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1. 发明申请

WO2008090329A1 WORKOUT GARMENT 审中-公开
标题翻译：工作服
公开(公告)号：WO2008090329A1
公开(公告)日：2008-07-31
申请号：PCT/GB2008/000215
申请日：2008-01-18
申请人： LEE, Maurice, Anthony , LEE, Leon, Patrick
发明人： LEE, Maurice, Anthony , LEE, Leon, Patrick
IPC分类号： A63B21/055 , A41D13/00
CPC分类号： A63B21/0552 , A41D13/0015 , A41D13/02 , A63B21/0555 , A63B21/4005 , A63B21/4011 , A63B21/4017 , A63B21/4021 , A63B21/4025
摘要： A workout garment comprises at least a shirt (10; 110) having a chest region (14; 114), a back region (16; 116), and a waist region (18; 118). The garment has a plurality of restrictor bands (24 to 30; 124 to 130) of elastic material extending, in use, over muscles of the body to be worked, whereby during activity involving movement which stretches said muscles the bands are stretched to provide resistance against said movement. The bands are integrated into the garment and include a two bands (24, 26; 124, 126) which extend continuously across the chest region and cross over in the chest region, and two bands (28, 30; 128, 130) which extend continuously across the back region and cross over in the back region. The crossover (36; 136) in the chest region is positioned higher than the crossover (38; 138) in the back region.
摘要翻译：锻炼衣服至少包括具有胸部区域（14; 114），后部区域（16; 116）和腰部区域（18; 118）的衬衫（10; 110）。该衣服具有多个弹性材料的限制器带（24至30; 124至130），其在使用中在待加工的身体的肌肉上延伸，由此在涉及使所述肌肉伸展的运动的活动期间，所述带被拉伸以提供阻力反对运动。这些带被整合到衣服中并且包括连续延伸穿过胸部区域并在胸部区域中交叉的两个带（24,26; 124,126）和两个带（28,30; 128,130），其延伸连续穿过后部区域并在后部区域交叉。胸部区域中的交叉（36; 136）定位成高于背部区域中的交叉（38; 138）。

2. 发明申请

WO1995002576A1 PROCESS FOR THE PREPARATION OF N-CARBONYLARYLIMINES USEFUL FOR THE SYNTHESIS OF THERAPEUTICALLY ACTIVE TAXOIDS 审中-公开
标题翻译：制备可用于治疗活性紫杉醇合成的N-羰基咪唑的方法
公开(公告)号：WO1995002576A1
公开(公告)日：1995-01-26
申请号：PCT/FR1994000880
申请日：1994-07-13
申请人： RHONE-POULENC RORER S.A. , BERNARD, Didier , LEON, Patrick
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07C269/06
CPC分类号： C07C269/06 , C07C249/02 , C07C317/28
摘要： Process for the preparation of N-carbonylarylimines of general formula (I) by desulphonating a sulphone of general formula (II). The N-carbonylarylimines of general formula (I) are particularly useful for the preparation of therapeutically active taxoids from baccatin III or 10-deacetyl baccatin III. In general formulae (I) and (II), Ar is an aryl radical, R is a t.butoxy or phenyl radical and Ph is an optionally substituted phenyl radical.
摘要翻译：制备通式（I）的N-羰基芳基亚胺的方法，通过使通式（II）的砜脱水。通式（I）的N-羰基芳基亚胺特别可用于从浆果赤霉素III或10-脱乙酰浆果赤霉素III制备治疗活性的紫杉烷类。在通式（I）和（II）中，Ar为芳基，R为叔丁氧基或苯基，Ph为任选取代的苯基。

3. 发明申请

WO1994024113A1 METHOD OF PREPARATION OF 6-FLUORO-2-HALOGEN QUINOLINE 审中-公开
标题翻译： 6-氟-2-卤代喹啉的制备方法
公开(公告)号：WO1994024113A1
公开(公告)日：1994-10-27
申请号：PCT/FR1994000391
申请日：1994-04-07
申请人： RHONE-POULENC RORER S.A. , GARCIA, Hervé , JACQUOT, Roland , LEON, Patrick
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07D251/54
CPC分类号： C07D215/54 , C07D471/04
摘要： Method of preparation of 6-fluoro-2-halogen quinoline of general formula (I) wherein R is a hydrogen atom or an alkyl radical and Hal and Hal' are identical or different halogen atoms. The invention is characterized in that a halogenating agent is made to act on hydroxy-1 quinoline of general formula (II) wherein Hal is defined as above and R1 is defined as R excepting a hydrogen atom, the acid function being optionally released if a 6-fluoro-2-halogen quinoline is to be obtained for which R is a hydrogen atom.
摘要翻译：通式（I）的6-氟-2-卤代喹啉的制备方法，其中R是氢原子或烷基，Hal和Hal'是相同或不同的卤素原子。本发明的特征在于使卤化剂作用于通式（II）的羟基-1-喹啉，其中Hal如上所定义，R 1定义为R除氢原子外，如果6 - 氟-2-卤代喹啉，其中R是氢原子。

4. 发明申请

WO1992010461A1 PROCESS FOR THE PREPARATION OF DERIVATIVES OF 3,5-DIHYDROXY PENTANOIC ACID 审中-公开
标题翻译：制备3,5-二羟基戊酸的衍生物的方法
公开(公告)号：WO1992010461A1
公开(公告)日：1992-06-25
申请号：PCT/FR1991000989
申请日：1991-12-10
申请人： RHONE-POULENC RORER S.A. , LEON, Patrick , MASSONEAU, Viviane , RADISSON, Xavier
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07C67/31
CPC分类号： C07C67/31 , C07C69/732 , C07C69/675
摘要： Process for the preparation of products having general formula (I) by stereoselective reduction of an hydroxyketone having the general formula (II) with the aid of borohydride or sodium or potassium cyanoborohydride associated with a titanium derivative. In formulae (I and II), z is an alkoxy, alkylthio, amino, alkylamino, dialkylamino radical, R is: either a R1-Y-(-Y-=-CH2CH2-,-CH=CH-,-C=C-radical and R1 is an optionally substituted aliphatic alicyclic, aromatic or heteroaromatic radical) or a radical (a) (R2=halogen, alkoxy, alkylthio, arylthio, amino, alkylamino, dialkylamino and R3=hydrogen or R2).

5. 发明申请

WO1998025921A1 PREPARATION OF [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-CHLORO-2-THIENYL) METHYL]PROPYL]AMINO]-3H-IMIDAZO[4,5-b]PYRIDIN-3-yl]-N-ETHYL-2,3-DIHYDROXYCYCLOPENTANECARBOXAMIDE 审中-公开
标题翻译： [1S- [1a，2b，3b，4a（S *）]] - 4- [7 - [[1-（3-氯-2-苯基）甲基]丙基]丙氨基] -3H-咪唑并[4 ，5-b]吡啶-3-基] -N-乙基-2,3- DIHYDROXYCYCLOPENTANECARBOXAMIDE
公开(公告)号：WO1998025921A1
公开(公告)日：1998-06-18
申请号：PCT/US1997021439
申请日：1997-11-24
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , O'BRIEN, Michael, K. , GARCIA, Hervé , LEON, Patrick , POWNER, Tory, H. , REILLY, Laurence, W. , SHAH, Harshavadan, C. , THOMPSON, Michael, D. , TSUEI, Ching, T. , VANASSE, Benoit, J. , WALTHER, Francis, L.
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： C07D409/12
CPC分类号： C07D213/69 , C07D409/12 , C07D409/14 , C07D471/04
摘要： This invention is directed to methods for the preparation of [1S-[1a,2b,3b,4a(S*)] ]-4-[7-[[1-(3-chloro-2-thienyl)methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2, 3-dihydroxycyclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselves.
摘要翻译：本发明涉及制备[1S- [1a，2b，3b，4a（S *）]] -4- [7 - [[1-（3-氯-2-噻吩基）甲基]丙基] 氨基] -3H-咪唑并[4,5-b]吡啶-3-基] -N-乙基-2,3-二羟基环戊烷甲酰胺，其中间体的制备方法和所述中间体本身。

6. 发明申请

WO1997003053A1 N-(ACYLOXYMETHYL OR HYDROXYMETHYL) (OPTIONALLY (OXA OR THIA) SUBSTITUTED)BICYCLO([2.2.1] OR [2.2.2])AZALK(AN OR EN)ONE COMPOUNDS 审中-公开
标题翻译： N-（乙酰甲基或羟甲基）（可选择地（OXA或THIA）取代的）双酚（[2.2.1]或[2.2.2]）AZALK（AN或EN）一种化合物
公开(公告)号：WO1997003053A1
公开(公告)日：1997-01-30
申请号：PCT/US1996011579
申请日：1996-07-10
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , PETRE, Dominique , DARNAND, Eliane , MARSEIGNE, Isabelle , LEON, Patrick , BOTANNET, Danielle
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： C07D221/02
CPC分类号： C07D491/08 , C07D209/52
摘要： The present invention is directed to N-(acyloxymethyl or hydroxymethyl)-(optionally (oxa or thia) substituted)bicyclo([2.2.1] or [2.2.2])azalk(an or en)one compounds which are useful as intermediates in the synthesis of cardiovascular agents, including anti-anginal agents, antihypertensives and anti-ischemics, anti-viral agents, anti-neoplastic agents, antifungal agents and antimicrobial agents, and to their preparation.
摘要翻译：本发明涉及可用作中间体的N-（酰氧基甲基或羟甲基） - （任选（氧杂或硫杂）取代的）双环（[2.2.1]或[2.2.2]）吖唑（an或en）在包括抗心绞痛剂，抗高血压药和抗缺血剂，抗病毒剂，抗肿瘤剂，抗真菌剂和抗微生物剂的心血管药物的合成中，以及它们的制备。

7. 发明申请

WO1995011900A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED THIOPYRAN-1-OXIDES 审中-公开
标题翻译：制备取代的噻咯-1-氧化物的方法
公开(公告)号：WO1995011900A1
公开(公告)日：1995-05-04
申请号：PCT/GB1994002332
申请日：1994-10-24
申请人： RHONE-POULENC RORER LIMITED , PITCHEN, Philippe , POWERS, Matthew, Rae , LEON, Patrick , PETRE, Dominique
发明人： RHONE-POULENC RORER LIMITED
IPC分类号： C07D409/04
CPC分类号： C07D409/04 , C07D213/32
摘要： A process is described for the preparation of a compound of formula (IX) from 4-hydroxybutyl 3-pyridyl ketone. The compound of formula (IX) is an intermediate useful in the preparation of (1R,2R)-2-(3-pyridyl)-N-alkyl-tetrahydro-2H-thiopyran-2-carbothioamide 1-oxides which possess useful pharmaceutical properties, for example anti-hypertensive properties.
摘要翻译：描述了从4-羟基丁基3-吡啶基酮制备式（Ⅸ）化合物的方法。式（IX）化合物是可用于制备具有有用的药物性质的（1R，2R）-2-（3-吡啶基）-N-烷基 - 四氢-2H-噻喃-2-硫代硫酰胺1-氧化物的中间体，例如抗高血压性质。

8. 发明申请

WO1998016510A1 PROCESS FOR PREPARING 2-AZADIHYDROXYBICYCLO[2.2.1]HEPTANE COMPOUNDS AND THE L-TARTARIC ACID SALT OF THE COMPOUND 审中-公开
标题翻译：制备2-亚氨基二羟基双环[2.2.1]庚二烯化合物和化合物的L-十八烷酸盐的方法
公开(公告)号：WO1998016510A1
公开(公告)日：1998-04-23
申请号：PCT/US1997018365
申请日：1997-10-15
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , O'BRIEN, Michael , LEON, Patrick , LARGEAU, Denis , POWERS, Matthew , DURAND, Thierry
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： C07D209/52
CPC分类号： C07D209/52 , C07D209/02 , Y02P20/55
摘要： A method according to the invention is directed to the preparation of a 2-azadihydroxybicyclo[2.2.1]heptane compound of formula (I) or (I') wherein * represents an R chirality, *' represents an S chirality, R is hydrogen or, respectively, a group of formula (II) or (II') wherein R1 is alkyl and Ar is optionally substituted aryl, comprising bishydroxylating a bicyclo[2.2.1]heptene compound of formula (III) or (III') wherein *, *' and R are as previously defined, in the presence of about 0.1 mol % to about 5 mol % of a metal osmate compound or about 0.06 mol % to about 0.07 mol % osmium tetroxide, and an oxidizing agent capable of regenerating osmium tetroxide. The invention is also directed to the treatment of the (1R) diastereomer of the 2-azadihydroxybicyclo[2.2.1]heptane compound (I) wherein R is a group of formula (II) with L-tartaric acid, and the L-tartaric acid salt product thereof. Furthermore, the invention is directed to using the (1R) diastereomer of the 2-azadihydroxybicyclo[2.2.1]heptane compound in an acid facilitated acetalizing or ketalizing reaction that results in the protection of the dihydroxy moieties thereof in isopropanol. In addition, the invention is directed to oxidizing a bis O-protected derivative of the (1R) diastereomer of the 2-azadihydroxybicyclo[2.2.1]heptane compound to a corresponding lactam compound in the presence of about 0.01 mol % to about 1 mol % of RuO2 with about 3 equivalents of an oxidant to form the lactam compound with an enantiomeric excess ("ee") of greater than or equal to about 95 %.
摘要翻译：根据本发明的方法涉及制备式（I）或（I'）的2-氮杂二羟基双环[2.2.1]庚烷化合物，其中*表示R手性，*'表示S手性，R为氢或分别为其中R 1为烷基且Ar为任选取代的芳基的式（II）或（II'）基团，其包含双羟基化式（III）或（III'）的双环[2.2.1]庚烯化合物，其中* ，*'和R如前所定义，在约0.1mol％至约5mol％的金属锇化合物或约0.06mol％至约0.07mol％的四氧化锇存在下，以及能够再生四氧化锇的氧化剂。本发明还涉及用L-酒石酸和L-酒石酸处理其中R为式（II）的基团的2-氮杂二羟基双环[2.2.1]庚烷化合物（I）的（1R）非对映异构体其酸盐产物。此外，本发明涉及使用2-氮杂二羟基双环[2.2.1]庚烷化合物的（1R）非对映体在酸促进缩醛化或缩酮化反应中，其导致保护其在异丙醇中的二羟基部分。此外，本发明涉及在约0.01mol％至约1mol的存在下将2-氮杂二羟基双环[2.2.1]庚烷化合物的（1R）非对映异构体的双O保护的衍生物氧化成相应的内酰胺化合物％的RuO 2与约3当量的氧化剂以形成具有大于或等于约95％的对映体过量（“ee”）的内酰胺化合物。

9. 发明申请

WO1998011064A1 STEREOSPECIFIC PREPARATION OF CHIRAL 1-ARYL- AND 1-HETEROARYL-2-SUBSTITUTED ETHYL-2-AMINES 审中-公开
标题翻译：化合物1-ARYL-和1-取代的2-取代的乙基-2-氨基的立体制备
公开(公告)号：WO1998011064A1
公开(公告)日：1998-03-19
申请号：PCT/US1997015729
申请日：1997-09-10
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , GRONDARD, Luc , CASIMIR, Jean-Paul , LEON, Patrick , O'BRIEN, Michael, K. , POWERS, Matthew, R. , ROBIN, Daniel
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： C07C303/38
CPC分类号： C07D333/28 , C07B2200/07 , C07C303/40 , C07D203/24
摘要： This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.
摘要翻译：本发明涉及立体选择性制备在2-位具有手性的[（1-任选取代的芳基） - 或（1-任选取代的杂芳基）] -2-取代的乙基-2-胺的方法，取代的乙基-2-胺。

10. 发明申请

WO1994022813A1 METHOD FOR THE PREPARATION OF beta-PHENYLISOSERINE DERIVATIVES 审中-公开
标题翻译：制备β-苯并二氢吡喃衍生物的方法
公开(公告)号：WO1994022813A1
公开(公告)日：1994-10-13
申请号：PCT/FR1994000339
申请日：1994-03-25
申请人： RHONE-POULENC RORER S.A. , DIDIER, Eric , LEON, Patrick
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07C269/04
CPC分类号： C07C269/04 , C07C231/02 , C07C231/18 , C07C233/87
摘要： Method for the preparation of beta -phenylisoserine derivatives of general formula (I) involving the action of an anhydride and hydrogen with a product of general formula (II). The products of general formula (I) are especially useful in the preparation of taxoids having outstanding antitumour properties. In general formulae (I) and (II), Ar is an aryl radical, Ph is a phenyl radical or an optionally substituted alpha or beta -naphtyl, R is a hydrogen atom or an alkyl radical optionally substituted by a phenyl radical and R1 is an optionally substituted phenyl radical or a R2-O radical wherein R2 is an alkyl, alkenyl, cycloalkyl, phenyl or heterocyclyl.
摘要翻译：制备通式（I）的β-苯基异丝氨酸衍生物的方法，其涉及酸酐和氢与通式（II）的产物的作用。通式（I）的产物在制备具有优异抗肿瘤性质的紫杉类药物中特别有用。在通式（I）和（II）中，Ar为芳基，Ph为苯基或任选取代的α或β-萘基，R为氢原子或任选被苯基取代的烷基，R 1为任选取代的苯基或R 2 -O基，其中R 2是烷基，烯基，环烷基，苯基或杂环基。

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