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1. 发明申请

WO2013163187A1 SYSTEMS AND METHODS FOR TARGETED IMAGING AND ABLATION OF CARDIAC CELLS 审中-公开
标题翻译：用于靶向成像和心脏细胞排列的系统和方法
公开(公告)号：WO2013163187A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/037807
申请日：2013-04-23
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KALIFA, Jerome , KOPELMAN, Raoul , AVULA, Uma Mahesh R. , KIM, Gwangseong , LEE, Yong-Eun Koo , YOON, Hyung Ki
发明人： KALIFA, Jerome , KOPELMAN, Raoul , AVULA, Uma Mahesh R. , KIM, Gwangseong , LEE, Yong-Eun Koo , YOON, Hyung Ki
IPC分类号： A61K38/00
CPC分类号： A61K41/0057 , A61K9/5138 , A61K31/5415 , A61K31/704 , A61K33/24 , A61K38/10 , A61K38/18 , A61K38/20 , A61K38/21
摘要： The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.
摘要翻译：本发明涉及纳米颗粒。特别地，本发明提供用于临床（例如，靶向治疗），诊断（例如成像）和心脏病领域的研究应用的纳米颗粒。例如，在一些实施方案中，本发明提供了一种治疗（例如，消融）心脏组织的方法，包括：a）使动物与包含基质，有毒（例如，消融）药物（例如，超声敏化剂，化疗剂（例如，多柔比星或顺铂）或光敏剂）和心脏靶向部分; 和b）向动物的心脏组织（例如心脏）的至少一部分施用毒性剂的活化剂（例如，轻的，化学的（例如药物）或超声））以活化毒性剂。

2. 发明申请

WO2012142179A3 MAGNETICALLY INDUCED MICROSPINNING FOR SUPER-DETECTION AND SUPER-CHARACTERIZATION OF BIOMARKERS AND LIVE CELLS 审中-公开
标题翻译：磁性诱导微生物用于超检测和超级生物标志物和活细胞的特征
公开(公告)号：WO2012142179A3
公开(公告)日：2013-01-10
申请号：PCT/US2012033152
申请日：2012-04-11
申请人： UNIV MICHIGAN , KOPELMAN RAOUL , ELBEZ REMY , HECHT ARIEL , MCNAUGHTON BRANDON H
发明人： KOPELMAN RAOUL , ELBEZ REMY , HECHT ARIEL , MCNAUGHTON BRANDON H
IPC分类号： G01N33/53 , G01N27/00 , G01N33/574
CPC分类号： G01N33/574 , G01N27/84 , G01N33/54333 , G01N33/587
摘要： Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking system. The spinning frequency response enables real-time monitoring of single (cancer) cell morphology, with sub-microscopic resolution, yielding previously undeterminable information. Likewise, it enables super-low detection limits for any (cancer) biomarker.
摘要翻译：借助于感应磁化，通过磁性旋转这些天然的非磁性系统，能够识别，定量和表征生物微纳米系统。生物友好磁性微纳米标签可在极弱的电磁场中进行磁共振。这些微型电动机的旋转可以通过简单的类CD光学跟踪系统来观察。旋转频率响应使得能够实时监测单个（癌症）细胞形态，具有亚显微镜分辨率，产生先前不可确定的信息。同样，它可以为任何（癌症）生物标志物提供超低检测限。

3. 发明申请

WO1994006040A1 MICRO OPTICAL FIBER LIGHT SOURCE AND SENSOR AND METHOD OF FABRICATION THEREOF 审中-公开
标题翻译：微光纤光源和传感器及其制造方法
公开(公告)号：WO1994006040A1
公开(公告)日：1994-03-17
申请号：PCT/US1993008350
申请日：1993-09-03
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN; , KOPELMAN, Raoul , TAN, Wei, Hong , SHI, Zhong-You
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN;
IPC分类号： G02B06/00
CPC分类号： G02B6/241 , G01Q60/22 , G02B6/2552 , G02B6/3624
摘要： This invention relates generally to the development of and a method of fabricating a fiber optic micro-light source and sensor (50). An optical fiber micro-light source (50) is presented whose aperture is extremely small yet able to act as an intense light source. Light sources of this type have wide ranging applications, including use as micro-sensors (22) in NSOM. Micro-sensor light sources have excellent detection limits as well as photo stability, reversibility, and millisecond response times. Furthermore, a method for manufacturing a micro optical fiber light source is provided. It involves the photo-chemical attachment of an optically active material onto the end surface of an optical fiber cable which has been pulled to form an end with an extremely narrow aperture. More specifically, photopolymerization has been applied as a means to photo-chemically attach an optically active material (60). This process allows significant control of the size of the micro light source (50). Furthermore, photo-chemically attaching an optically active material (60) enables the implementation of the micro-light source in a variety of sensor applications.
摘要翻译：本发明一般涉及光纤微光源和传感器（50）的制造和制造方法。提出了一种光纤微光源（50），其光圈非常小，但能够充当强光源。这种光源具有广泛的应用，包括在NSOM中用作微型传感器（22）。微传感器光源具有优异的检测限以及光稳定性，可逆性和毫秒响应时间。此外，提供了一种用于制造微型光纤光源的方法。它涉及光学活性材料的光化学附着到光纤电缆的端面上，该光缆被拉动以形成具有非常窄的孔径的端部。更具体地，已经应用光聚合作为光学化学连接光学活性材料（60）的手段。该过程允许显着控制微光源（50）的尺寸。此外，光学化学连接光学活性材料（60）使得能够在各种传感器应用中实现微光源。

4. 发明申请

WO2012142179A2 MAGNETICALLY INDUCED MICROSPINNING FOR SUPER-DETECTION AND SUPER-CHARACTERIZATION OF BIOMARKERS AND LIVE CELLS 审中-公开
标题翻译：磁性诱导微生物用于超检测和超级生物标志物和活细胞的特征
公开(公告)号：WO2012142179A2
公开(公告)日：2012-10-18
申请号：PCT/US2012/033152
申请日：2012-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KOPELMAN, Raoul , ELBEZ, Remy , HECHT, Ariel , MCNAUGHTON, Brandon, H.
发明人： KOPELMAN, Raoul , ELBEZ, Remy , HECHT, Ariel , MCNAUGHTON, Brandon, H.
IPC分类号： G01N33/53 , G01N33/574 , G01N27/00
CPC分类号： G01N33/574 , G01N27/84 , G01N33/54333 , G01N33/587
摘要： Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking system. The spinning frequency response enables real-time monitoring of single (cancer) cell morphology, with sub-microscopic resolution, yielding previously undeterminable information. Likewise, it enables super-low detection limits for any (cancer) biomarker.
摘要翻译：借助于感应磁化，通过磁性旋转这些天然的非磁性系统，能够识别，定量和表征生物微纳米系统。生物友好磁性微纳米标签可在极弱的电磁场中进行磁共振。这些微型电动机的旋转可以通过简单的类CD光学跟踪系统来观察。旋转频率响应使得能够实时监测单个（癌症）细胞形态，具有亚显微镜分辨率，产生先前不可确定的信息。同样，它可以为任何（癌症）生物标志物提供超低检测限。

5. 发明申请

WO2012027747A2 ASYNCHRONOUS MAGNETIC BEAD ROTATION SENSING SYSTEMS AND METHODS 审中-公开
标题翻译：异径磁珠旋转传感系统及方法
公开(公告)号：WO2012027747A2
公开(公告)日：2012-03-01
申请号：PCT/US2011049571
申请日：2011-08-29
申请人： UNIV MICHIGAN , MCNAUGHTON BRANDON H , KINNUNEN PAIVO , KOPELMAN RAOUL , HUNT ALAN , CLARKE ROY C , SINN IRENE , ELBEZ REMY , ALBERTSON THEODORE
发明人： MCNAUGHTON BRANDON H , KINNUNEN PAIVO , KOPELMAN RAOUL , HUNT ALAN , CLARKE ROY C , SINN IRENE , ELBEZ REMY , ALBERTSON THEODORE
IPC分类号： C12Q1/02 , C12M1/42 , G01N27/72 , G01N33/50
CPC分类号： C12M41/36 , G01N33/54326 , G01N33/569
摘要： Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is described. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles.
摘要翻译：本文描述了用于执行异步磁珠旋转（AMBR）以检测和监测细胞生长和/或行为的各种方法，装置和系统。描述了用于AMBR的磁性颗粒的簇旋转。特别地，本文描述了用于并行分析样品板的多个孔的系统。本文还描述了用于控制旋转磁性颗粒的照明和成像的方法。

6. 发明申请

WO2011050177A1 PAA NANOPARTICLES FOR ENHANCEMENT OF TUMOR IMAGING 审中-公开
标题翻译： PAA纳米颗粒增强肿瘤成像
公开(公告)号：WO2011050177A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053574
申请日：2010-10-21
申请人： HEALTH RESEARCH, INC. , PANDEY, Ravindra, K. , GUPTA, Anurag , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK STOR INTELLECTUAL PROPERTY DIVISION , SAJJAD, Munawwar , REGENTS OF THE UNIVERSITY OF MICHIGAN OFFICE OF TECHNOLOGY TRANFER , KOPELMAN, Raoul
发明人： PANDEY, Ravindra, K. , GUPTA, Anurag , SAJJAD, Munawwar , KOPELMAN, Raoul
IPC分类号： A61B5/00
CPC分类号： A61K41/0071 , A61K47/60 , A61K47/64 , A61K49/0002 , A61K49/0032 , A61K49/0052 , A61K49/0093 , A61K51/0451 , A61K51/1255 , B82Y15/00
摘要： A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
摘要翻译：一种包含PAA纳米颗粒的组合物，其包含后载荷的四光镜光敏剂和成像剂及其制备和使用方法。

7. 发明申请

WO2014022742A1 PAA NANOPLATFORMS CONTAINING FLUOROPHORES AND TARGETED MOIETIES COVALENTLY LINKED AND PHOTOSENSITIZER POST-LOADED 审中-公开
标题翻译：含有荧光素和目标物质的PAA纳米粒子共同连接和光敏剂后加载
公开(公告)号：WO2014022742A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/053350
申请日：2013-08-02
申请人： HEALTH RESEARCH, INC. , PANDEY, Ravindra, K. , KOPELMAN, Raoul , GUPTA, Anurag , SAJJAD, Munawwar , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： PANDEY, Ravindra, K. , KOPELMAN, Raoul , GUPTA, Anurag , SAJJAD, Munawwar
IPC分类号： A61K38/41
CPC分类号： A61K31/519 , A61K38/00 , C07D487/22 , C09B47/00
摘要： A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.ln a first embodiment, a composition comprising PAA nanoparticles containing a tetrapyrollic photosensitizer post loaded to the PAA nanoparticle after nanoparticle formation and an imaging agent covalently bonded to the PAA nanoparticle and a tumor targeting moiety covalently bonded to the PAA nanoparticles.
摘要翻译：一种包含共价连接的荧光染料和后加载的四吡咯光敏剂的PAA纳米颗粒。在第一实施方案中，包含PA纳米颗粒的组合物，其包含在纳米颗粒形成之后装载到PAA纳米颗粒上的四光敏光敏剂载体和与PAA纳米颗粒共价结合的成像剂和与PAA纳米颗粒共价结合的肿瘤靶向部分。

8. 发明申请

WO2008112626A1 NON-LINEAR ROTATION RATES OF REMOTELY DRIVEN PARTICLES AND USES THEREOF 审中-公开
标题翻译：远程驱动颗粒的非线性旋转速率及其用途
公开(公告)号：WO2008112626A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056394
申请日：2008-03-10
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MCNAUGHTON, Brandon, H. , KOPELMAN, Raoul , TORRES-ISEA, Ramon , CLARKE, Roy
发明人： MCNAUGHTON, Brandon, H. , KOPELMAN, Raoul , TORRES-ISEA, Ramon , CLARKE, Roy
IPC分类号： C12M1/34 , C12Q1/34 , G01N33/569 , G01N33/553
CPC分类号： G01N33/54313 , G01N33/54326 , G01N33/569
摘要： The present invention relates to biological sensors. In particular, the present invention relates to the use of remotely driven nonlinear rotation of particles (e.g., magnetic particles) for detection of cells such as microorganisms (e.g., bacteria and viruses). The present invention further relates to the use of remotely driven nonlinear rotation of particles for measurement of physical properties of a solution (e.g., viscosity).
摘要翻译：本发明涉及生物传感器。特别地，本发明涉及用于微粒（例如细菌和病毒）等细胞的微粒（例如磁性粒子）的远程非线性旋转的使用。本发明还涉及用于测量溶液的物理性质（例如粘度）的颗粒的远程非线性旋转的用途。

9. 发明申请

WO2011050177A8 PAA NANOPARTICLES FOR ENHANCEMENT OF TUMOR IMAGING 审中-公开
标题翻译： PAA纳米颗粒增强肿瘤成像
公开(公告)号：WO2011050177A8
公开(公告)日：2012-02-16
申请号：PCT/US2010053574
申请日：2010-10-21
申请人： HEALTH RESEARCH INC , PANDEY RAVINDRA K , GUPTA ANURAG , UNIV NEW YORK STATE RES FOUND , SAJJAD MUNAWWAR , UNIV MICHIGAN , KOPELMAN RAOUL
发明人： PANDEY RAVINDRA K , GUPTA ANURAG , SAJJAD MUNAWWAR , KOPELMAN RAOUL
IPC分类号： A61B5/00
CPC分类号： A61K41/0071 , A61K47/60 , A61K47/64 , A61K49/0002 , A61K49/0032 , A61K49/0052 , A61K49/0093 , A61K51/0451 , A61K51/1255 , B82Y15/00
摘要： A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
摘要翻译：一种包含PAA纳米颗粒的组合物，其包含后载荷的四光镜光敏剂和成像剂及其制备和使用方法。

10. 发明申请

WO2012027747A3 ASYNCHRONOUS MAGNETIC BEAD ROTATION SENSING SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2012027747A3
公开(公告)日：2012-03-01
申请号：PCT/US2011/049571
申请日：2011-08-29
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MCNAUGHTON, Brandon, H. , KINNUNEN, Paivo , KOPELMAN, Raoul , HUNT, Alan , CLARKE, Roy, C. , SINN, Irene , ELBEZ, Remy , ALBERTSON, Theodore
发明人： MCNAUGHTON, Brandon, H. , KINNUNEN, Paivo , KOPELMAN, Raoul , HUNT, Alan , CLARKE, Roy, C. , SINN, Irene , ELBEZ, Remy , ALBERTSON, Theodore
IPC分类号： C12Q1/02 , C12M1/42 , G01N33/50 , G01N27/72
摘要： Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles.

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