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1. 发明申请

WO2011163353A3 ON-DEMAND DUAL FREQUENCY LASER SOURCES FOR NON-LINEAR OPTICAL MICROSCOPY AND MICRO-SPECTROSCOPY IMAGING SYSTEMS 审中-公开
标题翻译：用于非线性光学显微镜和微光谱成像系统的双频激光源
公开(公告)号：WO2011163353A3
公开(公告)日：2012-02-23
申请号：PCT/US2011041441
申请日：2011-06-22
申请人： HARVARD COLLEGE , CORNELL RES FOUNDATION INC , XU CHRIS , XIE XIAOLIANG SUNNEY , FREUDIGER CHRISTIAN W , WANG KE , SAAR BRIAN G , LEE JENNIFER H
发明人： XU CHRIS , XIE XIAOLIANG SUNNEY , FREUDIGER CHRISTIAN W , WANG KE , SAAR BRIAN G , LEE JENNIFER H
IPC分类号： G01J3/10 , G01N21/01
CPC分类号： G01N21/65 , G01J3/10 , G01N2021/655
摘要： An illumination system is disclosed for use in non-linear modulation transfer microscopy and micro-spectroscopy. The illumination system includes a laser system for providing a first train of pulses at a center optical frequency ?1, and an optical assembly for collinearly combining a first train of pulses with a second train of pulses having a center optical frequency of ?2 as synchronized excitation fields for non¬ linear modulation transfer microscopy and micro-spectroscopy. The laser system includes a continuous wave laser for providing a first continuous wave field, a first chirp modulator system comprising a means to receive the first continuous wave field, a means to receive a trigger signal, a first phase modulator and a first electro-optic modulator; and a first pulse compression unit.
摘要翻译：公开了用于非线性调制转移显微镜和微光谱的照明系统。照明系统包括用于提供中心光频率λ1的第一脉冲序列的激光系统，以及用于将第一脉冲串与第二脉冲序列共线组合的光学组件，所述第二脉冲序列具有同步的中心光频率ω2 用于非线性调制转移显微镜和微光谱的激发场。激光系统包括用于提供第一连续波场的连续波激光器，包括接收第一连续波场的装置的第一线性调频系统，接收触发信号的装置，第一相位调制器和第一电光调制器; 和第一脉冲压缩单元。

2. 发明申请

WO2011163353A2 ON-DEMAND DUAL FREQUENCY LASER SOURCES FOR NON-LINEAR OPTICAL MICROSCOPY AND MICRO-SPECTROSCOPY IMAGING SYSTEMS 审中-公开
标题翻译：用于非线性光学显微镜和微光谱成像系统的双频激光源
公开(公告)号：WO2011163353A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041441
申请日：2011-06-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CORNELL RESEARCH FOUNDATION, INC. , XU, Chris , XIE, Xiaoliang, Sunney , FREUDIGER, Christian, W. , WANG, Ke , SAAR, Brian, G. , LEE, Jennifer, H.
发明人： XU, Chris , XIE, Xiaoliang, Sunney , FREUDIGER, Christian, W. , WANG, Ke , SAAR, Brian, G. , LEE, Jennifer, H.
IPC分类号： G01J3/10 , G01N21/01
CPC分类号： G01N21/65 , G01J3/10 , G01N2021/655
摘要： An illumination system is disclosed for use in non-linear modulation transfer microscopy and micro-spectroscopy. The illumination system includes a laser system for providing a first train of pulses at a center optical frequency ω 1 , and an optical assembly for collinearly combining a first train of pulses with a second train of pulses having a center optical frequency of ω 2 as synchronized excitation fields for non¬ linear modulation transfer microscopy and micro-spectroscopy. The laser system includes a continuous wave laser for providing a first continuous wave field, a first chirp modulator system comprising a means to receive the first continuous wave field, a means to receive a trigger signal, a first phase modulator and a first electro-optic modulator; and a first pulse compression unit.
摘要翻译：公开了用于非线性调制转移显微镜和微光谱的照明系统。照明系统包括用于提供中心光频率λ1的第一脉冲序列的激光系统，以及用于将第一脉冲串与第二脉冲序列共线组合的光学组件，所述第二脉冲序列具有同步的中心光频率ω2 用于非线性调制转移显微镜和微光谱的激发场。激光系统包括用于提供第一连续波场的连续波激光器，包括接收第一连续波场的装置的第一线性调频系统，接收触发信号的装置，第一相位调制器和第一电光调制器; 和第一脉冲压缩单元。

3. 发明申请

WO2011162787A1 SYSTEMS AND METHODS PROVIDING EFFICIENT DETECTION OF BACK-SCATTERED ILLUMINATION IN MODULATION TRANSFER MICROSCOPY OR MICRO-SPECTROSCOPY 审中-公开
标题翻译：在调制转移微观或微观光谱中提供反向散射的有效检测的系统和方法
公开(公告)号：WO2011162787A1
公开(公告)日：2011-12-29
申请号：PCT/US2010/054925
申请日：2010-11-01
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , XIE, Sunney, Xiaoliang , FREUDIGER, Christian, W. , SAAR, Brian, G.
发明人： XIE, Sunney, Xiaoliang , FREUDIGER, Christian, W. , SAAR, Brian, G.
IPC分类号： G01N21/47 , G01N21/63
CPC分类号： G01N21/53 , G01N21/171 , G01N21/636 , G01N21/65 , G01N2021/655
摘要： A microscopy or micro-spectroscopy system is disclosed that includes a first light source, a second light source, a modulator, an optical assembly and a processor. The first light source is for providing a first illumination field at a first optical frequency ω 1 and the second light source is for providing a second illumination field at a second optical frequency ω 2 . The modulator is for modulating a property of the second illumination field at a modulation frequency f of at least 100 kHz to provide a modulated second illumination field. The optical assembly includes focusing optics and an optical detector system, The focusing optics is for directing and focusing the first illumination field and the modulated second illumination field through an objective lens toward the common focal volume along an excitation path. The optical detector system includes at least one optical detector for detecting a detected first field intensity of the first illumination field that is back- scattered within a sample, wherein the optical detector provides an electrical signal representative of the detected first field intensity. The optical detector is located proximate a portion of the excitation path. The processor is for detecting a modulation at the frequency f of the electrical signal due to non-linear optical interaction within the common focal volume.
摘要翻译：公开了包括第一光源，第二光源，调制器，光学组件和处理器的显微镜或微光谱系统。第一光源用于以第一光学频率λ1提供第一照明场，并且第二光源用于在第二光频率ω2处提供第二照明场。调制器用于以至少100kHz的调制频率f调制第二照明场的特性以提供调制的第二照明场。光学组件包括聚焦光学器件和光学检测器系统。聚焦光学器件用于将第一照明场和经调制的第二照明场通过物镜沿着激励路径朝着公共焦距体积引导和聚焦。光检测器系统包括至少一个光检测器，用于检测在样品内被反向散射的第一照明场的检测到的第一场强，其中光检测器提供表示检测到的第一场强的电信号。光学检测器位于激励路径的一部分附近。该处理器用于由于在公共焦点体积内的非线性光学相互作用来检测在电信号的频率f处的调制。

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