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1. 发明申请

WO2008042686A2 MULTIFUNCTIONAL CARRIERS FOR THE DELIVERY OF NUCLEIC ACIDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于提供核酸的多功能载体及其使用方法
公开(公告)号：WO2008042686A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/079651
申请日：2007-09-27
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , LU, Zheng-rong , WANG, Xu-Li
发明人： LU, Zheng-rong , WANG, Xu-Li
IPC分类号： A61K48/00 , C07K7/08
CPC分类号： C07K14/003 , A61K47/543 , A61K47/60 , A61K47/62 , A61K47/6929 , C07K5/0606 , C12N15/87
摘要： Described herein are multifunctional compounds useful as devices for the delivery of nucleic acids to cells. Also described herein are methods for using the multifunctional compounds.
摘要翻译：本文描述了可用作将核酸递送至细胞的装置的多官能化合物。本文还描述了使用多官能化合物的方法。

2. 发明申请

WO2006060797A2 MRI GUIDED PHOTODYNAMIC THERAPY FOR CANCER 审中-公开
标题翻译：磁共振成像引导光动力治疗癌症
公开(公告)号：WO2006060797A2
公开(公告)日：2006-06-08
申请号：PCT/US2005/044012
申请日：2005-12-02
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , LU, Zheng-Rong , VIADYA, Anagha , KE, Tianyi
发明人： LU, Zheng-Rong , VIADYA, Anagha , KE, Tianyi
IPC分类号： A61K49/00
CPC分类号： A61K49/085 , A61K41/0071 , A61K47/645 , A61K49/146
摘要： Disclosed is a method of therapy used in combination with a diagnostic tool for enhanced photodynamic therapy using MRI, called (magnetic resonance imaging)-guided photodynamic therapy. The methods of the present invention includes administration of MRI contrast agent labeled polymer photosensitizer conjugates, detection and localization of tumor or cancer tissues with contrast-enhanced MRI and specific illumination and treatment of localized target tissues, such as tumors or cancer cells, using laser energy. The delivered laser energy activates the photosentizer accumulated in the target tissue, resulting in treatment. Also disclosed are novel conjugate compounds, such as PLGA-Mce 6 -DOTA-Gd complexes, having multi-functionality in that the complex may include an MRI contrasting agent linked to a photosensitizing agent.
摘要翻译：公开了一种与用于使用MRI的增强型光动力治疗的诊断工具联合使用的治疗方法，称为（磁共振成像）引导的光动力学治疗。本发明的方法包括施用MRI造影剂标记的聚合物光敏剂缀合物，利用对比增强的MRI检测和定位肿瘤或癌症组织，并且使用激光能量对局部靶组织（例如肿瘤或癌细胞）进行特定照射和治疗。输送的激光能量激活累积在目标组织中的光化剂，导致治疗。还公开了具有多功能性的新型缀合物化合物，例如PLGA-Mce6 -DOTA-Gd复合物，因为该复合物可以包括连接到光敏剂的MRI造影剂。

3. 发明申请

WO2006060797A3 MRI GUIDED PHOTODYNAMIC THERAPY FOR CANCER 审中-公开
标题翻译： MRI指导癌症的光化疗法
公开(公告)号：WO2006060797A3
公开(公告)日：2006-08-24
申请号：PCT/US2005044012
申请日：2005-12-02
申请人： UNIV UTAH RES FOUND , LU ZHENG-RONG , VIADYA ANAGHA , KE TIANYI
发明人： LU ZHENG-RONG , VIADYA ANAGHA , KE TIANYI
IPC分类号： A61K39/385
CPC分类号： A61K49/085 , A61K41/0071 , A61K47/645 , A61K49/146
摘要： Disclosed is a method of therapy used in combination with a diagnostic tool for enhanced photodynamic therapy using MRI, called (magnetic resonance imaging)-guided photodynamic therapy. The methods of the present invention includes administration of MRI contrast agent labeled polymer photosensitizer conjugates, detection and localization of tumor or cancer tissues with contrast-enhanced MRI and specific illumination and treatment of localized target tissues, such as tumors or cancer cells, using laser energy. The delivered laser energy activates the photosentizer accumulated in the target tissue, resulting in treatment. Also disclosed are novel conjugate compounds, such as PLGA-Mce 6 -DOTA-Gd complexes, having multi-functionality in that the complex may include an MRI contrasting agent linked to a photosensitizing agent.
摘要翻译：公开了一种治疗方法，与用于使用称为（磁共振成像） - 光导光疗法的MRI的增强光动力疗法的诊断工具结合使用。本发明的方法包括施用MRI造影剂标记的聚合物光敏剂缀合物，使用对比度增强的MRI和特定照明的肿瘤或癌组织的检测和定位以及使用激光能量的局部靶组织如肿瘤或癌细胞的治疗。递送的激光能量激活积聚在靶组织中的光敏剂，从而进行治疗。还公开了具有多官能度的新型缀合物化合物，例如PLGA-Mce 6-DTA-Gd络合物，因为该复合物可包括与光敏剂连接的MRI对比剂。

4. 发明申请

WO2002090390A1 HYALURONIC ACID CONTAINING BIOCONJUGATES : TARGETED DELIVERY OF ANTI-CANCER DRUGS TO CANCER CELLS 审中-公开
标题翻译：含有含硫酸的生物素化药物：将癌细胞递送给癌细胞
公开(公告)号：WO2002090390A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/014402
申请日：2002-05-06
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , LUO, Yi , PRESTWICH, Glenn, D. , KOPECEK, Jindrich , LU, Zheng-Rong
发明人： LUO, Yi , PRESTWICH, Glenn, D. , KOPECEK, Jindrich , LU, Zheng-Rong
IPC分类号： C08B37/00
CPC分类号： A61K31/74 , A61K31/704 , A61K41/00 , A61K47/58 , A61K47/61 , A61K47/65 , A61K2300/00
摘要： A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors overexpressed on cancer cell surface. The invention relates to compounds composed of a carrier molecule,5 wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid. The invention also relates to methods of making and using the compounds thereof.
摘要翻译：基于透明质酸（HA）与其在癌细胞表面上过表达的细胞表面受体之间的特异性相互作用设计了基于细胞的聚合物药物递送系统。本发明涉及由载体分子组成的化合物，其中载体分子含有至少一种抗癌剂残基和至少一种透明质酸残基。本发明还涉及制备和使用其化合物的方法。

5. 发明申请

WO2008121153A3 DENDRIMERS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译： DENDRIMERS及其制造和使用方法
公开(公告)号：WO2008121153A3
公开(公告)日：2008-11-27
申请号：PCT/US2007076100
申请日：2007-08-16
申请人： UNIV UTAH RES FOUND , LU ZHENG-RONG , KANESHIRO TODD
发明人： LU ZHENG-RONG , KANESHIRO TODD
IPC分类号： C08G77/00
CPC分类号： A61K49/0002 , A61K47/59 , A61K47/6455 , A61K49/124 , A61K51/065 , C08G83/003
摘要： Described herein are dendrimers derived from polyhedral silsesquioxanes and methods of making/using thereof.
摘要翻译：本文描述了衍生自多面体倍半硅氧烷的树枝状聚合物及其制造/使用方法。

6. 发明申请

WO2008042686A3 MULTIFUNCTIONAL CARRIERS FOR THE DELIVERY OF NUCLEIC ACIDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于递送核酸的多功能载体及其使用方法
公开(公告)号：WO2008042686A3
公开(公告)日：2008-10-23
申请号：PCT/US2007079651
申请日：2007-09-27
申请人： UNIV UTAH RES FOUND , LU ZHENG-RONG , WANG XU-LI
发明人： LU ZHENG-RONG , WANG XU-LI
IPC分类号： A61K38/04
CPC分类号： C07K14/003 , A61K47/543 , A61K47/60 , A61K47/62 , A61K47/6929 , C07K5/0606 , C12N15/87
摘要： Described herein are multifunctional compounds useful as devices for the delivery of nucleic acids to cells. Also described herein are methods for using the multifunctional compounds.
摘要翻译：本文描述了用作将核酸递送至细胞的装置的多功能化合物。本文还描述了使用多官能化合物的方法。

7. 发明申请

WO2010062502A1 CARRIERS FOR THE DELIVERY OF NUCLEIC ACIDS TO CELLS AND METHODS OF USE THEREOF 审中-公开
标题翻译：载体将核酸递送至细胞及其使用方法
公开(公告)号：WO2010062502A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/061428
申请日：2009-10-21
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , LU, Zheng-Rong , XU, Rongzuo
发明人： LU, Zheng-Rong , XU, Rongzuo
IPC分类号： A01N43/04
CPC分类号： C07K7/02 , C07K5/0606 , C12N15/88 , C12N2810/00
摘要： Described herein are compounds and methods useful for the delivery of nucleic acids to cells. The compounds and methods are useful in delivering all types of nucleic acids to cells including sensitive nucleic acids such as, for example, siRNA.
摘要翻译：本文描述了可用于将核酸递送至细胞的化合物和方法。所述化合物和方法可用于将所有类型的核酸递送至包括敏感核酸例如siRNA的细胞。

8. 发明申请

WO2009055542A1 USE OF MRI CONTRAST AGENTS FOR EVALUATING THE TREATMENT OF TUMORS 审中-公开
标题翻译：使用MRI对比剂评估肿瘤治疗
公开(公告)号：WO2009055542A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/080908
申请日：2008-10-23
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , LU, Zheng-Rong , FENG, Yi , WU, Xueming
发明人： LU, Zheng-Rong , FENG, Yi , WU, Xueming
IPC分类号： A61B8/00
CPC分类号： A61K49/16 , A61B5/055 , A61K49/085 , A61K49/128
摘要： Described herein are methods for using macromolecular MRI contrast agents to evaluate the effectiveness of anti-cancer treatments. The methods take advantage of MRI for evaluating more specifically and accurately one or more tumor properties of the tumor in response to a particular treatment. Ultimately, the methods described herein help evaluate the effectiveness of the anti-cancer treatment over time.
摘要翻译：本文描述了使用大分子MRI造影剂来评价抗癌治疗的有效性的方法。该方法利用MRI来更具体和准确地评估肿瘤响应于特定治疗的一种或多种肿瘤特性。最终，本文所述的方法有助于评估抗癌治疗随时间的有效性。

9. 发明申请

WO2009111273A3 PEPTIDE TARGETING IMAGING AGENTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：肽靶向成像剂及其使用方法
公开(公告)号：WO2009111273A3
公开(公告)日：2010-10-21
申请号：PCT/US2009035363
申请日：2009-02-27
申请人： UNIV UTAH RES FOUND , YE FURONG , LU ZHENG-RONG
发明人： YE FURONG , LU ZHENG-RONG
IPC分类号： A61K49/00 , A61K49/14 , A61K51/08 , C07K7/64
CPC分类号： A61K49/085 , A61K49/0017 , A61K49/0056 , A61K49/14 , A61K51/088
摘要： Described herein are peptide targeting imaging agents. The peptides are covalently attached to the imaging agent and have a specific peptide sequence that enables the imaging agent to accumulate specifically in tumor tissues. Additionally, the imaging agents are readily excreted by the subject within a short period of time after administration to the subject. Methods for using the imaging agents are also described herein.
摘要翻译：本文描述的是肽靶向成像剂。肽共价连接到成像剂上，并具有能使成像剂在肿瘤组织中特异性积聚的特异性肽序列。此外，成像剂在给予受试者之后在短时间内容易地被受试者排出。本文还描述了使用成像剂的方法。

10. 发明申请

WO2009111273A2 PEPTIDE TARGETING IMAGING AGENTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：肽靶向成像剂及其使用方法
公开(公告)号：WO2009111273A2
公开(公告)日：2009-09-11
申请号：PCT/US2009/035363
申请日：2009-02-27
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , YE, Furong , LU, Zheng-Rong
发明人： YE, Furong , LU, Zheng-Rong
IPC分类号： A61K49/00 , A61K49/14 , A61K51/08 , C07K7/64
CPC分类号： A61K49/085 , A61K49/0017 , A61K49/0056 , A61K49/14 , A61K51/088
摘要： Described herein are peptide targeting imaging agents. The peptides are covalently attached to the imaging agent and have a specific peptide sequence that enables the imaging agent to accumulate specifically in tumor tissues. Additionally, the imaging agents are readily excreted by the subject within a short period of time after administration to the subject. Methods for using the imaging agents are also described herein.
摘要翻译：本文描述的是肽靶向成像剂。这些肽共价连接到成像剂上，并且具有能使成像剂在肿瘤组织中特异性积聚的特异性肽序列。此外，成像剂在给予受试者之后在短时间内容易地被受试者排出。本文还描述了使用成像剂的方法。

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