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1. 发明申请

WO2007002053A2 NEEDLED PHARMACEUTICAL DELIVERY DEVICE WITH TRIGGERED AUTOMATIC NEEDLE INSERTION AND MANUALLY CONTROLLED PHARMACEUTICAL INJECTION 审中-公开
标题翻译：具有触发自动针插入和手动控制药物注射的需要的药物输送装置
公开(公告)号：WO2007002053A2
公开(公告)日：2007-01-04
申请号：PCT/US2006023930
申请日：2006-06-19
申请人： LILLY CO ELI , BISHOP STEVEN , JAMES ADRIAN BENTON , LAI JOHN W , LISTER ROBERT IAN , SERPIELLO NANCY J
发明人： BISHOP STEVEN , JAMES ADRIAN BENTON , LAI JOHN W , LISTER ROBERT IAN , SERPIELLO NANCY J
IPC分类号： A61M5/34 , A61M5/20
CPC分类号： A61M5/3287 , A61M5/24 , A61M2005/2407 , A61M2005/2488 , A61M2005/2492 , A61M2005/31508
摘要： A pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection. The pharmaceutical delivery device includes a housing, a pharmaceutical containing needled syringe having an injection tip that is recessed within the housing when the syringe is in a first position and which projects from the housing when the syringe is in a second position, a syringe advancing assembly operable to automatically advance the needled syringe from the first position to the second position, a plunger including an input portion projecting from the housing for manual access by a user, wherein the plunger is operable by the user directly shifting the input portion when the syringe is disposed in the second position to inject pharmaceutical from the syringe through the needle at a rate a djustably controlled by a user during the injection, and wherein the plunger includes a plunger extender automatically movable within the housing from a first location to a second location upon the needled syringe advancing from the first position to the second position, wherein the plunger extender, when in the second location, occupies a space vacated by the needled syringe during advancement from the first position to the second position, whereby the plunger input portion remains stationary relative to the housing during the advancement of the needled syringe.
摘要翻译：具有触发自动针插入和手动控制药物注射的药物输送装置。药物输送装置包括壳体，药物含有针刺注射器，其具有当注射器处于第一位置时凹入到壳体内并且当注射器处于第二位置时从壳体突出的注射尖端;注射器前进组件可操作地将针刺注射器自动地从第一位置推进到第二位置;柱塞，其包括从壳体突出以便用户手动接近的输入部分，其中当注射器是注射器时，柱塞可由用户直接移动输入部分设置在第二位置以通过注射器以注射器的剂量以使用者可调节地控制的速率从注射器注射药物，并且其中柱塞包括可在壳体内自动移动的柱塞延伸器，从第一位置到第二位置针刺注射器从第一位置推进到第二位置，其中柱塞e 当处于第二位置时，xtender占据由针刺注射器在从第一位置到第二位置前进期间腾出的空间，由此柱塞输入部分在针刺注射器的推进期间相对于壳体保持静止。

2. 发明申请

WO2008112472A3 DELAY MECHANISM FOR AUTOMATIC INJECTION DEVICE 审中-公开
标题翻译：自动注射装置延时机构
公开(公告)号：WO2008112472A3
公开(公告)日：2008-11-20
申请号：PCT/US2008055892
申请日：2008-03-05
申请人： LILLY CO ELI , JAMES ADRIAN BENTON , LISTER ROBERT IAN , SILBERSCHATZ PAUL JOSEPH , MASON BRIAN JOSEPH
发明人： JAMES ADRIAN BENTON , LISTER ROBERT IAN , SILBERSCHATZ PAUL JOSEPH , MASON BRIAN JOSEPH
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/2033 , A61M5/3202 , A61M5/3204 , A61M5/326 , A61M2005/206 , A61M2005/2073 , A61M2005/3143
摘要： A delay mechanism for staging the operation of an automatic injection apparatus (20) to ensure medication contents are properly delivered prior to the needled syringe (32) of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (50), a follower (110), a locking member, a damping compound, and a driver and a driver biasing element (44). The shuttle is for a needled syringe of the apparatus and includes a first latching element. The follower includes a second latching element and a cammable surface, which second latching element is for cooperating with the first latching element to limit motion of the shuttle relative to the follower in a second direction opposite the first direction. The locking member is movable from a locking position to a release position by engagement with the syringe plunger during an injection, the locking member, when in the locking position, preventing rotation of the follower relative to the shuttle, the locking member, when in the release position, allowing rotation of the follower relative to the shuttle. The damping compound is between the follower and a supporting surface to dampen rotation of the follower relative to the shuttle. The driver is rotatably fixed relative to the shuttle and includes a camming surface. The shuttle allowing retracting of the syringe needle into the housing of the automatic injection apparatus after injection.
摘要翻译：用于分级自动注射装置（20）的操作以确保药物内容物的操作的延迟机构在装置的针刺注射器（32）缩回之前被适当地递送。在一种形式中，延迟机构包括梭（50），从动件（110），锁定构件，阻尼组件以及驱动器和驱动器偏置元件（44）。梭子是针对该设备的针刺注射器，并且包括第一闭锁元件。从动件包括第二闭锁元件和可雕刻表面，该第二闩锁元件用于与第一闩锁元件配合，以在与第一方向相反的第二方向上相对于从动件限制梭的运动。锁定构件通过在注射期间与注射器柱塞接合而可从锁定位置移动到释放位置，当处于锁定位置时，锁定构件防止随动件相对于梭子的旋转，锁定构件当处于释放位置，允许从动件相对于梭子的旋转。阻尼复合物在从动件和支撑表面之间，以阻尼从动件相对于梭子的转动。驱动器相对于梭子可旋转地固定并且包括凸轮表面。穿梭器允许注射器针头在注射后将注射器针头缩回到自动注射装置的壳体中。

3. 发明申请

WO2007002052A8 APPARATUS AND METHOD FOR INJECTING A PHARMACEUTICAL 审中-公开
标题翻译：用于注射药物的装置和方法
公开(公告)号：WO2007002052A8
公开(公告)日：2008-05-29
申请号：PCT/US2006023929
申请日：2006-06-19
申请人： LILLY CO ELI , BISHOP STEVEN , JAMES ADRIAN BENTON , LAI JOHN W , LISTER ROBERT IAN , SERPIELLO NANCY J
发明人： BISHOP STEVEN , JAMES ADRIAN BENTON , LAI JOHN W , LISTER ROBERT IAN , SERPIELLO NANCY J
IPC分类号： A61M5/42 , A61M5/20
CPC分类号： A61M5/2033 , A61M5/42 , A61M2005/206 , A61M2005/2073 , A61M2005/2086 , A61M2205/584 , A61M2205/586

4. 发明申请

WO2007002053A3 NEEDLED PHARMACEUTICAL DELIVERY DEVICE WITH TRIGGERED AUTOMATIC NEEDLE INSERTION AND MANUALLY CONTROLLED PHARMACEUTICAL INJECTION 审中-公开
公开(公告)号：WO2007002053A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/023930
申请日：2006-06-19
申请人： ELI LILLY AND COMPANY , BISHOP, Steven , JAMES, Adrian, Benton , LAI, John, W. , LISTER, Robert, Ian , SERPIELLO, Nancy, J.
发明人： BISHOP, Steven , JAMES, Adrian, Benton , LAI, John, W. , LISTER, Robert, Ian , SERPIELLO, Nancy, J.
IPC分类号： A61M5/34 , A61M5/20
摘要： A pharmaceutical delivery device (20) with triggered automatic needle insertion and manually controlled pharmaceutical injection. The pharmaceutical delivery device includes a housing (22), a pharmaceutical containing needled syringe (110) having an injection tip that is recessed within the housing when the syringe is in a first position and which projects from the housing when the syringe is in a second position, a plunger (40) including an input portion projecting from the housing for manual access by a user, wherein the plunger is operable by the user directly shifting the input portion when the syringe is disposed in the second position to inject pharmaceutical from the syringe through the needle at a rate adjustably controlled by a user during the injection, and wherein the plunger includes a plunger extender (60) automatically movable within the housing from a first location to a second location upon the needled syringe advancing from the first position to the second position, wherein the plunger extender, when in the second location, occupies a space vacated by the needled syringe during advancement from the first position to the second position, whereby the plunger input portion remains stationary.

5. 发明申请

WO2007047200A1 APPARATUS FOR INJECTING A PHARMACEUTICAL 审中-公开
标题翻译：用于注射药物的装置
公开(公告)号：WO2007047200A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/039390
申请日：2006-10-10
申请人： ELI LILLY AND COMPANY , JAMES, Adrian, Benton , LISTER, Robert, Ian , MACDONALD, Peter, Scott
发明人： JAMES, Adrian, Benton , LISTER, Robert, Ian , MACDONALD, Peter, Scott
IPC分类号： A61M5/20 , A61M5/42 , A61M5/32
CPC分类号： A61M5/3287 , A61M5/3134 , A61M5/3202 , A61M5/3204 , A61M5/3243 , A61M5/42 , A61M2005/3215 , A61M2005/3247
摘要： A pharmaceutical delivery apparatus including a housing (22) , a syringe assembly, and a needle (44) cap. The syringe assembly is plungeable relative to the housing from a first position, at which its needle tip is disposed within the housing, to a second position, at which its needle tip projects from the housing beyond the proximal end for insertion into an injection site. A base (46) of the needle cap is exposed at the housing proximal end to be manually grippable for cap removal. A needle cap stem is upstanding from the base and sized and configured to insert through an opening is the housing proximal end to cover the needle tip when the syringe assembly is disposed in the first position. The needle cap base further includes a plurality of distally projecting cams (54, 258) located radially outward of the stem. The cams are fittable within slots (40, 240) in the housing proximal end when the cap is fully mounted to the apparatus.
摘要翻译：一种药物输送装置，包括壳体（22），注射器组件和针（44）盖。注射器组件相对于壳体可从第一位置（其针尖位于壳体内）设置到第二位置，第二位置处，针尖从壳体突出超过近端以插入注射部位。针帽的底座（46）在壳体近端处露出，以便手动地夹持以移除盖。针头杆从基座直立，并且其尺寸和构造成通过开口插入，即当注射器组件设置在第一位置时，壳体近端覆盖针尖。针帽基座还包括多个位于杆的径向外侧的向远侧突出的凸轮（54,258）。当盖完全安装到设备上时，凸轮可装配在壳体近端的狭槽（40,240）内。

6. 发明申请

WO2007002052A2 APPARATUS AND METHOD FOR INJECTING A PHARMACEUTICAL 审中-公开
标题翻译：用于注射药物的装置和方法
公开(公告)号：WO2007002052A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/023929
申请日：2006-06-19
申请人： ELI LILLY AND COMPANY , BISHOP, Steven , JAMES, Adrian, Benton , LAI, John , W. , LISTER, Robert, Ian , SERPIELLO, Nancy, J.
发明人： BISHOP, Steven , JAMES, Adrian, Benton , LAI, John , W. , LISTER, Robert, Ian , SERPIELLO, Nancy, J.
IPC分类号： A61M5/42 , A61M5/20
CPC分类号： A61M5/2033 , A61M5/42 , A61M2005/206 , A61M2005/2073 , A61M2005/2086 , A61M2205/584 , A61M2205/586
摘要： A method and apparatus for administering a pharmaceutical. The method employs a delivery device including a housing, a pharmaceutical containing needled syringe movable within the housing, an activation button disposed at one of the housing, and wherein the housing is flared radially outward at the other end and designed to allow visibility of the needled syringe. A skin-contacting surface of the housing at the flared end is designed to limit slippage along the skin, and at least one injection targeting guide is provided. When the device is sited for injection, and without pressing the delivery device housing toward the injection site with any predetermined force by the one hand holding the housing, the activation button may be plunged with the other hand toward the housing to trigger an advancing assembly within the device that first automatically advances the needled syringe to insert a needle into the injection site, and that second automatically advances the syringe piston to force pharmaceutical through the inserted needle.
摘要翻译：一种用于给予药物的方法和装置。该方法采用一种输送装置，该装置包括壳体，可在壳体内移动的含有针刺注射器的药物，设置在壳体中的一个上的致动按钮，并且其中壳体在另一端径向向外张开并设计成允许针刺注射器。外壳在扩口端的与皮肤接触的表面被设计成限制沿着皮肤的滑动，并且提供至少一个注射瞄准引导件。当设备位于注射位置时，并且通过一方面握住壳体而以任何预定的力将输送装置壳体朝向注射部位压紧时，另一只手可以朝向壳体突入以触发前进组件该装置首先自动前进针头注射器以将针头插入注射部位，并且该装置自动前进注射器活塞以迫使药物通过插入的针。

7. 发明申请

WO2008112472A2 DELAY MECHANISM FOR AUTOMATIC INJECTION DEVICE 审中-公开
标题翻译：自动注射装置延时机构
公开(公告)号：WO2008112472A2
公开(公告)日：2008-09-18
申请号：PCT/US2008/055892
申请日：2008-03-05
申请人： ELI LILLY AND COMPANY , JAMES, Adrian, Benton , LISTER, Robert, Ian , SILBERSCHATZ, Paul, Joseph , MASON, Brian, Joseph
发明人： JAMES, Adrian, Benton , LISTER, Robert, Ian , SILBERSCHATZ, Paul, Joseph , MASON, Brian, Joseph
IPC分类号： A61M5/20
CPC分类号： A61M5/2033 , A61M5/3202 , A61M5/3204 , A61M5/326 , A61M2005/206 , A61M2005/2073 , A61M2005/3143
摘要： A delay mechanism for staging the operation of an automatic injection apparatus to ensure medication contents are properly delivered prior to the needled syringe of the apparatus being retracted. In one form, the delay mechanism includes a shuttle, a follower, a locking member, a damping compound, and a driver and a driver biasing element. The shuttle is for a needled syringe of the apparatus and includes a first latching element. The follower includes a second latching element and a cammable surface, which second latching element is for cooperating with the first latching element to limit motion of the shuttle relative to the follower in a second direction opposite the first direction. The locking member is movable from a locking position to a release position by engagement with the syringe plunger during an injection, the locking member, when in the locking position, preventing rotation of the follower relative to the shuttle, the locking member, when in the release position, allowing rotation of the follower relative to the shuttle. The damping compound is between the follower and a supporting surface to dampen rotation of the follower relative to the shuttle. The driver is rotatably fixed relative to the shuttle and includes a camming surface. The driver biasing element is for forcing the driver from a first position to a second position when the locking member moves to the release position, whereby during movement of the driver to the second position, the driver camming surface engages the follower cammable surface to force the follower to rotate relative to the shuttle from a latching position, at which the first and second latching elements cooperate, to an unlatching position, at which the second latching element is disengaged from the first latching element to allow movement of the shuttle for retracting the syringe needle into the housing of the automatic injection apparatus after injection. X-17598
摘要翻译：用于分级自动注射装置的操作以确保药物内容物的延迟机构在装置的针刺注射器被收回之前被适当地递送。在一种形式中，延迟机构包括梭子，从动件，锁定构件，阻尼构件以及驱动器和驱动器偏置元件。梭子是针对该设备的针刺注射器，并且包括第一闭锁元件。从动件包括第二闩锁元件和可视表面，该第二闩锁元件用于与第一闩锁元件配合，以在与第一方向相反的第二方向上限制梭相对于从动件的运动。锁定构件可在注射期间通过与注射器柱塞的接合而从锁定位置移动到释放位置，当处于锁定位置时，锁定构件防止随动件相对于梭子的旋转，当处于锁定位置时释放位置，允许从动件相对于梭子的旋转。阻尼复合物在从动件和支撑表面之间，以阻尼从动件相对于梭的转动。驱动器相对于梭子可旋转地固定并且包括凸轮表面。当锁定构件移动到释放位置时，驾驶员偏置元件用于迫使驾驶员从第一位置到第二位置，由此在驾驶员移动到第二位置时，驾驶员凸轮表面接合随动可调表面以迫使驾驶员随动件相对于梭子相对于第一和第二闩锁元件协作的闩锁位置旋转到解锁位置，第二闩锁元件与第一闩锁元件脱离第一闩锁元件，以允许梭子的移动以缩回注射器针头注入注射器后进入自动注射装置的外壳。 X-17598

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