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1. 发明申请

WO2020132190A1 ANTIBODIES SPECIFIC TO MUC18 审中-公开
公开(公告)号：WO2020132190A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/067387
申请日：2019-12-19
申请人： MULTITUDE INC. , LIU, Shu-Hui
发明人： LIU, Shu-Hui , HOU, Bing , CHEN, Peng , LIU, Junli , MENG, Xun
IPC分类号： C07K16/30 , C07K16/28 , C07K16/18
摘要： Antibodies specific to MUC18 ( a.k.a. MCAM or CD146) and uses thereof for therapeutic and diagnostic purposes are provided. Also provided herein are chimeric antigen receptors (CARs) comprising an extracellular antigen-binding fragment that binds MUC18 and immune cells expressing such.

2. 发明申请

WO2020130157A1 KIT AND COSMETIC PROCESS USING MICRONEEDLE SHEET 审中-公开
公开(公告)号：WO2020130157A1
公开(公告)日：2020-06-25
申请号：PCT/JP2019/051644
申请日：2019-12-18
申请人： L'OREAL , LIU, Shu , AGARWAL, Gaurav
发明人： LIU, Shu , AGARWAL, Gaurav
IPC分类号： A61M37/00 , A61B5/15
摘要： The present invention relates to a kit comprising: at least one microneedle sheet comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; and at least one applicator comprising at least one application surface, wherein the substrate layer of the microneedle sheet is capable of being attached to the application surface of the applicator. The kit according to the present invention can allow a user to easily store an applicator for microneedles without breaking the microneedles.

3. 发明申请

WO2008067283A9 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2008067283A9
公开(公告)日：2008-07-17
申请号：PCT/US2007085585
申请日：2007-11-27
申请人： DIADEXUS INC , PAPKOFF JACKIE , DIEDRICH GUNDO , LIU SHU-HUI , NOWAKOWSKI AGNES
发明人： PAPKOFF JACKIE , DIEDRICH GUNDO , LIU SHU-HUI , NOWAKOWSKI AGNES
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.

4. 发明申请

WO2020132232A2 ANTIBODIES SPECIFIC TO MUC18 审中-公开
公开(公告)号：WO2020132232A2
公开(公告)日：2020-06-25
申请号：PCT/US2019/067457
申请日：2019-12-19
申请人： MULTITUDE INC. , LIU, Shu-hui
发明人： LIU, Shu-hui , HOU, Bing , CHENG, Guangcun , ZHANG, Shaofei , WANG, Na , MENG, Xun
IPC分类号： A61K47/68
摘要： Antibodies specific to MUC18 ( a.k.a . MCAM or CD146) and antibody-drug conjugates (ADCs) comprising such. Also provided herein are uses the the anti-MUC18 antibodies or ADCs for therapeutic and diagnostic purposes.

5. 发明申请

WO2011006072A3 CARDIOPROTECTIVE ROLE OF HEPATIC CELLS AND HEPATOCYTE SECRETORY FACTORS IN MYOCARDIAL ISCHEMIA 审中-公开
标题翻译：肝细胞和肝细胞分泌因子在心肌缺血中的心脏保护作用
公开(公告)号：WO2011006072A3
公开(公告)日：2011-05-19
申请号：PCT/US2010041534
申请日：2010-07-09
申请人： UNIV NORTHWESTERN , LIU SHU Q
发明人： LIU SHU Q
IPC分类号： A61K38/18 , A61K38/16 , A61K38/17 , A61P7/06 , A61P9/10 , C07K14/50 , C07K14/51
CPC分类号： A61K38/1709 , A61K35/407 , A61K38/1825 , A61K38/204 , A61K2300/00
摘要： The present invention provides methods, compositions, and systems for treating a subject at risk for, with, or suspected of having, myocardial ischemia using hepatocyte secretory factors (e.g., AGP2, BMPER, FGF21, NRG4, and/or TFF3) or using factors that promote liver cell migration to ischemic myocardial tissue (e.g.,IL-6 and/or MMP-2).
摘要翻译：本发明提供了使用肝细胞分泌因子（例如，AGP2，BMPER，FGF21，NRG4和/或TFF3）或利用因子治疗处于患心脏缺血的危险中，与或怀疑患有心肌缺血的受试者的方法，组合物和系统其促进肝细胞迁移至缺血性心肌组织（例如，IL-6和/或MMP-2）。

6. 发明申请

WO2008067283A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OVR110抗体组合物和使用方法
公开(公告)号：WO2008067283A2
公开(公告)日：2008-06-05
申请号：PCT/US2007085585
申请日：2007-11-27
申请人： DIADEXUS INC , PAPKOFF JACKIE , DIEDRICH GUNDO , LIU SHU-HUI , NOWAKOWSKI AGNES
发明人： PAPKOFF JACKIE , DIEDRICH GUNDO , LIU SHU-HUI , NOWAKOWSKI AGNES
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.
摘要翻译：提供了针对由头颈部，卵巢，子宫内膜，肾，胰腺，肺或乳腺癌表达的Ovr10的分离的抗体及其抗原结合片段。还提供了细胞和它们的制备方法以及它们用于杀死表达Ovr10的癌细胞和减轻或治疗哺乳动物中表达Ovr10的癌症的方法。抗Ovr10抗体在体外和体内结合由哺乳动物细胞表达的Ovr10时调节Ovr10功能或内化。还提供了包含抗Ovr10抗体和载体的组合物以及制品或其试剂盒。此外，提供了编码抗Ovr10抗体的分离的核酸，含有分离的核酸的表达载体和含有该载体的宿主细胞。

7. 发明申请

WO2007016590A2 OVR232V3 ANTIBODY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OVR232V3抗体组合物及其使用方法
公开(公告)号：WO2007016590A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/029995
申请日：2006-07-31
申请人： DIADEXUS, INC. , LIU, Shu-Hui , PAPKOFF, Jackie
发明人： LIU, Shu-Hui , PAPKOFF, Jackie
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/73 , C07K2317/77 , G01N33/5011 , G01N33/56966 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449 , G01N33/57492
摘要： The invention provides isolated anti-ovarian, colon, prostate, or lung cancer antigen (Ovr232v3) antibodies that bind to Ovr232v3 on a mammalian cell. The invention also encompasses compositions containing an anti-Ovr232v3 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr232v3 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr232v3 antibodies. The invention encompasses a method of producing the anti-Ovr232v3 antibodies. Other aspects of the invention are a method of killing an Ovr232v3-expressing cancer cell via contacting the cancer cell with an anti-Ovr232v3 antibody and a method of alleviating or treating an Ovr232v3 -expressing cancer in a mammal via administering a therapeutically effective amount of the anti-Ovr232v3 antibody to the mammal.
摘要翻译：本发明提供了结合哺乳动物细胞上的Ovr232v3的分离的抗卵巢，结肠，前列腺或肺癌抗原（Ovr232v3）抗体。本发明还包括含有抗Ovr232v3抗体和载体的组合物。这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Ovr232v3抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供产生抗Ovr232v3抗体的细胞。本发明包括产生抗Ovr232v3抗体的方法。本发明的其它方面是通过使癌细胞与抗Ovr232v3抗体接触来杀死表达Ovr232v3的癌细胞的方法，以及通过施用治疗有效量的哺乳动物缓解或治疗表达Ovr232v3的癌症的方法抗Ovr232v3抗体。

8. 发明申请

WO2003083049A2 CLONING AND CHARACTERIZATION OF G+C-RICH PROMOTER BINDING PROTEIN 审中-公开
标题翻译：克隆和表征G + C丰富的促蛋白结合蛋白
公开(公告)号：WO2003083049A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/007870
申请日：2003-03-17
申请人： MUNIN CORPORATION , YEUNG, Cho-Yau , HSU, Li-Chung , LIU, Shu
发明人： YEUNG, Cho-Yau , HSU, Li-Chung , LIU, Shu
IPC分类号： C12N
CPC分类号： C07K14/4702
摘要： The present disclosure pertains to the fields of Molecular Biology and Biotechnology, and more specifically to the field of Transcription Regulation. A novel transcription regulator of G+C rich promoters, the murine G+C rich Promoter Binding Protein (mGPBP) and its interaction pattern with other transcription factors are disclosed. A human homologue of mGPBP, hGPBP, is described as well.
摘要翻译：本公开涉及分子生物学和生物技术领域，更具体地涉及转录调控领域。公开了一种新型的G + C启动子转录调控因子，鼠G + C启动子结合蛋白（mGPBP）及其与其他转录因子的相互作用模式。也描述了mGPBP，hGPBP的人类同源物。

9. 发明申请

WO2021256214A1 KIT AND COSMETIC PROCESS USING MICRONEEDLE SHEET 审中-公开
公开(公告)号：WO2021256214A1
公开(公告)日：2021-12-23
申请号：PCT/JP2021/020314
申请日：2021-05-21
申请人： L'OREAL , AGARWAL, Gaurav , LIU Shu
发明人： AGARWAL, Gaurav , LIU Shu
IPC分类号： A61M37/00 , A61K8/06 , A61K8/73 , A61K2800/87 , A61K2800/91 , A61K8/735 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , A61M37/0015 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to a kit comprising: at least one microneedle sheet (1) comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; and a device comprising an applicator (2-3) comprising an application surface, a container (2-1) comprising a cosmetic composition and a valve, wherein the microneedle sheet (1) is capable being attached to the applicator (2-3) by attaching the substrate layer of the microneedle sheet to the application surface, the applicator (2-3), the container (2-1) and the valve are configured to supply the cosmetic composition via the valve onto the microneedle sheet (1). The kit according to the present invention can prevent the repeated use of microneedles (1), and can apply a cosmetic product in an easy and sanitary manner.

10. 发明申请

WO2016076442A1 MICRO-NEEDLE SHEET FOR REDUCING WRINKLES AND METHOD OF FORMING 审中-公开
标题翻译：用于减少皱纹的微针片和形成方法
公开(公告)号：WO2016076442A1
公开(公告)日：2016-05-19
申请号：PCT/JP2015/082633
申请日：2015-11-13
申请人： L'OREAL , LIU, Shu , OHNISHI, Kazuyuki
发明人： LIU, Shu , OHNISHI, Kazuyuki
IPC分类号： A61M37/00 , A61K9/00 , A61K8/02
CPC分类号： A61M37/0015 , A45D44/22 , A61K8/735 , A61K8/8164 , A61K8/85 , A61K8/86 , A61K9/0021 , A61K47/32 , A61K47/36 , A61K2800/805 , A61K2800/91 , A61M2037/0046 , A61M2037/0053 , A61M2205/0216 , A61M2207/00 , A61Q19/08 , B29C39/026 , B29K2033/00 , B29K2071/02 , B29K2105/0085 , B29L2031/7544
摘要： The present invention relates to a microneedle comprising a plurality of portions, wherein the plurality of portions comprise a distal end portion and a proximal end portion, at least two of the plurality of portions are made of different polymers, and the distal end portion is made of at least one polymer with high swellability and high viscoelasticity.
摘要翻译：本发明涉及一种包括多个部分的微针，其中所述多个部分包括远端部分和近端部分，所述多个部分中的至少两个部分由不同的聚合物制成，并且所述远端部分被制成的至少一种具有高溶胀性和高粘弹性的聚合物。

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