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    • 3. 发明申请
    • STRUCTURE FOR REDUCING THERMAL DISPLACEMENT OF MACHINE TOOL STRUCTURE
    • 减少机床结构热位移的结构
    • WO2013012224A3
    • 2013-04-04
    • PCT/KR2012005642
    • 2012-07-16
    • DOOSAN INFRACORE CO LTDKIM WON NYUNGIM TAE WEONLEE YOON JONGLEE SANG KYOO
    • KIM WON NYUNGIM TAE WEONLEE YOON JONGLEE SANG KYOO
    • B23Q11/12B23Q11/14
    • B23Q11/126B23Q11/141Y10T409/303976
    • The present invention pertains to a structure for reducing the thermal displacement of a machine tool structure. The structure for reducing the thermal displacement of a machine tool structure, according to the present invention, includes: a fixed structure (100) which is provided to a machine tool and has a guide rail (102) formed at one side; a movable structure (120) which is mounted to the guide rail (102) and carries out movement; and a cooling section (300) which circulates cooling oil in the fixed structure (100) for cooling the fixed structure (100) and makes the temperature distribution of the fixed structure (100) uniform. The cooling section (300) includes a first cooling unit which is disposed in the fixed structure (100) so as to be adjacent to the guide rail (102) and carries out heat exchange between heat generated in the guide rail (102) and the cooling oil; a second cooling unit which is disposed at the side lower than the first cooling unit at an interval with reference to the entire construction of the fixed structure (100) for carrying out heat exchange; and a pump section (400) which is disposed at one side of the cooling section (300) and forces the cooling oil to circulate along the first and second cooling units.
    • 本发明涉及一种用于减小机床结构的热位移的结构。 根据本发明的用于减小机床结构的热位移的结构包括:固定结构(100),其设置在机床上并且具有形成在一侧的导轨(102); 可移动结构(120),其安装到所述导轨(102)并执行运动; 以及使所述固定结构(100)中的冷却油循环以冷却所述固定结构(100)并使所述固定结构(100)的温度分布均匀的冷却部(300)。 冷却部(300)包括:第一冷却单元,其设置在固定结构(100)中以与导轨(102)相邻,并且在导轨(102)中产生的热量与 冷却油; 第二冷却单元,其相对于固定结构(100)的整体结构间隔设置在比第一冷却单元低的一侧,用于进行热交换; 以及设置在所述冷却部(300)的一侧并迫使所述冷却油沿着所述第一和第二冷却单元循环的泵部(400)。
    • 7. 发明申请
    • NOVEL FLAVI MYCIN COMPOUND, ANTIFUNGAL COMPOSITION INCLUDING SAME, AND METHOD FOR PRODUCING SAME
    • 新型黄曲霉MYCIN化合物,含有该化合物的抗真菌组合物以及生产该组合物的方法
    • WO2012093855A2
    • 2012-07-12
    • PCT/KR2012000093
    • 2012-01-04
    • KOREA RES INST OF BIOSCIENCEKIM WON GONKWON YUN JUSOHN MI JIN
    • KIM WON GONKWON YUN JUSOHN MI JIN
    • A61K31/343A61P31/00A61P31/04
    • C07D307/87C12P17/162C12R1/66
    • The present invention provides a flavi mycin compound represented by Formula 1 or Formula 2, an isomer thereof, a derivative thereof having peptide deformylase-inhibitory activity, a pharmaceutically acceptable salt thereof, or an antifungal composition including as an active ingredient a strain, a bacteria, or a culture thereof, which produce the flavi mycin compound that is represented by Formula 1 of Formula 2, and provides a composition for suppressing peptide deformylase activity. The present invention also provides a method for preventing or treating a microorganism-contracted disease using the antifungal composition, a method for sterilizing a microorganism or rendering same bacteriostatic, and a method for producing the compound or the derivative thereof using an Aspergillus flavips F543 strain. The compound or the strain of the present invention strongly inhibits the activity of the peptide deformylase, thereby having a strong antifungal property against a pathogenic microorganism or antibiotics-tolerant bacteria, and in particular, can be useful in treating contagious diseases which are caused by super bacteria by exhibiting antifungal activity to metacillin-resistant Staphyloscoccus aureus and quinolone-resistant Staphyloscoccus aureaus.
    • 本发明提供由式1或式2表示的黄假病毒化合物,其异构体,具有肽脱甲基酶抑制活性的衍生物,其药学上可接受的盐或包含作为活性成分的抗真菌组合物的菌株,细菌 或其培养物,其产生由式2的式1表示的黄黄霉素化合物,并提供用于抑制肽脱甲酰酶活性的组合物。 本发明还提供了一种使用该抗真菌组合物预防或治疗微生物感染疾病的方法,一种消毒微生物或赋予相同抑菌剂的方法,以及一种使用曲霉Aspergillus flavips F543菌株生产该化合物或其衍生物的方法。 本发明的化合物或菌株强烈抑制肽脱甲酰基酶的活性,因此对致病微生物或耐受抗生素的细菌具有强的抗真菌特性,特别是可用于治疗由超级细菌引起的传染性疾病 通过对耐甲氧西林的金黄色葡萄球菌和耐喹诺酮金黄色葡萄球菌表现出抗真菌活性。