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1. 发明申请

WO2002083188A3 DENSE/POROUS STRUCTURES FOR USE AS BONE SUBSTITUTES 审中-公开
公开(公告)号：WO2002083188A3
公开(公告)日：2002-10-24
申请号：PCT/US2002/011909
申请日：2002-04-16
申请人： CASSIDY, James, J. , NORBERG, Brian, L. , HECKENDORF, Bradley, R. , KO, Ying
发明人： CASSIDY, James, J. , NORBERG, Brian, L. , HECKENDORF, Bradley, R. , KO, Ying
IPC分类号： A61F2/36
摘要： A combination dense/porous structure includes a porous element having an outer surface defining a shape having a bulk volume, the element includes a continuous framework having struts defining a plurality of interconnecting interstices throughout the bulk volume. The porous element has interconnecting interstices extending throughout the volume and opening through the surface. The combination dens/porous structure also includes a dense element formed from a material and having a sintered density of at least 95%, contacting at least a portion of the porous element; and an interconnection zone formed by the inter-penetration of the material forming the dense element into the porous element. The combination dense/porous structures are particularly useful as bone substitute materials and extended release delivery systems, preferable sustained release, for physiologically active agents. The interconnection zone can also be formed by a bonding phase that may or may not be the same material as the dense and/or porous element. A process for producing a combination dense/porous structure includes: providing a porous element; providing a dispersion comprising a ceramic or metal powder and a binder; contacting the dispersion with the porous element whereby the slip at least partially penetrates into at least a portion of the porous element to form an interconnection zone and a dense element formed from the dispersion and adjacent to the interconnection zone to form a dense/porous structure; treating the dense/porous structure to form a green dens/porous structure; and curing, drying, and/or heating the green dense/porous structure to form the combination dense/porous structure.

2. 发明申请

WO02083188A9 DENSE/POROUS STRUCTURES FOR USE AS BONE SUBSTITUTES 审中-公开
标题翻译： DENSE /多孔结构用作骨髓替代品
公开(公告)号：WO02083188A9
公开(公告)日：2003-08-28
申请号：PCT/US0211909
申请日：2002-04-16
申请人： CASSIDY JAMES J , NORBERG BRIAN L , HECKENDORF BRADLEY R , KO YING
发明人： CASSIDY JAMES J , NORBERG BRIAN L , HECKENDORF BRADLEY R , KO YING
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/42 , A61F2/44 , A61F2/46 , A61L27/10 , A61L27/56 , B22F7/00 , B28B1/24 , B28B1/26 , B28B19/00 , B28B23/00 , B29C45/14 , C12N5/08 , A61L
CPC分类号： A61L27/425 , A61F2/28 , A61F2/2803 , A61F2/30767 , A61F2/3094 , A61F2/4225 , A61F2/4241 , A61F2/4465 , A61F2002/2817 , A61F2002/2825 , A61F2002/2892 , A61F2002/30011 , A61F2002/30013 , A61F2002/30057 , A61F2002/30092 , A61F2002/30225 , A61F2002/3023 , A61F2002/30576 , A61F2002/30578 , A61F2002/30622 , A61F2002/30677 , A61F2002/30678 , A61F2002/30785 , A61F2002/30841 , A61F2002/30878 , A61F2002/3092 , A61F2002/30929 , A61F2002/30957 , A61F2002/30958 , A61F2002/30968 , A61F2002/30981 , A61F2002/4212 , A61F2002/4271 , A61F2002/4648 , A61F2210/0014 , A61F2230/0069 , A61F2250/0023 , A61F2250/0024 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61F2310/00365 , A61L27/427 , A61L27/56 , A61L2430/02 , B22F7/004 , B22F2998/00 , B28B1/24 , B28B1/26 , B28B19/00 , B28B23/0068 , B29C45/14795 , B22F3/225
摘要： A combination dense/porous structure includes a porous element having an outer surface defining a shape having a bulk volume, the element includes a continuous framework having struts defining a plurality of interconnecting interstices throughout the bulk volume. The porous element has interconnecting interstices extending throughout the volume and opening through the surface. The combination dens/porous structure also includes a dense element formed from a material and having a sintered density of at least 95%, contacting at least a portion of the porous element; and an interconnection zone formed by the inter-penetration of the material forming the dense element into the porous element. The combination dense/porous structures are particularly useful as bone substitute materials and extended release delivery systems, preferable sustained release, for physiologically active agents. The interconnection zone can also be formed by a bonding phase that may or may not be the same material as the dense and/or porous element. A process for producing a combination dense/porous structure includes: providing a porous element; providing a dispersion comprising a ceramic or metal powder and a binder; contacting the dispersion with the porous element whereby the slip at least partially penetrates into at least a portion of the porous element to form an interconnection zone and a dense element formed from the dispersion and adjacent to the interconnection zone to form a dense/porous structure; treating the dense/porous structure to form a green dens/porous structure; and curing, drying, and/or heating the green dense/porous structure to form the combination dense/porous structure.
摘要翻译：组合致密/多孔结构包括具有限定具有本体体积的形状的外表面的多孔元件，所述元件包括具有在整个体积中限定多个互连间隙的支柱的连续框架。多孔元件具有延伸贯穿整个体积并通过表面打开的互连间隙。组合密度/多孔结构还包括由材料形成并且具有至少95％的烧结密度的致密元件，与多孔元件的至少一部分接触; 以及通过将形成致密元件的材料相互渗入多孔元件而形成的互连区。组合致密/多孔结构特别可用作生物活性剂的骨替代材料和延长释放递送系统，优选持续释放。互连区域也可以通过粘结相形成，所述粘合相可以是或可以不是与致密和/或多孔元件相同的材料。用于生产组合致密/多孔结构的方法包括：提供多孔元件; 提供包含陶瓷或金属粉末和粘合剂的分散体; 使所述分散体与所述多孔元件接触，由此所述滑移部至少部分地渗入所述多孔元件的至少一部分，以形成互连区域和由所述分散体形成并且邻近所述互连区域形成致密/多孔结构的致密元件; 处理致密/多孔结构以形成绿色/多孔结构; 并固化，干燥和/或加热绿色致密/多孔结构以形成组合致密/多孔结构。

3. 发明申请

WO2002083188A2 DENSE/POROUS STRUCTURES FOR USE AS BONE SUBSTITUTES 审中-公开
标题翻译： DENSE /多孔结构用作骨髓替代品
公开(公告)号：WO2002083188A2
公开(公告)日：2002-10-24
申请号：PCT/US2002/011909
申请日：2002-04-16
申请人： CASSIDY, James, J. , NORBERG, Brian, L. , HECKENDORF, Bradley, R. , KO, Ying
发明人： CASSIDY, James, J. , NORBERG, Brian, L. , HECKENDORF, Bradley, R. , KO, Ying
IPC分类号： A61L
CPC分类号： A61L27/425 , A61F2/28 , A61F2/2803 , A61F2/30767 , A61F2/3094 , A61F2/4225 , A61F2/4241 , A61F2/4465 , A61F2002/2817 , A61F2002/2825 , A61F2002/2892 , A61F2002/30011 , A61F2002/30013 , A61F2002/30057 , A61F2002/30092 , A61F2002/30225 , A61F2002/3023 , A61F2002/30576 , A61F2002/30578 , A61F2002/30622 , A61F2002/30677 , A61F2002/30678 , A61F2002/30785 , A61F2002/30841 , A61F2002/30878 , A61F2002/3092 , A61F2002/30929 , A61F2002/30957 , A61F2002/30958 , A61F2002/30968 , A61F2002/30981 , A61F2002/4212 , A61F2002/4271 , A61F2002/4648 , A61F2210/0014 , A61F2230/0069 , A61F2250/0023 , A61F2250/0024 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61F2310/00365 , A61L27/427 , A61L27/56 , A61L2430/02 , B22F7/004 , B22F2998/00 , B28B1/24 , B28B1/26 , B28B19/00 , B28B23/0068 , B29C45/14795 , B22F3/225
摘要： A combination dense/porous structure includes a porous element having an outer surface defining a shape having a bulk volume, the element includes a continuous framework having struts defining a plurality of interconnecting interstices throughout the bulk volume. The porous element has interconnecting interstices extending throughout the volume and opening through the surface. The combination dens/porous structure also includes a dense element formed from a material and having a sintered density of at least 95%, contacting at least a portion of the porous element; and an interconnection zone formed by the inter-penetration of the material forming the dense element into the porous element. The combination dense/porous structures are particularly useful as bone substitute materials and extended release delivery systems, preferable sustained release, for physiologically active agents. The interconnection zone can also be formed by a bonding phase that may or may not be the same material as the dense and/or porous element. A process for producing a combination dense/porous structure includes: providing a porous element; providing a dispersion comprising a ceramic or metal powder and a binder; contacting the dispersion with the porous element whereby the slip at least partially penetrates into at least a portion of the porous element to form an interconnection zone and a dense element formed from the dispersion and adjacent to the interconnection zone to form a dense/porous structure; treating the dense/porous structure to form a green dens/porous structure; and curing, drying, and/or heating the green dense/porous structure to form the combination dense/porous structure.
摘要翻译：组合致密/多孔结构包括具有限定具有本体体积的形状的外表面的多孔元件，所述元件包括具有在整个体积中限定多个互连间隙的支柱的连续框架。多孔元件具有延伸贯穿整个体积并通过表面打开的互连间隙。组合密度/多孔结构还包括由材料形成并且具有至少95％的烧结密度的致密元件，与多孔元件的至少一部分接触; 以及通过将形成致密元件的材料相互渗入多孔元件而形成的互连区。组合致密/多孔结构特别可用作生物活性剂的骨替代材料和延长释放递送系统，优选持续释放。互连区域也可以通过粘结相形成，所述粘合相可以是或可以不是与致密和/或多孔元件相同的材料。用于生产组合致密/多孔结构的方法包括：提供多孔元件; 提供包含陶瓷或金属粉末和粘合剂的分散体; 使所述分散体与所述多孔元件接触，由此所述滑移部至少部分地渗入所述多孔元件的至少一部分，以形成互连区域和由所述分散体形成并且邻近所述互连区域形成致密/多孔结构的致密元件; 处理致密/多孔结构以形成绿色/多孔结构; 并固化，干燥和/或加热绿色致密/多孔结构以形成组合致密/多孔结构。

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