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1. 发明申请

WO2012007510A1 COMPOUNDS FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE 审中-公开
标题翻译：用于结合和成像淀粉样蛋白的化合物及其用途
公开(公告)号：WO2012007510A1
公开(公告)日：2012-01-19
申请号：PCT/EP2011/061967
申请日：2011-07-13
申请人： BAYER PHARMA AKTIENGESELLSCHAFT , RÖHN, Ulrike , SCHMITT-WILLICH, Heribert , HEINRICH, Tobias , BERGER, Markus , FITZNER, Ansgar , KRAUSE, Sabine , BROCKSCHNIEDER, Damian , DYRKS, Thomas , THIELE, Andrea , MÖNNING, Ursula , BÖMER, Ulf
发明人： RÖHN, Ulrike , SCHMITT-WILLICH, Heribert , HEINRICH, Tobias , BERGER, Markus , FITZNER, Ansgar , KRAUSE, Sabine , BROCKSCHNIEDER, Damian , DYRKS, Thomas , THIELE, Andrea , MÖNNING, Ursula , BÖMER, Ulf
IPC分类号： C07D417/04 , C07D513/04 , A61K31/437 , A61K31/428 , A61K31/431 , A61P25/28
CPC分类号： C07D513/04 , C07D417/04 , C07D417/14
摘要： The present invention relates to novel compounds (benzothiazolopyrazoles and thiazolopyridin-pyrazoles) useful for binding and imaging amyloid deposits and their use in detecting or treating Alzheimer's disease and amyloidosis.
摘要翻译：本发明涉及可用于结合和成像淀粉样蛋白沉积物的新型化合物（苯并噻唑并吡唑和噻唑并吡啶 - 吡唑）及其在检测或治疗阿尔茨海默病和淀粉样变性中的用途。

2. 发明申请

WO2010066357A1 BENZOTHIAZOLE AMIDES FOR DETECTION OF AMYLOID BETA 审中-公开
标题翻译：用于检测AMYLOID BETA的苯并咪唑类
公开(公告)号：WO2010066357A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/008499
申请日：2009-11-28
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , HASSFELD, Jorma , RÖHN, Ulrike , FRIEBE, Matthias , LEHMANN, Lutz , HEINRICH, Tobias , KRAUSE, Sabine , BROCKSCHNIEDER, Damian , DYRKS, Thomas , THIELE, Andrea , BÖMER, Ulf , MÖNNING, Ursula , BERGER, Markus , SIEGEL, Stephan
发明人： HASSFELD, Jorma , RÖHN, Ulrike , FRIEBE, Matthias , LEHMANN, Lutz , HEINRICH, Tobias , KRAUSE, Sabine , BROCKSCHNIEDER, Damian , DYRKS, Thomas , THIELE, Andrea , BÖMER, Ulf , MÖNNING, Ursula , BERGER, Markus , SIEGEL, Stephan
IPC分类号： C07D277/82 , C07D417/12 , A61K31/428 , A61P25/28
CPC分类号： C07D277/82 , C07D417/12
摘要： This invention relates to compounds of formula I (benzothiazoles) suitable for labelling or already labelled by 18 F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
摘要翻译：本发明涉及适于标记或已被18F标记的式I化合物（苯并噻唑），制备这种化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒及其用途，用于诊断成像的组合物或试剂盒。

3. 发明申请

WO2010028776A8 PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE 审中-公开
标题翻译：用于结合和成像淀粉样蛋白的哌嗪衍生物及其用途
公开(公告)号：WO2010028776A8
公开(公告)日：2011-03-17
申请号：PCT/EP2009006406
申请日：2009-09-04
申请人： BAYER SCHERING PHARMA AG , SCHMITT-WILLICH HERIBERT , ROEHN ULRIKE , FRIEBE MATTHIAS , LEHMANN LUTZ , FITZNER ANSGAR , KRAUSE SABINE , BROCKSCHNIEDER DAMIAN , DYRKS THOMAS , THIELE ANDREA , BOEMER ULF , MOENNING URSULA , HEINRICH TOBIAS
发明人： SCHMITT-WILLICH HERIBERT , ROEHN ULRIKE , FRIEBE MATTHIAS , LEHMANN LUTZ , FITZNER ANSGAR , KRAUSE SABINE , BROCKSCHNIEDER DAMIAN , DYRKS THOMAS , THIELE ANDREA , BOEMER ULF , MOENNING URSULA , HEINRICH TOBIAS
IPC分类号： C07D209/24 , A61K31/496 , A61K51/04 , A61P25/00 , C07D213/81 , C07D213/82 , C07D239/42 , C07D295/185 , C07D405/12
CPC分类号： C07D239/42 , C07D209/24 , C07D213/81 , C07D213/82 , C07D295/185 , C07D405/12
摘要： The invention relates to compounds of formula (I), their synthesis and their use, in particular for detecting amyloid deposits in a patient.
摘要翻译：本发明涉及式（I）化合物，其合成及其用途，特别是用于检测患者中的淀粉样沉积物。

4. 发明申请

WO2010028776A1 PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE 审中-公开
标题翻译：用于结合和成像淀粉样蛋白的哌嗪衍生物及其用途
公开(公告)号：WO2010028776A1
公开(公告)日：2010-03-18
申请号：PCT/EP2009/006406
申请日：2009-09-04
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , SCHMITT-WILLICH, Heribert , RÖHN, Ulrike , FRIEBE, Matthias , LEHMANN, Lutz , FITZNER, Ansgar , KRAUSE, Sabine , BROCKSCHNEIDER, Damian , DYRKS, Thomas , THIELE, Andreas , BÖMER, Ulf , MÖNNING, Ursula , HEINRICH, Tobias
发明人： SCHMITT-WILLICH, Heribert , RÖHN, Ulrike , FRIEBE, Matthias , LEHMANN, Lutz , FITZNER, Ansgar , KRAUSE, Sabine , BROCKSCHNEIDER, Damian , DYRKS, Thomas , THIELE, Andreas , BÖMER, Ulf , MÖNNING, Ursula , HEINRICH, Tobias
IPC分类号： C07D209/24 , C07D213/81 , C07D213/82 , C07D239/42 , C07D405/12 , C07D295/185 , A61K31/496 , A61P25/00 , A61K51/04
CPC分类号： C07D239/42 , C07D209/24 , C07D213/81 , C07D213/82 , C07D295/185 , C07D405/12
摘要： The invention relates to compounds of formula (I), their synthesis and their use, in particular for detecting amyloid deposits in a patient.
摘要翻译：本发明涉及式（I）化合物，其合成及其用途，特别是用于检测患者中的淀粉样沉积物。

5. 发明申请

WO2004060409A1 ENHANCED SCINTIGRAPHIC IMAGING AGENTS FOR IMAGING OF INFECTION AND INFLAMMATION 审中-公开
标题翻译：用于成像感染和炎症的增强扫描成像剂
公开(公告)号：WO2004060409A1
公开(公告)日：2004-07-22
申请号：PCT/EP2004/000051
申请日：2004-01-07
申请人： SCHERING AG , Krause, Sabine , Manchanda, Rajesh
发明人： Krause, Sabine , Manchanda, Rajesh
IPC分类号： A61K51/08
CPC分类号： A61K31/70 , A61K51/08 , A61K51/088 , Y02A50/473
摘要： The invention describes enhanced scintigraphic imaging agents that can be used to localize infection and inflammation in a mammal. Specifically, the invention relates to radiolabeled, preferably technetium-99m labeled scintigraphic imaging agents that are compositions of a polysulfated glycan or mixture thereof and a compound comprising a polybasic peptide covalently linked to a radiolabel binding moiety. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body are also provided. The enhanced imaging agents exhibit improved binding affinity to the polysulfated glycans, better biodistribution and infection uptake, thus providing improved imaging results.
摘要翻译：本发明描述了可用于定位哺乳动物感染和炎症的增强的闪烁照相成像剂。具体地，本发明涉及放射性标记的，优选锝-99m标记的闪烁照相成像剂，其是多硫酸化聚糖或其混合物的组合物，以及包含与放射性标记结合部分共价连接的多碱性肽的化合物。还提供了用于制备这种组合物的方法和试剂盒，以及使用这些组合物来成像哺乳动物体内的感染和炎症部位的方法。增强的成像剂显示出对多硫酸化聚糖的改善的结合亲和力，更好的生物分布和感染摄取，从而提供改进的成像结果。

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