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1. 发明申请

WO2019195482A9 DATABASE LOCK 审中-公开
公开(公告)号：WO2019195482A9
公开(公告)日：2019-10-10
申请号：PCT/US2019/025670
申请日：2019-04-03
申请人： OTSUKA AMERICA PHARMACEUTICAL INC. , LEE, Angela , SAMALA, Padma , DACOSTA, Shameka , AGARWAL, Indra , DONG, Fugui , GOTTIPATI, Srikanth
发明人： LEE, Angela , SAMALA, Padma , DACOSTA, Shameka , AGARWAL, Indra , DONG, Fugui , GOTTIPATI, Srikanth
IPC分类号： G06Q10/06 , G16H10/20 , G06F16/23
摘要： Methods, systems, and apparatus, including computer programs encoded on a storage device, for monitoring the status of a database prior to locking the database. In one aspect, the method comprises receiving a request to generate a mock database, accessing a set of database lock readiness metrics, wherein the set of database lock readiness metrics include one or more attribute values that each specify a value of an attribute of database data that must be satisfied for the database to be locked, correlating information that includes (i) the set of database lock readiness metrics and (ii) database data of the database, and generating a database lock readiness report structure, based on a mock database lock representing a snapshot of the database at a particular point in time, that indicates whether each of the one or more attribute values specified by the set of database lock readiness metrics have been satisfied.

2. 发明申请

WO2011106545A1 POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：用作单酯酸序列的聚霉素
公开(公告)号：WO2011106545A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/026102
申请日：2011-02-24
申请人： RELYPSA, INC. , LEES, Inez , BIYANI, Kalpesh , CONNOR, Eric , HECKER, Scott , ZHANG, Hongmin , COPE, Michael James , GOKA, Elizabeth , LEE, Angela , MADSEN, Deidre , SHAO, Jun
发明人： LEES, Inez , BIYANI, Kalpesh , CONNOR, Eric , HECKER, Scott , ZHANG, Hongmin , COPE, Michael James , GOKA, Elizabeth , LEE, Angela , MADSEN, Deidre , SHAO, Jun
IPC分类号： A61K31/785 , A61K31/787 , A61K45/06 , C08G61/12 , C08G73/02 , C08G73/06 , C08G73/18
CPC分类号： C08F226/06 , A61K31/155 , A61K31/397 , A61K31/785 , A61K31/787 , A61K45/06 , C08G73/0273 , C08G73/0616 , C08G73/0627 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

3. 发明申请

WO2013033314A1 CONVERTIBLE CLUTCH PURSE 审中-公开
标题翻译：可转换离合器
公开(公告)号：WO2013033314A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/053015
申请日：2012-08-30
申请人： UNCAGED, LLC , LEE, Angela A.
发明人： LEE, Angela A.
IPC分类号： A45C9/00 , A45C7/00 , A45C1/00
CPC分类号： A45C9/00 , A45C1/02 , A45C3/06 , A45C2009/007 , A45F3/02 , A45F4/00
摘要： A convertible clutch purse is disclosed that converts to a billowy sash and vice versa. The purse is formed of an elongated composite fabric structure having an inner sheet and an outer billowed sheet attached together to form, in one embodiment, a generally oval shaped body. A selectively closable pocket is sandwiched between the inner and outer sheets, wherein the pocket is accessible along one edge joining the inner and outer sheets, and wherein the sash may be folded into the pocket to convert the sash into the clutch purse. An alternative embodiment converts from the purse to a stole or scarf having free ends.
摘要翻译：公开了一种可转换的离合器钱包，其转换成一个隆起的窗扇，反之亦然。该钱包由细长的复合织物结构形成，该复合织物结构具有一个内片和一个外凸起的片，在一个实施例中形成一个大致椭圆形的本体。可选择地关闭的袋被夹在内片和外片之间，其中口袋可沿着连接内片和外片的一个边缘接近，并且其中窗框可以折叠到口袋中以将窗框转换成离合器钱包。替代实施例将钱包转换成具有自由端的偷窃者或围巾。

4. 发明申请

WO2011106548A1 AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：用作纯化酸序列的胺聚合物
公开(公告)号：WO2011106548A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/026106
申请日：2011-02-24
申请人： RELYPSA, INC. , CONNOR, Eric , BIYANI, Kalpesh , HECKER, Scott , LEES, Inez , MANSKY, Paul , MU, YongQi , SALAYMEH, Felah , ZHANG, Hongmin , BERGBREITER, David , QUAKER, Grace , COPE, Michael James , GOKA, Elizabeth , LEE, Angela , MADSEN, Deidre , SHAO, Jun
发明人： CONNOR, Eric , BIYANI, Kalpesh , HECKER, Scott , LEES, Inez , MANSKY, Paul , MU, YongQi , SALAYMEH, Felah , ZHANG, Hongmin , BERGBREITER, David , QUAKER, Grace , COPE, Michael James , GOKA, Elizabeth , LEE, Angela , MADSEN, Deidre , SHAO, Jun
IPC分类号： C08G73/02 , C08L79/02 , A61P3/06 , A61P3/10 , A61K31/13
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

5. 发明申请

WO2011106542A3 CROSSLINKED POLYVRNYLAMINE, POLY ALL YLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：交联聚乙烯胺，聚烯丙基胺和聚乙烯亚胺用作胆汁酸分子
公开(公告)号：WO2011106542A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/026099
申请日：2011-02-24
申请人： RELYPSA, INC. , KOPPING, Jordon , BIYANI, Kalpesh , CONNOR, Eric , HECKER, Scott , LEES, Inez , QUAKER, Grace , SALAYMEH, Faleh , ZHANG, Hongmin , BERGBREITER, David , MANSKY, Paul , MU, YongQi , COPE, Michael James , GOKA, Elizabeth , LEE, Angela , MADSEN, Deidre , SHAO, Jun
发明人： KOPPING, Jordon , BIYANI, Kalpesh , CONNOR, Eric , HECKER, Scott , LEES, Inez , QUAKER, Grace , SALAYMEH, Faleh , ZHANG, Hongmin , BERGBREITER, David , MANSKY, Paul , MU, YongQi , COPE, Michael James , GOKA, Elizabeth , LEE, Angela , MADSEN, Deidre , SHAO, Jun
IPC分类号： C08F20/52 , C08F22/38 , C08L39/02 , C08F26/02 , C08F32/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效用于从胃肠道结合和除去胆汁盐的交联胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等等。

6. 发明申请

WO2006053207A2 DENTAL WHITENING SYSTEMS 审中-公开
标题翻译：牙科白色系统
公开(公告)号：WO2006053207A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040910
申请日：2005-11-09
申请人： DISCUS DENTAL IMPRESSIONS, INC , MACDONALD, Jeff , LEE, Angela , QUAN, Nancy
发明人： MACDONALD, Jeff , LEE, Angela , QUAN, Nancy
IPC分类号： A61K8/19 , A61K8/24 , A61K8/25 , A61K8/34 , A61K8/38 , A61K8/42 , A61K8/46 , A61K8/55 , A61K8/73 , A61Q11/00 , A61Q11/02
CPC分类号： A61K8/22 , A61C19/066 , A61K8/19 , A61K8/60 , A61K2800/88 , A61Q11/00
摘要： A system and method for tooth whitening are disclosed wherein at least one peroxide-containing gel and at least one transition metal compound- containing gel, particularly at least one lower atomic number transition metal compound, more particularly at least a ferrous compound including gluconate, sulfate, nitrate, acetate or mixtures thereof, are applied to a patient's mouth. Gelling agent is also included. The activation of the peroxide whitens the patient's teeth. The system may be used with or without the application of light. The system further provides an additional gel including a sensitivity reduction compound including potassium nitrate, sodium nitrate or mixtures thereof for possible sensitivity treatment if needed.
摘要翻译：公开了一种用于牙齿美白的系统和方法，其中至少一种含过氧化物的凝胶和至少一种含过渡金属化合物的凝胶，特别是至少一种较低原子序数的过渡金属化合物，更特别是至少含有葡萄糖酸盐，硫酸盐，硝酸盐，乙酸盐或其混合物施用于患者的口腔。还包括胶凝剂。过氧化物的激活使患者的牙齿变白。该系统可以在使用或不使用光的情况下使用。该系统还提供另外的凝胶，其包括包含硝酸钾，硝酸钠或其混合物的灵敏度降低化合物，以便在需要时进行敏感性处理。

7. 发明申请

WO2011106542A2 CROSSLINKED POLYVRNYLAMINE, POLY ALL YLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：交联聚乙烯胺，聚烯丙基胺和聚乙烯亚胺用作胆汁酸分子
公开(公告)号：WO2011106542A2
公开(公告)日：2011-09-01
申请号：PCT/US2011026099
申请日：2011-02-24
申请人： RELYPSA INC , KOPPING JORDON , BIYANI KALPESH , CONNOR ERIC , HECKER SCOTT , LEES INEZ , QUAKER GRACE , SALAYMEH FALEH , ZHANG HONGMIN , BERGBREITER DAVID , MANSKY PAUL , MU YONGQI , COPE MICHAEL JAMES , GOKA ELIZABETH , LEE ANGELA , MADSEN DEIDRE , SHAO JUN
发明人： KOPPING JORDON , BIYANI KALPESH , CONNOR ERIC , HECKER SCOTT , LEES INEZ , QUAKER GRACE , SALAYMEH FALEH , ZHANG HONGMIN , BERGBREITER DAVID , MANSKY PAUL , MU YONGQI , COPE MICHAEL JAMES , GOKA ELIZABETH , LEE ANGELA , MADSEN DEIDRE , SHAO JUN
IPC分类号： C08F20/52
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效用于从胃肠道结合和除去胆汁盐的交联胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

8. 发明申请

WO2019195482A1 DATABASE LOCK 审中-公开
公开(公告)号：WO2019195482A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/025670
申请日：2019-04-03
申请人： OTSUKA AMERICA PHARMACEUTICAL INC. , LEE, Angela , SAMALA, Padma , DACOSTA, Shameka , AGARWAL, Indra , DONG, Fugui , GOTTIPATI, Srikanth
发明人： LEE, Angela , SAMALA, Padma , DACOSTA, Shameka , AGARWAL, Indra , DONG, Fugui , GOTTIPATI, Srikanth
IPC分类号： G06Q10/06 , G16H10/20 , G06F16/23
摘要： Methods, systems, and apparatus, including computer programs encoded on a storage device, for monitoring the status of a database prior to locking the database. In one aspect, the method comprises receiving a request to generate a mock database, accessing a set of database lock readiness metrics, wherein the set of database lock readiness metrics include one or more attribute values that each specify a value of an attribute of database data that must be satisfied for the database to be locked, correlating information that includes (i) the set of database lock readiness metrics and (ii) database data of the database, and generating a database lock readiness report structure, based on a mock database lock representing a snapshot of the database at a particular point in time, that indicates whether each of the one or more attribute values specified by the set of database lock readiness metrics have been satisfied.

9. 发明申请

WO2006053207A3 DENTAL WHITENING SYSTEMS COMPRISING TRANSITION METAL SALT ACTIVATOR 审中-公开
标题翻译：包含过渡金属盐激活剂的牙科白色系统
公开(公告)号：WO2006053207A3
公开(公告)日：2006-09-08
申请号：PCT/US2005040910
申请日：2005-11-09
申请人： DISCUS DENTAL IMPRESSIONS INC , MACDONALD JEFF , LEE ANGELA , QUAN NANCY
发明人： MACDONALD JEFF , LEE ANGELA , QUAN NANCY
IPC分类号： A61K8/19 , A61K8/24 , A61K8/25 , A61K8/34 , A61K8/38 , A61K8/42 , A61K8/46 , A61K8/55 , A61K8/73 , A61Q11/00 , A61Q11/02
CPC分类号： A61K8/22 , A61C19/066 , A61K8/19 , A61K8/60 , A61K2800/88 , A61Q11/00
摘要： A system and method for tooth whitening are disclosed wherein at least one peroxide-containing gel and at least one transition metal compound- containing gel, particularly at least one lower atomic number transition metal compound, more particularly at least a ferrous compound including gluconate, sulfate, nitrate, acetate or mixtures thereof, are applied to a patient's mouth. Gelling agent is also included. The activation of the peroxide whitens the patient's teeth. The system may be used with or without the application of light. The system further provides an additional gel including a sensitivity reduction compound including potassium nitrate, sodium nitrate or mixtures thereof for possible sensitivity treatment if needed.
摘要翻译：公开了一种用于牙齿美白的系统和方法，其中至少一种含过氧化物的凝胶和至少一种含过渡金属化合物的凝胶，特别是至少一种低原子序数过渡金属化合物，更特别是至少含有葡萄糖酸盐，硫酸盐，硝酸盐，乙酸盐或其混合物施用于患者的口腔。还包括胶凝剂。过氧化物的激活使患者的牙齿变白。该系统可以在使用或不使用光的情况下使用。该系统进一步提供另外的凝胶，其包括灵敏度降低化合物，包括硝酸钾，硝酸钠或其混合物，如果需要可能的灵敏度处理。

10. 发明申请

WO0051750A9 SYSTEM AND METHOD FOR SECURE TIME-SHARED ELECTRONIC ACCESS PARCEL DISTRIBUTION 审中-公开
标题翻译：用于安全时分电子访问PARCEL分配的系统和方法
公开(公告)号：WO0051750A9
公开(公告)日：2001-10-11
申请号：PCT/US0005663
申请日：2000-03-03
申请人： CHEN JIAN , LEE ANGELA T
发明人： CHEN JIAN , LEE ANGELA T
IPC分类号： A47G29/14 , G07F17/12 , B07C5/00 , G06F7/00
CPC分类号： A47G29/141 , G07F17/12
摘要： A method and system for receiving parcels in a secure manner. The method comprises the steps of: providing a plurality of controlled receptacles (14), acquiring recipient data (30) and parcel data (34), dynamically assigning (36) an appropriately-sized container based on parcel size data prior to the delivery of the parcel, accepting delivery to the container, identifying the recipient upon presentation of identification by the recipient, and releasing (40) the parcel to the recipient. The system includes a plurality of securable storage containers (14), a controller (18) coupled to the securable storage containers (14), and a memory (18) coupled to the controller. The memory (18) contains a database of parcel delivery and recipient information, a database of container status, and program code. The program code directs the controller (18) to allow access to the storage containers (14), and dynamically assigns (36) containers (14) to allow parcels to be stored in one of the securable storage containers (14).
摘要翻译：一种以安全方式接收包裹的方法和系统。该方法包括以下步骤：提供多个受控的插座（14），获取接收者数据（30）和包裹数据（34），在传送之前基于包裹尺寸数据动态分配（36）适当尺寸的容器包裹，接受送达集装箱，由收件人呈现身份识别接收者，并将包裹（40）发送给收件人。该系统包括多个可固定存储容器（14），耦合到可固定存储容器（14）的控制器（18）以及耦合到控制器的存储器（18）。存储器（18）包含包裹递送和收件人信息的数据库，容器状态数据库和程序代码。程序代码指示控制器（18）允许访问存储容器（14），并动态分配（36）容器（14）以允许包裹存储在可安全存储容器（14）之一中。

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