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1. 发明申请

WO2008006102A3 USE OF RETRO-ALDOL REACTION TO GENERATE REACTIVE VINYL KETONE FOR ATTACHMENT TO ANITIBODY MOLECULES BY MICHAEL ADDITION REACTION FOR USE IN IMMUNOSTAINING AND IMMUNOTARGETING 审中-公开
公开(公告)号：WO2008006102A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/073046
申请日：2007-07-09
申请人： THE SCRIPPS RESEARCH INSTITUTE , SINHA, Subhash, C. , BARBAS, Carlos, F., III , LERNER, Richard, A.
发明人： SINHA, Subhash, C. , BARBAS, Carlos, F., III , LERNER, Richard, A.
IPC分类号： C12P7/26 , C07K16/00 , C12N9/02
摘要： The present invention is directed to methods for formation of a chemically programmed antibody comprising the steps of: (1) reacting a conjugate comprising a signal module covalently linked to a proadapter with a catalytic moiety selected from the group consisting of a catalytic antibody and a Fab fragment of a catalytic antibody, wherein the proadapter includes therein a precursor to a reactive moiety activated to a reactive moiety by a reaction catalyzed by the catalytic moiety; and (2) crosslinking the reactive moiety to a side chain of an amino acid residue in the active site of the catalytic moiety to produce the chemically programmed antibody. The invention also encompasses chemically programmed antibodies formed by these methods, methods for their use, and pharmaceutical compositions, as well as proadaptors and conjugates including them. Chemically programmed antibodies are useful for the treatment of cancer, particularly in metastasis.

2. 发明申请

WO2003059251A3 ANTIBODY TARGETING COMPOUNDS 审中-公开
公开(公告)号：WO2003059251A3
公开(公告)日：2003-07-24
申请号：PCT/US2002/033991
申请日：2002-10-22
申请人： THE SCRIPPS RESEARCH INSTITUTE , BARBAS, Carlos, F. , RADER, Christoph , SINHA, Subhash, C. , LERNER, Richard
发明人： BARBAS, Carlos, F. , RADER, Christoph , SINHA, Subhash, C. , LERNER, Richard
IPC分类号： A61K39/395
摘要： The present invention provides antibody targeting compounds in which the specificity of the antibody has been reprogrammed by covalently or noncovalently linking a targeting agent to the combining site of an antibody. By this approach, the covalently modified antibody takes on the binding specificity of the targeting agent. The compound may have biological activity provided by the targeting agent or by a separate biological agent. Various uses of the invention compounds are provided.

3. 发明申请

WO1995011317A1 SYNTHETIC HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS 审中-公开
标题翻译：人类免疫缺陷病毒合成人单核细胞抗体
公开(公告)号：WO1995011317A1
公开(公告)日：1995-04-27
申请号：PCT/US1994011907
申请日：1994-10-19
申请人： THE SCRIPPS RESEARCH INSTITUTE , BARBAS, Carlos, F. , BURTON, Dennis, R. , LERNER, Richard, A.
发明人： THE SCRIPPS RESEARCH INSTITUTE
IPC分类号： C12Q01/70
CPC分类号： C07K16/1063 , A61K49/00 , C07K2319/00 , G01N33/56988 , Y10S435/975
摘要： The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization ability to gp120. Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell lines for producing the monoclonal antibodies.
摘要翻译：本发明描述了与人免疫缺陷病毒（HIV）免疫反应和中和的合成人单克隆抗体。本发明的合成单克隆抗体对gp120表现出增强的结合亲和力和中和能力。还公开了使用单克隆抗体的免疫治疗和诊断方法，以及用于产生单克隆抗体的细胞系。

4. 发明申请

WO2015095511A3 FUNCTIONAL ANTIBODIES THAT MODULATE CELL DEATH AND RELATED METHODS 审中-公开
公开(公告)号：WO2015095511A3
公开(公告)日：2015-06-25
申请号：PCT/US2014/071136
申请日：2014-12-18
申请人： THE SCRIPPS RESEARCH INSTITUTE , LERNER, Richard, A. , XIE, Jia , ZHANG, Hongkai
发明人： LERNER, Richard, A. , XIE, Jia , ZHANG, Hongkai
IPC分类号： A61K39/00 , C12P21/08 , C12N5/02 , C40B40/02 , G01N33/566 , C07H21/04
摘要： The invention provides methods for identifying antibody modulators of cell death from an intracellularly expressed library of intrabodies or membrane-tethered antibodies. The antibody modulators can promote or inhibit death of various target cells (e.g., tumor cells or neurons). Also provided in the invention are specific functional antibodies which can prevent death of cells caused by viral infections, as well as therapeutic applications of the antibodies. Further provided in the invention are polynucleotide sequences and vectors for expressing the functional antibodies disclosed herein.

5. 发明申请

WO2014035693A3 METHODS AND COMPOSITIONS RELATED TO MODULATORS OF EUKARYOTIC CELLS 审中-公开
标题翻译：与真核细胞调节剂相关的方法和组合物
公开(公告)号：WO2014035693A3
公开(公告)日：2014-04-24
申请号：PCT/US2013055362
申请日：2013-08-16
申请人： SCRIPPS RESEARCH INST , ZHANG HONGKAI , WILSON IAN A , LERNER RICHARD A
发明人： ZHANG HONGKAI , WILSON IAN A , LERNER RICHARD A
IPC分类号： C40B50/06 , C12N5/00 , C12P21/06
CPC分类号： C07K16/2863 , C07K14/71 , C07K14/7153 , C07K16/2839 , C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/622 , C07K2317/74 , C07K2317/75 , C07K2317/92 , C07K2319/30 , C40B30/06 , G01N33/6845 , G01N33/6854 , G01N33/746
摘要： Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.
摘要翻译：通过在真核细胞内表达潜在激动剂的组合文库，然后直接选择靶分子的激动剂来鉴定真核细胞的蛋白质调节剂的方法。一些方法涉及共培养表达潜在激动剂和第二细胞的组合文库的细胞，然后选择调节第二细胞中表型或期望细胞应答的药剂。优选地，激动剂是引入起始细胞中并在起始细胞中表达的抗体，例如激动剂抗EpoR，抗TpoR或G-CSFR抗体。还公开了从组合抗体文库中选择可以调节细胞表型的双特异性抗体的方法。

6. 发明申请

WO2014035693A2 METHODS AND COMPOSITIONS RELATED TO MODULATORS OF EUKARYOTIC CELLS 审中-公开
标题翻译：与真核细胞调节剂相关的方法和组合物
公开(公告)号：WO2014035693A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/055362
申请日：2013-08-16
申请人： THE SCRIPPS RESEARCH INSTITUTE , ZHANG, Hongkai , WILSON, Ian, A. , LERNER, Richard, A.
发明人： ZHANG, Hongkai , WILSON, Ian, A. , LERNER, Richard, A.
IPC分类号： C40B30/06
CPC分类号： C07K16/2863 , C07K14/71 , C07K14/7153 , C07K16/2839 , C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/622 , C07K2317/74 , C07K2317/75 , C07K2317/92 , C07K2319/30 , C40B30/06 , G01N33/6845 , G01N33/6854 , G01N33/746
摘要： The invention provides methods for identifying protein modulators (e.g., antibody agonists) of eukaryotic cells. The methods typically involve expressing a combinatorial agent library (e.g., via lentiviral vectors) inside a eukaryotic cell type (e.g., a mammalian cell) and then directly selecting for agents (e.g., antibodies) that are agonist, of a target molecule (e.g.,. a signaling receptor) that modulates a phenotype of or elicits a cellular response in the cell. Some related methods involve co-culturing a cell expressing a combinatorial agent library and a second cell, and then selecting agents that modulate a phenotype of or elicit a cellular response in the second cell. Preferably, the agents are antibodies and are introduced into and expressed in the starting cells under conditions each individual cell expresses no more than 3 different members of the antibody library. In addition, the invention provides methods for identifying protein agonists that capable of reprograming or trans-differentiating a target cell. Also provided in the invention are specific agonist antibodies of signaling receptors or biomolecules that modulate a phenotype or effectuate a cellular response in a eukaryotic cell (e.g., agonist antibodies of EpoR, TpoR or G-CSFR). Further provided in the invention are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.
摘要翻译：本发明提供鉴定真核细胞的蛋白质调节剂（例如抗体激动剂）的方法。方法通常涉及在真核细胞类型（例如，哺乳动物细胞）内表达组合试剂文库（例如通过慢病毒载体），然后直接选择靶分子的激动剂（例如，抗体）（例如，一种信号受体），其调节细胞中的表型或引起细胞反应。一些相关方法涉及共培养表达组合试剂文库和第二细胞的细胞，然后选择调节第二细胞中表型或引起细胞应答的试剂。优选地，所述试剂是抗体，并且在每个单个细胞表达不超过3个抗体文库的不同成员的条件下被引入并在起始细胞中表达。此外，本发明提供了鉴定能够重新编程或反向分化靶细胞的蛋白质激动剂的方法。本发明还提供了调节表型或在真核细胞（例如EpoR，TpoR或G-CSFR的激动剂抗体）中调节细胞应答的信号传导受体或生物分子的特异性激动剂抗体。本发明还提供了从组合抗体文库中选择可以调节细胞表型的双特异性抗体的方法。

7. 发明申请

WO2014014897A2 IMMUNOGLOBULIN-BINDING HUMAN MYCOPLASMA ANTIGENS AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫组织结合人MYCOPLASMA抗原及其使用方法
公开(公告)号：WO2014014897A2
公开(公告)日：2014-01-23
申请号：PCT/US2013/050656
申请日：2013-07-16
申请人： THE SCRIPPS RESEARCH INSTITUTE , GROVER, Rajesh , LERNER, Richard , WILSON, Ian , ZHU, Xueyong
发明人： GROVER, Rajesh , LERNER, Richard , WILSON, Ian , ZHU, Xueyong
IPC分类号： C07K14/35 , C07K16/12 , A61K39/04 , A61K39/40 , A61P35/00
CPC分类号： C07K14/30 , A61K39/0241 , A61K39/04 , C07K14/35 , C07K16/1253 , C07K16/3061 , C07K2317/10 , C07K2317/55
摘要： Provided herein methods of alleviating the symptoms of multiple myeloma in a patient or subject in need thereof, methods of treating multiple myeloma in a patient or subject, and methods of preventing development of multiple myeloma in a patient at risk thereof, such as a patient with monoclonal gammopathy of undetermined significance (MGUS), which methods include administering an agent effective to treat a Mycoplasma infection. The invention also relates to a new class of antigen, MG281 protein {also referenced as Protein M), that binds to various immunoglobulins with high affinity, and their uses in purifying immunoglobulins. The invention additionally relates to using MG281 protein and analog or derivative molecules for treating autoimmune diseases. Further provided are antigens and antibodies for use in the disclosed methods, and the identification of molecules that bind to MG281 protein.
摘要翻译：本文提供减轻患者或受试者的多发性骨髓瘤症状的方法，治疗患者或受试者中的多发性骨髓瘤的方法，以及在患有风险的患者中预防多发性骨髓瘤发展的方法，例如具有具有未确定意义的单克隆丙种球蛋白病（MGUS），该方法包括施用有效治疗支原体感染的药剂。本发明还涉及以高亲和力结合各种免疫球蛋白的新一类抗原MG281蛋白（也称为蛋白M），以及它们在纯化免疫球蛋白中的用途。本发明还涉及使用MG281蛋白和类似物或衍生物分子来治疗自身免疫性疾病。还提供了用于所公开的方法中的抗原和抗体，以及鉴定结合MG281蛋白的分子。

8. 发明申请

WO2013115425A1 METHODS FOR SCREENING AN ANTIBODY BY ONE-CYCLE PANNING 审中-公开
标题翻译：通过单循环筛选筛选抗体的方法
公开(公告)号：WO2013115425A1
公开(公告)日：2013-08-08
申请号：PCT/KR2012/000934
申请日：2012-02-08
申请人： SCRIPPS KOREA ANTIBODY INSTITUTE , THE SCRIPPS RESEARCH INSTITUTE , ZHANG, Hongkai , LERNER, Richard A.
发明人： ZHANG, Hongkai , LERNER, Richard A.
IPC分类号： G01N33/53 , G01N33/543 , C12Q1/68
CPC分类号： C07K16/005 , C07K16/1063 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/565 , C07K2317/569 , C07K2317/622
摘要： The present invention relates to a method for screening an antibody specifically binding to a target antigen and a method for producing a polypeptide specifically binding to a target polypeptide. This method could be applied to select an antibody or polypeptide from a large collection of homologous or heterogeneous molecules that are contained in combinatorial libraries.
摘要翻译：本发明涉及用于筛选特异性结合靶抗原的抗体的方法和用于产生与靶多肽特异性结合的多肽的方法。该方法可用于从组合文库中包含的大量同源或异质分子中选择抗体或多肽。

9. 发明申请

WO2003090675A2 METHODS AND COMPOSITIONS USEFUL FOR TREATING PROSTATE CANCER 审中-公开
标题翻译：用于治疗前列腺癌的方法和组合物
公开(公告)号：WO2003090675A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/012392
申请日：2003-04-21
申请人： THE SCRIPPS RESEARCH INSTITUTE , LERNER, Richard A., , SAVEN, Alan
发明人： LERNER, Richard A., , SAVEN, Alan
IPC分类号： A61K
CPC分类号： A61K39/0011 , A61K38/4853 , A61K2039/6031
摘要： Immunopeptides are provided that are composed of a prostate specific antigen (PSA) coupled to an autoimmune tag, or a prostate specific polypeptide (PSP) coupled to an autoimmune tag. Pharmaceutical compositions containing the immunopeptides are provided. Methods to treat prostate cancer are also provided. Antibodies to the immunopeptides are provided.
摘要翻译：提供由与自身免疫标签偶联的前列腺特异性抗原（PSA）或与自身免疫标记偶联的前列腺特异性多肽（PSP）组成的免疫肽。提供含有免疫肽的药物组合物。还提供了治疗前列腺癌的方法。提供免疫肽的抗体。

10. 发明申请

WO0222573A3 METHODS AND COMPOSITIONS RELATING TO HYDROGEN PEROXIDE AND SUPEROXIDE PRODUCTION BY ANTIBODIES 审中-公开
标题翻译：与过氧化氢和抗氧化剂生产过程相关的方法和组合物
公开(公告)号：WO0222573A3
公开(公告)日：2003-10-02
申请号：PCT/US0129165
申请日：2001-09-17
申请人： SCRIPPS RESEARCH INST , WENTWORTH PAUL , WENTWORTH ANITA D , JONES LYN H , JANDA KIM D , LERNER RICHARD A
发明人： WENTWORTH PAUL , WENTWORTH ANITA D , JONES LYN H , JANDA KIM D , LERNER RICHARD A
IPC分类号： G01N33/50 , A61K9/127 , A61K31/05 , A61K31/19 , A61K31/352 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K35/12 , A61K35/76 , A61K38/06 , A61K38/44 , A61K38/45 , A61K39/395 , A61K45/00 , A61K45/06 , A61K48/00 , A61M35/00 , A61N5/06 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/00 , A61P13/08 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P25/32 , A61P25/34 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P39/06 , C07K16/32 , C12N15/09 , G01N33/15 , G01N33/53 , G01N33/543
CPC分类号： A61K38/45 , A61K31/05 , A61K31/19 , A61K31/352 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K38/06 , A61K38/44 , A61K38/446 , A61K45/06 , G01N33/53
摘要： The invention relates generally to the field of immunology. More specifically, the invention relates the finding that antibodies can generate superoxide and hydrogen peroxide from singlet oxygen. Accordingly, methods and compositions able to increase or decrease oxidative stress are provided. Also provided are screening assays to identify agents that modulate the ability of a antibody to generate superoxide and hydrogen peroxide. Such agents can be used therapeutically to treat patients in need. Further, the invention provides methods to use antibodies in immunoassays.
摘要翻译：本发明一般涉及免疫学领域。更具体地，本发明涉及抗体可以从单线态氧产生超氧化物和过氧化氢的发现。因此，提供了能够增加或减少氧化应激的方法和组合物。还提供了用于鉴定调节抗体产生超氧化物和过氧化氢的能力的试剂的筛选试验。这些药剂可用于治疗需要治疗的患者。此外，本发明提供了在免疫测定中使用抗体的方法。

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