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1. 发明申请

WO2010058974A3 METHOD FOR COLLECTIVELY DETERMINING SENSITIVITY TO ANTI-CANCER THERAPEUTIC DRUG 审中-公开
标题翻译：综合判定抗癌治疗药物灵敏度的方法
公开(公告)号：WO2010058974A3
公开(公告)日：2010-09-23
申请号：PCT/KR2009006822
申请日：2009-11-19
申请人： ASAN FOUNDATION , KIM JIN CHEON , KIM MOON BO
发明人： KIM JIN CHEON , KIM MOON BO
IPC分类号： G01N33/574 , G01N33/48 , G01N33/53
CPC分类号： G01N33/5088 , G01N33/5011 , G01N2800/52
摘要： The present invention relates to a method for collectively testing sensitivity to both primary and secondary anti-cancer drugs through a one-time test under closely in vivo conditions. The present invention includes a method for collectively testing sensitivity of primary and secondary anti-cancer drugs to a tumor. The method comprises: (i) a step of preparing primary and secondary anti-cancer drug reaction plates; (ii) a step of injecting a tumor tissue specimen prepared from a patient to the reaction tablets of the primary and secondary anti-cancer drug reaction plates and culturing; (iii) a step of administering and reacting primary anti-cancer drug candidates to the reaction tablets of primary and secondary reaction plates; (iv) a step of measuring and analyzing sensitivity of the primary anti-cancer drug candidates treated to the reaction tablet of the primary anti-cancer drug reaction plate and administering and reacting secondary anti-cancer drug candidates to the tablet of the secondary anti-cancer drug reaction plate which have different combination with the primary anti-cancer drug; and (v) a step of measuring and analyzing sensitivity of secondary anti-cancer drug candidates treated to the reaction tablet of the secondary anti-cancer drug reaction plate.
摘要翻译：本发明涉及一种在紧密体内条件下通过一次性测试来共同测试初级和次级抗癌药物敏感性的方法。本发明包括一种一次和二次抗癌药物对肿瘤敏感性的方法。该方法包括：（i）制备一级和二级抗癌药物反应板的步骤; （ii）将从患者制备的肿瘤组织标本注射到一级和二级抗癌药物反应板的反应片中并进行培养的步骤; （iii）将初级抗癌药物候选物施用和反应到一级和二级反应板的反应片剂的步骤; （iv）测定和分析对初次抗癌药物反应板的反应片剂进行处理的初级抗癌药物候选物的敏感性的步骤，并将次级抗癌药物候选物施用于二次抗癌药物反应片的片剂，癌症药物反应板与初级抗癌药物有不同的组合; 和（v）对二次抗癌药物反应板的反应片剂进行处理的二次抗癌药物候选物的测定和分析敏感性的步骤。

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