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1. 发明申请

WO2015137449A1 トリアシルグリセロール高生産性藻類の作製法审中-公开
标题翻译：制备三氯乙烯高生产率的方法
公开(公告)号：WO2015137449A1
公开(公告)日：2015-09-17
申请号：PCT/JP2015/057302
申请日：2015-03-12
申请人：国立大学法人東京工業大学
发明人：岩井　雅子 , 太田　啓之 , 下嶋　美恵
IPC分类号： A01H1/00 , A01H5/00 , C12N15/09 , C12P7/64
CPC分类号： C12P7/64 , C12N9/1029 , C12N15/8237 , C12N15/8247 , C12P7/6463 , C12Y203/01085
摘要：　藻類の細胞中にトリアシルグリセロールを効率的に蓄積させることを目的として、トリアシルグリセロール合成酵素遺伝子とリン欠乏応答プロモーターと3'非翻訳領域を藻類に導入する方法を提供する。
摘要翻译：本发明的目的是在藻类细胞中有效地积聚三酰基甘油，本发明提供了一种将三酰基甘油合成酶基因，缺磷应答启动子和3'非翻译区引入藻类的方法。

2. 发明申请

WO2016079317A1 MEANS AND METHODS FOR TREATMENT OF EARLY-ONSET PARKINSON'S DISEASE 审中-公开
标题翻译：治疗早期帕金森病的方法和方法
公开(公告)号：WO2016079317A1
公开(公告)日：2016-05-26
申请号：PCT/EP2015/077263
申请日：2015-11-20
申请人： VIB VZW , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
发明人： VERSTREKEN, Patrik , MORAIS EPIFÂNIO, Vanessa , VOS, Melissa
IPC分类号： A61K31/00 , A61P25/16
CPC分类号： A61K31/713 , A61K31/7105 , C12N9/1029 , C12Y203/01085
摘要： The present invention relates to the field of neurodegenerative diseases, more particularly to the field of Parkinson's disease. In particular the invention has found that inhibitors reducing FAS activity can be used for treatment of Parkinson's disease, in particular the treatment of patients suffering from Parkinson's disease having loss of function mutations in PINK1 or PARKIN genes.
摘要翻译：本发明涉及神经变性疾病领域，更具体地涉及帕金森病领域。特别地，本发明已经发现，降低FAS活性的抑制剂可用于治疗帕金森病，特别是治疗患有PINK1或PARKIN基因功能突变丧失的帕金森病患者。

3. 发明申请

WO2012142930A1 抗脂肪酸合成酶多肽及其应用审中-公开
公开(公告)号：WO2012142930A1
公开(公告)日：2012-10-26
申请号：PCT/CN2012/074107
申请日：2012-04-16
申请人：天津托普泰克生物科技有限公司 , 张晓东 , 叶丽虹
发明人：张晓东 , 叶丽虹
IPC分类号： C07K7/08 , C12N15/11 , C12N15/63 , A61K38/10 , A61P35/00 , A61P1/16 , A61P3/04
CPC分类号： C07K7/08 , A61K38/00 , C12N9/1029 , C12Y203/01085

4. 发明申请

WO2013016546A2 PRODUCTION OF DHA AND OTHER LC-PUFAS IN PLANTS 审中-公开
标题翻译：在植物中生产DHA和其他LC-PUFAS
公开(公告)号：WO2013016546A2
公开(公告)日：2013-01-31
申请号：PCT/US2012/048355
申请日：2012-07-26
申请人： DOW AGROSCIENCES LLC , DSM IP ASSETS B.V. , WALSH, Terence A. , GACHOTTE, Daniel , MERLO, Ann Owens , PAREDDY, Dayakar Reddy , METZ, James , BEVAN, Scott , KUNER, Jerry
发明人： WALSH, Terence A. , GACHOTTE, Daniel , MERLO, Ann Owens , PAREDDY, Dayakar Reddy , METZ, James , BEVAN, Scott , KUNER, Jerry
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8247 , A01H5/10 , A23L11/07 , A23V2002/00 , A61K31/202 , C12N9/1029 , C12N9/1288 , C12P7/6427 , C12P7/6472 , C12Y203/01085
摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.
摘要翻译：本发明提供了用多不饱和脂肪酸（PUFA）合成酶遗传修饰的重组宿主生物体，以及允许和/或改善宿主生物体中PUFA生产的一种或多种辅助蛋白质。本发明还涉及制造和使用这些生物以及从这些生物获得的产品的方法。

5. 发明申请

WO2007037708A1 ANTHELMINTIC AND/OR INSECTICIDE DEVELOPMENT 审中-公开
标题翻译：安全和/或杀虫剂的开发
公开(公告)号：WO2007037708A1
公开(公告)日：2007-04-05
申请号：PCT/NZ2006/000253
申请日：2006-10-02
申请人： AGRESEARCH LIMITED , GRANT, Warwick Norman , ISSA, Zainab Ibrahi , PERNTHANER, Anton , SHOEMAKER, Charles Bix , SHU, Dairu , STASIUK, Susan Josephine
发明人： GRANT, Warwick Norman , ISSA, Zainab Ibrahi , PERNTHANER, Anton , SHOEMAKER, Charles Bix , SHU, Dairu , STASIUK, Susan Josephine
IPC分类号： C12Q1/25 , A01N25/00 , C12N9/99
CPC分类号： G01N33/5088 , C12N9/1029 , C12Y203/01085
摘要： The use of a nucleic acid molecule encoding FAS in a nematode or arthropod, or a fragment or variant thereof, to identify or produce FAS as a target for: endectocide; anthelmintic and/or insecticide; development.
摘要翻译：在线虫或节肢动物或其片段或变体中使用编码FAS的核酸分子来鉴定或产生作为以下目的的FAS：结核菌素; 驱虫和/或杀虫剂; 发展。

6. 发明申请

WO2005066347A1 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2005066347A1
公开(公告)日：2005-07-21
申请号：PCT/IB2004/004378
申请日：2004-12-23
申请人： DANISCO A/S , KELLET-SMITH, Anja Hemmingsen , LORENTSEN, Rikke, Høegh , SØE, jørn, Borch , MIKKELSON, Jørn, Dalgaard , KREIJ, Arno de
发明人： KELLET-SMITH, Anja Hemmingsen , LORENTSEN, Rikke, Høegh , SØE, jørn, Borch , MIKKELSON, Jørn, Dalgaard , KREIJ, Arno de
IPC分类号： C12N15/54
CPC分类号： C12N9/1029 , C12Y203/01085
摘要： The present invention relates to a method of producing a variant glycolipid acyltransferase enzyme comprising: (a) selecting a parent enzyme which is a glycolipid acyltransferase enzyme characterised in that the enzyme comprises the amino acid sequence motif GDSX, wherein X is one or more of the following amino acid residues L, A, V, I, F, Y, H, Q, T, N, M or S; (b) modifying one or more amino acids to produce a variant glycolipid acyltransferase; (c) testing the variant glycolipid acyltransferase for transferase activity, an optionally hydrolytic activity, on a galactolipid substrate, and optionally a phospholipid substrate and/or optionally a triglyceride substrate; (d) selecting a variant enzyme with an enhanced activity towards galactolipids compared with the parent enzyme; and optionally (e) preparing a quantity of the variant enzyme. The present invention further relates to variant lipid acyltransferase enzyme characterised in that the enzyme comprises the amino acid sequence motif GDSX, wherein X is one or more of the following amino acid residues L, A, V, I, F, Y, H, Q, T, N, M or S, and wherein the variant enzyme comprises one or more amino acid modifications compared with a parent sequence at any one or more of the amino acid residues defined in set 2, set 4, set 6 or set 7.
摘要翻译：本发明涉及一种生产变体糖脂酰基转移酶的方法，包括：（a）选择亲糖基酶，其为糖脂酰基转移酶，其特征在于该酶包含氨基酸序列基序GDSX，其中X是一个或多个以下氨基酸残基L，A，V，I，F，Y，H，Q，T，N，M或S; （b）修饰一个或多个氨基酸以产生变体糖脂酰基转移酶; （c）测试变体糖脂酰基转移酶对半乳糖脂底物和任选的磷脂底物和/或任选的甘油三酯底物的转移酶活性，任选水解活性; （d）与母体酶相比，选择对半乳糖脂增强活性的变体酶; 和（e）制备一定量的变体酶。本发明还涉及变体脂质酰基转移酶，其特征在于该酶包含氨基酸序列基序GDSX，其中X是以下氨基酸残基中的一个或多个L，A，V，I，F，Y，H，Q ，T，N，M或S，并且其中所述变体酶与第2组，第4组，第6组或第7组中定义的任何一个或多个氨基酸残基与母体序列相比包含一个或多个氨基酸修饰。

7. 发明申请

WO02074907A3 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
标题翻译：调节表面活性剂生产的方法
公开(公告)号：WO02074907A3
公开(公告)日：2002-11-21
申请号：PCT/US0205134
申请日：2002-01-30
申请人： BAYER AG , MASON ROBERT JAMES , NEBEN STEVEN , ECKART MICHAEL R , LONGPHRE MALINDA
发明人： MASON ROBERT JAMES , NEBEN STEVEN , ECKART MICHAEL R , LONGPHRE MALINDA
IPC分类号： A61K38/00 , A61K48/00 , C12N9/10 , A01N43/04 , C07H21/04 , C07K1/00 , C12N1/20 , C12N5/00 , C12N15/00 , C12P21/06 , C12Q1/00
CPC分类号： C12N9/1029 , A61K38/00 , A61K48/00 , C12Y203/01085
摘要： The present invention provides methods of modulating surfactant production using FAS polypeptides, and agonists or antagonists that are capable of modulating FAS activity. More particularly, the present invention encompasses the use of FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis, small airway disease and maintaining airway patency, and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.
摘要翻译：本发明提供了使用FAS多肽和能够调节FAS活性的激动剂或拮抗剂调节表面活性剂产生的方法。更特别地，本发明包括FAS多肽或能够调节FAS活性的激动剂或拮抗剂多肽用于治疗疾病或临床病症的用途，其中表面活性剂产生与疾病或临床病症的因果关系或治疗相关，如肺部疾病，包括成人/婴儿呼吸窘迫综合征，急性肺损伤，慢性阻塞性肺病（肺气肿和慢性支气管炎），哮喘，肺泡蛋白沉积症，小气道疾病和保持呼吸道通畅以及相关的肺部疾病。本发明还包括含有FAS多肽或能够调节FAS活性的激动剂或拮抗剂多肽的药物组合物，以及这些药物组合物用于治疗上述疾病或临床症状的用途。

8. 发明申请

WO2002074907A2 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
标题翻译：调节表面活性剂生产的方法
公开(公告)号：WO2002074907A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/005134
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： C12N
CPC分类号： C12N9/1029 , A61K38/00 , A61K48/00 , C12Y203/01085
摘要： The present invention provides methods of modulating surfactant production using FAS polypeptides, and agonists or antagonists that are capable of modulating FAS activity. More particularly, the present invention encompasses the use of FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis, small airway disease and maintaining airway patency, and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.
摘要翻译：本发明提供使用FAS多肽调节表面活性剂生产的方法，以及能调节FAS活性的激动剂或拮抗剂。更具体地说，本发明包括使用能够调节FAS活性的FAS多肽或者能够调节FAS活性的激动剂或拮抗剂多肽用于治疗疾病或临床状况，其中表面活性剂的产生与疾病或临床状况的因果关系或治疗有关，如肺部疾病，包括成人/婴儿呼吸窘迫综合征，急性肺损伤，慢性阻塞性肺病（肺气肿和慢性支气管炎），哮喘，肺泡蛋白沉积，小气道疾病和维持气道通畅以及相关的肺部疾病。本发明还包括含有FAS多肽或能够调节FAS活性的激动剂或拮抗剂多肽的药物组合物，以及这些药物组合物用于治疗上述疾病或临床病症的药物组合物。

9. 发明申请

WO2017194683A1 METHOD OF INCREASING OMEGA-3 POLYUNSATURATED FATTY ACIDS PRODUCTION IN MICROALGAE 审中-公开
标题翻译：提高微藻中OMEGA-3多不饱和脂肪酸生产的方法
公开(公告)号：WO2017194683A1
公开(公告)日：2017-11-16
申请号：PCT/EP2017/061347
申请日：2017-05-11
申请人： DSM IP ASSETS B.V.
发明人： BAYNE, Anne-Cecile, V. , ZIRKLE, Ross, E.
IPC分类号： C12N9/10 , C12P7/64 , C12N1/12 , C12N15/82
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y203/01085
摘要： The subject disclosure features, in one aspect, a method for producing lipids enriched for EPA, comprising modifying a microalga to increase expression of PFA1, and/or PFA3, and culturing the modified microalga under conditions which allow the expression of PFA1, and/or PFA3, wherein lipids enriched for EPA are produced. Also featured is a recombinant microalga in which PFA1, and/or PFA3, is overexpressed. Such recombinant microalgae have been demonstrated herein to produce very favorable fatty acid lipid profiles (e.g., increased levels of EPA, increased ratio of EPA:DHA, decreased levels of DPA n-6, etc.).
摘要翻译：在一个方面，本公开内容的特征在于生产富含EPA的脂质的方法，包括修饰微藻以增加PFA1和/或PFA3的表达，并在允许改变的微藻的条件下培养修饰的微藻 PFA1和/或PFA3的表达，其中产生富含EPA的脂质。其中还有一种重组微藻，其中PFA1和/或PFA3过表达。此类重组微藻已经在本文中证明产生非常有利的脂肪酸脂质谱（例如，EPA水平增加，EPA：DHA比率增加，DPA n-6水平降低等）。

10. 发明申请

WO2015081270A1 PRODUCTION OF OMEGA-3 LONG-CHAIN POLYUNSATURATED FATTY ACIDS IN OILSEED CROPS BY A THRAUSTOCHYTRID PUFA SYNTHASE 审中-公开
标题翻译：通过豆蔻脂肪酸合成酶在油菜籽中生产欧米茄-3长链多糖脂肪酸
公开(公告)号：WO2015081270A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/067729
申请日：2014-11-26
申请人： DOW AGROSCIENCES LLC , DSM IP ASSETS B.V.
发明人： WALSH, Terence A. , GACHOTTE, Daniel J. , LARSEN, Cory M. , BEVAN, Scott A. , MERLO, P. Ann Owens , METZ, James G. , ZIRKLE, Ross
IPC分类号： A01H5/00 , A23D9/00 , A23L1/29 , C12N15/82
CPC分类号： C12N9/1029 , A23D9/00 , A23K20/158 , C11B1/00 , C11B1/04 , C11B1/10 , C12N9/1288 , C12N15/82 , C12N15/8247 , C12Y203/01085
摘要： This disclosure concerns recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.
摘要翻译：本公开涉及用多不饱和脂肪酸（PUFA）合酶系统遗传修饰的重组宿主生物体，以及允许和/或改善宿主生物体中PUFA生产的一种或多种辅助蛋白质。本公开还涉及制造和使用这些生物以及从这些生物获得的产品的方法。

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