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1. 发明申请

WO9904767A3 OSMOTIC DELIVERY SYSTEM WITH SEMIPERMEABLE PLUG 审中-公开
标题翻译：具有可切换插头的OSMOTIC传送系统
公开(公告)号：WO9904767A3
公开(公告)日：1999-04-22
申请号：PCT/US9814812
申请日：1998-07-24
申请人： ALZA CORP , CHEN GUOHUA , DIONNE KEITH E , LAUTENBACH SCOTT D , JORDAN SCOTT D , BERRY STEPHEN A , RODENBERGER CRAIG I , AYER RUPAL
发明人： CHEN GUOHUA , DIONNE KEITH E , LAUTENBACH SCOTT D , JORDAN SCOTT D , BERRY STEPHEN A , RODENBERGER CRAIG I , AYER RUPAL
IPC分类号： A61K9/00 , A61K9/22 , A61K9/24 , A61K9/52
CPC分类号： A61K9/0004
摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.
摘要翻译：渗透输送系统半透性体组件，其从包含半透性体组件的渗透输送系统中控制有益剂的输送速率。半透性体组件或塞子包括半渗透体，其可定位在渗透递送系统的开口中。半透明体具有中空的内部部分，其具有选择的尺寸以获得通过半透性体的预定液体渗透速率。由于渗透输送系统中的有益剂以基本上相同的速率递送，所以渗透剂吸收从周围环境渗透通过塞子的液体，通过塞子的液体渗透速率控制有益剂从渗透压的输送速率输送系统。可以改变通过半透性体的液体渗透速率，以通过改变半透性体的厚度或通过改变暴露于液体的半透明体的表面积的量来控制有益剂从渗透递送系统的输送速率，渗透输送系统位于使用的液体环境中。

2. 发明申请

WO1997027840A1 SUSTAINED DELIVERY OF AN ACTIVE AGENT USING AN IMPLANTABLE SYSTEM 审中-公开
标题翻译：使用可植入系统可持续地提供活性剂
公开(公告)号：WO1997027840A1
公开(公告)日：1997-08-07
申请号：PCT/US1997000722
申请日：1997-01-15
申请人： ALZA CORPORATION , ECKENHOFF, Bonnie, J. +lf , PEERY, John, R. , DIONNE, Keith, E. , LANDRAU, Felix, A. , LAUTENBACH, Scott, D. , MAGRUDER, Judy, A. , WRIGHT, Jeremy, C.
发明人： ALZA CORPORATION , ECKENHOFF, Bonnie, J. +lf , ECKENHOFF, James, B. +di
IPC分类号： A61K09/00
CPC分类号： A61K9/0004 , A61K9/0024 , A61K38/09 , A61M5/14526 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译：本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。不可渗透的储存器分为水溶胀剂室和活性剂配制室。来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。交付期限达2年。

3. 发明申请

WO2005046639A3 MODULAR IMBIBITION RATE REDUCER FOR USE WITH IMPLANTABLE OSMOTIC PUMP 审中-公开
标题翻译：用于可植入渗透泵的模块式比例减速器
公开(公告)号：WO2005046639A3
公开(公告)日：2005-07-07
申请号：PCT/US2004036350
申请日：2004-11-01
申请人： ALZA CORP , AYER RUPAL A , LAUTENBACH SCOTT D , DESJARDIN MICHAEL A , HIGA ADRIENNE T
发明人： AYER RUPAL A , LAUTENBACH SCOTT D , DESJARDIN MICHAEL A , HIGA ADRIENNE T
IPC分类号： A61K9/00 , A61K9/22 , A61K9/48
CPC分类号： A61K9/0004
摘要： An osmotic pump system includes a capsule having at least one delivery port, a membrane plug retained at an open end of the capsule remote from the delivery port, the membrane plug providing a fluid-permeable barrier between an interior and an exterior of the capsule, and a removable imbibition rate reducer attachable to the capsule. The imbibition rate reducer comprises one or more flow controllers selected from the group consisting of an orifice having a selected size smaller than a surface area of the membrane plug and a membrane having a selected thickness, surface area, radial compression, and permeability. The imbibition rate reducer allows customizable delivery of medicaments.
摘要翻译：一种渗透泵系统包括具有至少一个输送口的胶囊，在胶囊的远离输送口的敞开端处保持的膜塞，膜塞在胶囊的内部和外部之间提供流体可渗透屏障，以及可附接到胶囊的可移除渗吸速率减小器。吸液速率减小器包括一个或多个流量控制器，所述流量控制器选自由具有小于膜插塞的表面面积的选定尺寸的孔和具有选定厚度，表面积，径向压缩和渗透性的膜组成的组。吸液速率减速器允许定制输送药物。

4. 发明申请

WO2005046639A2 MODULAR IMBIBITION RATE REDUCER FOR USE WITH IMPLANTABLE OSMOTIC PUMP 审中-公开
标题翻译：具有可塑性动力泵的模块化减速器
公开(公告)号：WO2005046639A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/036350
申请日：2004-11-01
申请人： ALZA CORPORATION , AYER, Rupal A. , LAUTENBACH, Scott D. , DESJARDIN, Michael A. , HIGA, Adrienne T.
发明人： AYER, Rupal A. , LAUTENBACH, Scott D. , DESJARDIN, Michael A. , HIGA, Adrienne T.
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： An osmotic pump system includes a capsule having at least one delivery port, a membrane plug retained at an open end of the capsule remote from the delivery port, the membrane plug providing a fluid-permeable barrier between an interior and an exterior of the capsule, and a removable imbibition rate reducer attachable to the capsule. The imbibition rate reducer comprises one or more flow controllers selected from the group consisting of an orifice having a selected size smaller than a surface area of the membrane plug and a membrane having a selected thickness, surface area, radial compression, and permeability. The imbibition rate reducer allows customizable delivery of medicaments.
摘要翻译：渗透泵系统包括具有至少一个输送端口的胶囊，保持在远离输送端口的胶囊的开口端处的膜塞，膜塞在胶囊的内部和外部之间提供流体可渗透屏障，以及可附接到胶囊的可移除的吸入减速器。吸入减速器包括一个或多个流量控制器，其选自具有选定尺寸小于膜塞的表面积的孔口和选择的厚度，表面积，径向压缩和渗透性的膜。吸入减速器允许定制的药物递送。

5. 发明申请

WO2008021133A3 OSMOTIC DELIVERY SYSTEMS AND PISTON ASSEMBLIES 审中-公开
标题翻译：渗透输送系统和活塞组件
公开(公告)号：WO2008021133A3
公开(公告)日：2008-07-17
申请号：PCT/US2007017634
申请日：2007-08-08
申请人： INTARCIA THERAPEUTICS INC , ALESSI THOMAS R , DESJARDIN MICHAEL A , LAM STAN , LAUTENBACH SCOTT D , ZAMORA PAULINE C
发明人： ALESSI THOMAS R , DESJARDIN MICHAEL A , LAM STAN , LAUTENBACH SCOTT D , ZAMORA PAULINE C
IPC分类号： A61K9/00
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
摘要翻译：公开了用于将活性剂制剂递送至流体环境的渗透递送系统。渗透递送系统通常包括具有内腔的贮存器，内腔含有活性剂制剂和渗透剂制剂以及定位在内腔中的活塞组件以将活性剂制剂与渗透剂制剂隔离。活塞组件通常包括构造和布置成用于定位在内腔中的主体。主体通常由例如耐有机溶剂浸出的聚合物材料制成。在一个实施例中，所述主体是圆柱形主体，所述圆柱形主体在其远端处具有边缘，用于接合并密封所述容器的壁，并且所述活塞组件还包括保持在所述柱体的远端处的弹簧，柱状体靠在储存器的壁上。

6. 发明申请

WO2007140416A3 TWO-PIECE, INTERNAL-CHANNEL OSMOTIC DELIVERY SYSTEM FLOW MODULATOR 审中-公开
公开(公告)号：WO2007140416A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/069990
申请日：2007-05-30
申请人： INTARCIA THERAPEUTICS, INC. , LAUTENBACH, Scott D. , DE LA SERNA, Pedro E. , ZAMORA, Pauline C. , DESJARDIN, Michael A.
发明人： LAUTENBACH, Scott D. , DE LA SERNA, Pedro E. , ZAMORA, Pauline C. , DESJARDIN, Michael A.
IPC分类号： A61K9/00 , A61M5/142
摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.

7. 发明申请

WO2008021133A2 OSMOTIC DELIVERY SYSTEMS AND PISTON ASSEMBLIES 审中-公开
标题翻译： OSMOTIC传送系统和活塞组件
公开(公告)号：WO2008021133A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/017634
申请日：2007-08-08
申请人： INTARCIA THERAPEUTICS, INC. , ALESSI, Thomas, R. , DESJARDIN, Michael, A. , LAM, Stan , LAUTENBACH, Scott, D. , ZAMORA, Pauline, C.
发明人： ALESSI, Thomas, R. , DESJARDIN, Michael, A. , LAM, Stan , LAUTENBACH, Scott, D. , ZAMORA, Pauline, C.
IPC分类号： A61K9/00
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
摘要翻译：公开了用于将活性剂制剂递送到流体环境的渗透递送系统。渗透递送系统通常包括储存器，其具有包含活性剂制剂的内腔和渗透剂制剂以及位于内腔中的活塞组件，以将活性剂制剂与渗透剂制剂隔离。活塞组件通常包括构造和布置成用于定位在内腔中的主体。主体通常由例如耐有机溶剂中浸出的聚合材料制成。在一个实施例中，主体是一个柱状体，其具有在其远端处的边缘，用于接合和密封储存器的壁，并且活塞组件还包括保持在柱状体的远端处的弹簧，用于偏置柱状体抵靠水库的墙壁。

8. 发明申请

WO2007140416A2 TWO-PIECE, INTERNAL-CHANNEL OSMOTIC DELIVERY SYSTEM FLOW MODULATOR 审中-公开
标题翻译：两通道，内部通道输送系统流量调节器
公开(公告)号：WO2007140416A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069990
申请日：2007-05-30
申请人： ALZA CORP , LAUTENBACH SCOTT D , DE LA SERNA PEDRO E , ZAMORA PAULINE C , DESJARDIN MICHAEL A
发明人： LAUTENBACH SCOTT D , DE LA SERNA PEDRO E , ZAMORA PAULINE C , DESJARDIN MICHAEL A
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61K9/0004 , A61K38/21 , Y10T29/49236 , Y10T29/494 , Y10T137/0402
摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
摘要翻译：渗透输送系统流调节器包括构造和布置成用于定位在渗透输送系统的储存器的开口中的外壳，插入外壳中的内芯，以及限定在外壳和内核。流体通道适于从渗透递送系统的储存器输送活性剂制剂。

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