disclosed.
摘要翻译：公开了式（I）的聚乙二醇，其中L是选自-O-（CH 2）m - ， - NH-（CH 2）m - ， - O-（CH 2）m X - 和-NH - （CH 2）m X-，其中X = S或O，m为2-10，其中R 1和R 2选自糖部分，并且其中n为1至2000。还公开了产生聚乙二醇的方法。

9. 发明申请

WO2006014872A3 NOVEL PROCESSES FOR STEREOSELECTIVE SYNTHESIS OF TRANS ISATX 247 审中-公开
标题翻译：用于异位选择性合成的ISATX的新方法247
公开(公告)号：WO2006014872A3
公开(公告)日：2006-08-10
申请号：PCT/US2005026319
申请日：2005-07-26
申请人： AMR TECHNOLOGY INC , MOLINO BRUCE F , YANG ZHICAI , MAENG JUN-HO , MANNING DAVID D
发明人： MOLINO BRUCE F , YANG ZHICAI , MAENG JUN-HO , MANNING DAVID D
IPC分类号： A61K38/12
CPC分类号： C07K7/645
摘要： The present invention relates to a process for preparation of a trans ISA TX 247 compound of the formula: where R 1 = H or D; R 2 = H or D; and R 3 = H or D, by application of organozirconium chemistry. The process involves reacting an acetyl cyclosporin aldehyde with an organozirconium reagent to provide acetyl cyclosporin diene (the acetate of trans ISA TX 247) and deacetylating the acetyl cyclosporin diene to produce the trans-isomer of ISA TX 247. The present invention also relates to a process for preparing the same trans ISA TX 247 compound, using olefin cross metathesis. The process involves: olefin cross metathesis of acetyl cyclosporin A to afford acetyl cyclosporin a,ß-unsaturated aldehyde; Wittig reaction of the acetyl cyclosporin a,ß-unsaturated aldehyde to provide acetyl cyclosporin diene; and deacetylation of the acetyl cyclosporin diene to produce the trans ISA TX 247 compound. Also disclosed are processes for preparing an acetyl cyclosporin a,ß-unsaturated aldehyde compound and a cyclosporin triene analogue compound.
摘要翻译：本发明涉及制备下式的反式ISA II 247化合物的方法：其中R 1 = H或D; R 2 = H或D; 和R 3 = H或D，通过应用有机锆化学。该方法包括使乙酰环孢菌素醛与有机锆试剂反应以提供乙酰环孢菌素二烯（反式ISA TX 247的乙酸酯）和乙酰环己烷二烯的脱乙酰化产生反式异构体 ISA _{TX 247。本发明还涉及使用烯烃交叉复分解制备相同的反式异构体化合物247的方法。该方法包括：乙酰环孢菌素A的烯烃交叉复分解，得到乙酰环孢菌素a，β-不饱和醛; 乙酰环孢菌素a，β-不饱和醛的维蒂希反应提供乙酰环孢素二烯; 和乙酰环孢菌素二烯的脱乙酰化以产生反式ISAX 247化合物。还公开了制备乙酰环孢菌素a，β-不饱和醛化合物和环孢菌素三烯类似物化合物的方法。}

10. 发明申请

WO2013074657A2 SOLID PHASE MICRO-EXTRACTION (SPME) DEVICES 审中-公开
标题翻译：固相微萃取（SPME）装置
公开(公告)号：WO2013074657A2
公开(公告)日：2013-05-23
申请号：PCT/US2012/065056
申请日：2012-11-14
申请人： SMITHS DETECTION INC , MANNING, David D. , SCHREIBER, Kenneth C. , FREDEEN, Kenneth J. , RIEHM, George E. , WEAVER, Greg , LAVERACK, John R.
发明人： MANNING, David D. , SCHREIBER, Kenneth C. , FREDEEN, Kenneth J. , RIEHM, George E. , WEAVER, Greg , LAVERACK, John R.
IPC分类号： G01N30/50
CPC分类号： B01D15/00 , G01N1/405 , G01N2030/009 , G01N2030/062 , G01N2035/1053
摘要： Provided herein are improved solid phase micro-extraction (SPME) devices, systems comprising such devices, and methods of use and manufacture thereof. In particular, SPME devices provided herein are configured to prevent damage (e.g., to the device and/or to a system in which they are employed) incurred, for example, through user error.
摘要翻译：本文提供了改进的固相微萃取（SPME）装置，包括这种装置的系统及其使用和制造方法。特别地，本文提供的SPME设备被配置为防止例如通过用户错误而引起的损坏（例如，对其使用的设备和/或其系统）。

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