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1. 发明申请

WO2014149480A1 DIGITAL ASSAYS WITH A GENERIC REPORTER 审中-公开
标题翻译：一般报告人的数字测定
公开(公告)号：WO2014149480A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/018785
申请日：2014-02-26
申请人： BIO-RAD LABORATORIES, INC. , DO, Duc , LITTERST, Claudia , MAAR, Dianna
发明人： DO, Duc , LITTERST, Claudia , MAAR, Dianna
IPC分类号： C07H21/04
CPC分类号： C12Q1/6844 , C12Q1/686 , C12Q2537/143 , C12Q2565/119 , C12Q2527/143 , C12Q2545/101 , C12Q2563/159 , C12Q2563/173
摘要： Digital assay system, including methods, apparatus, and compositions, for assay of one or more targets in a set of partitions containing a generic reporter of target amplification. Digital assays generally rely on the ability to detect the presence or activity of individual copies of an analyte in a sample. In an exemplary digital assay, a sample is separated into a set of partitions, generally of equal volume, with each containing, on average, less than about one copy of the analyte.
摘要翻译：数字测定系统，包括方法，装置和组合物，用于在包含靶扩增的通用报告物的一组分区中测定一个或多个靶。数字测定通常依赖于检测样品中分析物的单个拷贝的存在或活性的能力。在示例性的数字测定中，将样品分成通常具有相等体积的一组分隔体，每个分隔物平均含有小于约一份的分析物。

2. 发明申请

WO2011059802A1 RAPID DETECTION OF MYCOPLASMA CONTAMINATION IN CELL CULTURE SAMPLES 审中-公开
标题翻译：在细胞培养物样品中快速检测MYCOPLASMA污染
公开(公告)号：WO2011059802A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/054658
申请日：2010-10-29
申请人： BIO-RAD LABORATORIES, INC. , LITTERST, Claudia , UGOZZOLI, Luis A.
发明人： LITTERST, Claudia , UGOZZOLI, Luis A.
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention provides for methods of detecting mycoplasma, for example in cell culture media.
摘要翻译：本发明提供了检测支原体的方法，例如在细胞培养基中。

3. 发明申请

WO2003006995A3 METHOD FOR IDENTIFYING SUBSTANCES WHICH MODULATE INTERLEUKIN 4 (IL-4) SIGNALING 审中-公开
公开(公告)号：WO2003006995A3
公开(公告)日：2003-01-23
申请号：PCT/EP2002/006920
申请日：2002-06-22
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , PFITZNER, Edith , LITTERST, Claudia
发明人： PFITZNER, Edith , LITTERST, Claudia
IPC分类号： G01N33/68
摘要： The present invention relates to a method to identify substances and a use of such substances which can modulate IL-4 dependent signaling involved in tumor diseases, preferably Hodgkin Lymphomas or inflammatory airway diseases, preferably asthma and a method for determining whether a substance can modulate the interaction of STAT6 with NCoA-1, characterized in that a) STAT6 or fragments or derivatives thereof having the ability to bind to NcoA-1 are brought into contact with NCoA-1 or fragments or derivatives of NCoA-1 having the ability to bind STAT6 under conditions where STAT6 and NCoA-1 or said fragments or derivatives are capable of forming a complex, and said complex can be used to induce a measurable readout; b) a readout is measured in the absence or presence of the substance of interest; c) the readout in absence of substance of interest is compared with readout in presence of substance of interest.

4. 发明申请

WO03006995A2 METHOD FOR IDENTIFYING SUBSTANCES WHICH MODULATE INTERLEUKIN 4 (IL-4) SIGNALING 审中-公开
标题翻译：用于鉴定调节性白细胞介素4（IL-4）信号的物质的方法
公开(公告)号：WO03006995A2
公开(公告)日：2003-01-23
申请号：PCT/EP0206920
申请日：2002-06-22
申请人： BOEHRINGER INGELHEIM INT , PFITZNER EDITH , LITTERST CLAUDIA
发明人： PFITZNER EDITH , LITTERST CLAUDIA
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P11/06 , A61P35/00 , C12N15/09 , C12Q1/02 , G01N33/68
CPC分类号： G01N33/6872 , G01N2500/02
摘要： The present invention relates to a method to identify substances and a use of such substances which can modulate IL-4 dependent signaling involved in tumor diseases, preferably Hodgkin Lymphomas or inflammatory airway diseases, preferably asthma and a method for determining whether a substance can modulate the interaction of STAT6 with NCoA-1, characterized in that a) STAT6 or fragments or derivatives thereof having the ability to bind to NcoA-1 are brought into contact with NCoA-1 or fragments or derivatives of NCoA-1 having the ability to bind STAT6 under conditions where STAT6 and NCoA-1 or said fragments or derivatives are capable of forming a complex, and said complex can be used to induce a measurable readout; b) a readout is measured in the absence or presence of the substance of interest; c) the readout in absence of substance of interest is compared with readout in presence of substance of interest.
摘要翻译：本发明涉及一种鉴定物质的方法以及可调节涉及肿瘤疾病，优选霍奇金淋巴瘤或炎性气道疾病（优选哮喘）的IL-4依赖性信号的物质的用途，以及用于确定物质是否可调制 STAT6与NCoA-1的相互作用，其特征在于a）具有结合NcoA-1能力的STAT6或其片段或衍生物与NCoA-1或具有结合STAT6能力的NCoA-1的片段或衍生物接触在STAT6和NCoA-1或所述片段或衍生物能够形成复合物的条件下，所述复合物可用于诱导可测量的读数; b）在不存在或存在感兴趣物质的情况下测量读数; c）在不存在感兴趣物质的情况下的读数与在感兴趣的物质存在下的读数进行比较。

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