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1. 发明申请

WO2011055270A1 INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS 审中-公开
标题翻译：基于受体的CRTH2拮抗剂
公开(公告)号：WO2011055270A1
公开(公告)日：2011-05-12
申请号：PCT/IB2010/054845
申请日：2010-10-26
申请人： WYETH LLC , FOLLOWS, Bruce Christopher , HUANG, Adrian , JANZ, Kristin Marie , KAILA, Neelu , LOWE, Michael Dennis , MANSOUR, Tarek Suhayl , MORETTO, Alessandro Fabio , SAIAH, Eddine , THOMASON, Jennifer Romanic , WILLIAMS, Cara Margaret May
发明人： FOLLOWS, Bruce Christopher , HUANG, Adrian , JANZ, Kristin Marie , KAILA, Neelu , LOWE, Michael Dennis , MANSOUR, Tarek Suhayl , MORETTO, Alessandro Fabio , SAIAH, Eddine , THOMASON, Jennifer Romanic , WILLIAMS, Cara Margaret May
IPC分类号： C07D403/04 , C07D403/06 , A61K31/404 , A61P11/00 , A61P17/00 , C07D401/04 , C07D401/06
CPC分类号： C07D403/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D417/14
摘要： Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.
摘要翻译：公开了式（I）的化合物：其可用作CRTH2受体的拮抗剂。还公开了含有式（I）化合物和式（I）化合物用于治疗对抑制内源性配体与CRTH2受体的结合有反应的疾病或病症的药物组合物。进一步描述制备和使用这些化合物的方法。

2. 发明申请

WO2008097350A2 TOP LOCK SECURITY HOLSTER 审中-公开
标题翻译：顶级锁安全舱
公开(公告)号：WO2008097350A2
公开(公告)日：2008-08-14
申请号：PCT/US2007/076550
申请日：2007-08-22
申请人： ABERLE, Gregory , JENKINS, Taylor , SENN, Anthony , LOWE, Michael, V.
发明人： ABERLE, Gregory , JENKINS, Taylor , SENN, Anthony , LOWE, Michael, V.
IPC分类号： F41C33/04
CPC分类号： F41C33/0209 , F41C33/0245 , F41C33/0263
摘要： The Invention is a security holster for securing a hand gun from unauthorized access from the holster. The holster of the invention has a locking tab which moves vertically into engagement with the ejection port of a semi-automatic hand gun, and is configured for activation from either a left or a right handed user, by use of a finger or thumb release positioned on either the right or the left side. The hand gun may also be configured to contain both a thumb and a finger release tab, and may be so configured for either a left or a right handed user without changing the basic configuration of the device.
摘要翻译：本发明是一种安全手枪套，用于保护手枪免受枪套的未授权访问。本发明的枪套具有锁定突起，该锁定突起垂直移动以与半自动手持式喷枪的喷射口接合，并且被配置为通过使用位于手指或拇指释放位置的左手或右手使用者来启动在右侧或左侧。手枪也可以配置为包含拇指和手指释放片，并且可以为左手或右手使用者配置，而不改变装置的基本配置。

3. 发明申请

WO2007100438A1 PARTICULATE TRAP REGENERATION TEMPERATURE CONTROL SYSTEM 审中-公开
标题翻译：颗粒捕获再生温度控制系统
公开(公告)号：WO2007100438A1
公开(公告)日：2007-09-07
申请号：PCT/US2007/002867
申请日：2007-02-02
申请人： CATERPILLAR INC. , KAPPAROS, David, J. , LOWE, Michael, D.
发明人： KAPPAROS, David, J. , LOWE, Michael, D.
IPC分类号： F01N3/025 , F01N9/00 , F02D41/02
CPC分类号： F01N9/002 , F01N3/0256 , F02D41/0245 , F02D41/029 , F02D2200/0802 , Y02T10/26 , Y02T10/47
摘要： In one aspect, the present disclosure is directed to a particulate trap regeneration temperature control system (16). The system may include a particulate trap (19) configured to remove one or more types of particulate matter from an exhaust flow of an engine (14). The system may also include a heating system (26) configured to increase the temperature of the particulate trap. The system may further include a controller (32) configured to control operation of the heating system during execution of a thermal regeneration event of the particulate trap. The controller may control operation of the heating system by effectuating a first temperature increase of the particulate trap at a predetermined rate up to a first predetermined temperature. The controller may also be configured to effectuate a first temperature hold by maintaining the temperature of the particulate trap at the first predetermined temperature for a predetermined amount of time. The controller may further be configured to effectuate at least a second temperature increase of the particulate trap at a predetermined rate to a higher second predetermined temperature. In addition, the controller may also be configured to effectuate at least a second temperature hold by maintaining the temperature of the particulate trap at the second predetermined temperature for a predetermined amount of time.
摘要翻译：在一个方面，本公开涉及一种颗粒捕集器再生温度控制系统（16）。该系统可以包括被配置成从发动机（14）的排气流中去除一种或多种类型的颗粒物质的颗粒捕集器（19）。该系统还可以包括被配置为增加颗粒捕集器的温度的加热系统（26）。该系统还可以包括控制器（32），其被配置为在颗粒捕集器的热再生事件的执行期间控制加热系统的操作。控制器可以通过以预定速率直到第一预定温度来实现颗粒捕集器的第一温度升高来控制加热系统的操作。控制器还可以被配置为通过将颗粒捕集器的温度保持在第一预定温度达预定的时间量来实现第一温度保持。控制器还可以被配置为以预定的速率将颗粒捕集器的至少第二温度升高实现到更高的第二预定温度。此外，控制器还可以被配置为通过将颗粒捕集器的温度保持在第二预定温度达预定的时间量来实现至少第二温度保持。

4. 发明申请

WO2014039434A1 ALKOXY PYRAZOLES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS 审中-公开
公开(公告)号：WO2014039434A1
公开(公告)日：2014-03-13
申请号：PCT/US2013/057826
申请日：2013-09-03
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BRENNEMAN, Jehrod Burnett , GINN, John David , LOWE, Michael D. , SARKO, Christopher Ronald , TASBER, Edward S. , ZHANG, Zhonghua
发明人： BRENNEMAN, Jehrod Burnett , GINN, John David , LOWE, Michael D. , SARKO, Christopher Ronald , TASBER, Edward S. , ZHANG, Zhonghua
IPC分类号： C07D401/14 , A61K31/4439 , A61P9/00 , A61P13/00 , A61P25/00 , A61P3/00
CPC分类号： C07D401/14 , C07D405/14 , C07D493/08 , C07D498/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

5. 发明申请

WO2012167010A2 MANGANESE OXIDE NANOPARTICLES, METHODS AND APPLICATIONS 审中-公开
标题翻译：锰氧化物纳米颗粒，方法和应用
公开(公告)号：WO2012167010A2
公开(公告)日：2012-12-06
申请号：PCT/US2012040360
申请日：2012-06-01
申请人： UNIV CORNELL , ABRUNA HECTOR D , GAO JIE , LOWE MICHAEL
发明人： ABRUNA HECTOR D , GAO JIE , LOWE MICHAEL
IPC分类号： C01G45/02 , B82B3/00 , B82Y40/00 , C01D15/00
CPC分类号： H01M4/505 , B82Y30/00 , B82Y40/00 , C01G45/02 , C01P2002/72 , C01P2004/03 , C01P2004/64 , H01M4/50 , Y10T428/2982
摘要： Manganese oxide nanoparticles having a chemical composition that includes ?n3O4, a sponge like morphology and a particle size from about 65 to about 95 nanometers may be formed by calcining a manganese hydroxide material at a temperature from about 200 to about 400 degrees centigrade for a time period from about 1 to about 20 hours in an oxygen containing environment. The particular manganese oxide nanoparticles with the foregoing physical features may be used within a battery component, and in particular an anode within a lithium battery to provide enhanced performance.
摘要翻译：可以通过在约200至约400摄氏度的温度下煅烧氢氧化锰材料来形成化学组成包括ηnO 4，海绵状形态和约65至约95纳米的粒度的氧化锰纳米颗粒一段时间在含氧环境中约1至约20小时。具有上述物理特征的具体的氧化锰纳米颗粒可以用在电池组件内，特别是锂电池内的阳极以提供增强的性能。

6. 发明申请

WO2016014463A1 HETEROCYCLIC CARBOXYLIC ACIDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE 审中-公开
标题翻译：作为可溶性葡萄糖酸环化酶的活化剂的杂环羧酸
公开(公告)号：WO2016014463A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/041245
申请日：2015-07-21
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BRENNEMAN, Jehrod Burnett , GINN, John David , SARKO, Christopher Ronald , WESTBROOK, John , ZHANG, Zhonghua , YU, Maolin , HOPKINS, Tamara Denise , LOWE, Michael D.
发明人： BRENNEMAN, Jehrod Burnett , GINN, John David , SARKO, Christopher Ronald , WESTBROOK, John , ZHANG, Zhonghua , YU, Maolin , HOPKINS, Tamara Denise , LOWE, Michael D.
IPC分类号： C07D405/14 , C07D417/14 , A61K31/55 , A61P13/12
CPC分类号： C07D405/14 , C07D417/14
摘要： The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof, wherein R 1 , R 2, R 3 , R 5 , R 6 , R 7 , R 8 , R 9 , B, V, W, X, Y, Z and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，其中R1，R2，R3，R5，R6，R7，R8，R9，B，V，W，X，Y，Z和m如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

7. 发明申请

WO2005003675A1 GUN HOLSTER 审中-公开
公开(公告)号：WO2005003675A1
公开(公告)日：2005-01-13
申请号：PCT/US2004/020724
申请日：2004-06-25
申请人： TACTICAL DESIGN LABS , LOWE, Michael, V. , SENN, Anthony, J. , YATES, Eric
发明人： LOWE, Michael, V. , SENN, Anthony, J. , YATES, Eric
IPC分类号： F41C33/02
CPC分类号： F41C33/0236 , F41C33/0209 , F41C33/0254 , F41C33/0263 , Y10S224/912
摘要： A security holster (10) for handguns which utilizes a U-shaped rod (14) as part of the locking and releasing mechanism. The user presses a handgun (2) against a portion of the U-shaped rod (14) , which pushed the U-shaped rod (14) forward, and causes the locking tab (18) to seat against the ejection port or another feature of the handgun (2) .
摘要翻译：用于手枪的安全皮套（10），其利用U形杆（14）作为锁定和释放机构的一部分。使用者将手枪（2）按压在U形杆（14）的一部分上，U形杆（14）向前推动U形杆（14），并使锁定片（18）抵靠弹出口或另一特征的手枪（2）。

8. 发明申请

WO1996006716A1 METHOD FOR PRODUCING SLABS OF CEMENTITIOUS MATERIAL 审中-公开
标题翻译：生产化学材料的方法
公开(公告)号：WO1996006716A1
公开(公告)日：1996-03-07
申请号：PCT/US1995010898
申请日：1995-08-30
申请人： LOWE, Michael, L.
IPC分类号： B28B01/08
CPC分类号： B28B11/0872 , B28B7/007 , B28B7/0073 , B28B11/001 , B28B11/04 , B28B11/0818 , B44C1/227 , B44F9/04 , C04B28/02 , E04F13/147
摘要： A method for producing a wall, roadway, sidewalk, or floor (10) of cementitious material having the appearance of natural stone (16) and mortar (18) including a base (12) with an outer surface (14) with a plurality of irregular shaped protrusions (16) disposed in a random pattern to simulate natural stones (16) and a plurality of simulated grout lines (18) formed therebetween, the method including the steps of preparing a cementitious material, pouring the cementitious material into a form, vibrating the cementitious material, allowing the cementitious material to cure, forming the base (12) with the outer surface (14), releasing the base (12) with the plurality of irregular shaped protrusions (16) disposed in the random pattern to simulate natural stones (16) and the plurality of simulated grout lines (18) formed therebetween from the form, coloring the outer surface (14) and accenting the plurality of simulated grout lines (18).
摘要翻译：一种用于生产具有天然石材（16）和砂浆（18）外观的水泥质材料的墙壁，道路，人行道或地板（10）的方法，所述砂浆（18）包括具有外表面（14）的基座（12）不规则形状的突起（16）以随机图案设置以模拟天然石（16）和在其间形成的多个模拟灌浆线（18），所述方法包括以下步骤：制备水泥质材料，将水泥质材料倒入一种形式，振动水泥质材料，使水泥材料固化，与外表面（14）形成基座（12），以随机图案设置的多个不规则形状的突起（16）释放基座（12）以模拟自然石块（16）和形成在其间的多个模拟灌浆线（18），使外表面（14）着色，并且重音多个模拟灌浆线（18）。

9. 发明申请

WO2012167010A3 MANGANESE OXIDE NANOPARTICLES, METHODS AND APPLICATIONS 审中-公开
公开(公告)号：WO2012167010A3
公开(公告)日：2012-12-06
申请号：PCT/US2012/040360
申请日：2012-06-01
申请人： CORNELL UNIVERSITY , ABRUÑA, Héctor D. , GAO, Jie , LOWE, Michael
发明人： ABRUÑA, Héctor D. , GAO, Jie , LOWE, Michael
IPC分类号： C01G45/02 , C01D15/00 , B82B3/00 , B82Y40/00
摘要： Manganese oxide nanoparticles having a chemical composition that includes Μn 3 O 4 , a sponge like morphology and a particle size from about 65 to about 95 nanometers may be formed by calcining a manganese hydroxide material at a temperature from about 200 to about 400 degrees centigrade for a time period from about 1 to about 20 hours in an oxygen containing environment. The particular manganese oxide nanoparticles with the foregoing physical features may be used within a battery component, and in particular an anode within a lithium battery to provide enhanced performance.

10. 发明申请

WO2011056260A1 IMPROVED VIBRATING DENTAL DEVICES 审中-公开
标题翻译：改进的振动牙科装置
公开(公告)号：WO2011056260A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/034303
申请日：2010-05-11
申请人： SPAULDING, Glen , LING, Jeremy , KAUFMAN, Michael E. , LOWE, Michael K. , ORTHOACCEL TECHNOLOGIES, INC.
发明人： SPAULDING, Glen , LING, Jeremy , KAUFMAN, Michael E. , LOWE, Michael K.
IPC分类号： A61C7/06
CPC分类号： A61C7/008 , A61C1/0015 , A61C7/00 , A61C7/002 , A61C7/08 , A61C7/12 , A61C2204/005
摘要： A variety of improvements to the vibrating devices for dental remodeling are provided, including improved bite plate designs that accomodate common patient bite structure, a connector for a bite plate, a sizing tray for same, as well as better motors providing improved performance characteristics for an extraoral vibrator, and a completely intraoral vibrating dental plate with very thin cross section.
摘要翻译：提供了用于牙齿重塑的振动装置的各种改进，包括改进的咬合板设计以适应常见的患者咬合结构，用于咬合板的连接器，用于其的定型托盘，以及更好的马达，其为口外振动器和具有非常薄横截面的完全口腔内振动的牙板。

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