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1. 发明申请

WO2012170603A1 SILICONE HYDROGEL LENSES WITH NANO-TEXTURED SURFACES 审中-公开
标题翻译：硅胶水镜与纳米纹理表面
公开(公告)号：WO2012170603A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041207
申请日：2012-06-07
申请人： NOVARTIS AG , BAUMAN, R., Erich , HAGMANN, Peter , PRUITT, John, Dallas , RAPPON, Joseph, Michael
发明人： BAUMAN, R., Erich , HAGMANN, Peter , PRUITT, John, Dallas , RAPPON, Joseph, Michael
IPC分类号： G02B1/04 , B29D11/00
CPC分类号： G02C7/049 , B29D11/00346 , G02B1/043 , G02C2202/16
摘要： The invention is related to a method for making a silicone hydrogel contact lens having a nano-textured surface which mimics the surface texture of cornea of human eye. A method of the invention comprises creating a prime coating having nano-textures through controlled imbibition and/or depositions of a reactive polymeric coating material and fixing the nano-textures by crosslinking a hydrophilic polymeric material onto the prime coating to form a crosslinked polymeric coating that perserves the nano-textures of the prime coating and provides a nano-textured surface to the contact lens.
摘要翻译：本发明涉及制备具有模仿人眼角膜表面纹理的纳米纹理表面的硅酮水凝胶隐形眼镜的方法。本发明的方法包括通过控制的吸收和/或沉积反应性聚合物涂层来形成具有纳米纹理的初始涂层，并通过将亲水性聚合物材料交联到初始涂层上来固定纳米纹理以形成交联的聚合物涂层维持主涂层的纳米纹理，并为隐形眼镜提供纳米纹理表面。

2. 发明申请

WO2012015639A1 METHOD FOR MAKING UV-ABSORBING OPHTHALMIC LENSES 审中-公开
标题翻译：制造紫外线吸收光学眼镜的方法
公开(公告)号：WO2012015639A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/044618
申请日：2011-07-20
申请人： NOVARTIS AG , SAMUEL, Newton, T. , PRUITT, John, Dallas , WU, Daqing , KUYU, Selma
发明人： SAMUEL, Newton, T. , PRUITT, John, Dallas , WU, Daqing , KUYU, Selma
IPC分类号： G02C7/04 , C08L83/04
CPC分类号： G02B1/043 , B29D11/00038 , B29D11/00048 , G02C7/04 , G02C7/049 , C08L101/14
摘要： Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.
摘要翻译：本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。与使紫外线吸收性隐形眼镜相关的常规方法与包含紫外线吸收性乙烯基单体的透镜形成组合物共聚，本发明的方法涉及将具有第二反应性官能团的紫外线吸收性化合物与其中和/或其上具有第一反应性官能团的预成型隐形眼镜。

3. 发明申请

WO2012016097A3 AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF 审中-公开
公开(公告)号：WO2012016097A3
公开(公告)日：2012-02-02
申请号：PCT/US2011/045809
申请日：2011-07-29
申请人： NOVARTIS AG , CHANG, Frank , SCOTT, Robert , HUANG, Jinyu , MEDINA, Arturo, N. , SMITH, Dawn, A. , SANDERS, Laura, Ann , PRUITT, John, Dallas
发明人： CHANG, Frank , SCOTT, Robert , HUANG, Jinyu , MEDINA, Arturo, N. , SMITH, Dawn, A. , SANDERS, Laura, Ann , PRUITT, John, Dallas
IPC分类号： C08F26/02 , C08F226/00
摘要： The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

4. 发明申请

WO2008055085A1 METHOD FOR APPLYING A COATING ONTO A SILICONE HYDROGEL LENS 审中-公开
标题翻译：将涂层涂覆在硅胶水镜上的方法
公开(公告)号：WO2008055085A1
公开(公告)日：2008-05-08
申请号：PCT/US2007/082771
申请日：2007-10-29
申请人： NOVARTIS AG , PRUITT, John Dallas , WINTERTON, Lynn Cook , KUMAR, Sai Ramamurthy , SMITH, Dawn A.
发明人： PRUITT, John Dallas , WINTERTON, Lynn Cook , KUMAR, Sai Ramamurthy , SMITH, Dawn A.
IPC分类号： A61L12/04 , A61L27/34 , C08J7/04 , C11D3/00 , G02B1/04 , G02B1/10
CPC分类号： G02B1/10 , A61L12/04 , A61L12/14 , B29D11/00038 , B29D11/00865 , C08J7/04 , C08J2383/00 , G02B1/043 , G02C7/04
摘要： The invention provides a cost-effective and in-situ method for applying an LbL coating onto a silicone hydrogel contact lens directly in a lens package. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, intactness and durability and also can be used directly from the lens package by a patient without washing and/or rising. In addition, the invention provides a packaging solution for in-situ coating of a silicone hydrogel contact lens in a lens package and an ophthalmic lens product.
摘要翻译：本发明提供了一种成本有效和原位的方法，用于将LbL涂层直接应用于透镜包装中的硅酮水凝胶隐形眼镜上。所得的硅酮水凝胶隐形眼镜具有良好的亲水性，完整性和耐久性的涂层，并且也可以由患者直接从镜片包装中使用而无需洗涤和/或上升。此外，本发明提供了一种用于在镜片包装和眼用透镜产品中原位涂覆硅酮水凝胶隐形眼镜的包装溶液。

5. 发明申请

WO2014209939A3 LENS CARE PRODUCT FOR OZONE-BASED CLEANING/DISINFECTING OF CONTACT LENSES 审中-公开
标题翻译：镜片护理产品用于基于臭氧的清洁/消毒接触镜片
公开(公告)号：WO2014209939A3
公开(公告)日：2015-04-23
申请号：PCT/US2014043772
申请日：2014-06-24
申请人： NOVARTIS AG , TUCKER ROBERT CAREY , PRUITT JOHN DALLAS , MUYA LEROY WAINAINA
发明人： TUCKER ROBERT CAREY , PRUITT JOHN DALLAS , MUYA LEROY WAINAINA
IPC分类号： A61L12/08
CPC分类号： A61L12/122 , C11D3/0078 , C11D3/166 , C11D3/2079 , C11D7/08 , C11D7/10 , C11D7/265
摘要： The present invention provides an aqueous lens care solution for disinfecting and/or cleaning contact lenses in an ozone-based lens care system. The lens care solution of the invention is a hypotonic solution, has an osmolality at about 25C of from about 200 mOsm/kg to about 260mOsm/kg, and comprises at least one relatively-ozone-inert buffering agent selected from the group consisting of boric acid, sodium tetraborate, potassium tetraborate, acetic acid, sodium acetate, potassium acetate, and a mixture thereof. The aqueous lens care solution is compatible with ozone electrolytically generated in an ozone-based lens care system as characterized by comprising about 30 mM or less of chloride ion and less than about 10 mM of one or more ozone-interfering buffering agents.
摘要翻译：本发明提供一种用于在基于臭氧的镜片护理系统中消毒和/或清洁隐形眼镜的水性透镜护理液。本发明的晶状体护理溶液是低渗溶液，约25℃的重量摩尔渗透压浓度为约200mOsm / kg至约260mOsm / kg，并且包含至少一种相对臭氧惰性的缓冲剂，其选自硼酸酸，四硼酸钠，四硼酸钾，乙酸，乙酸钠，乙酸钾及其混合物。水性透镜护理溶液与基于臭氧的晶状体护理系统中电解产生的臭氧相容，其特征在于包含约30mM或更少的氯离子和小于约10mM的一种或多种臭氧干扰缓冲剂。

6. 发明申请

WO2012078457A1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：制造硅胶水凝胶接触透镜的方法
公开(公告)号：WO2012078457A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/062986
申请日：2011-12-02
申请人： NOVARTIS AG , SAMUEL, Newton, T. , HUANG, Horngyih , WU, Daqing , HAKEN, Uwe , PRUITT, John, Dallas , DOMSCHKE, Angelika, Maria , MATSUZAWA, Yasuo
发明人： SAMUEL, Newton, T. , HUANG, Horngyih , WU, Daqing , HAKEN, Uwe , PRUITT, John, Dallas , DOMSCHKE, Angelika, Maria , MATSUZAWA, Yasuo
IPC分类号： B29D11/00
CPC分类号： B29D11/00153 , B08B9/00 , G02B1/043 , C08L83/04 , C08L101/14
摘要： The invention provides a method for washing, with a water-based system, reusable molds for making silicone hydrogel contact lenses. The water-based washing system comprises an ethoxylated silicone polyether surfactant. The water-based system of the invention can effectively wash away silicone-containing components and other components of a lens formulation left behind on the molding surfaces of a reusable mold, after removing a silicone hydrogel contact lens cast molded in the reusable mold.
摘要翻译：本发明提供了一种用水洗系统清洗可重复使用的模具以制造硅酮水凝胶隐形眼镜的方法。水基洗涤系统包括乙氧基化硅氧烷聚醚表面活性剂。在去除在可重复使用的模具中铸造的硅酮水凝胶隐形眼镜之后，本发明的水基系统可以有效地洗掉留在可重复使用的模具的模制表面上的透镜制剂的含硅酮组分和其它组分。

7. 发明申请

WO2012016098A1 A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 审中-公开
标题翻译：具有交联水解涂层的硅胶水镜
公开(公告)号：WO2012016098A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045810
申请日：2011-07-29
申请人： NOVARTIS AG , QIU, Yongxing , SAMUEL, Newton, T. , PRUITT, John, Dallas , KOLLURU, Chandana , MEDINA, Arturo, N. , WINTERTON, Lynn, Cook , WU, Daqing , QIAN, Xinming , NELSON, Jared
发明人： QIU, Yongxing , SAMUEL, Newton, T. , PRUITT, John, Dallas , KOLLURU, Chandana , MEDINA, Arturo, N. , WINTERTON, Lynn, Cook , WU, Daqing , QIAN, Xinming , NELSON, Jared
IPC分类号： G02C7/04 , B05D5/06 , B29D11/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： A cost-effective method for making a silicone hydrogel contact lens has a crosslinked hydrophilic coating applied thereon. The method involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally- crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, and at a temperature from 40 Centigrade to 140 Centigrade for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译：制造硅酮水凝胶隐形眼镜的成本有效的方法具有涂覆在其上的交联的亲水涂层。该方法包括在具有带正电的氮杂环丁烷基团的水溶性，高度支化，可热交联的亲水性聚合物材料的存在下，在40℃至140℃的温度存在下，在水溶液中加热硅氧烷水凝胶隐形眼镜，用于足以将热交联亲水性聚合物材料共价连接到硅酮水凝胶隐形眼镜的表面上的共价键，每个共价键在硅氧烷水凝胶的表面上和/或附近的一个氮杂环丁烷基与一个反应性官能团之间形成接触透镜，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

8. 发明申请

WO2012074861A1 ATMOSPHERIC PLASMA COATING FOR OPHTHALMIC DEVICES 审中-公开
标题翻译：大气等离子体涂料用于眼科装置
公开(公告)号：WO2012074861A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/061984
申请日：2011-11-23
申请人： NOVARTIS AG , QIU, Yongxing , PRUITT, John, Dallas , KOLLURU, Chandana , DUNKLE, Maria, A. , MATSUZAWA, Yasuo
发明人： QIU, Yongxing , PRUITT, John, Dallas , KOLLURU, Chandana , DUNKLE, Maria, A. , MATSUZAWA, Yasuo
IPC分类号： B29D11/00
CPC分类号： B29D11/00038 , B29D11/00865
摘要： The invention provides a method of coating and thereby affecting the surface properties of a substrate such as a contact lens or other ophthalmic device. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a substrate surface.
摘要翻译：本发明提供一种涂覆方法，从而影响诸如隐形眼镜或其它眼科装置之类的基底的表面性质。该方法包括以下步骤：从工作气体产生大气等离子体流，并用发电机控制大气等离子体流的连续性，以及将大气等离子体流引入衬底表面。

9. 发明申请

WO2010071691A1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：制造硅胶水凝胶接触透镜的方法
公开(公告)号：WO2010071691A1
公开(公告)日：2010-06-24
申请号：PCT/US2009/047428
申请日：2009-06-16
申请人： NOVARTIS AG , CHANG, Frank , VOGT, Jürgen , PRUITT, John, Dallas , QIAN, Xinming , SMITH, Dawn, A. , DOMSCHKE, Angelika, Maria , HOLLAND, Troy, Vernon , TUREK, Richard, Charles , WU, Daqing
发明人： CHANG, Frank , VOGT, Jürgen , PRUITT, John, Dallas , QIAN, Xinming , SMITH, Dawn, A. , DOMSCHKE, Angelika, Maria , HOLLAND, Troy, Vernon
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C08F283/124 , C08L83/04 , C08L51/085
摘要： A method for producing silicone hydrogel contact lenses and silicon hydrogel contact lens thereof. The method comprising the steps of: providing a mold for making a soft contact lens, wherein the mold has a first mold half with a first molding surface defining the anterior surface of a contact lens and a second mold half with a second molding surface defining the posterior surface of the contact lens, wherein said first and second mold halves are configured to receive each other such that a cavity is formed between said first and second molding surfaces; introduce a monomer mixture of lens-forming materials into the cavity, wherein the monomer mixture comprises at least one hydrophilic amide-type vinylic monomer, at least one siloxane-containing (meth)acrylamide monomer, at least one polysiloxane vinylic monomer or macromer, and from about 0.05 % to about 1.5 % by weight of a photoinitiator, wherein the lens forming material is characterized by having an ability to be cured by a UV light having an UV-intensity of about 4.1 mW/cm 2 within about 100 seconds; and irradiating, under a spatial limitation of actinic radiation, the lens-forming material in the mold for a time period of about 120 seconds or less, so as to crosslink the lens-forming material to form the silicone hydrogel contact lens, wherein the produced contact lens comprises an anterior surface defined by the first molding surface, an opposite posterior surface defined by the second molding surface, and a lens edge defined by the spatial limitation of actinic radiation.
摘要翻译：硅酮水凝胶隐形眼镜及其硅水凝胶隐形眼镜的制造方法。该方法包括以下步骤：提供用于制造软性隐形眼镜的模具，其中所述模具具有第一半模，其具有限定隐形眼镜的前表面的第一模制表面和具有限定所述隐形眼镜的第二模制表面的第二半模接触透镜的后表面，其中所述第一和第二半模被配置为彼此接收，使得在所述第一和第二模制表面之间形成空腔; 将透镜形成材料的单体混合物引入空腔中，其中单体混合物包含至少一种亲水性酰胺型乙烯基单体，至少一种含硅氧烷的（甲基）丙烯酰胺单体，至少一种聚硅氧烷乙烯基单体或大分子单体，以及约0.05重量％至约1.5重量％的光引发剂，其中所述透镜形成材料的特征在于具有在约100秒内具有约4.1mW / cm 2的UV强度的UV光固化的能力; 并且在光化辐射的空间限制下将模具中的透镜形成材料照射大约120秒或更短的时间，以使透镜形成材料交联以形成硅氧水凝胶隐形眼镜，其中所产生的隐形眼镜包括由第一成型表面限定的前表面，由第二成型表面限定的相对的后表面和由光化辐射的空间限制限定的透镜边缘。

10. 发明申请

WO2009085902A1 METHOD FOR MAKING CONTACT LENSES 审中-公开
标题翻译：制造接触镜的方法
公开(公告)号：WO2009085902A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087345
申请日：2008-12-18
申请人： NOVARTIS AG , PRUITT, John, Dallas , WINTERTON, Lynn, Cook , SEIFERLING, Bernhard , VOGT, Juergen , BOTHE, Harald
发明人： PRUITT, John, Dallas , WINTERTON, Lynn, Cook , SEIFERLING, Bernhard , VOGT, Juergen , BOTHE, Harald
IPC分类号： G02B1/04 , B29D11/00
CPC分类号： G02B1/043 , B29C33/60
摘要： Method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
摘要翻译：用于制造具有改善的镜片质量和增加的产品产率的隐形眼镜的方法和流体组合物。本发明的方法包括将磷脂添加到包含透镜形成材料的流体组合物中，其量足以将平均的模具分离力与没有磷脂的模具分离力相比降低至少约40％。

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