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1. 发明申请

WO1985000367A1 11-HALOGENE-PROSTANE DERIVATIVES, PROCESS FOR OBTAINING THEM AND UTILIZATION THEREOF AS DRUGS 审中-公开
标题翻译： 11-卤代 - 衍生物衍生物，用于获得它们的方法和作为药物的利用
公开(公告)号：WO1985000367A1
公开(公告)日：1985-01-31
申请号：PCT/DE1984000139
申请日：1984-07-05
申请人： SCHERING AKTIENGESELLSCHAFT , VORBRÜGGEN, Helmut , SCHWARZ, Norbert , LOGE, Olaf , STÜRZEBECHER, Claus-Steffen , ELGER, Walter
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C177/00
CPC分类号： C07C405/0016 , C07C405/00 , C07C405/0041 , C07D317/20
摘要： 11-halogene-prostane derivatives of the general formula (I), wherein X is F, Cl or Br; R1 is CH2OH or (II) wherein R2 is a hydrogen atom, a rest of alkyl, cycloalkyl, aryl, phenacyl or heterocyclic rest; A is a group -CH2-CH2- or cis -CH=CH-; B is a group -CH2-CH2-, or trans -CH=CH- or -C=C-; W is an ethylenedioxymethylene group or a hydroxymethylene group; D and E form together a direct bound or D is C1-10-alkylene group and E an oxygen atom or a sulphur atom, a direct bound, -C=C- bound or -CR6=CR7- group wherein R6 and R7 are a hydrogen atom, a chlorane atom or an alkyl group; R4 is a hydroxy group; R5 represents an hydrogen atom, an alkyl, cycloalkyl, aryle or heterocyclic group and the salts thereof with physiologically acceptable bases, method for the preparation thereof and utilization thereof as inhibitors of the secretion of gastric juice.
摘要翻译：通式（I）的11-卤代 - 前列腺衍生物，其中X为F，Cl或Br; R 1为CH 2 OH或（II）其中R 2为氢原子，其余为烷基，环烷基，芳基，苯甲酰基或杂环基; A是基团-CH 2 -CH 2 - 或顺式-CH = CH-; B是基团-CH 2 -CH 2 - 或反-CH = CH-或-C = C-; W是亚乙基二氧基亚甲基或羟基亚甲基; D和E一起形成直接结合或D为C 1-10 - 亚烷基，E为氧原子或硫原子，直接结合，-C = C-结合或-CR 6 = CR 7 - 基，其中R 6和R 7为氢原子，氯原子或烷基; R4是羟基; R5表示氢原子，烷基，环烷基，芳基或杂环基，其盐与生理上可接受的碱，其制备方法和作为胃液分泌抑制剂的应用。

2. 发明申请

WO1986002840A1 PHARMACEUTICAL COMPOSITION, ITS PRODUCTION AND USE 审中-公开
标题翻译：药物组合物及其生产和使用
公开(公告)号：WO1986002840A1
公开(公告)日：1986-05-22
申请号：PCT/DE1985000434
申请日：1985-10-30
申请人： SCHERING AKTIENGESELLSCHAFT , LOGE, Olaf
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K45/06
CPC分类号： A61K31/40 , A61K31/275 , A61K2300/00
摘要： A description is given of a pharmaceutical composition consisting of verapamil and a beta-receptor stimulator for the treatment of bronchial asthma.

3. 发明申请

WO1986000808A1 PROSTACYCLINE DERIVATIVES WITH A CYTOPROTECTIVE ACTION ON THE LIVER, THE PANCREAS AND THE KIDNEY 审中-公开
标题翻译：在肝脏，胰腺和胃肠上具有CYPOPROTECTIVE行动的前列腺素衍生物
公开(公告)号：WO1986000808A1
公开(公告)日：1986-02-13
申请号：PCT/DE1985000245
申请日：1985-07-18
申请人： SCHERING AKTIENGESELLSCHAFT , ADLER, Guido , SCHULTE-HERMANN, Rolf , LOGE, Olaf
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/557
CPC分类号： A61K31/34 , A61K31/557 , Y10S514/893
摘要： Drug for the cytoprotection of the liver, the pancreas and the kidneys, characterized in that it comprises prostacycline derivative having the formula (I) wherein R1 is hydrogen or alkyl with 1 to 10 atoms of carbon, A is group -CH2-CH2-, trans-CH=CH- or -C=C-, W is a hydroxy methyl group, free or functionally transformable on the hydroxy group, wherein the group OH is in position alpha or beta , X is a group CH2 or an oxygen atom, Z is hydrogen or a cyano group, D is a straight or branched chain saturated alkylene group or with 1 to 5 atoms of carbon, E is -C=C- bound or a direct bound, R2 is a straight or branched chain saturated alkyl group with 1 to 7 atoms of carbon, R3 is a free or functionally transformable hydroxy group and, in the case where R1 is hydrogen, their salts with the physiologically acceptable bases.
摘要翻译：用于肝脏，胰腺和肾脏的细胞保护的药物，其特征在于其包含具有式（I）的前列环素衍生物，其中R 1是氢或具有1至10个碳原子的烷基，A是基团-CH 2 -CH 2 - ，反式-CH = CH-或-C = C-，W是在羟基上游离或功能转化的羟基甲基，其中基团OH位于α或β位置，X是基团CH 2或氧原子， Z是氢或氰基，D是直链或支链饱和亚烷基或具有1-5个碳原子，E是-C = C-结合或直链，R 2是直链或支链饱和烷基具有1至7个碳原子，R3是游离或功能可转化的羟基，并且在R1是氢的情况下，其与生理上可接受的碱的盐。

4. 发明申请

WO1986005488A1 9-HALOGENPROSTAGLANDINES, PROCESS FOR THEIR MANUFACTURE 审中-公开
标题翻译： 9-HALOGENPROSTAGLANDINES，其制造方法
公开(公告)号：WO1986005488A1
公开(公告)日：1986-09-25
申请号：PCT/DE1986000122
申请日：1986-03-19
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , RADÜCHEL, Bernd , SKUBALLA, Werner , VORBRÜGGEN, Helmut , LOGE, Olaf , SCHILLINGER, Ekkehard
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： C07C177/00
CPC分类号： C07C405/00
摘要： 9-Halogen-15-cycloalkyl-prostaglandine derivates of formula (I), wherein R1 signifies hydrogen or methyl, R2 signifies fluorine or chlorine, n signifies 0 or 1, and, if R1 signifies hydrogen, their salts with physiologically tolerable bases, or their cyclodextrinclathrates. Process for their manufacture and their pharmaceutical use.
摘要翻译：式（I）的9-卤代-15-环烷基 - 前列腺素衍生物，其中R1表示氢或甲基，R2表示氟或氯，n表示0或1，如果R1表示氢，则表示其与生理上可耐受的碱的盐，或他们的环糊精。其制造及其制药用途。

5. 发明申请

WO1986004504A1 9-HALOGEN PROSTAGLANDINE CLATHRATES AND UTILIZATION THEREOF AS DRUGS 审中-公开
标题翻译： 9-HALOGEN PROSTAGLANDINE CLATHRATES和其作为药物的利用
公开(公告)号：WO1986004504A1
公开(公告)日：1986-08-14
申请号：PCT/DE1986000039
申请日：1986-02-04
申请人： SCHERING AKTIENGESELLSCHAFT , RADÜCHEL, Bernd , SKUBALLA, Werner , LOGE, Olaf , TACK, Johann-Wilhelm
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/557
CPC分类号： B82Y5/00 , A61K31/557 , A61K47/6951 , C08B37/0015
摘要： Pharmaceutical preparations are characterized in that they contain as active compound cyclodextrine clathrate of prostaglandine having the general formula (I), wherein R1 is a hydrogen atom or a straight or branched chain alkyl radical having up to 10 atoms of carbon, R2 is an alkyl, cycloalkyl, or optionally substituted phenyl group, A and B form together a direct bound or A is a straight or branched chain alkyl group having up to 10 atoms of carbon and B is an oxygen atom, a direct bound or -C = C bound and X is a chlorine or fluorine atom.
摘要翻译：药物制剂的特征在于它们含有具有通式（I）的前列腺素的活性化合物环糊精包合物，其中R 1是氢原子或具有至多10个碳原子的直链或支链烷基，R 2是烷基，环烷基或任选取代的苯基，A和B一起形成直接键合或A是具有至多10个碳原子的直链或支链烷基，B是氧原子，直接键合或-C = C键合， X是氯或氟原子。

6. 发明申请

WO1985004656A1 NEW 9-HALOGEN-PROSTAGLANDINE 审中-公开
标题翻译：新的9-HALOGEN-PROSTAGLANDINE
公开(公告)号：WO1985004656A1
公开(公告)日：1985-10-24
申请号：PCT/DE1985000120
申请日：1985-04-12
申请人： SCHERING AKTIENGESELLSCHAFT , RADÜCHEL, Bernd , SKUBALLA, Werner , VORBRÜGGEN, Helmut , LOGE, Olaf , ELGER, Walter
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C177/00
CPC分类号： C07C405/0016 , C07C405/00 , C07C405/0033 , C07C405/0041
摘要： 9-halogen-prostane having the formula (I) wherein Hal represents a chlorine or fluorine atom in position alpha or beta; R1 represents the rest CH2OH or the formula (A) with R2 representing a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic rest or R1 represents the rest of formula (B) with R3 representing an acid rest or the rest R2; A is a group -CH2-CH2-, -CH=CH- trans or -C=C-; W is free or functionally transformed hydroxy methylene group or a free or functionally transformed group having the formula (C), the group OH susceptible of being in position alpha or beta; D and E represent together a direct bound or D represents a straight branched or cyclic chain alkylene group with 1 to 10 atoms of carbon, substituted optionally by fluorine atoms, and E represents oxygen or sulfur, a direction bound, a bound -C=C- or a group -CR6=CR7, R6 and R7 being different and representing hydrogen, chlorine or alkyl with 1 to 4 atoms of carbon; R4 is a free or functionally modified hydroxy group; R5 is a hydrogen atom, an alkyl, a halogen-substituted alkyl, a cycloalkyl, an optionally substituted aryl or a heterocyclic group; as well as, if R2 represents a hydrogen atom, the salts thereof with physiologically acceptable bases, the preparation process thereof and the pharmaceutical utilization thereof.

7. 发明申请

WO1985002841A1 9-HALOGEN-'DELTA'2-PROSTAGLANDINE DERIVATIVES, PREPARATION PROCESS AND UTILIZATION THEREOF AS DRUGS 审中-公开
标题翻译： 9-恶嗪-2β-丙氨酸衍生物，其制备方法和作为药物的利用
公开(公告)号：WO1985002841A1
公开(公告)日：1985-07-04
申请号：PCT/DE1984000280
申请日：1984-12-21
申请人： SCHERING AKTIENGESELLSCHAFT , SKUBALLA, Werner , RADÜCHEL, Bernd , VORBÜGGEN, Helmut , ELGER, Walter , LOGE, Olaf
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C177/00
CPC分类号： C07C405/0041 , C07C405/00
摘要： 9-halogen- DELTA -prostaglandine derivatives having the general formula (I), wherein Hal may be a fluorine or chlorine atom in alpha or beta position; R1 may be the rest OR2, R2 being a hydrogen atom, an alkyl, a cycloalkyl, an aryl or a heterocyclic rest, or the rest NHR3, R3 being an acid rest or the rest R2; A may represent a group -CH2-CH2- or cis-CH=CH-; B may represent -CH2-CH2-, trans-CH=CH- or -C=C-; W may represent a free or functionally modified hydroxymethylene or group, the respective OH groups being in position alpha or beta ; D and E may represent together a direct bound or D may represent a straight or branched chain alkylene group with 1 to 10 atoms of carbon, which may optionally be substituted by fluorine atoms; E may represent an oxygen atom or sulphur, a direct bound, -C=C- bound or a group -CR6=CR7, R6 representing an hydrogen atom or an alkyl group and R7 representing an oxygen atom, an alkyl group or a halogen atom; R4 is a free or functionally modified hydroxy group; R5 represents an oxygen atom, an alkyl group, an halogen substituted alkyl, cycloalkyl, aryl optionally substituted or a heterocyclic group and, if R2 is a hydrogen atom, the salts thereof with physiologically acceptable bases.
摘要翻译：具有通式（I）的9-卤素-Δta-前列环素衍生物，其中Hal可以是α或β位的氟或氯原子; R 1可以是其余的OR 2，R 2是氢原子，烷基，环烷基，芳基或杂环基，或其余的NHR 3，R 3是酸基或其余的R 2; A可以表示基团-CH 2 -CH 2 - 或顺式-CH = CH-; B可以表示-CH 2 -CH 2 - ，反式-CH = CH-或-C = C-; W可以代表游离或官能改性的羟基亚甲基或基团，各个OH基团位于α或β位置; D和E可以一起代表直接键合，或者D可以表示具有1-10个碳原子的直链或支链亚烷基，该烷基可以任选被氟原子取代; E可以表示氧原子或硫，直接键合-C = C-结合或基团-CR 6 = CR 7，R 6表示氢原子或烷基，R 7表示氧原子，烷基或卤素原子 ; R4是游离或官能改性的羟基; R5表示氧原子，烷基，卤素取代的烷基，环烷基，任选取代的芳基或杂环基，如果R2是氢原子，则其与生理上可接受的碱的盐。

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