会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • NOVEL AMIDES ACTING ON THE ADENOSINE RECEPTORS
    • 对腺苷受体的新陈代谢作用
    • WO2008058679A2
    • 2008-05-22
    • PCT/EP2007009721
    • 2007-11-09
    • ACURE PHARMA ABLUNDSTEDT TORBJOERNSEIFERT ELISABETHLEK PERBOMAN ARNE
    • LUNDSTEDT TORBJOERNSEIFERT ELISABETHLEK PERBOMAN ARNE
    • C07K5/023A61K38/05A61P19/02C07K5/027
    • C07D209/14
    • There are described Compounds of formula (I) in which R 3 to R 8 are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide; R 1 is an optionally substituted phenyl, benzyl or cyclohexyl group; R 2 is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C 1-5 hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The Compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, Osteoarthritis, mental disorders, or for inducing central nerve regeneration.
    • 描述了式(I)的化合物,其中R 3至R 8独立地选自氢,卤素,三卤代烷基,具有1,2,3,4或4个碳原子的烷基 5个碳原子,选自具有1,2,3,4或5个碳原子的烷氧基的电子给体基团,三卤代烷氧基,羟基或氨基,选自氰基,磺酸,硝基或酰胺的电子受体基团; R 1是任选取代的苯基,苄基或环己基; R 2选自氨基,取代的氨基或胍基,Z是饱和或不饱和的C 1-5 - 烃链,及其盐。 还描述了其制备方法和含有它们的组合物。 化合物是特定腺苷受体的激动剂或拮抗剂或多种腺苷受体,并且可用于治疗炎症,关节炎病症,类风湿性关节炎,骨关节炎,精神障碍或诱导中枢神经再生。