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1. 发明申请

WO2008038046A1 ION FILTER 审中-公开
标题翻译：离子过滤器
公开(公告)号：WO2008038046A1
公开(公告)日：2008-04-03
申请号：PCT/GB2007/050581
申请日：2007-09-25
申请人： OWLSTONE LTD , HART, Matthew , KOEHL, Andrew
发明人： HART, Matthew , KOEHL, Andrew
IPC分类号： G01N27/64 , H01J49/42
CPC分类号： H01J49/061 , G01N27/622 , H01J49/0018 , H01J49/421
摘要： An ion filter (10) for use in ion mobility spectrometry is described, together with a method for manufacturing the filter. The filter (10) is manufactured by removing portions from a monolithic structure to form a pair of electrodes which remain mechanically connected. The connecting portion (22) provides sufficient electrical impedance between the electrodes to effectively electrically separate the electrodes. The connecting portion may be doped or chemically modified to obtain a desired impedance, or this may be obtained through appropriate selection of physical dimensions.
摘要翻译：与用于制造过滤器的方法一起描述了用于离子迁移谱的离子过滤器（10）。过滤器（10）通过从单片结构中移除部分以形成保持机械连接的一对电极来制造。连接部分（22）在电极之间提供足够的电阻抗以有效地电分离电极。连接部分可以被掺杂或化学修饰以获得期望的阻抗，或者这可以通过适当选择物理尺寸来获得。

2. 发明申请

WO2007044379A2 COMPACT IONIZATION SOURCE 审中-公开
标题翻译：紧密的离子源
公开(公告)号：WO2007044379A2
公开(公告)日：2007-04-19
申请号：PCT/US2006038744
申请日：2006-10-02
申请人： OWLSTONE NANOTECH INC , RUSH MARTYN , BOYLE PAUL , RUIZ-ALONSO DAVID , KOEHL ANDREW , PARRIS RUSSELL , WILKS ASHLEY
发明人： RUSH MARTYN , BOYLE PAUL , RUIZ-ALONSO DAVID , KOEHL ANDREW , PARRIS RUSSELL , WILKS ASHLEY
IPC分类号： H01T19/04
CPC分类号： H01T19/04 , H01T19/00
摘要： A compact ionization source includes first and second electrodes, each having a plurality of fingers that are interdigitated with each other. The spacing between the first and second electrode, preferably less than 1 mm, creates a large electric field when a potential is applied across the first and second electrodes. The large electric field creates an ionization volume between the fingers of the first and second electrode and ionizes a portion of the molecules occupying the ionization volume. The interdigitated fingers of the first and second electrodes allow for a narrow gap separating the electrodes while presenting a large flow area for ionizing molecules for downstream analysis.
摘要翻译：紧凑的电离源包括第一和第二电极，每个电极具有彼此交叉指向的多个指状物。当跨越第一和第二电极施加电位时，第一和第二电极之间的间隔优选小于1mm，产生大的电场。大电场在第一和第二电极的指状物之间产生离子化体积，并且电离占据电离体积的分子的一部分。第一和第二电极的交叉指状物允许分离电极的窄间隙，同时呈现用于电离分子的大流动面积用于下游分析。

3. 发明申请

WO2008094299A3 SMART FAIMS SENSOR 审中-公开
标题翻译： SMART FAIMS传感器
公开(公告)号：WO2008094299A3
公开(公告)日：2008-09-25
申请号：PCT/US2007073717
申请日：2007-07-17
申请人： OWLSTONE NANOTECH INC , BOYLE PAUL , RUSH MARTYN , RUIZ-ALONSO DAVID , KOEHL ANDREW , PARRIS RUSSELL , WILKS ASHLEY
发明人： BOYLE PAUL , RUSH MARTYN , RUIZ-ALONSO DAVID , KOEHL ANDREW , PARRIS RUSSELL , WILKS ASHLEY
IPC分类号： H01J49/00
CPC分类号： G01N27/624
摘要： A smart FAIMS sensor system and method includes an array of two or more FAIMS sensors and a controller configured to control independently each of the FAIMS sensors in the array In a preferred embodiment, the sensor array is normally operated with one FAIMS sensor operating in a high sensitivity mode while the remaining sensors are turned off When the high sensitivity FAIMS sensor detects a possible event, each of the remaining sensors is turned on in sequence Io confirm the possible event Each of the remaining sensors is operated in a different selectivity mode that together forms a characteristic signature of a target analyte The characteristic signature is more robust against false positives and an alarm is registered only when all remaining sensors confirm the possible event detected by the high sensitivity sensor
摘要翻译：智能FAIMS传感器系统和方法包括两个或更多个FAIMS传感器的阵列和被配置为独立地控制阵列中的每个FAIMS传感器的控制器。在优选实施例中，传感器阵列通常在一个操作在高的FAIMS传感器灵敏度模式，而其他传感器关闭当高灵敏度FAIMS传感器检测到可能的事件时，其余传感器中的每一个依次打开，以确认可能的事件。每个剩余的传感器以不同的选择性模式操作，共同形成目标分析物的特征签名特征签名对于假阳性更加鲁棒，只有当所有剩余的传感器确认高灵敏度传感器检测到的可能事件时才会记录报警

4. 发明申请

WO2008048247A3 METHODS OF SYNTHESIS OF NANOTUBES AND USES THEREOF 审中-公开
标题翻译：纳米管的合成方法及其用途
公开(公告)号：WO2008048247A3
公开(公告)日：2008-09-25
申请号：PCT/US2006038566
申请日：2006-09-29
申请人： OWLSTONE NANOTECH INC , BOYLE PAUL , RUIZ-ALONSO DAVID , KOEHL ANDREW , RUSH MARTYN , PARRIS RUSSELL , WILKS ASHLEY
发明人： BOYLE PAUL , RUIZ-ALONSO DAVID , KOEHL ANDREW , RUSH MARTYN , PARRIS RUSSELL , WILKS ASHLEY
IPC分类号： C23C16/00
CPC分类号： B01J23/70 , B01J20/205 , B01J20/28007 , B01J20/281 , B01J37/0238 , B82B3/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/02 , C23C16/0281 , Y02P20/135
摘要： The invention relates to novel methods of incorporating nanotubes for use in micro- or nano-devices. The invention further relates to incorporating nanotubes in micro or nano- devices and particularly synthesizing or growing nanotubes directly in or on components of a micro- or nano-device. In a particular embodiment, the invention relates to methods of synthesizing or growing nanotubes in a gas chromatography column and their use in portable gas chromatography devices.
摘要翻译：本发明涉及纳入用于微米或纳米器件的纳米管的新方法。本发明进一步涉及将纳米管结合到微米或纳米装置中，特别是将纳米管直接合成或生长在微米或纳米装置的部件中或部件上。在一个具体的实施方案中，本发明涉及在气相色谱柱中合成或生长纳米管的方法及其在便携式气相色谱装置中的应用。

5. 发明申请

WO2008054376A2 NANOSTRUCTURES CONTAINING INORGANIC NANOTUBES AND METHODS OF THEIR SYNTHESIS AND USE 审中-公开
标题翻译：含有无机纳米粒子的纳米结构及其合成与使用方法
公开(公告)号：WO2008054376A2
公开(公告)日：2008-05-08
申请号：PCT/US2006/038561
申请日：2006-09-29
申请人： OWLSTONE NANOTECH, INC. , BOYLE, Paul , RUIZ-ALONSO, David , KOEHL, Andrew , RUSH, Martyn , PARRIS, Russell , WILKS, Ashley
发明人： BOYLE, Paul , RUIZ-ALONSO, David , KOEHL, Andrew , RUSH, Martyn , PARRIS, Russell , WILKS, Ashley
IPC分类号： G01N30/96
CPC分类号： G01N30/6095 , B01J20/28007 , B82Y30/00
摘要： The invention relates to novel micro- or nanostructures incorporating nanotubes, wherein nanotubes are synthesized or grown directly in or on components of a micro- or nano-structure. In a particular embodiment, the invention relates to methods of synthesizing or growing nanotubes in a gas chromatography column and their use in portable gas chromatography devices.
摘要翻译：本发明涉及纳入纳米管的新型微结构或纳米结构，其中纳米管直接在微结构或纳米结构的组分中或组分上合成或生长。在一个具体实施方案中，本发明涉及在气相色谱柱中合成或生长纳米管的方法及其在便携式气相色谱装置中的应用。

6. 发明申请

WO2009136190A1 SENSOR 审中-公开
标题翻译：传感器
公开(公告)号：WO2009136190A1
公开(公告)日：2009-11-12
申请号：PCT/GB2009/050466
申请日：2009-05-06
申请人： OWLSTONE LTD. , KOEHL, Andrew
发明人： KOEHL, Andrew
IPC分类号： G01N27/66
CPC分类号： G01N27/66
摘要： A method and sensor for monitoring chemical species in a gas flow are described. An ionised sample of gas is passed through a flow channel, with a DC electric field applied transverse to the longitudinal axis of the channel. Any electric current produced by the ion flow is measured, with variations in the current being indicative of a change in composition of the gas flow. In certain embodiments, the DC field may be varied over time, to sweep the field voltage. The detected current against field voltage graph may be taken as a profile of a particular gas composition. Variations in the profile again are indicative of a change in gas composition.
摘要翻译：描述了用于监测气流中的化学物质的方法和传感器。气体的电离样品通过流动通道，其中DC电场横向于通道的纵向轴线施加。测量由离子流产生的任何电流，其中电流的变化表示气流的组成变化。在某些实施例中，DC场可以随时间变化，以扫描场电压。检测到的电场电压图可以视为特定气体组成的轮廓。轮廓的变化再次表明气体成分的变化。

7. 发明申请

WO2008094299A2 SMART FAIMS SENSOR 审中-公开
标题翻译： SMART FAIMS传感器
公开(公告)号：WO2008094299A2
公开(公告)日：2008-08-07
申请号：PCT/US2007/073717
申请日：2007-07-17
申请人： OWLSTONE NANOTECH, INC. , BOYLE, Paul , RUSH, Martyn , RUIZ-ALONSO, David , KOEHL, Andrew , PARRIS, Russell , WILKS, Ashley
发明人： BOYLE, Paul , RUSH, Martyn , RUIZ-ALONSO, David , KOEHL, Andrew , PARRIS, Russell , WILKS, Ashley
CPC分类号： G01N27/624
摘要： A smart FAIMS sensor system and method includes an array of two or more FAIMS sensors and a controller configured to control independently each of the FAIMS sensors in the array. In a preferred embodiment, the sensor array is normally operated with one FAIMS sensor operating in a high sensitivity mode while the remaining sensors are turned off. When the high sensitivity FAIMS sensor detects a possible event, each of the remaining sensors is turned on in sequence to confirm the possible event. Each of the remaining sensors is operated in a different selectivity mode that together forms a characteristic signature of a target analyte. The characteristic signature is more robust against false positives and an alarm is registered only when all remaining sensors confirm the possible event detected by the high sensitivity sensor. In another embodiment, a smart FAIMS sensor system and method includes a 2/2-electrode filter that pumps the ions through the system and separates the ionic species, a detector for collecting the separated ions and generating a detector signal in response to the collected ions, and a controller configured to change the operating parameters of the system in response to changes in the sensor's environment detected by the sensor. The ability to dynamically change the operating parameters of the sensor enables the sensor to maintain high sensitivity to environmental threats while decreasing the incidences of false positive events.
摘要翻译：智能FAIMS传感器系统和方法包括两个或更多个FAIMS传感器的阵列和被配置为独立地控制阵列中的每个FAIMS传感器的控制器。在优选实施例中，传感器阵列通常以一个在高灵敏度模式下运行的FAIMS传感器工作，而剩下的传感器被关闭。当高灵敏度FAIMS传感器检测到可能的事件时，依次打开每个剩余的传感器以确认可能的事件。每个剩余的传感器以不同的选择性模式操作，共同形成目标分析物的特征。只有当所有剩余传感器确认高灵敏度传感器检测到的可能事件时，特征识别才能抵抗误报，而且只能报警。在另一个实施例中，智能FAIMS传感器系统和方法包括：2/2电极过滤器，其通过系统泵送离子并分离离子物质;用于收集分离离子的检测器，并响应于所收集的离子产生检测器信号以及控制器，被配置为响应于由传感器检测到的传感器的环境的变化而改变系统的操作参数。动态改变传感器工作参数的能力使传感器能够保持对环境威胁的高度敏感性，同时减少假阳性事件的发生率。

8. 发明申请

WO2008048247A2 METHODS OF SYNTHESIS OF NANOTUBES AND USES THEREOF 审中-公开
标题翻译：纳米管的合成方法及其用途
公开(公告)号：WO2008048247A2
公开(公告)日：2008-04-24
申请号：PCT/US2006/038566
申请日：2006-09-29
申请人： OWLSTONE NANOTECH, INC. , BOYLE, Paul , RUIZ-ALONSO, David , KOEHL, Andrew , RUSH, Martyn , PARRIS, Russell , WILKS, Ashley
发明人： BOYLE, Paul , RUIZ-ALONSO, David , KOEHL, Andrew , RUSH, Martyn , PARRIS, Russell , WILKS, Ashley
IPC分类号： H01L21/20
CPC分类号： B01J23/70 , B01J20/205 , B01J20/28007 , B01J20/281 , B01J37/0238 , B82B3/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/02 , C23C16/0281 , Y02P20/135
摘要： The invention relates to novel methods of incorporating nanotubes for use in micro- or nano-devices. The invention further relates to incorporating nanotubes in micro or nano- devices and particularly synthesizing or growing nanotubes directly in or on components of a micro- or nano-device. In a particular embodiment, the invention relates to methods of synthesizing or growing nanotubes in a gas chromatography column and their use in portable gas chromatography devices.
摘要翻译：本发明涉及纳入用于微纳米器件的纳米管的新方法。本发明进一步涉及将纳米管纳入微纳米器件，特别是在微纳米器件的组件中或其组件上直接合成或生长纳米管。在一个具体实施方案中，本发明涉及在气相色谱柱中合成或生长纳米管的方法及其在便携式气相色谱装置中的应用。

9. 发明申请

WO2007035825A3 ION GATE 审中-公开
标题翻译：离子门
公开(公告)号：WO2007035825A3
公开(公告)日：2007-06-28
申请号：PCT/US2006036687
申请日：2006-09-19
申请人： OWLSTONE NANOTECH INC , RUIZ-ALONSO DAVID , KOEHL ANDREW , BOYLE PAUL , RUSH MARTYN , PARRIS RUSSELL , WILKS ASHLEY
发明人： RUIZ-ALONSO DAVID , KOEHL ANDREW , BOYLE PAUL , RUSH MARTYN , PARRIS RUSSELL , WILKS ASHLEY
IPC分类号： H01J49/00
CPC分类号： H01J49/42
摘要： An ion gate is disposed between a first volume occupied by a first carrier gas and ions of the first carrier gas and a second volume occupied by a second carrier gas. The ion gate includes at least one channel connecting the first volume to the second volume, a first electrode disposed on an inlet surface of the ion gate facing the first volume, and a second electrode disposed on an outlet surface of the ion gate facing the second volume. Ions are transported from the first volume to the second volume through the channel under an electric field produced by the first and second electrode.
摘要翻译：离子门设置在由第一载气占据的第一体积和第一载气的离子和由第二载气占据的第二体积之间。离子浇口包括连接第一体积与第二体积的至少一个通道，设置在面向第一体积的离子门的入口表面上的第一电极，以及设置在面向第二体积的离子门的出口表面上的第二电极卷。在由第一和第二电极产生的电场下，离子通过通道从第一体积传送到第二体积。

10. 发明申请

WO2007050475A2 ION DRIVE AND ODOR EMITTER 审中-公开
标题翻译：离子驱动和气味发射器
公开(公告)号：WO2007050475A2
公开(公告)日：2007-05-03
申请号：PCT/US2006041178
申请日：2006-10-20
申请人： OWLSTONE NANOTECH INC , PARRIS RUSSELL , RUIZ-ALONSO DAVID , KOEHL ANDREW , RUSH MARTYN , BOYLE PAUL , WILKS ASHLEY
发明人： PARRIS RUSSELL , RUIZ-ALONSO DAVID , KOEHL ANDREW , RUSH MARTYN , BOYLE PAUL , WILKS ASHLEY
IPC分类号： H01J49/10 , H01J27/02 , H01J49/40
CPC分类号： H01J49/40
摘要： The present invention relates to an ion drive for selectively isolating an analyte of interest and methods of use thereof. The ion drive includes a substrate with channels therethrough, a conductive material coating on the bottom and top of the substrate, a top electrical lead connected to the conductive material coating covering the top of the substrate, and a bottom electrical lead connected to the conductive material coating covering the bottom of the substrate. The invention further relates to an odor emitter which is made up of an ion drive mounted towards the top of a vessel.
摘要翻译：本发明涉及用于选择性分离感兴趣分析物的离子驱动器及其使用方法。离子驱动器包括具有通道的衬底，在衬底的底部和顶部涂覆导电材料，连接到覆盖衬底顶部的导电材料涂层的顶部电引线和连接到导电材料的底部电引线涂层覆盖基底的底部。本发明还涉及一种气味发射器，其由朝向容器顶部安装的离子驱动器构成。

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