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1. 发明申请

WO2009038396A3 N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
公开(公告)号：WO2009038396A3
公开(公告)日：2009-03-26
申请号：PCT/KR2008/005574
申请日：2008-09-19
申请人： HANALL PHARMACEUTICAL COMPANY. LTD , KIM, Sung Wuk , JUN, Sung Soo , JO, Young Gwan , KOO, Ja Seong , KIM, Young Woong , KIM, Byoung Ha , KIM, Duck
发明人： KIM, Sung Wuk , JUN, Sung Soo , JO, Young Gwan , KOO, Ja Seong , KIM, Young Woong , KIM, Byoung Ha , KIM, Duck
IPC分类号： C07C279/26
摘要： Disclosed herein are a novel dicarboxylic acid salt of N,N- dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N- dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.

2. 发明申请

WO2009038396A2 N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译： N，N-二甲基咪唑二甲酰亚胺二酰胺二羧酸盐，生产该组合物的方法和包含该组合物的药物组合物
公开(公告)号：WO2009038396A2
公开(公告)日：2009-03-26
申请号：PCT/KR2008005574
申请日：2008-09-19
申请人： HANALL PHARMACEUTICAL CO LTD , KIM SUNG WUK , JUN SUNG SOO , JO YOUNG GWAN , KOO JA SEONG , KIM YOUNG WOONG , KIM BYOUNG HA , KIM DUCK
发明人： KIM SUNG WUK , JUN SUNG SOO , JO YOUNG GWAN , KOO JA SEONG , KIM YOUNG WOONG , KIM BYOUNG HA , KIM DUCK
IPC分类号： C07C279/26
CPC分类号： C07C279/26 , C07C55/08 , C07C55/12 , C07C55/14 , C07C59/245
摘要： Disclosed herein are a novel dicarboxylic acid salt of N,N- dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N- dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.
摘要翻译：本文公开了N，N-二甲基亚氨基二甲酰亚胺二酰胺的新型二羧酸盐，其制备方法和包含其的药物组合物。更具体地，本文公开了N的新颖的二羧酸盐，N- dimethylimidodicarbonimidic二酰胺，通过允许N，N-二酰胺dimethylimidodicarbonimidic与特定的二羧酸，其具有改善的物理和化学性质，包括溶解度反应制备的结晶酸加成盐性，稳定性，非吸湿性和抗粘接性，低毒性，因此是在不仅糖尿病及其并发症的预防和治疗患者的所谓的代谢综合征非常有效的，其中糖尿病，肥胖症，高脂血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊性卵巢综合征等出现在组合，而且p53基因缺陷型癌症，肌肉疼痛，肌肉细胞毒性和横纹肌溶解，以及它们的制备方法和包含其的药物组合物。

3. 发明申请

WO2011049400A3 PHARMACEUTICAL COMPOSITION CONTAINING ACID ADDITION SALT OF N,N-DIMETHYL IMIDOCARBONIMIDIC DIAMIDE FOR ANTI-CANCER 审中-公开
标题翻译：含有N，N-二甲基咪唑并二恶烷的抗酸剂的酸加成盐的药物组合物
公开(公告)号：WO2011049400A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007273
申请日：2010-10-22
申请人： HANALL BIOPHARMA CO LTD , KIM SUNG WUK , JUN SUNG SOO , KIM YOUNG WOONG , OH BYUNG KYU , LEE SEUNG HO
发明人： KIM SUNG WUK , JUN SUNG SOO , KIM YOUNG WOONG , OH BYUNG KYU , LEE SEUNG HO
IPC分类号： A61K31/155 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A61K31/155 , A61K45/06 , A61K2300/00
摘要： Provided is a use for anticancer of dichloroacetic acid salt or aminooxyacetic acid salt of N,N-dimethyl imidodicarbonimidic diamide (metformin). According to the present invention, the acid addition salt of metformin synergistically causes anticancer effect by AMPK enzyme activation of metformin and anticancer effect of organic acids used as a salt, and thus shows a remarkable anticancer effect. In addition, the acid addition salt has superior physiochemical properties such as solubility, stability, non-hygroscopicity, processibility as a tablet formulation and the like, and has lower toxicity compared with metformin hydrochloride. Therefore, the acid addition salt can be useful as a pharmaceutically acceptable salt.
摘要翻译：提供了N，N-二甲基亚氨基二甲酰亚胺二酰胺（二甲双胍）的二氯乙酸盐或氨基氧乙酸盐的抗癌剂的用途。根据本发明，二甲双胍的酸加成盐协同地引起二甲双胍的AMPK酶活化和作为盐的有机酸的抗癌作用的抗癌作用，因此显示出显着的抗癌作用。此外，酸加成盐具有优异的物理化学性质如溶解性，稳定性，非吸湿性，作为片剂制剂的加工性等，并且与二甲双胍盐酸盐相比具有较低的毒性。因此，酸加成盐可用作药学上可接受的盐。

4. 发明申请

WO2008093984A1 N, N- DIMETHYL IMIDODICARBONIMIDIC DIAMIDE ACETATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译： N，N-二甲基咪唑二羧酸二乙酸酯，其制备方法和包含其的药物组合物
公开(公告)号：WO2008093984A1
公开(公告)日：2008-08-07
申请号：PCT/KR2008/000529
申请日：2008-01-29
申请人： HANALL PHARMACEUTICAL COMPANY. LTD , KIM, Sung Wuk , JUN, Sung Soo , JO, Young Gwan , KOO, Ja Seong , KIM, Young Woong
发明人： KIM, Sung Wuk , JUN, Sung Soo , JO, Young Gwan , KOO, Ja Seong , KIM, Young Woong
IPC分类号： A61K31/155
CPC分类号： A61K31/155 , C07C279/26
摘要： The present invention relates to N,N -dimethyl imidodicarbonimidic diamide acetate, a method of preparing the same and a pharmaceutical composition comprising the same, and more particularly, to N,N-dimethyl imidodicarbonimidic diamide acetate which is a crystalline acid addition salt prepared by reacting N,N-dimethyl imidodicarbonimidic diamide with acetic acid, and which is very effective as a therapeutic agent for treating metabolic syndromes that glycosuria and diabetes mellitus, obesity, hyperlipidemia, fatty liver, coronary heart disease, osteoporosis, polycystic ovarian syndrome, a cancer depleted of gene P53, etc. are complexly occurred; treating diabetes mellitus and preventing its complication; and treating a cancer and preventing myalgia, muscle cell cytotoxicity and rhabdomyolysis, etc. since the acid addition salt is excellent in physicochemical properties such as solubility, stability, non-hygroscopicity, anti-adhering property, etc., and low toxicity, a method of preparing the same and a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及N，N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐，其制备方法和包含其的药物组合物，更具体地说，涉及作为结晶酸加成盐的N，N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐，其是由使N，N-二甲基亚氨基二亚甲基二酰胺与乙酸反应，作为治疗代谢综合征的糖尿病，糖尿病，肥胖症，高脂血症，脂肪肝，冠心病，骨质疏松症，多囊卵巢综合症，癌症，贫血基因P53等复杂发生; 治疗糖尿病并预防其并发症; 并且由于酸加成盐在溶解性，稳定性，非吸湿性，抗附着性等等的物理化学性质和低毒性方面都是优异的，因此治疗癌症并防止肌肉痛，肌肉细胞毒性和横纹肌溶解等。的制备方法和包含其的药物组合物。

5. 发明申请

WO2009088220A3 N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE NICOTINATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N，N-二甲基咪唑偶氮二异氰酸酯，其制备方法和包含其的药物组合物
公开(公告)号：WO2009088220A3
公开(公告)日：2009-09-03
申请号：PCT/KR2009000071
申请日：2009-01-07
申请人： HANALL PHARMACEUTICAL CO LTD , KIM SUNG WUK , JUN SUNG SOO , JO YOUNG GWAN , KOO JA SEONG , KIM YOUNG WOONG , KIM BYOUNG HA , KANG MIN SEOK
发明人： KIM SUNG WUK , JUN SUNG SOO , JO YOUNG GWAN , KOO JA SEONG , KIM YOUNG WOONG , KIM BYOUNG HA , KANG MIN SEOK
IPC分类号： C07D213/80
CPC分类号： C07D213/80
摘要： Disclosed herein are a novel nicotinic acid salt of N,N-dimethyl imidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are the nicotinic acid salt of N,N-dimethyl imidodicarbonimidic diamide, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also of p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as the preparation method thereof and the pharmaceutical composition comprising the same.
摘要翻译：本文公开了N，N-二甲基亚氨基二甲酰亚胺二酰胺的新型烟酸盐，其制备方法和包含其的药物组合物。更具体地说，本文公开了N，N-二甲基亚氨基二甲酰亚胺二酰胺的烟酸盐，其具有改善的物理和化学性质，包括溶解性，稳定性，非吸湿性和抗粘性，以及低毒性，因此非常有效出现糖尿病，肥胖，高脂血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征等所有代谢综合征患者的糖尿病及其并发症的预防与治疗， p53基因缺陷型癌症，肌肉疼痛，肌肉细胞毒性和横纹肌溶解症，以及其制备方法和包含其的药物组合物。

6. 发明申请

WO2011083998A3 BIGUANIDE DERIVATIVE, A PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE BIGUANIDE DERIVATIVE AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：双胍衍生物及其制备方法和含有双胍衍生物作为活性成分的药物组合物
公开(公告)号：WO2011083998A3
公开(公告)日：2011-10-27
申请号：PCT/KR2011000097
申请日：2011-01-06
申请人： HANALL BIOPHARMA CO LTD , KIM SUNG WUK , JUN SUNG SOO , MIN CHANG HEE , KIM YOUNG WOONG , KANG MIN SEOK , OH BYUNG KYU , PARK SE HWAN , KIM YONG EUN , KIM DUCK , LEE JI SUN , OH JU HOON
发明人： KIM SUNG WUK , JUN SUNG SOO , MIN CHANG HEE , KIM YOUNG WOONG , KANG MIN SEOK , OH BYUNG KYU , PARK SE HWAN , KIM YONG EUN , KIM DUCK , LEE JI SUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P3/10 , A61P35/00 , C07C277/02
CPC分类号： A61K31/155 , A61K31/341 , A61K31/4406 , A61K31/472 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07C279/26 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20
摘要： The present invention provides a biguanide derivative or pharmaceutically allowable salt thereof represented by Formula 1 with N1-N5 substitution, a preparation method thereof and a pharmaceutical composition containing the biguanide derivative as an active ingredient. Compared with conventional drugs, even a small amount of the biguanide derivative of the present invention exhibits excellent effects of AMPKa activation and inhibition of cancer cell proliferation, which makes it useful for the treatment of diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer and the like.
摘要翻译：本发明提供由式1表示的双胍衍生物或其药学允许的盐以及N1-N5取代物，其制备方法和含有该双胍衍生物作为活性成分的药物组合物。与常规药物相比，即使少量本发明的双胍衍生物也表现出优异的AMPKα活化作用和抑制癌细胞增殖的作用，这使其可用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉动脉疾病，骨质疏松症，多囊卵巢综合征，代谢综合征，癌症等。

7. 发明申请

WO2008066344A1 RF RECEIVER, RF TRANSCEIVER AND MIMO RF TRANSCEIVER EMBEDDING BALUN 审中-公开
标题翻译： RF接收器，RF收发器和MIMO射频收发器嵌入式BALUN
公开(公告)号：WO2008066344A1
公开(公告)日：2008-06-05
申请号：PCT/KR2007/006129
申请日：2007-11-30
申请人： XRONET CORPORATION , KIM, Young Woong
发明人： KIM, Young Woong
IPC分类号： H04B1/16
CPC分类号： H04B1/403
摘要： A radio frequency (RF) receiver, an RF transceiver and a multiple-input multiple-output (MIMO) RF transceiver for decreasing the number of pins are disclosed. The RF receiver, an RF transceiver, and a MIMO RF transceiver include a balun that is included in a chip. The balun converts a single-ended signal to a differential signal. Consequently, the number of pins may be decreased, and the costs may be reduced because around the balun, a matching circuit having an impedance of 50 ohms may not be required.
摘要翻译：公开了一种用于减少引脚数的射频（RF）接收器，RF收发器和多输入多输出（MIMO）RF收发器。 RF接收机，RF收发器和MIMO RF收发器包括包括在芯片中的平衡 - 不平衡转换器。平衡 - 不平衡变换器将单端信号转换为差分信号。因此，可以减少引脚数量，并且由于在平衡 - 不平衡变压器周围可能会降低成本，因此可能不需要具有50欧姆阻抗的匹配电路。

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