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1. 发明申请

WO2015116671A3 FACTORS FOR THE PRODUCTION AND ACCUMULATION OF POLYUNSATURATED FATTY ACIDS (PUFAS) DERIVED FROM PUFA SYNTHASES 审中-公开
公开(公告)号：WO2015116671A3
公开(公告)日：2015-08-06
申请号：PCT/US2015/013274
申请日：2015-01-28
申请人： DSM IP ASSETS B.V. , METZ, James George , KUNER, Jerry M. , MCCASKILL, David Glen , FOSTER, Mendy Louise
发明人： METZ, James George , KUNER, Jerry M. , MCCASKILL, David Glen , FOSTER, Mendy Louise
IPC分类号： C12N1/20 , C12N1/28 , C12P7/64
摘要： Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.

2. 发明申请

WO2015116671A2 FACTORS FOR THE PRODUCTION AND ACCUMULATION OF POLYUNSATURATED FATTY ACIDS (PUFAS) DERIVED FROM PUFA SYNTHASES 审中-公开
标题翻译： PUFA合成多不饱和脂肪酸（PUFAS）生产和积累的因素
公开(公告)号：WO2015116671A2
公开(公告)日：2015-08-06
申请号：PCT/US2015013274
申请日：2015-01-28
申请人： DSM IP ASSETS BV , METZ JAMES GEORGE , KUNER JERRY M , MCCASKILL DAVID GLEN , FOSTER MENDY LOUISE
发明人： METZ JAMES GEORGE , KUNER JERRY M , MCCASKILL DAVID GLEN , FOSTER MENDY LOUISE
IPC分类号： C12P7/64 , C12N1/16
CPC分类号： C12N9/20 , A23L33/115 , A23V2002/00 , A61K31/202 , C07K14/00 , C07K14/405 , C12N9/16 , C12N15/79 , C12P7/6427 , C12Y301/01
摘要： Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.
摘要翻译： PUFA合成酶衍生的多不饱和脂肪酸（PUFA）的产生和积累的因素摘要公开了PUFA合酶系统的新型增强因子蛋白，编码其的核酸分子，重组核酸分子和包含此类核酸分子的重组宿主细胞，包含其的基因修饰的微生物，以及制备和使用微生物的方法。还公开了遗传修饰的微生物，其已经被遗传修饰以表达用于生产PUFA的PUFA合酶系统，其中微生物已经被修饰以表达PUFA合酶系统的新增强因子蛋白。

3. 发明申请

WO2013016546A3 PRODUCTION OF DHA AND OTHER LC-PUFAS IN PLANTS 审中-公开
标题翻译：生产植物中的DHA和其他LC-PUFAS
公开(公告)号：WO2013016546A3
公开(公告)日：2013-05-10
申请号：PCT/US2012048355
申请日：2012-07-26
申请人： DOW AGROSCIENCES LLC , DSM IP ASSETS BV , WALSH TERENCE A , GACHOTTE DANIEL , MERLO ANN OWENS , PAREDDY DAYAKAR REDDY , METZ JAMES , BEVAN SCOTT , KUNER JERRY
发明人： WALSH TERENCE A , GACHOTTE DANIEL , MERLO ANN OWENS , PAREDDY DAYAKAR REDDY , METZ JAMES , BEVAN SCOTT , KUNER JERRY
IPC分类号： C12N5/04
CPC分类号： A01H5/10 , A23L11/07 , A23V2002/00 , A61K31/202 , C12N9/1029 , C12N9/1288 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y203/01085
摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.
摘要翻译：本发明提供了用多不饱和脂肪酸（PUFA）合酶系统遗传修饰的重组宿主生物以及允许和/或改善宿主生物体中PUFAs产生的一种或多种辅助蛋白。本发明还涉及制造和使用这样的生物体的方法以及从这些生物体获得的产品。

4. 发明申请

WO2011146524A1 PRODUCTION OF DHA AND OTHER LC-PUFAS IN PLANTS 审中-公开
标题翻译：在植物中生产DHA和其他LC-PUFAS
公开(公告)号：WO2011146524A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/036869
申请日：2011-05-17
申请人： Dow AgroSciences LLC , Martek Biosciences Corporation , WALSH, Terence A. , MERLO, Ann Owens , GACHOTTE, Daniel , ROESSLER, Paul Gordon , BEVAN, Scott , KUNER, Jerry M. , METZ, James G.
发明人： WALSH, Terence A. , MERLO, Ann Owens , GACHOTTE, Daniel , ROESSLER, Paul Gordon , BEVAN, Scott , KUNER, Jerry M. , METZ, James G.
IPC分类号： C12N15/82 , C12N15/87 , C12N5/00 , C12N5/02 , C12N5/04 , C12N5/10
CPC分类号： C12N15/8247 , C12N9/1029 , C12N9/1288 , C12P7/6427
摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
摘要翻译：本发明提供了用多不饱和脂肪酸（PUFA）合酶系统和一种或多种辅助蛋白（例如，PPT酶和/或ACoAS）进行遗传修饰的重组宿主生物（例如，植物），其允许和/或改善PUFA的生产宿主生物体。本发明还涉及制备和使用这些生物体（例如获得PUFA）以及从这些生物（例如油和/或种子）获得的产品的方法。

5. 发明申请

WO2007106905A3 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 审中-公开
标题翻译：使用多不饱和脂多糖合成酶系统进行异构体生物聚合脂肪酸生产
公开(公告)号：WO2007106905A3
公开(公告)日：2008-11-27
申请号：PCT/US2007064106
申请日：2007-03-15
申请人： MARTEK BIOSCIENCES CORP , SEMBIOSYS GENETICS INC , METZ JAMES G , KUNER JERRY M , LIPPMEIER JAMES CASEY , MOLONEY MAURICE MARTIN , NYKIFORUK CORY LEE
发明人： METZ JAMES G , KUNER JERRY M , LIPPMEIER JAMES CASEY , MOLONEY MAURICE MARTIN , NYKIFORUK CORY LEE
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N9/1029 , C12N9/93 , C12N15/8247 , C12P7/6427 , C12P7/6472 , Y02P20/52
摘要： Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the plant or plant cell, and in one aspect, to inhibit KASII or KASIII. Additional modifications, and methods to make and use such organisms, in addition to PUFAs and oils obtained from such organisms, are disclosed, alone with various products including such PUFAs and oils.
摘要翻译：公开了新的酰基辅酶A合成酶和新的酰基转移酶，编码它们的核酸分子，重组核酸分子和包含该核酸分子的重组宿主细胞，包含该核酸分子的转基因生物（微生物和植物），以及制备和使用一样。还公开了经遗传修饰以表达用于生产PUFA（PUFA PKS系统或PUFA合酶）的PKS样系统的遗传修饰生物体（例如，植物，微生物），其中生物体被修饰以表达酰基 -CoA合成酶，以表达酰基转移酶，以删除或失活由生物表达的脂肪酸合成酶（FAS），以减少与PUFA合酶的丙二酰辅酶A竞争或增加植物或植物细胞中丙二酰辅酶A的水平，并且在一个方面，抑制KASII或KASIII。除了PUFA和从这些生物获得的油之外，还公开了另外的修饰和制造和使用这些生物体的方法，其中包括各种产品，包括这种PUFA和油。

6. 发明申请

WO2006135866A2 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 审中-公开
标题翻译： PUFA多肽合成系统及其用途
公开(公告)号：WO2006135866A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022893
申请日：2006-06-12
申请人： MARTEK BIOSCIENCES CORPORATION , METZ, James, G. , FLATT, James, H. , KUNER, Jerry, M.
发明人： METZ, James, G. , FLATT, James, H. , KUNER, Jerry, M.
IPC分类号： C12P7/64
CPC分类号： C12P7/6472 , A23D9/00 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6463
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译：公开了来自裂殖壶菌的完全多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）系统及其生物活性片段及其同源物。更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质及其结构域，包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用本文公开的PUFA PKS系统。本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS））有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。

7. 发明申请

WO2013016546A2 PRODUCTION OF DHA AND OTHER LC-PUFAS IN PLANTS 审中-公开
标题翻译：在植物中生产DHA和其他LC-PUFAS
公开(公告)号：WO2013016546A2
公开(公告)日：2013-01-31
申请号：PCT/US2012/048355
申请日：2012-07-26
申请人： DOW AGROSCIENCES LLC , DSM IP ASSETS B.V. , WALSH, Terence A. , GACHOTTE, Daniel , MERLO, Ann Owens , PAREDDY, Dayakar Reddy , METZ, James , BEVAN, Scott , KUNER, Jerry
发明人： WALSH, Terence A. , GACHOTTE, Daniel , MERLO, Ann Owens , PAREDDY, Dayakar Reddy , METZ, James , BEVAN, Scott , KUNER, Jerry
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8247 , A01H5/10 , A23L11/07 , A23V2002/00 , A61K31/202 , C12N9/1029 , C12N9/1288 , C12P7/6427 , C12P7/6472 , C12Y203/01085
摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.
摘要翻译：本发明提供了用多不饱和脂肪酸（PUFA）合成酶遗传修饰的重组宿主生物体，以及允许和/或改善宿主生物体中PUFA生产的一种或多种辅助蛋白质。本发明还涉及制造和使用这些生物以及从这些生物获得的产品的方法。

8. 发明申请

WO2005079367A3 SCHIZOCHYTRIUM FATTY ACID SYNTHASE (FAS) AND PRODUCTS AND METHODS RELATED THERETO 审中-公开
标题翻译：调味酸脂肪酸合成酶（FAS）及其相关产品及方法
公开(公告)号：WO2005079367A3
公开(公告)日：2007-04-19
申请号：PCT/US2005004611
申请日：2005-02-14
申请人： MARTEK BIOSCIENCES CORP , METZ JAMES G , WEAVER CRAIG A , KUNER JERRY M
发明人： METZ JAMES G , WEAVER CRAIG A , KUNER JERRY M
IPC分类号： C12P7/62 , A61K31/202 , C07H21/04 , C12N1/10 , C12N9/10 , C12N9/80 , C12P7/64 , C12Q1/44 , C12Q1/48 , C12Q1/68
CPC分类号： C12N9/1029
摘要： Disclosed are a fatty acid synthase (FAS) from Schizochytrium, biologically active fragments and homologues thereof, a nucleic acid sequence encoding such FAS, fragments and homologues thereof, the gene encoding Schizochytrium FAS, host cells and organisms that recombinantly express the FAS, host cells and organisms in which the expression and/or activity of the endogenous FAS has been attenuated, and various methods for making and using any of these proteins, nucleic acid molecules, genes, host cells or organisms.
摘要翻译：公开了来自裂殖壶菌的脂肪酸合成酶（FAS），其生物活性片段及其同源物，编码这种FAS的核酸序列，其片段和同系物，编码裂殖酵母FAS的基因，重组表达FAS的宿主细胞和生物体宿主细胞和其中内源性FAS的表达和/或活性已被减弱的生物体，以及用于制备和使用这些蛋白质，核酸分子，基因，宿主细胞或生物体中的任何一种的各种方法。

9. 发明申请

WO2006135866A3 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 审中-公开
标题翻译：多不饱和脂多糖合成酶系统及其用途
公开(公告)号：WO2006135866A3
公开(公告)日：2009-04-23
申请号：PCT/US2006022893
申请日：2006-06-12
申请人： MARTEK BIOSCIENCES CORP , METZ JAMES G , FLATT JAMES H , KUNER JERRY M
发明人： METZ JAMES G , FLATT JAMES H , KUNER JERRY M
IPC分类号： C12N15/87 , A23L25/00
CPC分类号： C12P7/6472 , A23D9/00 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6463
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译：公开了来自裂殖壶菌的完全多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）系统及其生物活性片段及其同源物。更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用本文公开的PUFA PKS系统。本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。

10. 发明申请

WO2007106903A3 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 审中-公开
标题翻译：使用多不饱和脂多糖合成酶系统进行异构体生物聚合脂肪酸生产
公开(公告)号：WO2007106903A3
公开(公告)日：2009-04-09
申请号：PCT/US2007064104
申请日：2007-03-15
申请人： MARTEK BIOSCIENCES CORP , METZ JAMES G , KUNER JERRY M , LIPPMEIER JAMES CASEY
发明人： METZ JAMES G , KUNER JERRY M , LIPPMEIER JAMES CASEY
IPC分类号： C12Q1/68
CPC分类号： C12N9/1029 , C12N9/93 , C12N15/8247 , C12P7/6427 , C12P7/6472 , Y02P20/52
摘要： Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII. Additional modifications, and methods to make and use such organisms, in addition to PUFAs and oils obtained from such organisms, are disclosed, alone with various products including such PUFAs and oils.
摘要翻译：公开了新型酰基辅酶A合成酶和新型酰基转移酶，编码该酰基转移酶的核酸分子，重组核酸分子和包含该核酸分子的重组宿主细胞，包含该核酸分子的转基因生物（微生物和植物），以及制备和使用一样。还公开了经遗传修饰以表达用于生产PUFA（PUFA PKS系统或PUFA合酶）的PKS样系统的遗传修饰生物体（例如，植物，微生物），其中生物体被修饰以表达酰基 -CoA合成酶，以表达酰基转移酶，以删除或失活由生物体表达的脂肪酸合酶（FAS），以减少与PUFA合酶的丙二酰辅酶A竞争或增加生物体中丙二酰辅酶A的水平，以及一方面抑制KASII或KASIII。除了PUFA和从这些生物获得的油之外，还公开了另外的修饰和制造和使用这些生物体的方法，其中包括各种产品，包括这种PUFA和油。

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