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    • 5. 发明申请
    • GEL FORM OF A VACCINE
    • 疫苗的凝胶形式
    • WO1996025951A1
    • 1996-08-29
    • PCT/CA1996000100
    • 1996-02-21
    • LEE, Eng-Hong
    • A61K47/36
    • A61K47/36A61K9/0056A61K39/012
    • The present invention provides for a gel form of a live vaccine for administration of live vaccine to poultry hatchlings. The gel form comprises approximately 1.5 to 5.0 percent of an edible polysaccharide temperature setting gelling agent having suspended therein sufficient levels of a live vaccine to provide for immunization of a poultry hatchling flock. The present invention also provides a method for immunizing a poultry flock utilizing a live vaccine of viable organisms, the method comprising preparing a gel form of a live vaccine by preparing a suspension of the viable organisms in cold water, dissolving an edible polysaccharide temperature setting gelling agent in an aqueous solution at or above the melting point of the polysaccharide gelling agent, mixing the organism suspension and the gelling agent solution, pouring the mixture into a suitable container then allowing the mixture to cool and gel to produce a gelled live vaccine comprising from about 1 to about 2.5 percent of an edible polysaccharide gel having suspended therein sufficient levels of the organism to provide immunization to the flock and allowing the poultry flock to feed from the gelled vaccine suspension.
    • 本发明提供了一种用于向家禽幼体施用活疫苗的活疫苗的凝胶形式。 凝胶形式包括约1.5-5.0%的可食用多糖温度凝胶化剂,其中悬浮有足够水平的活疫苗以提供家禽孵化群的免疫。 本发明还提供一种利用活生物体的活疫苗免疫家禽群的方法,所述方法包括通过在冷水中制备活生物体的悬浮液来制备活疫苗的凝胶形式,溶解食用多糖温度凝胶化 在多糖胶凝剂的熔点以上的水溶液中混合生物体悬浮液和胶凝剂溶液,将混合物倒入合适的容器中,然后使混合物冷却并凝胶化以产生凝胶活的疫苗,其包含 约1至约2.5%的可食用多糖凝胶,其中悬浮有足够水平的生物体以向羊群提供免疫并允许家禽群从凝胶化疫苗悬浮液进料。