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1. 发明申请

WO2010009079A1 APPARATUS AND METHODS FOR RETAINING A NEEDLE ON A MEDICAL INJECTOR 审中-公开
标题翻译：医用注射器保持针头的装置及方法
公开(公告)号：WO2010009079A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/050469
申请日：2009-07-14
申请人： AESTHETIC SCIENCES CORPORATION , KRUMME, John, F.
发明人： KRUMME, John, F.
IPC分类号： A61M5/32
CPC分类号： A61M5/344 , A61M5/347
摘要： Medical injectors are described herein. In some embodiments, an apparatus includes a medicament container, a needle assembly, a coupler, and a retainer. The medicament container has a distal end and a proximal end and is configured to contain a medicament. The coupler is configured to couple the needle assembly, which includes a needle and a hub, to the distal end of the medicament container. The retainer is configured to be coupled to the needle assembly and the medicament container. The retainer is configured to limit the movement of the needle assembly when the coupler fails to maintain the position of the needle assembly relative to the distal end of the medicament container.
摘要翻译：这里描述了医疗注射器。在一些实施例中，装置包括药物容器，针组件，联接器和保持器。药物容器具有远端和近端，并且构造成容纳药物。联接器构造成将包括针和轮毂的针组件连接到药物容器的远端。保持器构造成联接到针组件和药物容器。保持器构造成当联接器不能相对于药物容器的远端保持针组件的位置时限制针组件的移动。

2. 发明申请

WO2008066657A9 COMPOSITIONS, DEVICES AND METHODS FOR MODIFYING SOFT TISSUE 审中-公开
公开(公告)号：WO2008066657A9
公开(公告)日：2008-10-23
申请号：PCT/US2007023226
申请日：2007-11-01
申请人： AESTHETIC SCIENCES CORP , SCHMITT EDWARD E , KRUMME JOHN F , WALTON CHRISTIAN
发明人： SCHMITT EDWARD E , KRUMME JOHN F , WALTON CHRISTIAN
IPC分类号： A61L27/14 , A61F2/10
CPC分类号： A61M5/14526 , A61L27/14 , A61L27/50 , A61L2400/06 , A61M5/28 , A61M5/347 , A61M5/44
摘要： Compositions which comprise side chain crystalline (SCC) polymers and which are useful for modifying the soft tissue of human beings and other mammals. The modification can result in cosmetic and/or reconstructive improvement of the soft tissue. The compositions can remain effective for extended periods of time, or if desired, for selected shorter periods. Injection devices which are particularly suitable for dispensing such compositions include a reservoir (1) having an outlet (2) to which a needle is fixed, a piston (2) which is movable within the reservoir so that composition within the reservoir can be urged towards the outlet, and a heater (3) for heating composition near the outlet to a temperature substantially higher than composition relatively remote from the outlet.

3. 发明申请

WO2007122505A3 A CUFF FOR A LUMEN 审中-公开
标题翻译：一个厨师的CUFF
公开(公告)号：WO2007122505A3
公开(公告)日：2007-12-27
申请号：PCT/IB2007001071
申请日：2007-04-25
申请人： BETA MICROPUMP PARTNERS LLC , KRUMME JOHN
发明人： KRUMME JOHN
IPC分类号： A61F2/00
CPC分类号： A61F2/004
摘要： A cuff (1) for a lumen comprises at least one support strip (2) having a base (3) and first and second arms (4, 5) extending from the base. Each of the first and second arms has a receiving face (6, 7) which can receive a lumen between them, in which at least one of the receiving faces is associated with at least one inflatable bladder arranged (8) to compress the lumen when inflated. An aperture (10) is in fluid communication with the bladder such that the bladder can be inflated or deflated by passage of fluid through the aperture.
摘要翻译：用于腔的袖带（1）包括至少一个具有基部（3）的支撑条（2）和从基部延伸的第一和第二臂（4,5）。第一和第二臂中的每一个具有接收面（6,7），其可以容纳在它们之间的管腔，其中至少一个接收面与至少一个可膨胀的囊相连，充气。孔（10）与气囊流体连通，使得气囊可以通过流体通过孔而膨胀或放气。

4. 发明申请

WO2007044221A3 EYEGLASSES 审中-公开
标题翻译：眼镜
公开(公告)号：WO2007044221A3
公开(公告)日：2007-07-19
申请号：PCT/US2006037433
申请日：2006-09-26
申请人： BETA FRAMES LLC , KRUMME JOHN J , ZIDER ROBERT B , PLOUGH DAVID C
发明人： KRUMME JOHN J , ZIDER ROBERT B , PLOUGH DAVID C
IPC分类号： G02C1/00
CPC分类号： G02C1/023 , G02C1/02 , G02C1/06 , G02C1/08 , G02C1/10 , G02C5/00 , G02C13/001
摘要： Eyeglass assemblies including an eyeglass lens having an engaging portion. Under typical conditions of use, the engaging portion is maintained in contact with an eyeglass frame member by means of a removable bonding member (RBM). Under selected atypical ambient conditions, the RBM changes so that the engaging portion and the frame member can be separated. The engaging portion can extend from the lens, or can be a recess in the lens. The RBM can be a suitable adhesive (RBA), or a component composed of a shape memory metal (RBSMA) or a material which softens when subjected to heat or other atypical codition. The engaging portion can be shaped and treated to reduce stresses therein. Similarly, the open ends of an eyeglass rim can be maintained in contact with each other under typical conditions of use by an RBA or an RBSMA so that the rim is positioned around an eyeglass lens, but can be released under selected atypical ambient conditions.
摘要翻译：眼镜组件包括具有接合部分的眼镜镜片。在典型的使用条件下，接合部分通过可拆卸接合部件（RBM）与眼镜框架部件保持接触。在选择的非典型环境条件下，RBM改变，使得接合部分和框架构件可以分离。接合部分可以从透镜延伸，或者可以是透镜中的凹部。 RBM可以是合适的粘合剂（RBA）或由形状记忆金属（RBSMA）组成的组分或当经受热或其它非典型编码时软化的材料。接合部分可以被成形和处理以减小其中的应力。类似地，眼镜边缘的开口端可以在典型的RBA或RBSMA使用条件下保持彼此接触，使得边缘位于眼镜镜片周围，但可以在选定的非典型环境条件下释放。

5. 发明申请

WO2007044221A2 EYEGLASSES 审中-公开
标题翻译：眼镜
公开(公告)号：WO2007044221A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/037433
申请日：2006-09-26
申请人： BETA FRAMES LLC. , KRUMME, John, J. , ZIDER, Robert, B. , PLOUGH, David, C.
发明人： KRUMME, John, J. , ZIDER, Robert, B. , PLOUGH, David, C.
IPC分类号： G02C5/00
CPC分类号： G02C1/023 , G02C1/02 , G02C1/06 , G02C1/08 , G02C1/10 , G02C5/00 , G02C13/001
摘要： Eyeglass assemblies including an eyeglass lens having an engaging portion. Under typical conditions of use, the engaging portion is maintained in contact with an eyeglass frame member by means of a removable bonding member (RBM). Under selected atypical ambient conditions, the RBM changes so that the engaging portion and the frame member can be separated. The engaging portion can extend from the lens, or can be a recess in the lens. The RBM can be a suitable adhesive (RBA), or a component composed of a shape memory metal (RBSMA) or a material which softens when subjected to heat or other atypical codition. The engaging portion can be shaped and treated to reduce stresses therein. Similarly, the open ends of an eyeglass rim can be maintained in contact with each other under typical conditions of use by an RBA or an RBSMA so that the rim is positioned around an eyeglass lens, but can be released under selected atypical ambient conditions.
摘要翻译：包括具有接合部分的眼镜片的眼镜组件。在典型的使用条件下，接合部分通过可移除的接合构件（RBM）保持与眼镜框架构件接触。在选定的非典型环境条件下，RBM改变，使得接合部分和框架构件可以分开。接合部分可以从透镜延伸，或者可以是透镜中的凹部。 RBM可以是合适的粘合剂（RBA），或由形状记忆金属（RBSMA）构成的组件或当受到热量或其他非典型编码时软化的材料。接合部分可以被成形和处理以减少其中的应力。类似地，在RBA或RBSMA的典型使用条件下，眼镜边缘的开口端可保持彼此接触，使得边缘位于眼镜片周围，但可在选择的非典型环境条件下释放。 / p>

6. 发明申请

WO2005058427A3 AN INTERCHANGEABLE ALIGNMENT SYSTEM FOR GOLF PUTTERS 审中-公开
标题翻译：高尔夫球杆的交换对准系统
公开(公告)号：WO2005058427A3
公开(公告)日：2006-04-06
申请号：PCT/US2004042622
申请日：2004-12-16
申请人： PIXL GOLF COMPANY , ZIDER ROBERT B , KRUMME JOHN F , DICKINSON FRANK C
发明人： ZIDER ROBERT B , KRUMME JOHN F , DICKINSON FRANK C
IPC分类号： A63B53/04 , A63B69/36
CPC分类号： A63B53/0487 , A63B69/3685 , A63B2053/0441 , A63B2209/08 , A63B2209/10
摘要： An alignment system (10) for a golf putter (12), having a plurality of interchangeable top plates (20) for a putter head (16), wherein each of the interchangeable top plates (20) has differing alignment indicia (21A, 21B, 21C, 21D).
摘要翻译：一种用于高尔夫推杆（12）的对准系统（10），具有用于推杆头（16）的多个可互换顶板（20），其中每个可互换顶板（20）具有不同的对准标记（21A，21B ，21C，21D）。

7. 发明申请

WO2004082523A2 MITRAL VALVE REPAIR SYSTEM AND METHOD FOR USE 审中-公开
标题翻译：麻醉阀维修系统及使用方法
公开(公告)号：WO2004082523A2
公开(公告)日：2004-09-30
申请号：PCT/US2004007383
申请日：2004-03-11
申请人： EDWARDS LIFESCIENCES CORP , ZARBATANY DAVID , TIEU TAI , PUNG PONAKA , VIDELL JOSEPH , PERRY KENNETH E , KRUMME JOHN , BUCHBINDER MAURICE
发明人： ZARBATANY DAVID , TIEU TAI , PUNG PONAKA , VIDELL JOSEPH , PERRY KENNETH E , KRUMME JOHN , BUCHBINDER MAURICE
IPC分类号： A61B17/00 , A61B17/04 , A61B17/22 , A61B17/30 , A61F2/24 , A61F
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/0487 , A61B2017/00243 , A61B2017/00371 , A61B2017/00783 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0472 , A61B2017/0488 , A61B2017/22052 , A61B2017/22069 , A61B2017/306 , A61F2/2442
摘要： The present invention is directed to various systems for repairing tissue within the heart of a patient. The mitral valve repair system of the present invention comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. In addition, the present invention discloses various methods for repairing tissue within the heart of the patient. In one embodiment, the method of repairing heart valve tissue includes advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.
摘要翻译：本发明涉及用于修复患者心脏内的组织的各种系统。本发明的二尖瓣修复系统包括具有近端，远端和形成在其中的至少一个内腔的引导导管，能够将缝合线施加到组织上的治疗导管，以及能够附接紧固件到缝合线。治疗导管和紧固导管能够穿过引导导管的内腔。此外，本发明公开了用于修复患者心脏内的组织的各种方法。在一个实施例中，修复心脏瓣膜组织的方法包括使引导导管通过循环路径前进到靠近心脏瓣膜的心脏中的位置，将治疗导管通过引导导管推进到心脏瓣膜，使第一传单与所述治疗导管将第一缝合线部署到所述稳定化的第一小叶中，使所述第一传播带与所述治疗导管脱离接合，同时使所述第一缝合线附接到所述导管，使所述治疗导管稳定第二传播片，将第二缝合线部署到所述第二传单中，第二传单，同时离开附接到其上的第二缝合线，并且通过减小第一和第二缝合线之间的距离来接合第一和第二小叶。

8. 发明申请

WO2003093893A1 EYEGLASS FRAME ASSEMBLY 审中-公开
标题翻译：眼镜框架组件
公开(公告)号：WO2003093893A1
公开(公告)日：2003-11-13
申请号：PCT/IB2003/001862
申请日：2003-05-02
申请人： THE BETA GROUP INC , KRUMME, John
发明人： KRUMME, John
IPC分类号： G02C1/02
CPC分类号： G02C5/10 , G02C1/02 , G02C1/023 , G02C1/04 , G02C5/00 , G02C5/16
摘要： An eyeglass assembly which comprises a lens and a frame member, in which the lens has a lug at one edge. The assembly includes a connector by which the frame member is fastened to the lug. The connector comprises a band formed from a shape memory alloy which has (a) been treated so that the band shrinks inwardly when it is heated to a temperature at which the alloy transforms from martensite phase to austenite phase, and (b) been exposed to an increase in temperature so that the phase of the alloy changes from the martensite phase to the austenite phase and so that the connector band shrinks inwardly to grip the lens lug.
摘要翻译：一种眼镜组件，其包括透镜和框架构件，其中透镜在一个边缘具有凸耳。组件包括连接器，框架构件通过该连接器固定到凸耳上。连接器包括由形状记忆合金形成的带，其具有（a）被处理，使得当加热到合金从马氏体相转变为奥氏体相的温度时，带向内收缩，和（b）暴露于温度的升高使得合金的相位从马氏体相变为奥氏体相，并且使得连接器带向内收缩以夹持透镜凸耳。

9. 发明申请

WO2002058765A1 A DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2002058765A1
公开(公告)日：2002-08-01
申请号：PCT/IB2002/000266
申请日：2002-01-25
申请人： KRUMME, John, F.
发明人： KRUMME, John, F.
IPC分类号： A61M5/168
CPC分类号： A61M5/16877 , A61M5/1452 , A61M5/148 , A61M5/16804 , A61M2005/14506 , A61M2205/0266
摘要： A drug delivery device which can be implanted in a patient, includes a reservoir for the drug with at least one discharge outlet through which the drug can be discharged. A drive member comprising a shape memory alloy is arranged in the device in a deformed configuration to act against the reservoir directly or indirectly by recovering from its deformed configuration by virtue of its elastic properties to cause the volume of the reservoir available for the drug to be reduced and to cause drug in the reservoir to be discharged from the reservoir. A flow controller for controlling the flow of the drug through the discharge outlet comprises a close-packed array of elongate rod members extending generally in the direction in which the drug flows out of the reservoir.
摘要翻译：可植入患者体内的药物输送装置包括用于药物的储存器，该储存器具有至少一个排出口，药物可通过该排出口排出。包括形状记忆合金的驱动构件以变形构型布置在装置中，以通过其弹性特性从其变形构型中恢复而直接或间接地作用于容器，以使可用于药物的容器的体积为减少并导致储层中的药物从储层中排出。用于控制通过排出口的药物流量的流量控制器包括大致在药物流出储存器的方向上延伸的细长杆构件的密集排列。

10. 发明申请

WO2011081913A1 APPARATUS AND METHODS FOR LIMITING PRESSURE AND FLOW WITHIN A MEDICAL INJECTOR 审中-公开
标题翻译：用于限制医用注射器内的压力和流量的装置和方法
公开(公告)号：WO2011081913A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060225
申请日：2010-12-14
申请人： NORDSON CORPORATION , KRUMME, John , HENEVELD, Scott
发明人： KRUMME, John , HENEVELD, Scott
IPC分类号： A61M5/168
CPC分类号： A61M5/24 , A61M5/20 , A61M5/3134 , A61M5/34 , A61M5/488 , A61M39/22 , A61M2005/2488 , A61M2005/2492 , A61M2005/3128 , A61M2205/14
摘要： A medical injector (200) includes a medicament container (210) including a main lumen (214) and a reduced-diameter protrusion (220), a needle assembly (230) coupled to the protrusion (220), and a flow control member (250). The medicament container (210) is configured to contain a medicament, such as, for example, a dermal filler. The flow control member (250) is disposed within the protrusion (220) of the medicament container (210), and includes a flow control lumen (254) configured to control a pressure or a flow of the medicament. Thus, the flow control member (250) reduces decoupling forces applied to the needle assembly (230) by the flow of medicament. Alternatively, the flow control member (250) may move from a first position allowing flow from the main lumen (214) to the needle assembly (230) to a second position blocking flow from the medicament container (210) when the needle assembly (230) decouples from the protrusion (220).
摘要翻译：医疗注射器（200）包括药物容器（210），其包括主腔（214）和缩径直径突起（220），联接到突起（220）的针组件（230）和流动控制构件 250）。药物容器（210）构造成容纳药物，例如皮肤填充剂。流量控制构件（250）设置在药物容器（210）的突出部（220）内，并且包括配置成控制药物的压力或流动的流动控制腔（254）。因此，流动控制构件（250）通过药物流减小施加到针组件（230）的去耦力。或者，流动控制构件（250）可以从第一位置移动，允许从主腔（214）到针组件（230）的流动到针组件（230）处阻止从药物容器（210）流动的第二位置）与突起（220）分离。

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