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1. 发明申请

WO2013039438A1 PROTEASOME DEUBIQUINATING INHIBITOR SCREENING 审中-公开
标题翻译：耐腐蚀抑制剂筛选
公开(公告)号：WO2013039438A1
公开(公告)日：2013-03-21
申请号：PCT/SE2012/000129
申请日：2012-09-06
申请人： VIVOLUX AB , BRNJIC, Slavica , D'ARCY, Padraig , LARSSON, Rolf , LINDER, Stig
发明人： BRNJIC, Slavica , D'ARCY, Padraig , LARSSON, Rolf , LINDER, Stig
IPC分类号： G01N33/574 , C12N9/50 , C12Q1/37
CPC分类号： C12Q1/37 , C12Q1/34 , G01N33/5011 , G01N33/573 , G01N2500/00 , G01N2500/02
摘要： A method for screening a compound to determine whether the compound is a proteasome deubiquinating inhibitor of high specificity comprises contacting the compound with human 19S regulatory particles (19S RP) of 26S proteasome and determining whether the compound inhibits activity of deubiquinating (DUB) enzymes UCHL5 and USP14; inhibition of UCHL5 and USP14 activities indicates that the compound is a proteasome deubiquinating inhibitor of high specificity.
摘要翻译：筛选化合物以确定化合物是否是高特异性蛋白酶体脱泛性抑制剂的方法包括使化合物与26S蛋白酶体的人19S调节颗粒（19S RP）接触，并确定该化合物是否抑制脱琥（DUB）酶UCHL5和 USP14; UCHL5和USP14活性的抑制表明该化合物是具有高特异性的蛋白酶体脱泛性抑制剂。

2. 发明申请

WO2007004975A1 HEPARIN COATING OF BIOLOGICAL TISSUE 审中-公开
标题翻译：生物组织的HEPARIN涂层
公开(公告)号：WO2007004975A1
公开(公告)日：2007-01-11
申请号：PCT/SE2006/050224
申请日：2006-06-28
申请人： CORLINE SYSTEMS AB , LARSSON, Rolf
发明人： LARSSON, Rolf
IPC分类号： A61K31/727 , A61F2/02 , A61K35/12 , A61P37/06 , C12N5/08 , A61K35/39
CPC分类号： C12N5/0006 , A61K9/0024 , A61K31/4188 , A61K31/715 , A61K31/727 , A61K35/12 , A61K47/6957 , A61L27/34 , A61L27/3687 , A61L33/0029 , A61L2430/40 , C12N5/0677 , C12N5/0691 , C08L5/10
摘要： The present invention discloses an in vitro method to provide biological t issue with a heparin coating comprising the following steps; linking a biotin reagent to biological tissue, linking an avidin reagent to the biotinylated biological tissue, and linking a heparin reagent to the formed layer of avidin on the biological t issue thus forming a heparin coating. The invention further discloses a heparin coating on biological t issue, the use of a heparin coating, and the biological t issue coated with a heparin layer according to the method.
摘要翻译：本发明公开了一种体外方法，用于提供包含以下步骤的肝素涂层的生物学问题：将生物素试剂连接到生物组织上，将亲和素试剂与生物素化的生物组织连接，并将肝素试剂与形成的抗生物素蛋白层的生物学问题连接起来形成肝素涂层。本发明还公开了根据该方法的生物学问题上的肝素涂层，肝素涂层的使用以及用肝素层涂覆的生物学问题。

3. 发明申请

WO2004050095A1 USE OF A KNOWN SUBSTANCE FOR THE TREATMENT OF CANCER AND BACTERIAL AND FUNGAL INFECTIONS 审中-公开
标题翻译：使用已知的物质治疗癌症和细菌和真菌感染
公开(公告)号：WO2004050095A1
公开(公告)日：2004-06-17
申请号：PCT/SE2003/001809
申请日：2003-11-21
申请人： AGRIVIR AB , HEDMAN, Rikard , LEVENFORS, Jolanta , STANISLAW, Pietr , WELCH, Christopher, Folkeson , DAUGHERTY, Sean , LARSSON, Rolf, Lennart , GULLBO, Joakim , GERHARDSON, Berndt
发明人： HEDMAN, Rikard , LEVENFORS, Jolanta , STANISLAW, Pietr , WELCH, Christopher, Folkeson , DAUGHERTY, Sean , LARSSON, Rolf, Lennart , GULLBO, Joakim , GERHARDSON, Berndt
IPC分类号： A61K31/555
CPC分类号： C12R1/38 , A61K31/555 , A61K45/06 , C12P9/00 , A61K2300/00
摘要： The present invention concerns a previously known chemical entity, fluopsin C, and its use as an agent for the treatment of cancer and bacterial and fungal infections as well as two novel bacterial isolates of Pseudomonas sp., which produce fluopsin C. The invention also relates to pharmaceutical compositions and methods for treating cancer and bacterial and fungal infections with fluopsin C.
摘要翻译：本发明涉及一种先前已知的化学实体，荧光素C及其作为治疗癌症和细菌和真菌感染的试剂的用途，以及产生荧光素C的两种新的假单胞菌属细菌分离物。本发明还涉及用于治疗癌症的药物组合物和方法，用荧光素C治疗细菌和真菌感染

4. 发明申请

WO1997039304A1 PROGRAMMABLE BARREL WEAPON 审中-公开
标题翻译：可编程巴尔武器
公开(公告)号：WO1997039304A1
公开(公告)日：1997-10-23
申请号：PCT/SE1997000607
申请日：1997-04-11
申请人： BOFORS AB , LARSSON, Rolf , JOHANSSON, Nils , FOHRMAN, Erik , HAGSTRÖM, Björn , JERN, Sven-Åke
发明人： BOFORS AB
IPC分类号： F42C17/04
CPC分类号： F42C17/04
摘要： The present invention relates to a shell-firing barrel weapon which fires shells (3) provided with programmable electronic fuses (7) and in which the fuses (7) are programmed inside the cartridge chamber (12) of the weapon. Since the barrel (11) of the weapon is presupposed to be made of steel, the programming pulses are transmitted to the fuses (7) via one or more contact pins (13) which are let into the barrel (11) and are electrically insulated in relation to this and which are arranged in such a manner that, when the shells (3) are rammed home in the cartridge chamber (12) of the weapon, the pins come into contact with an electrically conductive contact band (9) which is let into the respective shell and has an external diameter which is slightly smaller than the internal diameter of the barrel and therefore does not come into contact with the inside of the barrel. Said contact band (9) is then in turn electrically insulated in relation to the main part (5) of the shell (3). The feedback of the programming pulses then takes place via the main part (5) of the shell body to the barrel (11) and back to the programming device (17) concerned.
摘要翻译：本发明涉及一种炮击炮弹武器，其燃烧具有可编程电子熔丝（7）的壳体（3），并且其中熔丝（7）被编程在武器的暗盒室（12）内。由于武器的枪管（11）预先由钢制成，编程脉冲经由一个或多个进入枪管（11）的接触销（13）传送到熔丝（7），并且是电绝缘的相对于此并且以这样的方式布置，即当壳体（3）在武器的暗盒室（12）中被撞到家中时，销与导电接触带（9）接触，导电接触带放入相应的外壳中，其外径略小于筒体内径，因此不会与筒体内部接触。所述接触带（9）又相对于壳体（3）的主要部分（5）电绝缘。然后，编程脉冲的反馈通过壳体的主要部分（5）发送到机筒（11）并返回到所涉及的编程装置（17）。

5. 发明申请

WO1991004125A1 METHOD OF LOCATING A WELDING STARTING-POINT 审中-公开
标题翻译：定位焊接起点的方法
公开(公告)号：WO1991004125A1
公开(公告)日：1991-04-04
申请号：PCT/SE1990000580
申请日：1990-09-13
申请人： ESAB AKTIEBOLAG , LARSSON, Rolf
发明人： ESAB AKTIEBOLAG
IPC分类号： B23K37/02
CPC分类号： B23K9/127
摘要： A method of locating, by means of a sensor (13), the welding starting point in continuous bead welding operations to produce butt joints (1) in a workpiece (3) by means of the welding head (12) of an arc-welding apparatus, the method comprising moving the sensor towards the joint and lowering the welding head towards the surface (19) of the workpiece from a predetermined initial position externally of the joint, whereupon the welding head is moved towards the joint until the sensor detects the latter, whereupon the sensor determines the centre line of the joint and the welding head is set with respect to the latter to be finally lowered into the welding position.
摘要翻译：一种通过传感器（13）定位焊接起始点的连续焊道焊接操作中的方法，以通过电弧焊接的焊接头（12）在工件（3）中产生对接接头（1）装置，该方法包括将传感器朝向关节移动并且从焊接外部的预定初始位置朝向工件的表面（19）降低焊接头，然后焊接头朝向接头移动，直到传感器检测到后者因此，传感器确定接头的中心线，并且相对于后者设置焊接头以最终降低到焊接位置。

6. 发明申请

WO1991001919A1 ARRANGEMENT FOR DE-WIRING BALES 审中-公开
标题翻译：拆线的安排
公开(公告)号：WO1991001919A1
公开(公告)日：1991-02-21
申请号：PCT/SE1990000486
申请日：1990-07-10
申请人： SUNDS DEFIBRATOR INDUSTRIES AKTIEBOLAG , EDSTRÖM, Sten-Erik , SÖDERBERG, Carl-Johan , ÖHRBERG, Tord , LARSSON, Rolf, T.
发明人： SUNDS DEFIBRATOR INDUSTRIES AKTIEBOLAG
IPC分类号： B65B69/00
CPC分类号： B65B69/0025
摘要： Arrangement for cutting binding wires on bales, such as pulp bales, paper bales and the like, comprising a conveyor (1) for the bale (2), a de-wiring station with fixing means (4-7) for the bale and cutting members in the form of two long cutting and, respectively, counter steels (14, 28 and, respectively, 15, 29) movable relative to each other, each provided with a plurality of teeth (17, 31 and, respectively, 21, 30) for cutting the binding wire, which cutting members are arranged on cutting arms (8, 9) movable to and from the bale (2). The fixing means comprise two plates (4, 5) movable relative to each other for lifting and fixing the bale (2). The teeth (17, 31) of the cutting steel (14, 28) are formed with a pocket (19) on the underside for taking up the binding wire, which pocket is defined upwardly by the lower flank (20) of the cutting tooth (17, 31). The counter steel (15, 29) extends from the side a distance inward beneath the teeth (17, 31) of the cutting steel for clamping the binding wire in the pocket (19) between the lower flank (20) of the cutting teeth (17, 31) and the counter steel (15, 29) prior to the cutting of the wire.
摘要翻译：包括用于捆包（2）的输送机（1），包括用于捆包和切割的固定装置（4-7）的拆线站的捆包装上的装订线的装置，例如纸浆捆，纸捆包等两个长切割形式的构件，分别相对于彼此可移动的反向钢（14,28和15,29），每个设置有多个齿（17,31，并且分别为21,30 ），用于切割装订线，该切割构件布置在可移动和移出捆（2）的切割臂（8,9）上。固定装置包括可相对于彼此移动的两个板（4,5），用于提升和固定捆包（2）。切割钢（14,28）的齿（17,31）在下侧形成有用于卷绕捆扎线的袋（19），该袋由切割齿的下侧（20）向上限定（17,31）。对位钢（15,29）从切割钢的齿（17,31）的内侧的一侧向内延伸，用于将装订线夹紧在切割齿的下侧面（20）之间的凹部（19）中 17,31）和对准钢（15,29）。

7. 发明申请

WO1986005441A1 HOT PRESS FOR TREATING A WEB OF MATERIAL 审中-公开
标题翻译：用于处理材料网的热压机
公开(公告)号：WO1986005441A1
公开(公告)日：1986-09-25
申请号：PCT/SE1986000096
申请日：1986-03-07
申请人： KMW AKTIEBOLAG , LARSSON, Rolf, Tage , CARLSSON, Bengt, Johan
发明人： KMW AKTIEBOLAG
IPC分类号： B30B05/06
CPC分类号： B30B5/067
摘要： A hot press for treating a web of material (1) and comprising upper and lower press platens (3, 4), upper and lower movable press belts (12, 13), an upper movable bed (14) of rods (16) arranged between the upper press platen (3) and the upper press belt (12), and a lower movable bed (15) of rods (16) arranged between the lower press platen (4) and the lower press belt (13), said press belts (12, 13) defining between them within the region of the press platens (3, 4), a pressing zone (22) having an entry section (23) for introducing the web (1). According to the invention an aligning and feeding means (35, 36) is arranged for each bed (14, 15) of rods (16) and comprises a wheel unit (37) arranged within the entry section (23) and comprising a rotatable shaft (38) journalled perpendicularly to the direction of movement of the press belt (12, 13), and a plurality of wheels (39) secured to said shaft (38), said wheels peripherally supporting a plurality of short rollers (40). The rollers (40) of one wheel (39) are aligned with the the rollers of the other wheels (39) to form rows of rollers (40) located transverse to the direction of movement of the press belt (12, 13) and having coinciding central axes (41). The rows of rollers (40) are brought into contact with the rods (16) recirculated to the entry section (23) in such a manner that, upon contact with one rod (16), one row of rollers (40) retards the movement of said one rod in relation to the press platen (3 and 4, respectively), thus packing the other rods (16) located next upstream closely together, and then delivers said one rod (16) to the pressing zone (22) for free rolling.

8. 发明申请

WO1986002288A1 ARRANGEMENT IN AEROSOL CONTAINERS 审中-公开
标题翻译：航空器集装箱安装
公开(公告)号：WO1986002288A1
公开(公告)日：1986-04-24
申请号：PCT/SE1985000398
申请日：1985-10-17
申请人： LARSSON, Rolf
IPC分类号： B05B01/28
CPC分类号： B65D83/30
摘要： A device (1) to prevent unnecessary spreading of goods from aerosol containers when the goods are discharged and showing a holder (2) with a sleeve (5) in which a displaceable body (3) is arranged. Said body shows a channel to receive at least an end portion of a discharge nozzle of the container and a recess (17) to communicate with the intended place of entering or discharge of the goods of the container. The body (3) is brought to displacement to influence said discharge nozzle of the container to effect discharge of the goods by connecting the sleeve (5) bearing on or around said place of entering or discharge, wherey the goods are prevented to be spread by said recess (17) of the body (3).
摘要翻译：一种装置（1），用于在货物排出时防止货物从气溶胶容器中不必要地展开，并且示出了具有其中布置有可移动主体（3）的套筒（5）的保持器（2）。所述主体示出了容纳容器的排出喷嘴的至少端部的通道和与容器的货物的进入或排出的预期位置连通的凹部（17）。使主体（3）移动以影响容器的排放喷嘴，以通过连接在所述进入或排出的地方或其周围的套筒（5）来排出货物，从而防止货物被传播所述主体（3）的所述凹部（17）。

9. 发明申请

WO2011078782A1 A COMPOSITION COMPRISING OF MELPHALAN DERIVATIVES AND GEMCITABINE OR ETOPOSIDE USEFUL IN THE TREATMENT OF CANCER 审中-公开
标题翻译：包含有效治疗癌症的芬太尼衍生物和孕激素或雌二醇的组合物
公开(公告)号：WO2011078782A1
公开(公告)日：2011-06-30
申请号：PCT/SE2010/051466
申请日：2010-12-22
申请人： ONCOPEPTIDES AB , GULLBO, Joachim , LARSSON, Rolf , SPIRA, Jack , VIKTORSSON, Emma Kristina
发明人： GULLBO, Joachim , LARSSON, Rolf , SPIRA, Jack , VIKTORSSON, Emma Kristina
IPC分类号： A61K38/05 , A61K31/165 , A61P35/00 , A61K31/36 , A61K31/7068
CPC分类号： A61K38/05 , A61K31/165 , A61K31/36 , A61K31/7068 , C07K5/06191
摘要： The present invention is directed to a composition comprising melphalan, or a derivative thereof having essentially the biological activity of melphalan, and gemcitabine. The combination of melphalan or a derivative thereof and gemcitabine results in a synergistic effect when used for treating cancer. The invention therefore also relates to the use of the composition for the preparation of medicaments for the treatment and/or prevention of cancer, as well as methods for cancer treatment and/or prevention. The invention is also directed to a composition comprising a combination of melphalan, or a derivative thereof having essentially the biological activity of melphalan, and etoposide for the preparation of a medicament for the treatment and/or prevention of ovarian cancer, bladder cancer and/or lung cancer, as well as methods for treating and/or preventing such cancers.
摘要翻译：本发明涉及包含基本上具有美法仑的生物学活性的美法仑或其衍生物和吉西他滨的组合物。美法仑或其衍生物和吉西他滨的组合在用于治疗癌症时导致协同效应。因此，本发明还涉及组合物用于制备用于治疗和/或预防癌症的药物的用途，以及用于癌症治疗和/或预防的方法。本发明还涉及包含具有基本上美法仑的生物活性的美法仑或其衍生物和依托泊苷的组合物，其用于制备用于治疗和/或预防卵巢癌，膀胱癌和/或肺癌，以及用于治疗和/或预防这种癌症的方法。

10. 发明申请

WO2011075032A1 TUMOUR TREATMENT AGENTS AND METHOD 审中-公开
标题翻译：肿瘤治疗剂和方法
公开(公告)号：WO2011075032A1
公开(公告)日：2011-06-23
申请号：PCT/SE2010/000289
申请日：2010-12-08
申请人： VIVOLUX AB , LARSSON, Rolf , NYGREN, Peter , GULLBO, Joakim , WESTMAN, Gunnar
发明人： LARSSON, Rolf , NYGREN, Peter , GULLBO, Joakim , WESTMAN, Gunnar
IPC分类号： A61K31/4402 , A61P35/00 , C07D213/53
CPC分类号： C07D213/53 , A61K31/4402
摘要： N 1-(3-Methoxypropyl)-2-(pyridylmethylidene)-hydrazine-1-carbothioamide (I) and its Cu 2+ , Pd 2+ and Pt 2+ complexes are effective anti-tumor agents. Also disclosed are compositions comprising (I) and its Cu 2+ , Pd 2+ and Pt 2+ complexes, and the use of the compositions in the treatment of malignant tumors.
摘要翻译： N1-（3-甲氧基丙基）-2-（吡啶亚甲基） - 肼-1-硫代酰胺（I）及其Cu2 +，Pd2 +和Pt2 +配合物是有效的抗肿瘤剂。还公开了包含（I）及其Cu 2+，Pd 2+和Pt 2+络合物的组合物，以及该组合物在治疗恶性肿瘤中的用途。

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