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    • 4. 发明申请
    • UNIVERSAL TRANSDUCER
    • 通用变频器
    • WO0101120A3
    • 2001-05-17
    • PCT/DE0002003
    • 2000-06-15
    • KNOLL MEINHARD
    • KNOLL MEINHARD
    • G01N33/487G01N27/26G01N27/30G01N27/403G01N27/404G01N27/414G01N27/416
    • G01N27/3271G01N27/3335
    • The invention relates to a universal transducer and to chemosensors and biosensors based on miniaturized universal transducers of the aforementioned type which are used, for example, in analytical chemistry, medical diagnosis and the like for determining substance concentrations or ion activities in fluids. The inventive universal transducer comprises a substrate which is comprised of at least two flat substrate layers (1, 2), whereby each of the substrate layers (1, 2) has at least one opening (4, 5). These openings (4, 5) form a coherent cavity which extends from a first active surface of the substrate over the first and the second substrate layers (1, 2). An electrically conductive layer which is in contact with a filling material of the cavity is at least partially arranged on the surfaces of at least one of the two substrate layers (1, 2), said surfaces facing away from the first active surface (10).
    • 本申请涉及一种Universaltransducer以及基于这样的小型化的Universaltransducer其中使用,例如,在化学分析,医学诊断等,用于确定流体中的材料浓度或离子活动的化学和生物传感器。 本发明的Universaltransducer包括具有至少两个平坦的载体层的支撑(1,2),其中,每个所述两个载体层(1,2)的至少一个开口(4,5)。 这些开口(4,5)形成通过所述第一和第二载体层(1,2)从所述载体的第一有源表面延伸的连续空腔。 来自两个载体层中的至少一个的表面背对所述第一有源表面(10)(1,2)被至少部分地设置的导电层,其与所述腔的填充接触。
    • 7. 发明申请
    • IMPLANTABLE SENSOR SYSTEM FOR DETERMINING CONCENTRATIONS OF SUBSTANCES IN LIVING ORGANISMS
    • 植入式传感器系统,燃料浓度在活测定
    • WO1996026668A1
    • 1996-09-06
    • PCT/DE1996000356
    • 1996-02-27
    • KNOLL, Meinhard
    • A61B05/00
    • A61B5/6865A61B5/14528A61B5/14532A61B5/4839A61B5/686
    • The invention concerns an implantable sensor system for determining concentrations of substances in living organisms, and a method for producing the same. Said system is characterized in that the substance-recognizing surface (1, 1') of at least one sensor (2, 2') is connected to at least one microtube-like permeable and flexible capillary membrane (3, 3') which, after implantation, contacts the living organism well. The capillary membrane is filled with a substance (4) enabling the substance to be analyzed, which has passed from the exterior into the interior of the capillary membrane (3, 3'), to be transported to the substance-recognizing sensor surface (1, 1'). The capillary membrane is connected by means of a duct (11, 11') in a holder (5, 5') to at least one septum (6, 6') such that substances can be introduced into and removed from the interior of the capillary membrane through the septum by means of an injection needle. Sensors of this type can be used for continuously measuring concentrations of glucose, lactate and other substances to be analyzed in the tissue or blood vessels of humans, animals and other organisms.
    • 一种可植入的传感器系统,用于确定在活的有机体和方法及其制备的材料浓度。 本发明涉及一种可植入的传感器系统,用于确定在活的有机体的物质的浓度,其特征在于具有至少一个微孔管状可渗透的和灵活的毛细管膜的材料,识别面(1,1“)的至少一个传感器(2,2”)(3,3“) 被连接,其进入与注入后的活生物体的良好接触,在另外的毛细管填充有物质(4)中,材料识别外部的输送到毛细管膜的内部(3,3“)输入的分析物 传感器表面(1,1“)还允许毛细管通过的通道(11,11的装置”)在保持器(5,5“)的至少一个隔片(6,6”)连接,与的帮助下 可以通过添加到毛细管膜和除去的内部隔膜材料是注射针。 这样的传感器可以用于连续测量在人,动物和其他生物的组织或血管葡萄糖,乳酸和其它分析物的浓度。